HOME LIGAND hPROTEOME OTHERS DOCUMENT

P15056 | BRAF_HUMAN | Serine/threonine-protein kinase B-raf (BRAF)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: "Ubiquitin-like" // RBD ]

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[ Domain: "Kinase suppressor of Ras 1 helical hairpin domain" // EUF08088 ]

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[ Domain: "Kinase suppressor of Ras 1 helical hairpin domain" // UNK_F_TYPE ]

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[ Domain: "Cysteine-rich domain" // C1_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4855730 OBDepict F NH S N O O H 2 N O HN IC50 = -41800.0 nM 452.51 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804349 cell-based format
CHEMBL4868141 OBDepict H 2 N N O O HN NH S O O IC50 = -41500.0 nM 532.67 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2OC2CCCCC2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804349 cell-based format
CHEMBL4867931 OBDepict H 3 C O N H S N O O H 2 N O HN IC50 = -35800.0 nM 464.55 COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(-c2ccc3c(c2)CCNC3=O)c1 Homo sapiens CHEMBL4804349 cell-based format
CHEMBL4860979 OBDepict F S N O O CH 3 N H 2 N O N H IC50 = -4600.0 nM 466.54 CN(C1CC1)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3ccc4c(c3)CCNC4=O)c2)c(F)c1 Homo sapiens CHEMBL4804349 cell-based format
CHEMBL500659 OBDepict OH N N N CH 3 N IC50 = 0.02 nM 304.35 Cn1cc(-c2ccc3c(c2)CC/C3=NO)c(-c2ccncc2)n1 Homo sapiens CHEMBL1008210 single protein format
CHEMBL526479 OBDepict OH N N N N HN IC50 = 0.03 nM 373.46 O/N=C1CCc2cc(-c3cn(C4CCNCC4)nc3-c3ccncc3)ccc21 Homo sapiens CHEMBL1008210 single protein format
CHEMBL498344 OBDepict OH N N N H N H HO IC50 = 0.04 nM 388.47 O/N=C1CCc2cc(-c3cn([C@@H]4CCC[C@H](O)C4)nc3-c3ccncc3)ccc21 Homo sapiens CHEMBL1008210 single protein format
CHEMBL527029 OBDepict OH N N N N HO IC50 = 0.05 nM 348.41 OCCCn1cc(-c2ccc3c(c2)CC/C3=NO)c(-c2ccncc2)n1 Homo sapiens CHEMBL1008210 single protein format
CHEMBL4749470 OBDepict F S F N H O O F N H Cl O S N N NH 2 Ki <= 0.08 nM 513.91 Nc1ncnc2c(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)csc12 Homo sapiens CHEMBL4673067 cell-based format
CHEMBL4755886 OBDepict F S F HN O O F N H Cl O N N NH 2 N Ki <= 0.08 nM 584.97 Nc1ncnc2c(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)cc(-c3cccnc3)cc12 Homo sapiens CHEMBL4673067 cell-based format
CHEMBL4757144 OBDepict CH 3 N H O N NH 2 N Cl F N H S O O F F Ki <= 0.08 nM 521.91 Cc1cc(C(=O)Nc2c(Cl)ccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)c2ncnc(N)c2c1 Homo sapiens CHEMBL4673067 cell-based format
CHEMBL4758903 OBDepict N CH 3 H 3 C NH O F CH 3 N O N H 3 C Ki < 0.08 nM 454.51 Cc1cc(F)c(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1ccc2c(=O)n(C)ncc2c1 Homo sapiens CHEMBL4715072 single protein format
CHEMBL4778772 OBDepict O HN N H F CH 3 H 3 C CH 3 CH 3 N O N H 3 C Ki < 0.08 nM 410.49 Cc1cc(F)c(NC(=O)NCCC(C)(C)C)cc1-c1ccc2c(=O)n(C)ncc2c1 Homo sapiens CHEMBL4715072 single protein format
CHEMBL4775998 OBDepict O NH N H F H 3 C CH 3 H 3 C CH 3 N NH 2 Ki < 0.08 nM 394.49 Cc1cc(F)c(NC(=O)NCCC(C)(C)C)cc1-c1ccc2cc(N)ncc2c1 Homo sapiens CHEMBL4715072 single protein format
CHEMBL4780060 OBDepict O HN N H F N H CH 3 H 3 C CH 3 CH 3 F N O N CH 3 Ki < 0.08 nM 443.5 Cc1cc(F)c(NC(=O)NCCC(C)(C)C)cc1Nc1ccc2ncn(C)c(=O)c2c1F Homo sapiens CHEMBL4715072 single protein format
CHEMBL4752754 OBDepict CH 3 N N H 3 C N H O N NH 2 N Cl F HN S O O F Ki <= 0.08 nM 584.01 Cc1nn(C)cc1-c1cc(C(=O)Nc2c(Cl)ccc(NS(=O)(=O)c3ccccc3F)c2F)c2ncnc(N)c2c1 Homo sapiens CHEMBL4673067 cell-based format
CHEMBL3651664 OBDepict CH 3 S N H O O F Cl N N H N H 3 C CH 3 H 3 C N NH 2 IC50 = 0.08 nM 466.97 CCCS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C(C)(C)C)nc2-c2ccnc(N)n2)c1F Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651683 OBDepict N N H N N N N H F Cl N H S O O CH 3 IC50 = 0.08 nM 475.94 CS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C3CC3)nc2-c2ccnc(NCCC#N)n2)c1F Homo sapiens CHEMBL3887046 single protein format
CHEMBL521562 OBDepict OH N N N H N H HO IC50 = 0.09 nM 388.47 O/N=C1CCc2cc(-c3cn([C@@H]4CCC[C@@H](O)C4)nc3-c3ccncc3)ccc21 Homo sapiens CHEMBL1008210 single protein format
CHEMBL1276170 OBDepict Cl N N N H N H N CH 3 N N N H IC50 < 0.1 nM 533.04 CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(Cl)c1 Homo sapiens CHEMBL1285565 single protein format
CHEMBL3651609 OBDepict CH 3 S N H O O Cl N N H N H 3 C CH 3 H 3 C N N H N H H 3 C H O O CH 3 IC50 = 0.1 nM 564.11 CCCS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C(C)(C)C)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651613 OBDepict CH 3 O N H O H 3 C H N H N N N N H H 3 C CH 3 H 3 C Cl N H S O O CH 3 IC50 = 0.1 nM 550.09 CCS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C(C)(C)C)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651610 OBDepict CH 3 O N H O H 3 C H N H N N N N H H 3 C H 3 C CH 3 Cl N H S O O IC50 = 0.1 nM 562.1 COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)C3CC3)c2)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651662 OBDepict Cl N H S F N O O F F H N N N H 2 N IC50 = 0.1 nM 520.92 Nc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)c3c(F)cccc3F)c2F)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL1276185 OBDepict F N N N H N H N CH 3 N N N F H IC50 < 0.1 nM 534.57 CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4ccc(F)c5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1 Homo sapiens CHEMBL1285565 single protein format
CHEMBL3752213 OBDepict H 3 C S N H O O F F O H 3 C N N H HN CH 3 H O O CH 3 IC50 = 0.1 nM 522.57 CCCS(=O)(=O)Nc1ccc(F)c(-c2cc3cnc(NC[C@H](C)NC(=O)OC)cc3cc2OC)c1F Homo sapiens CHEMBL3755449 single protein format
CHEMBL4740241 OBDepict CH 3 N H N N N CH 3 O CH 3 NH F N H O H 3 C CH 3 H 3 C Ki = 0.102 nM 440.52 CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(=O)n(C)c2n1 Homo sapiens CHEMBL4715072 single protein format
CHEMBL3651680 OBDepict CH 3 S N H O O Cl F N N H N N N H CH 3 IC50 = 0.11 nM 464.95 CCCS(=O)(=O)Nc1cc(F)cc(-c2[nH]c(C3CC3)nc2-c2ccnc(NC)n2)c1Cl Homo sapiens CHEMBL3887046 single protein format
CHEMBL1276186 OBDepict F N F N N H N H N CH 3 N N N F H IC50 = 0.11 nM 552.56 CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(-c2ccnc3c(-c4ccc(F)c5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1 Homo sapiens CHEMBL1285565 single protein format
CHEMBL3651658 OBDepict N N H N N N N H H 3 C F Cl N H S O O CH 3 IC50 = 0.11 nM 489.96 CC1(c2nc(-c3ccnc(NCCC#N)n3)c(-c3cc(Cl)cc(NS(C)(=O)=O)c3F)[nH]2)CC1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL2047875 OBDepict F S HN O O F NH Cl O N N NH 2 IC50 = 0.11 nM 455.87 Nc1ncnc2c(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)CCCF)c3F)cccc12 Homo sapiens CHEMBL2050455 cell-based format
CHEMBL3651703 OBDepict CH 3 S N H O O F F N N H N H 3 C CH 3 H 3 C N N H N H H 3 C H O O CH 3 IC50 = 0.12 nM 565.65 CCCS(=O)(=O)Nc1c(F)ccc(-c2[nH]c(C(C)(C)C)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F Homo sapiens CHEMBL3887046 single protein format
CHEMBL4776565 OBDepict O NH F CH 3 CH 3 H 3 C CH 3 N O N H 3 C Ki = 0.12 nM 409.51 Cc1cc(F)c(C(=O)NCCCC(C)(C)C)cc1-c1ccc2c(=O)n(C)ncc2c1 Homo sapiens CHEMBL4715072 single protein format
CHEMBL3651701 OBDepict N N H N N N N H F N H S O O CH 3 IC50 = 0.13 nM 469.55 CCCS(=O)(=O)Nc1cccc(-c2[nH]c(C3CC3)nc2-c2ccnc(NCCC#N)n2)c1F Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651661 OBDepict Cl N H S F N O O F F N H N CH 3 H 3 C CH 3 N NH 2 IC50 = 0.13 nM 536.97 CC(C)(C)c1nc(-c2ccnc(N)n2)c(-c2cc(Cl)cc(NS(=O)(=O)c3c(F)cccc3F)c2F)[nH]1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651695 OBDepict CH 3 S N H O O Cl N N H N N N H N H H 3 C H O O CH 3 IC50 = 0.13 nM 548.07 CCCS(=O)(=O)Nc1cccc(-c2[nH]c(C3CC3)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1Cl Homo sapiens CHEMBL3887046 single protein format
CHEMBL525191 OBDepict HO N N N N HO IC50 = 0.13 nM 334.38 OCCn1cc(-c2ccc3c(c2)CC/C3=NO)c(-c2ccncc2)n1 Homo sapiens CHEMBL1008210 single protein format
CHEMBL3577124 OBDepict CH 3 N H N N N H 3 C CH 3 NH F N H O H 3 C CH 3 H 3 C Ki = 0.139 nM 424.52 CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(C)nc2n1 Homo sapiens CHEMBL4715072 single protein format
CHEMBL500406 OBDepict OH N N N H N IC50 = 0.15 nM 290.33 O/N=C1CCc2cc(-c3c[nH]nc3-c3ccncc3)ccc21 Homo sapiens CHEMBL1008210 single protein format
CHEMBL3933272 OBDepict CH 3 N N N H N O S O F F F IC50 = 0.152 nM 498.53 Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1nc(N2CCOCC2)c2sccc2n1 Homo sapiens CHEMBL3887883 single protein format
CHEMBL477989 OBDepict HO N N H N N O N CH 3 H 3 C Ki = 0.16 nM 453.55 CN(C)CCOc1ccc(-c2nc(-c3ccncc3)c(-c3ccc4c(c3)CC/C4=NO)[nH]2)cc1 Homo sapiens CHEMBL2039767 single protein format
CHEMBL3651697 OBDepict CH 3 S N H O O F N N H N N N H N H H 3 C H O O CH 3 IC50 = 0.16 nM 531.61 CCCS(=O)(=O)Nc1cccc(-c2[nH]c(C3CC3)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F Homo sapiens CHEMBL3887046 single protein format
CHEMBL1276179 OBDepict F N F N N H N H N CH 3 N N N H IC50 = 0.16 nM 534.57 CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1 Homo sapiens CHEMBL1285565 single protein format
CHEMBL3651628 OBDepict CH 3 O N H O H 3 C H NH N N N N H Cl Cl HN S O O H 3 C IC50 = 0.18 nM 554.46 COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(C)(=O)=O)c2Cl)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651629 OBDepict CH 3 O NH O H 3 C H N H N N N N H F Cl NH S O O IC50 = 0.18 nM 564.04 COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)C3CC3)c2F)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL2047879 OBDepict F S NH O O F N H Cl O S N N H 2 N IC50 = 0.18 nM 461.9 Nc1ncnc2c(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)CCCF)c3F)csc12 Homo sapiens CHEMBL2050455 cell-based format
CHEMBL4778419 OBDepict N CH 3 H 3 C NH O F CH 3 N N O N H 3 C Ki = 0.19 nM 455.49 Cc1cc(F)c(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cnc2c(=O)n(C)ncc2c1 Homo sapiens CHEMBL4715072 single protein format
CHEMBL525191 OBDepict HO N N N N HO Ki = 0.19 nM 334.38 OCCn1cc(-c2ccc3c(c2)CC/C3=NO)c(-c2ccncc2)n1 Homo sapiens CHEMBL2173451 assay format
CHEMBL3651674 OBDepict F N H S Cl N O O F F H N N N H 2 N IC50 = 0.19 nM 520.92 Nc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(F)cc(NS(=O)(=O)c3c(F)cccc3F)c2Cl)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651606 OBDepict CH 3 O N H O H 3 C H NH N N N N H F CH 3 HN S O O H 3 C IC50 = 0.2 nM 517.59 COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(C)cc(NS(C)(=O)=O)c2F)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3932572 OBDepict H 3 C S N H O O Cl N N N H 3 C CH 3 N N H N H H 3 C H O O CH 3 IC50 = 0.2 nM 550.09 CCCS(=O)(=O)Nc1cc(Cl)cc(-c2nn(C(C)C)cc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1 Homo sapiens CHEMBL3881301 single protein format
CHEMBL1668922 OBDepict OH N HN O N N N IC50 = 0.2 nM 357.37 O/N=C1CCc2cc(Nc3c(-c4ncccn4)oc4cnccc34)ccc21 Homo sapiens CHEMBL1671058 assay format
CHEMBL3651675 OBDepict CH 3 S N H O O Cl F N N H N N NH 2 IC50 = 0.2 nM 450.93 CCCS(=O)(=O)Nc1cc(F)cc(-c2[nH]c(C3CC3)nc2-c2ccnc(N)n2)c1Cl Homo sapiens CHEMBL3887046 single protein format
CHEMBL1822264 OBDepict CH 3 O N N H N N H O F F N H S O O S IC50 = 0.2 nM 465.46 COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4cccs4)c3F)cc12 Homo sapiens CHEMBL1827040 assay format
CHEMBL3613198 OBDepict H 3 C N H S O O N H N CH 3 H 3 C N N Br N H IC50 = 0.2 nM 425.31 CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]cc(Br)c23)c1 Homo sapiens CHEMBL3615800 assay format
CHEMBL3236471 OBDepict H 3 C S N H O O N O F N O N H 3 C IC50 = 0.2 nM 416.43 CCCS(=O)(=O)Nc1ccc(F)c(Oc2ccc3ncn(C)c(=O)c3c2)c1C#N Homo sapiens CHEMBL3240201 assay format
CHEMBL3236470 OBDepict H 3 C S N H O O N O Cl N O N H 3 C IC50 = 0.2 nM 432.89 CCCS(=O)(=O)Nc1ccc(Cl)c(Oc2ccc3ncn(C)c(=O)c3c2)c1C#N Homo sapiens CHEMBL3240201 assay format
CHEMBL3651626 OBDepict CH 3 O N H O H 3 C H NH N N N N H F F HN S O O H 3 C IC50 = 0.2 nM 521.55 COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(F)cc(NS(C)(=O)=O)c2F)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3236463 OBDepict H 3 C S N H O O N N H Cl N O N H 3 C IC50 = 0.2 nM 431.91 CCCS(=O)(=O)Nc1ccc(Cl)c(Nc2ccc3ncn(C)c(=O)c3c2)c1C#N Homo sapiens CHEMBL3240201 assay format
CHEMBL4216073 OBDepict CH 3 NH O N N CH 3 HN O F F F IC50 = 0.2 nM 452.44 CC(=O)Nc1cn2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 Homo sapiens CHEMBL4181655 cell-based format
CHEMBL4438001 OBDepict Cl N H O NH CH 3 O N N N H IC50 = 0.2 nM 445.91 Cc1ccc(C(=O)Nc2cccc(Cl)c2)cc1NC(=O)C1(c2ncnc3[nH]ccc23)CC1 Homo sapiens CHEMBL4331432 single protein format
CHEMBL3705042 OBDepict CH 3 O N H O H 3 C H NH N N N N H F Cl HN S O O H 3 C IC50 = 0.2 nM 538.01 COC(=O)N[C@@H](C)CNc1nccc(-c2[nH]c(C3CC3)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL497671 OBDepict OH N N N N O IC50 = 0.22 nM 374.44 O/N=C1CCc2cc(-c3cn(C4CCOCC4)nc3-c3ccncc3)ccc21 Homo sapiens CHEMBL1008210 single protein format
CHEMBL3651667 OBDepict H 2 N N N N N H H 3 C H 3 C CH 3 Cl N H S O O F F IC50 = 0.22 nM 518.98 CC(C)(C)c1nc(-c2ccnc(N)n2)c(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2Cl)[nH]1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651676 OBDepict H 3 C O N H O CH 3 H N H N N N N H F Cl N H S O O CH 3 IC50 = 0.23 nM 552.03 COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CCC3)[nH]c2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651655 OBDepict N N H N N N N H H 3 C Cl F N H S O O CH 3 IC50 = 0.23 nM 489.96 CC1(c2nc(-c3ccnc(NCCC#N)n3)c(-c3cc(F)cc(NS(C)(=O)=O)c3Cl)[nH]2)CC1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL1276169 OBDepict F N N N H N H N CH 3 N N N H IC50 = 0.23 nM 516.58 CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1 Homo sapiens CHEMBL1285565 single protein format
CHEMBL498688 OBDepict CH 3 N H N N N N HO IC50 = 0.23 nM 401.51 CNC1CCCC(n2cc(-c3ccc4c(c3)CC/C4=NO)c(-c3ccncc3)n2)C1 Homo sapiens CHEMBL1008210 single protein format
CHEMBL3651630 OBDepict CH 3 O N H O H 3 C H N H N N N N H F Cl N H S O O CH 3 IC50 = 0.24 nM 552.03 CCS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C3CC3)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651671 OBDepict CH 3 O N H O H 3 C H HN N N N N H F CH 3 N H S O O F F F IC50 = 0.25 nM 585.58 COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(C)cc(NS(=O)(=O)CC(F)(F)F)c2F)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651672 OBDepict F N H S Cl N O O F F N H N CH 3 H 3 C CH 3 N NH 2 IC50 = 0.26 nM 536.97 CC(C)(C)c1nc(-c2ccnc(N)n2)c(-c2cc(F)cc(NS(=O)(=O)c3c(F)cccc3F)c2Cl)[nH]1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651633 OBDepict CH 3 O HN O CH 3 H N H N N N N H F Cl N H S O O IC50 = 0.26 nM 578.07 COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)CC3CC3)c2F)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651684 OBDepict H 3 C O HN O CH 3 H NH N N N N H CH 3 H 3 C CH 3 F NH S O O IC50 = 0.27 nM 545.64 COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cccc(NS(=O)(=O)C3CC3)c2F)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651639 OBDepict H 3 C O N H O CH 3 H N H N N N N H CH 3 CH 3 H 3 C F Cl N H S O O CH 3 IC50 = 0.28 nM 554.05 COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651656 OBDepict N N H N N N N H CH 3 Cl CH 3 N H S O O CH 3 IC50 = 0.29 nM 486.0 Cc1cc(NS(C)(=O)=O)c(Cl)c(-c2[nH]c(C3(C)CC3)nc2-c2ccnc(NCCC#N)n2)c1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3301612 OBDepict H 3 C O N H O CH 3 H N H N N N N H 3 C CH 3 F Cl N H S O O CH 3 IC50 = 0.3 nM 540.02 COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 Homo sapiens CHEMBL3881301 single protein format
CHEMBL578391 OBDepict H 3 C N O N N N N OH Cl IC50 = 0.3 nM 473.96 CC(=O)N1C2CCC1CC(c1ccnc3c(-c4ccc(Cl)c(O)c4)c(-c4ccncc4)nn13)C2 Homo sapiens CHEMBL1043507 single protein format
CHEMBL4061139 OBDepict H 3 C N H N N N H O CH 3 N H O Cl IC50 = 0.3 nM 435.92 CNc1cc(C2(C(=O)Nc3cc(C(=O)Nc4cccc(Cl)c4)ccc3C)CC2)ncn1 Homo sapiens CHEMBL4050071 assay format
CHEMBL3236472 OBDepict H 3 C S N H O O N O N O N H 3 C IC50 = 0.3 nM 398.44 CCCS(=O)(=O)Nc1cccc(Oc2ccc3ncn(C)c(=O)c3c2)c1C#N Homo sapiens CHEMBL3240201 assay format
CHEMBL3236464 OBDepict H 3 C S N H O O N N H N O N H 3 C IC50 = 0.3 nM 397.46 CCCS(=O)(=O)Nc1cccc(Nc2ccc3ncn(C)c(=O)c3c2)c1C#N Homo sapiens CHEMBL3240201 assay format
CHEMBL4216386 OBDepict H 3 C N H O N N CH 3 HN O Cl IC50 = 0.3 nM 418.88 CC(=O)Nc1cn2cc(-c3cc(NC(=O)c4cccc(Cl)c4)ccc3C)ccc2n1 Homo sapiens CHEMBL4181655 cell-based format
CHEMBL4217462 OBDepict CH 3 NH O N N CH 3 HN O H 3 C H 3 C CH 3 IC50 = 0.3 nM 440.55 CC(=O)Nc1cn2cc(-c3cc(NC(=O)c4cccc(C(C)(C)C)c4)ccc3C)ccc2n1 Homo sapiens CHEMBL4181655 cell-based format
CHEMBL570421 OBDepict H 3 C O N O N N N N OH CH 3 IC50 < 0.3 nM 483.57 CCOC(=O)N1C2CCC1CC(c1ccnc3c(-c4ccc(C)c(O)c4)c(-c4ccncc4)nn13)C2 Homo sapiens CHEMBL1043507 single protein format
CHEMBL1667922 OBDepict H N N Cl HN CH 3 O N N N IC50 = 0.3 nM 376.81 Cc1cc(Nc2c(-c3ncccn3)oc3cnccc23)c2cn[nH]c2c1Cl Homo sapiens CHEMBL1670302 assay format
CHEMBL3651611 OBDepict H 3 C O N H O CH 3 H HN N N N N H H 3 C H 3 C CH 3 Cl N H S O O CH 3 CH 3 IC50 = 0.3 nM 578.14 COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)CC(C)C)c2)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL3651635 OBDepict CH 3 O NH O H 3 C H N H N N N N H Cl F NH S O O IC50 = 0.3 nM 564.04 COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(F)cc(NS(=O)(=O)C3CC3)c2Cl)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL1276196 OBDepict F N F N N H N H N N N N H IC50 < 0.32 nM 574.64 Fc1cc(N2C[C@@H]3C[C@H]2CN3C2CCC2)cc(F)c1-c1ccnc2c(-c3cccc4[nH]ncc34)c(-c3ccncc3)nn12 Homo sapiens CHEMBL1285565 single protein format
CHEMBL1276195 OBDepict H 3 C CH 3 N H H N F F N N N N N N H IC50 < 0.32 nM 576.66 CC(C)CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1 Homo sapiens CHEMBL1285565 single protein format
CHEMBL1276171 OBDepict Br N N N H N H N CH 3 N N N H IC50 < 0.32 nM 577.49 CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(Br)c1 Homo sapiens CHEMBL1285565 single protein format
CHEMBL1276193 OBDepict H 3 C N H H N F F N N N N N N H IC50 < 0.32 nM 548.6 CCN1C[C@@H]2C[C@H]1CN2c1cc(F)c(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1 Homo sapiens CHEMBL1285565 single protein format
CHEMBL1276184 OBDepict H 3 C N N N H N H N CH 3 N N N F H IC50 < 0.32 nM 530.61 Cc1cc(N2C[C@@H]3C[C@H]2CN3C)ccc1-c1ccnc2c(-c3ccc(F)c4[nH]ncc34)c(-c3ccncc3)nn12 Homo sapiens CHEMBL1285565 single protein format
CHEMBL1081284 OBDepict H 3 C N N N H N H N CH 3 N HO F IC50 < 0.32 nM 506.59 Cc1cc(N2C[C@@H]3C[C@H]2CN3C)ccc1-c1ccnc2c(-c3ccc(F)c(O)c3)c(-c3ccncc3)nn12 Homo sapiens CHEMBL1115841 cell-based format
CHEMBL1276194 OBDepict H 3 C N CH 3 H H N F F N N N N N N H IC50 < 0.32 nM 562.63 CC(C)N1C[C@@H]2C[C@H]1CN2c1cc(F)c(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1 Homo sapiens CHEMBL1285565 single protein format
CHEMBL1081283 OBDepict HO F N N N N N H H N CH 3 IC50 < 0.32 nM 492.56 CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4ccc(F)c(O)c4)c(-c4ccncc4)nn23)cc1 Homo sapiens CHEMBL1115841 cell-based format
CHEMBL1087013 OBDepict HO N N N N F N H H N CH 3 IC50 < 0.32 nM 492.56 CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc(O)c4)c(-c4ccncc4)nn23)c(F)c1 Homo sapiens CHEMBL1115841 cell-based format
CHEMBL1086882 OBDepict OH N N N N CH 3 N H H N H 3 C IC50 < 0.32 nM 488.6 Cc1cc(N2C[C@@H]3C[C@H]2CN3C)ccc1-c1ccnc2c(-c3cccc(O)c3)c(-c3ccncc3)nn12 Homo sapiens CHEMBL1115841 cell-based format
CHEMBL1088439 OBDepict OH F N N N N N H H HN IC50 < 0.32 nM 478.53 Oc1cc(-c2c(-c3ccncc3)nn3c(-c4ccc(N5C[C@@H]6C[C@H]5CN6)cc4)ccnc23)ccc1F Homo sapiens CHEMBL1115841 cell-based format
CHEMBL3651607 OBDepict H 3 C O N H O CH 3 H N H N N N N H CH 3 CH 3 H 3 C Cl N H S O O CH 3 IC50 = 0.32 nM 536.06 COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cc(Cl)cc(NS(C)(=O)=O)c2)n1 Homo sapiens CHEMBL3887046 single protein format
CHEMBL1088438 OBDepict OH N N N N Cl N H H HN IC50 < 0.32 nM 494.99 Oc1cccc(-c2c(-c3ccncc3)nn3c(-c4ccc(N5C[C@@H]6C[C@H]5CN6)cc4Cl)ccnc23)c1 Homo sapiens CHEMBL1115841 cell-based format
CHEMBL1088437 OBDepict OH N N N N F N H H HN IC50 < 0.32 nM 478.53 Oc1cccc(-c2c(-c3ccncc3)nn3c(-c4ccc(N5C[C@@H]6C[C@H]5CN6)cc4F)ccnc23)c1 Homo sapiens CHEMBL1115841 cell-based format