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P16234 | PGFRA_HUMAN | Platelet-derived growth factor receptor alpha (PDGFRA)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3904768 OBDepict F N H O HN O N N F N F H 3 C N IC50 = 0.09 nM 504.47 Cn1nccc1-c1ccn2c(C(=O)Nc3cc(C(=O)NCc4ccc(F)c(F)c4)ccc3F)cnc2c1 Homo sapiens CHEMBL3855037 single protein format
CHEMBL3983564 OBDepict H 3 C N N NH O N H F O N N N N H IC50 < 0.1 nM 552.61 CN1CCN(c2ccccc2CNC(=O)c2ccc(F)c(NC(=O)c3cnc4cc(-c5cc[nH]n5)ccn34)c2)CC1 Homo sapiens CHEMBL3855037 single protein format
CHEMBL3979322 OBDepict CH 3 N N HN O N H F O N N N H 3 C N IC50 = 0.18 nM 566.64 CN1CCN(c2ccccc2CNC(=O)c2ccc(F)c(NC(=O)c3cnc4cc(-c5ccnn5C)ccn34)c2)CC1 Homo sapiens CHEMBL3855037 single protein format
CHEMBL3940697 OBDepict H 3 C N N N N N H O F N H O N CH 3 CH 3 IC50 = 0.19 nM 503.58 Cn1cc(-c2ccn3c(C(=O)Nc4cc(C(=O)NCCN5CCCC5(C)C)ccc4F)cnc3c2)cn1 Homo sapiens CHEMBL3855037 single protein format
CHEMBL3915941 OBDepict H 3 C N N N N N H O H 3 C N N H O N CH 3 CH 3 IC50 = 0.2 nM 500.61 Cc1ncc(C(=O)NCCN2CCCC2(C)C)cc1NC(=O)c1cnn2cc(-c3cnn(C)c3)ccc12 Homo sapiens CHEMBL3855037 single protein format
CHEMBL1668411 OBDepict CH 3 O OH O O H HO H CH 3 H HO O IC50 = 0.24 nM 362.38 COc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)/C=CC[C@H](C)OC2=O Homo sapiens CHEMBL1670765 single protein format
CHEMBL3913766 OBDepict H 3 C N N NH O N H F O N N N N H 3 C IC50 = 0.32 nM 566.64 CN1CCN(c2ccccc2CNC(=O)c2ccc(F)c(NC(=O)c3cnc4cc(-c5cnn(C)c5)ccn34)c2)CC1 Homo sapiens CHEMBL3855037 single protein format
CHEMBL3975580 OBDepict F N H O HN O N N O CH 3 H 3 C N H 3 C N IC50 = 0.53 nM 490.54 Cn1nccc1-c1ccn2c(C(=O)Nc3cc(C(=O)NCC4CCC(C)(C)O4)ccc3F)cnc2c1 Homo sapiens CHEMBL3855037 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 0.6 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL3820664 single protein format
CHEMBL3642837 OBDepict Cl N H O F F F NH O N H CH 3 N N N IC50 = 0.73 nM 540.93 Cc1ccc(C(=O)Nc2ccc(NC(=O)CCl)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1 Homo sapiens CHEMBL3705146 single protein format
CHEMBL3950278 OBDepict H 3 C N N NH O N H F O N N N IC50 = 0.75 nM 563.64 CN1CCN(c2ccccc2CNC(=O)c2ccc(F)c(NC(=O)c3cnc4cc(-c5cccnc5)ccn34)c2)CC1 Homo sapiens CHEMBL3855037 single protein format
CHEMBL3985689 OBDepict CH 3 N N NH O N N H CH 3 O N N N CH 3 N IC50 = 0.96 nM 563.67 Cc1ncc(C(=O)NCc2ccccc2N2CCN(C)CC2)cc1NC(=O)c1cnn2cc(-c3ccnn3C)ccc12 Homo sapiens CHEMBL3855037 single protein format
CHEMBL1173411 OBDepict CH 3 O N H N H O N H O N H CH 3 O HO IC50 = 0.98 nM 432.44 COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=Cc2[nH]cc(C(=O)O)c2C)cc1 Homo sapiens CHEMBL1176415 single protein format
CHEMBL3322565 OBDepict CH 3 O N H O N H O N H O N H 3 C H CH 3 O OH IC50 < 1.0 nM 488.5 COc1ccc(NC(=O)CC(=O)Nc2ccc3c(c2)NC(=O)/C3=Cc2[nH]c(C)c(C(=O)O)c2C)cc1 Homo sapiens CHEMBL3362105 single protein format
CHEMBL3322566 OBDepict CH 3 O N H O N H O N H O N CH 3 H H 3 C N H O N IC50 < 1.0 nM 584.68 COc1ccc(NC(=O)CC(=O)Nc2ccc3c(c2)NC(=O)/C3=Cc2[nH]c(C)c(C(=O)NCCN3CCCC3)c2C)cc1 Homo sapiens CHEMBL3362105 single protein format
CHEMBL2071201 OBDepict H 3 C N N N H N N NH Br H H H O NH 2 H IC50 = 1.0 nM 404.27 Cn1cc(Nc2ncc(Br)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)cn1 Homo sapiens CHEMBL2073512 single protein format
CHEMBL3947262 OBDepict CH 3 N N HN O N H F O N N N H 3 C N IC50 = 1.2 nM 566.64 CN1CCN(c2ccccc2CNC(=O)c2ccc(F)c(NC(=O)c3cnn4cc(-c5ccnn5C)ccc34)c2)CC1 Homo sapiens CHEMBL3855037 single protein format
CHEMBL2347053 OBDepict H N N + N O N H O _ O IC50 = 1.2 nM 332.32 O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-] Homo sapiens CHEMBL2350671 single protein format
CHEMBL3895824 OBDepict F N H O HN O N N N H H 3 C H CH 3 N CH 3 N IC50 = 1.3 nM 517.61 C[C@H]1CCC[C@@H](C)N1CCNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(-c4ccnn4C)ccn23)c1 Homo sapiens CHEMBL3855037 single protein format
CHEMBL1784637 OBDepict HO N N F F F N H O CH 3 N N CH 3 N H O CH 3 IC50 = 1.3 nM 582.63 CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C Homo sapiens CHEMBL1785334 single protein format
CHEMBL3955987 OBDepict F N H O N H O N N N H 3 C H 3 C N CH 3 N IC50 = 1.3 nM 503.58 Cn1nccc1-c1ccn2c(C(=O)Nc3cc(C(=O)NCCN4CCCC4(C)C)ccc3F)cnc2c1 Homo sapiens CHEMBL3855037 single protein format
CHEMBL3642835 OBDepict CH 3 N H 3 C N H O F F F N H O N H CH 3 N N N IC50 = 1.4 nM 575.6 Cc1ccc(NC(=O)c2ccc(NC(=O)/C=C/CN(C)C)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1 Homo sapiens CHEMBL3705146 single protein format
CHEMBL179698 OBDepict CH 3 O O CH 3 O N N H NH O F F IC50 = 1.6 nM 451.43 COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4F)cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL3902237 OBDepict CH 3 N H 3 C H 3 C CH 3 NH O N H F O N N N CH 3 N IC50 = 1.6 nM 505.6 CCN(CCNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(-c4ccnn4C)ccn23)c1)C(C)(C)C Homo sapiens CHEMBL3855037 single protein format
CHEMBL2087167 OBDepict CH 3 N N H N H O N N H CH 3 F IC50 = 2.0 nM 445.54 CCN1CCC(Nc2ccc3c(c2)C(=C(c2cccc(F)c2)c2nc(C)c[nH]2)C(=O)N3)CC1 Homo sapiens CHEMBL2090043 single protein format
CHEMBL4638981 OBDepict O N H H 3 C Cl N N N N N H N IC50 = 2.0 nM 507.99 Cc1ccc(C(=O)Nc2ccc(CN3Cc4cn[nH]c4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 Homo sapiens CHEMBL4605663 single protein format
CHEMBL178156 OBDepict CH 3 O N H N H O O N O H 3 C O CH 3 IC50 = 2.0 nM 445.48 COc1cccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)c1 Homo sapiens CHEMBL832771 assay format
CHEMBL179593 OBDepict CH 3 O N H N H O O N O CH 3 O CH 3 IC50 = 2.0 nM 445.48 COc1ccc(NC(=O)Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2)cc1 Homo sapiens CHEMBL832771 assay format
CHEMBL4640297 OBDepict O N H CH 3 Cl N N N N HN N IC50 = 2.1 nM 524.03 Cc1ccc(C(=O)Nc2ccc(CN3CCC4C=NNC4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 Homo sapiens CHEMBL4605663 single protein format
CHEMBL3642830 OBDepict CH 2 N H O F F F N H O N H H 3 C N N N IC50 = 2.2 nM 518.5 C=CC(=O)Nc1ccc(C(=O)Nc2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc1C(F)(F)F Homo sapiens CHEMBL3705146 single protein format
CHEMBL1289494 OBDepict CH 3 O O H 3 C O N Cl N H NH O N O H 3 C IC50 = 2.26 nM 454.87 COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC Homo sapiens CHEMBL3429406 single protein format
CHEMBL2012519 OBDepict CH 3 O OH O O H HO H CH 3 H HO O IC50 = 2.38 nM 364.39 COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)C(=O)/C=CC[C@H](C)OC2=O Homo sapiens CHEMBL1656379 assay format
CHEMBL1171837 OBDepict H 3 C N N F F F N H O CH 3 N N N IC50 = 2.6 nM 532.57 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 Homo sapiens CHEMBL4002772 single protein format
CHEMBL2087168 OBDepict CH 3 N N H N H O N N H CH 3 F F IC50 = 3.0 nM 463.53 CCN1CCC(Nc2ccc3c(c2)C(=C(c2cc(F)cc(F)c2)c2nc(C)c[nH]2)C(=O)N3)CC1 Homo sapiens CHEMBL2090043 single protein format
CHEMBL2086760 OBDepict CH 3 N N H N H O N N H Cl IC50 = 3.0 nM 447.97 CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(Cl)cc2)c2ncc[nH]2)C(=O)N3)CC1 Homo sapiens CHEMBL2090043 single protein format
CHEMBL2086753 OBDepict CH 3 N N H N H O N N H IC50 = 3.0 nM 463.59 CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccccc2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 Homo sapiens CHEMBL2090043 single protein format
CHEMBL2023489 OBDepict CH 3 O O N H O N N CH 3 N H 3 C O CH 3 IC50 = 3.0 nM 432.48 COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1 Homo sapiens CHEMBL2026456 single protein format
CHEMBL279351 OBDepict CH 3 O O N CH 3 O Cl N H N H O F F IC50 < 3.0 nM 485.87 COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(Cl)c3)c2cc1OC Homo sapiens CHEMBL829472 assay format
CHEMBL2403377 OBDepict N N H O N H N O CH 3 IC50 < 3.0 nM 332.36 CC(=O)N1CCc2[nH]c(/C=C3C(=O)Nc4ccc(C#N)cc43)cc2C1 Homo sapiens CHEMBL2406183 single protein format
CHEMBL3967097 OBDepict H 3 C N CH 3 CH 3 CH 3 HN O N H F O N N N H 3 C N IC50 = 3.2 nM 491.57 CN(CCNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(-c4ccnn4C)ccn23)c1)C(C)(C)C Homo sapiens CHEMBL3855037 single protein format
CHEMBL3426917 OBDepict O N H N H N Cl O H 3 C O N O O D D D D D D IC50 = 3.26 nM 460.91 [2H]C([2H])([2H])Oc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC([2H])([2H])[2H] Homo sapiens CHEMBL3429406 single protein format
CHEMBL369760 OBDepict CH 3 O O CH 3 O N N H NH O CH 3 IC50 = 3.3 nM 429.48 COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(C)c4)cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL360526 OBDepict CH 3 O O N CH 3 O N H N H O F F IC50 = 3.4 nM 451.43 COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL179307 OBDepict CH 3 O O CH 3 O N N H NH O F F IC50 = 3.5 nM 451.43 COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(F)cccc4F)cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL179603 OBDepict CH 3 O N H N H O O N N O CH 3 O CH 3 IC50 = 3.6 nM 446.46 COc1ccc(NC(=O)Nc2ccc(Oc3ncnc4cc(OC)c(OC)cc34)cc2)cc1 Homo sapiens CHEMBL832771 assay format
CHEMBL368252 OBDepict CH 3 O O CH 3 O N N H NH O IC50 = 3.6 nM 415.45 COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4)cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL179061 OBDepict CH 3 O O CH 3 O N N H NH O CH 3 IC50 = 3.6 nM 429.48 COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4C)cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL179227 OBDepict CH 3 O O CH 3 O N N H NH O F IC50 = 3.9 nM 433.44 COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4F)cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL491429 OBDepict O NH Cl O N N N N H F F F IC50 = 4.0 nM 433.78 O=C(Nc1cncnc1)c1c(Cl)ccc2c(Nc3cccc(C(F)(F)F)c3)noc12 Homo sapiens CHEMBL990807 single protein format
CHEMBL2180604 OBDepict CH 3 N N H 3 C NH O CH 3 O N N N N H O IC50 = 4.3 nM 445.48 Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1 Homo sapiens CHEMBL2353587 single protein format
CHEMBL4165429 OBDepict CH 3 O O NH O N H N H N O N H 3 C IC50 = 4.4 nM 535.6 COC(=O)c1ccc2c(c1)NC(=O)/C2=C(Nc1ccc2[nH]c(C(=O)N3CCN(C)CC3)cc2c1)c1ccccc1 Homo sapiens CHEMBL4132790 assay format
CHEMBL179522 OBDepict CH 3 O O CH 3 O N N H NH O F F IC50 = 4.7 nM 451.43 COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)ccc4F)cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL2086754 OBDepict CH 3 N N H N H O N N H H 3 C IC50 = 5.0 nM 477.61 CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(C)cc2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 Homo sapiens CHEMBL2090043 single protein format
CHEMBL2087169 OBDepict CH 3 N N H N H O N N F H CH 3 IC50 = 5.0 nM 445.54 CCN1CCC(Nc2ccc3c(c2)C(=C(c2nc(C)c[nH]2)c2ccccc2F)C(=O)N3)CC1 Homo sapiens CHEMBL2090043 single protein format
CHEMBL4558664 OBDepict H 2 N N H N N N N H N H H H 2 N IC50 = 5.0 nM 482.64 Nc1ccccc1-c1ccc(Nc2nc(N[C@H]3CC[C@H](N)CC3)nc3c2ncn3C2CCCC2)cc1 Homo sapiens CHEMBL4343086 cell-based format
CHEMBL4091628 OBDepict CH 3 N N F F F HN O Cl N N O IC50 = 5.6 nM 598.07 CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(C#Cc4cncc(N5CCOCC5)c4)c3)cc2C(F)(F)F)CC1 Homo sapiens CHEMBL4002772 single protein format
CHEMBL180331 OBDepict CH 3 O O N CH 3 O N H N H O F IC50 = 5.8 nM 433.44 COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4)cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL426047 OBDepict H 3 C O O H 3 C O N N H HN O O CH 3 IC50 = 5.8 nM 445.48 COc1ccccc1NC(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cc1 Homo sapiens CHEMBL832771 assay format
CHEMBL3642836 OBDepict CH 3 N CH 3 NH O F F F HN O N H CH 3 N N N IC50 = 5.9 nM 575.6 Cc1ccc(C(=O)Nc2ccc(NC(=O)/C=C/CN(C)C)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1 Homo sapiens CHEMBL3705146 single protein format
CHEMBL2086759 OBDepict CH 3 N N H N H O N N H F IC50 = 6.0 nM 431.52 CCN1CCC(Nc2ccc3c(c2)C(=C(c2cccc(F)c2)c2ncc[nH]2)C(=O)N3)CC1 Homo sapiens CHEMBL2090043 single protein format
CHEMBL2086757 OBDepict CH 3 N N H N H O N N H F F IC50 = 6.0 nM 499.57 CCN1CCC(Nc2ccc3c(c2)C(=C(c2cc(F)cc(F)c2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 Homo sapiens CHEMBL2090043 single protein format
CHEMBL2086751 OBDepict CH 3 N N H N H O N N H O H 3 C IC50 = 6.0 nM 493.61 CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccccc2)c2nc4cc(OC)ccc4[nH]2)C(=O)N3)CC1 Homo sapiens CHEMBL2090043 single protein format
CHEMBL4576574 OBDepict H NH 2 H HN N N N H N N N N N IC50 = 6.0 nM 458.57 N[C@H]1CC[C@H](Nc2nc(Nc3ccc(-n4cnnc4)cc3)c3ncn(C4CCCC4)c3n2)CC1 Homo sapiens CHEMBL4343086 cell-based format
CHEMBL2203434 OBDepict H 3 C N O N N H O N H N H O N O CH 3 H 3 C CH 3 IC50 = 6.2 nM 506.61 CCN1CCC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1 Homo sapiens CHEMBL2213406 cell-based format
CHEMBL426602 OBDepict CH 3 O O CH 3 O N N H NH O F IC50 = 6.4 nM 433.44 COc1cc2nccc(Oc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL4069394 OBDepict CH 3 O O N H O NH N N CH 3 H 3 C IC50 = 6.6 nM 492.58 COC(=O)c1ccc2c(c1)NC(=O)/C2=C(Nc1ccc(-n2cccc2CN(C)C)cc1)c1ccccc1 Homo sapiens CHEMBL3994000 single protein format
CHEMBL179719 OBDepict CH 3 O O N CH 3 O N H N H O F F IC50 = 6.8 nM 451.43 COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)c(F)c4)cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL360781 OBDepict CH 3 O O CH 3 O N N H NH O + N O _ O IC50 = 6.8 nM 460.45 COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccccc4[N+](=O)[O-])cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL2086756 OBDepict CH 3 N N H N H O N N H F IC50 = 7.0 nM 481.58 CCN1CCC(Nc2ccc3c(c2)C(=C(c2cccc(F)c2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 Homo sapiens CHEMBL2090043 single protein format
CHEMBL2086755 OBDepict CH 3 N N H N H O N N H O H 3 C IC50 = 7.0 nM 493.61 CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(OC)cc2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 Homo sapiens CHEMBL2090043 single protein format
CHEMBL525909 OBDepict CH 3 O O N H O NH N O H 3 C N CH 3 H 3 C IC50 = 7.0 nM 512.61 COC(=O)c1ccc2c(c1)NC(=O)/C2=C(Nc1ccc(N(CCCN(C)C)C(C)=O)cc1)c1ccccc1 Homo sapiens CHEMBL1017193 single protein format
CHEMBL4444476 OBDepict H NH 2 H HN N N N H N N N N IC50 = 7.0 nM 457.59 N[C@H]1CC[C@H](Nc2nc(Nc3ccc(-n4cccn4)cc3)c3ncn(C4CCCC4)c3n2)CC1 Homo sapiens CHEMBL4343086 cell-based format
CHEMBL3322563 OBDepict O N H N H O N H O F N H IC50 = 7.2 nM 404.4 O=C(CC(=O)Nc1ccc2c(c1)NC(=O)/C2=Cc1ccc[nH]1)Nc1ccc(F)cc1 Homo sapiens CHEMBL3362105 single protein format
CHEMBL4072731 OBDepict O NH N H CH 3 N O N H 3 C N N H IC50 = 7.2 nM 442.52 Cc1cc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(C)c34)cc2)ccc1N1CCOCC1 Homo sapiens CHEMBL4012619 single protein format
CHEMBL1651521 OBDepict CH 3 O OH O O H HO H CH 3 O IC50 = 7.23 nM 348.4 COc1cc(O)c2c(c1)CCC[C@H](O)CC(=O)/C=CC[C@H](C)OC2=O Homo sapiens CHEMBL1656379 assay format
CHEMBL2206278 OBDepict H 3 C N CH 3 H 3 C H 3 C H 3 C O N N H O N H N H O N O CH 3 H 3 C CH 3 IC50 = 7.7 nM 562.72 CCN1C(C)(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1(C)C Homo sapiens CHEMBL2213406 cell-based format
CHEMBL3642840 OBDepict CH 2 N O HN O N H CH 3 N N N IC50 = 7.9 nM 490.57 C=CC(=O)N1CCc2cc(C(=O)Nc3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)ccc2C1 Homo sapiens CHEMBL3705146 single protein format
CHEMBL498265 OBDepict CH 3 O O N H O NH N O H 3 C N CH 3 H 3 C IC50 = 8.0 nM 498.58 COC(=O)c1ccc2c(c1)NC(=O)/C2=C(Nc1ccc(N(CCN(C)C)C(C)=O)cc1)c1ccccc1 Homo sapiens CHEMBL1017193 single protein format
CHEMBL4216073 OBDepict CH 3 NH O N N CH 3 HN O F F F IC50 = 8.0 nM 452.44 CC(=O)Nc1cn2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 Homo sapiens CHEMBL4181663 single protein format
CHEMBL524453 OBDepict H 3 C O O HN O N H N CH 3 O N N IC50 = 8.0 nM 507.55 COC(=O)c1ccc2c(c1)NC(=O)/C2=C(Nc1ccc(N(C)C(=O)Cn2ccnc2)cc1)c1ccccc1 Homo sapiens CHEMBL1017193 single protein format
CHEMBL2311806 OBDepict CH 3 HN N O N CH 3 N H H 3 C N N N IC50 = 8.2 nM 475.56 Cc1cc(NC(=O)c2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc(-n2cnc(C)c2)c1 Homo sapiens CHEMBL2319489 single protein format
CHEMBL4636995 OBDepict H 3 C O O H 3 C N N N O NH 2 N S N H 3 C IC50 = 9.0 nM 466.57 COc1ccc(-c2cnn3c(N)c(-c4nccs4)c(OC4CCN(C)CC4)nc23)cc1OC Homo sapiens CHEMBL4605813 cell-based format
CHEMBL3780091 OBDepict O N H NH N N H H H H 2 N IC50 = 9.0 nM 323.4 N[C@H]1CC[C@@H](Nc2cc[nH]c(=O)c2-c2nc3ccccc3[nH]2)CC1 Homo sapiens CHEMBL3784666 single protein format
CHEMBL504805 OBDepict H 2 N N N H 3 C O N F F F IC50 = 9.0 nM 396.37 Cc1ccn(-c2cccc(C(F)(F)F)c2)c(=O)c1-c1ccc2nc(N)ncc2c1 Homo sapiens CHEMBL955829 single protein format
CHEMBL498088 OBDepict CH 3 O O N H O NH N O H 3 C N O CH 3 H 3 C IC50 = 9.0 nM 512.57 COC(=O)c1ccc2c(c1)NC(=O)/C2=C(Nc1ccc(N(CC(=O)N(C)C)C(C)=O)cc1)c1ccccc1 Homo sapiens CHEMBL1017193 single protein format
CHEMBL2206277 OBDepict O HN HN N O CH 3 CH 3 H 3 C N H O N O CH 3 CH 3 N H 3 C CH 3 CH 3 IC50 = 9.2 nM 548.69 CN1C(C)(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1(C)C Homo sapiens CHEMBL2213406 cell-based format
CHEMBL1421 OBDepict HO N N N N N H CH 3 N S N H O H 3 C Cl Ki < 10.0 nM 488.02 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4312062 single protein format
CHEMBL179165 OBDepict CH 3 O O N CH 3 O N H N H O Cl IC50 = 10.0 nM 449.89 COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)cc4)cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL179816 OBDepict CH 3 O O CH 3 O N N H NH O F F IC50 = 10.0 nM 451.43 COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(F)cc(F)c4)cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL2086752 OBDepict CH 3 O N N H N H O N N H IC50 = 10.0 nM 493.61 COCCN1CCC(Nc2ccc3c(c2)C(=C(c2ccccc2)c2nc4ccccc4[nH]2)C(=O)N3)CC1 Homo sapiens CHEMBL2090043 single protein format
CHEMBL179082 OBDepict CH 3 O O CH 3 O N N H NH O Cl Cl IC50 < 10.0 nM 484.34 COc1cc2nccc(Oc3ccc(NC(=O)Nc4c(Cl)cccc4Cl)cc3)c2cc1OC Homo sapiens CHEMBL832771 assay format
CHEMBL495727 OBDepict O NH NH N N H N N H N O IC50 = 10.0 nM 381.44 O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 Homo sapiens CHEMBL1009914 assay format
CHEMBL3642843 OBDepict O N O HN O N H CH 3 N N N IC50 = 10.69 nM 490.52 Cc1ccc(NC(=O)c2ccc(CN3C(=O)C=CC3=O)cc2)cc1Nc1nccc(-c2cccnc2)n1 Homo sapiens CHEMBL3705146 single protein format
CHEMBL4444046 OBDepict H H 2 N H NH N N N H N N N N N IC50 = 11.0 nM 458.57 N[C@H]1CC[C@H](Nc2nc(Nc3ccc(-n4cncn4)cc3)c3ncn(C4CCCC4)c3n2)CC1 Homo sapiens CHEMBL4343086 cell-based format
CHEMBL525550 OBDepict CH 3 O O N H O NH N O H 3 C N CH 3 CH 3 IC50 = 11.0 nM 498.58 COC(=O)c1ccc2c(c1)NC(=O)/C2=C(Nc1ccc(C(=O)N(C)CCN(C)C)cc1)c1ccccc1 Homo sapiens CHEMBL1017193 single protein format
CHEMBL3621299 OBDepict H 3 C S N H O N H O N CH 3 H CH 3 IC50 = 11.8 nM 369.49 CSCCCNC(=O)c1ccc2c(c1)/C(=C/c1[nH]c(C)cc1C)C(=O)N2 Homo sapiens CHEMBL3626704 single protein format
CHEMBL2409778 OBDepict CH 3 N N H 3 C NH O F O N N N N H O IC50 = 12.0 nM 449.45 Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Homo sapiens CHEMBL2410827 single protein format
CHEMBL498266 OBDepict CH 3 O O N H O NH N S O O H 3 C N CH 3 H 3 C IC50 = 12.0 nM 534.64 COC(=O)c1ccc2c(c1)NC(=O)/C2=C(Nc1ccc(N(CCN(C)C)S(C)(=O)=O)cc1)c1ccccc1 Homo sapiens CHEMBL1017193 single protein format
CHEMBL2086744 OBDepict H 3 C HN O N H O N N H IC50 = 13.0 nM 436.52 CCCCNC(=O)c1ccc2c(c1)C(=C(c1ccccc1)c1nc3ccccc3[nH]1)C(=O)N2 Homo sapiens CHEMBL2090043 single protein format
CHEMBL3971140 OBDepict CH 3 N N N H O NH F O N N IC50 = 13.0 nM 486.55 CN1CCN(c2ccccc2CNC(=O)c2ccc(F)c(NC(=O)c3cnc4ccccn34)c2)CC1 Homo sapiens CHEMBL3855037 single protein format