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P15086 | CBPB1_HUMAN | Carboxypeptidase B (CPB1)

3D structures mapped by conservation among orthologs

[ Domain: "Zn-dependent exopeptidases" // Peptidase_M14 ]

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[ Domain: "Protease propeptides/inhibitors" // Propep_M14 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4460840 OBDepict H 3 C CH 3 N H H NH O O CH 3 P H O OH H O OH Ki = 0.12 nM 502.55 CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)P(=O)(O)C[C@@H](Cc1ccccc1)C(=O)O Homo sapiens CHEMBL4413961 single protein format
CHEMBL302054 OBDepict CH 3 CH 3 N N O HO N H 3 C H 2 N IC50 = 1.0 nM 330.43 Cc1cc(CC(C(=O)O)c2cn(CCCC(C)C)cn2)cnc1N Homo sapiens CHEMBL655448 single protein format
CHEMBL308195 OBDepict OH O N N H H H 2 N H 3 C CH 3 H 3 C IC50 = 1.0 nM 307.44 CC(C)(C)CCn1cnc(C(C[C@H]2CC[C@H](N)C2)C(=O)O)c1 Homo sapiens CHEMBL655448 single protein format
CHEMBL66512 OBDepict CH 3 H 3 C N N O OH N CH 3 NH 2 IC50 = 1.0 nM 316.41 Cc1cc(CC(C(=O)O)c2cn(CCC(C)C)cn2)cnc1N Homo sapiens CHEMBL655448 single protein format
CHEMBL3577425 OBDepict H 2 N HN H O HO HN O H N H O H 3 C H 3 C CH 3 IC50 = 1.0 nM 478.68 CC12CCC(C(NC(=O)[C@@H](CC3CCCCC3)NC(=O)N[C@@H](CCCCN)C(=O)O)C1)C2(C)C Homo sapiens CHEMBL3580150 single protein format
CHEMBL3694281 OBDepict OH O N N N H 2 N CH 3 CH 3 IC50 = 3.0 nM 342.44 CC1(C)CCC(n2cnc(C(Cc3ccc(N)nc3)C(=O)O)c2)CC1 Homo sapiens CHEMBL3706209 single protein format
CHEMBL70177 OBDepict CH 3 H 3 C N N O HO N H 2 N IC50 = 4.0 nM 316.41 CC(C)CCCn1cnc(C(Cc2ccc(N)nc2)C(=O)O)c1 Homo sapiens CHEMBL655448 single protein format
CHEMBL68399 OBDepict H 3 C H 3 C N N O OH N H 2 N IC50 = 4.0 nM 302.38 CC(C)CCn1cnc(C(Cc2ccc(N)nc2)C(=O)O)c1 Homo sapiens CHEMBL655448 single protein format
CHEMBL3694275 OBDepict NH 2 N N O HO N N O IC50 = 11.0 nM 523.64 Nc1ccc(CC(C(=O)O)c2cn(CC3CCCN(C(=O)C(c4ccccc4)c4ccccc4)C3)cn2)cn1 Homo sapiens CHEMBL3706209 single protein format
CHEMBL3694273 OBDepict HO O N N N N NH 2 O IC50 = 12.0 nM 433.51 Nc1ccc(CC(C(=O)O)c2cn(CC3CCCCN3C(=O)c3ccccc3)cn2)cn1 Homo sapiens CHEMBL3706209 single protein format
CHEMBL3694272 OBDepict H 2 N N N O OH N N O IC50 = 12.0 nM 537.66 Nc1ccc(CC(C(=O)O)c2cn(CCC3CCN(C(=O)C(c4ccccc4)c4ccccc4)CC3)cn2)cn1 Homo sapiens CHEMBL3706209 single protein format
CHEMBL3694271 OBDepict O NH N H N N O OH N NH 2 IC50 = 15.0 nM 442.48 Nc1ccc(CC(C(=O)O)c2cn(-c3ccc(NC(=O)Nc4ccccc4)cc3)cn2)cn1 Homo sapiens CHEMBL3706209 single protein format
CHEMBL3694267 OBDepict HO O N N N NH 2 IC50 = 16.0 nM 300.36 Nc1ccc(CC(C(=O)O)c2cn(C3CCCC3)cn2)cn1 Homo sapiens CHEMBL3706209 single protein format
CHEMBL303664 OBDepict OH O N N H N CH 3 H 2 N IC50 = 20.0 nM 246.27 Cc1cc(CC(C(=O)O)c2c[nH]cn2)cnc1N Homo sapiens CHEMBL655448 single protein format
CHEMBL3694276 OBDepict HO O N N N NH 2 N O IC50 = 21.0 nM 475.59 Nc1ccc(CC(C(=O)O)c2cn(CCC3CCN(C(=O)CCc4ccccc4)CC3)cn2)cn1 Homo sapiens CHEMBL3706209 single protein format
CHEMBL3694270 OBDepict O HN N N O HO N H 2 N IC50 = 23.0 nM 455.52 Nc1ccc(CC(C(=O)O)c2cn(CC(=O)NC(c3ccccc3)c3ccccc3)cn2)cn1 Homo sapiens CHEMBL3706209 single protein format
CHEMBL589645 OBDepict NH 2 O H O HO N N Ki = 27.0 nM 275.31 NCCO[C@@H](Cc1cn(-c2ccccc2)cn1)C(=O)O Homo sapiens CHEMBL1069124 single protein format
CHEMBL594359 OBDepict H 2 N O H O OH N N Ki = 27.0 nM 309.41 NCCO[C@@H](Cc1cn(CCC2CCCCC2)cn1)C(=O)O Homo sapiens CHEMBL1069124 single protein format
CHEMBL3694266 OBDepict HO O N N N NH 2 IC50 = 30.0 nM 314.39 Nc1ccc(CC(C(=O)O)c2cn(C3CCCCC3)cn2)cn1 Homo sapiens CHEMBL3706209 single protein format
CHEMBL3694274 OBDepict HO O N N N NH 2 N O IC50 = 38.0 nM 475.59 Nc1ccc(CC(C(=O)O)c2cn(CCC3CCCN(C(=O)CCc4ccccc4)C3)cn2)cn1 Homo sapiens CHEMBL3706209 single protein format
CHEMBL3694282 OBDepict CH 3 N H N H O N N O HO N H 2 N IC50 = 49.0 nM 408.46 CCCNC(=O)Nc1ccc(-n2cnc(C(Cc3ccc(N)nc3)C(=O)O)c2)cc1 Homo sapiens CHEMBL3706209 single protein format
CHEMBL589646 OBDepict H 2 N O H O HO N N CH 3 CH 3 CH 3 Ki = 49.0 nM 331.42 CC(C)(C)c1ccc(-n2cnc(C[C@H](OCCN)C(=O)O)c2)cc1 Homo sapiens CHEMBL1069124 single protein format
CHEMBL302067 OBDepict OH O N N H N H 2 N IC50 = 70.0 nM 232.24 Nc1ccc(CC(C(=O)O)c2c[nH]cn2)cn1 Homo sapiens CHEMBL655448 single protein format
CHEMBL302817 OBDepict CH 3 N N O HO H H H 2 N IC50 = 150.0 nM 251.33 CCn1cnc(C(C[C@H]2CC[C@H](N)C2)C(=O)O)c1 Homo sapiens CHEMBL655448 single protein format
CHEMBL66508 OBDepict H 2 N N O HO N CH 3 H 3 C IC50 = 160.0 nM 267.37 CC(C)CCn1cnc(C(CCCCN)C(=O)O)c1 Homo sapiens CHEMBL655448 single protein format
CHEMBL3577333 OBDepict H 2 N N H H O HO N H O H NH O HN H 3 C CH 3 O O IC50 = 190.0 nM 521.66 CC(C)CCNC(=O)[C@@H](CCCCNC(=O)OCc1ccccc1)NC(=O)N[C@@H](CCCCN)C(=O)O Homo sapiens CHEMBL3580150 single protein format
CHEMBL398110 OBDepict CH 3 N N H O HO H 2 N Ki = 206.0 nM 239.32 CCCn1cnc(C[C@H](CCCN)C(=O)O)c1 Homo sapiens CHEMBL1069124 single protein format
CHEMBL609577 OBDepict CH 3 N N O H O HO H 2 N Ki = 238.0 nM 241.29 CCCn1cnc(C[C@H](OCCN)C(=O)O)c1 Homo sapiens CHEMBL1069124 single protein format
CHEMBL601926 OBDepict H 2 N O CH 3 H H O OH N N Ki = 240.0 nM 289.34 C[C@H](CN)O[C@@H](Cc1cn(-c2ccccc2)cn1)C(=O)O Homo sapiens CHEMBL1069124 single protein format
CHEMBL590857 OBDepict H 2 N O CH 3 H H O OH N N N Ki = 265.0 nM 290.32 C[C@H](CN)O[C@@H](Cc1cn(-c2ccccn2)cn1)C(=O)O Homo sapiens CHEMBL1069124 single protein format
CHEMBL253846 OBDepict H 2 N HN NH O OH O OH IC50 = 360.0 nM 215.21 N=C(N)NCC/C=C(/CC(=O)O)C(=O)O Homo sapiens CHEMBL945071 single protein format
CHEMBL590859 OBDepict H 3 C N N O O HO H 2 N Ki = 360.0 nM 255.32 CCCCn1cnc(CC(OCCN)C(=O)O)c1 Homo sapiens CHEMBL1069124 single protein format
CHEMBL3694269 OBDepict HO O N N N O N NH 2 IC50 = 439.0 nM 391.43 Nc1ccc(CC(C(=O)O)c2cn(C3CCN(c4ccccc4)C3=O)cn2)cn1 Homo sapiens CHEMBL3706209 single protein format
CHEMBL69883 OBDepict NH 2 CH 3 CH 3 N O OH N H IC50 = 600.0 nM 225.29 CC(C)(CN)CCC(C(=O)O)c1c[nH]cn1 Homo sapiens CHEMBL655448 single protein format
CHEMBL3694280 OBDepict HC N N O OH N H 2 N IC50 = 870.0 nM 270.29 C#CCn1cnc(C(Cc2ccc(N)nc2)C(=O)O)c1 Homo sapiens CHEMBL3706209 single protein format