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P16499 | PDE6A_HUMAN | "Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha" (PDE6A)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL565305 OBDepict CH 3 O N O N N H N N N N O CH 3 IC50 = 4.7 nM 447.5 CCCOCCn1c(=O)c(NCc2cnccn2)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL584270 OBDepict CH 3 O N O N N H N N O O CH 3 IC50 = 8.6 nM 439.52 CCCOCCn1c(=O)c(NCC2CCCO2)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL566797 OBDepict H 3 C O N O N HN N N O O CH 3 CH 3 IC50 = 9.3 nM 427.51 CCCOCCn1c(=O)c(NCCOCC)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL567470 OBDepict CH 3 O N O N N H N H N O H OH CH 3 IC50 = 9.8 nM 453.54 CCCOCCn1c(=O)c(N[C@H]2CC[C@H](O)CC2)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL569481 OBDepict CH 3 O N O N N H N N N O CH 3 IC50 = 10.8 nM 446.51 CCCOCCn1c(=O)c(NCc2ccccn2)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL551052 OBDepict CH 3 O N O N H N N N N O O CH 3 IC50 = 11.3 nM 468.56 CCCOCCn1c(=O)c(NCCN2CCOCC2)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL567447 OBDepict H 3 C O N O N HN N N HO O CH 3 IC50 = 13.8 nM 413.48 CCCOCCn1c(=O)c(NCCCO)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL585918 OBDepict CH 3 O N O N H N N N O N O N CH 3 CH 3 IC50 = 14.7 nM 495.58 CCCOCCn1c(=O)c(NCC(=O)N2CCN(C)CC2)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL567471 OBDepict H 3 C O N O N HN N N OH H 3 C H O CH 3 IC50 = 15.1 nM 413.48 CCCOCCn1c(=O)c(NC[C@@H](C)O)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL568839 OBDepict H 3 C O N O N HN N N NH O H 3 C O CH 3 IC50 = 15.2 nM 426.48 CCCOCCn1c(=O)c(NCC(=O)NC)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL566820 OBDepict CH 3 O N O N N N H H N O H OH CH 3 IC50 = 15.3 nM 453.54 CCCOCCn1c(=O)c(N[C@H]2CC[C@H](O)CC2)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL566367 OBDepict H 3 C O N O N HN N N OH H 3 C H O CH 3 IC50 = 15.3 nM 413.48 CCCOCCn1c(=O)c(NC[C@H](C)O)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL565306 OBDepict CH 3 O N O N H N N N O N O O CH 3 IC50 = 16.1 nM 482.54 CCCOCCn1c(=O)c(NCC(=O)N2CCOCC2)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL569492 OBDepict H 3 C O N O N HN N H 3 C H N OH O CH 3 IC50 = 17.7 nM 413.48 CCCOCCn1c(=O)c(N[C@H](C)CO)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL566375 OBDepict H 3 C O N O N HN N H 3 C H N OH O CH 3 IC50 = 17.9 nM 413.48 CCCOCCn1c(=O)c(N[C@@H](C)CO)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL583854 OBDepict H 3 C O N O N HN N H OH H 3 C N O CH 3 IC50 = 23.2 nM 427.51 CCCOCCn1c(=O)c(N[C@H](CC)CO)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL569045 OBDepict CH 3 O N O N N N H N N N O CH 3 IC50 = 23.6 nM 447.5 CCCOCCn1c(=O)c(NCc2cnccn2)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL569264 OBDepict CH 3 O N O N H N N N O N O CH 3 OH IC50 = 24.6 nM 496.57 CCCOCCn1c(=O)c(NCC(=O)N2CCC(O)CC2)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL585327 OBDepict CH 3 O N O N NH N N OH O H 3 C IC50 = 26.3 nM 399.45 CCCOCCn1c(=O)c(NCCO)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL567016 OBDepict CH 3 O N O N N N H N O O CH 3 IC50 = 31.4 nM 453.54 CCCOCCn1c(=O)c(NCC2CCOCC2)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL569491 OBDepict CH 3 O N O N N N H N N O CH 3 IC50 = 34.5 nM 446.51 CCCOCCn1c(=O)c(NCc2ccccn2)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL566598 OBDepict H 3 C O N O N N H N N N O O H 3 C IC50 = 39.5 nM 466.54 CCCOCCn1c(=O)c(NCC(=O)N2CCCC2)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL565308 OBDepict H 3 C O N O N HN N N O HO O CH 3 IC50 = 45.5 nM 413.43 CCCOCCn1c(=O)c(NCC(=O)O)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL585015 OBDepict H 3 C O N O N N HN N OH H 3 C H O CH 3 IC50 = 49.7 nM 413.48 CCCOCCn1c(=O)c(NC[C@@H](C)O)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL584056 OBDepict H 3 C O N O N N HN N OH H 3 C H O CH 3 IC50 = 51.8 nM 413.48 CCCOCCn1c(=O)c(NC[C@H](C)O)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL567445 OBDepict CH 3 O N O N H N N N O N O N CH 3 H 3 C IC50 = 55.9 nM 509.61 CCCOCCn1c(=O)c(NCC(=O)N2CCN(CC)CC2)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL584317 OBDepict H 3 C O N O N N HN N O O CH 3 CH 3 IC50 = 57.4 nM 427.51 CCCOCCn1c(=O)c(NCCOCC)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL4099219 OBDepict H N O N S O O O IC50 = 58.0 nM 402.43 O=c1c2ccccc2oc2c(Cc3ccc4c(c3)OCO4)[nH]c(-c3nccs3)c12 Homo sapiens CHEMBL4014054 assay format
CHEMBL551250 OBDepict CH 3 O N O N H N N N N O O CH 3 IC50 = 61.8 nM 468.56 CCCOCCn1c(=O)c(NCCN2CCOCC2)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL585352 OBDepict H 3 C O N O N N HN H 3 C H N OH O CH 3 IC50 = 63.2 nM 413.48 CCCOCCn1c(=O)c(N[C@H](C)CO)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL567446 OBDepict H 3 C O N O N N HN H 3 C H N OH O CH 3 IC50 = 68.2 nM 413.48 CCCOCCn1c(=O)c(N[C@@H](C)CO)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL584285 OBDepict CH 3 O N O N H N N N O N O N CH 3 CH 3 IC50 = 80.2 nM 495.58 CCCOCCn1c(=O)c(NCC(=O)N2CCN(C)CC2)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL571693 OBDepict H 3 C O N O N HN N N O H 2 N O CH 3 IC50 = 86.6 nM 412.45 CCCOCCn1c(=O)c(NCC(N)=O)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL571469 OBDepict H 3 C O N O N HN N N N O CH 3 H 3 C O CH 3 IC50 = 86.6 nM 440.5 CCCOCCn1c(=O)c(NCC(=O)N(C)C)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL579669 OBDepict CH 3 O N O N H N N N O N O N CH 3 H 3 C IC50 = 98.9 nM 509.61 CCCOCCn1c(=O)c(NCC(=O)N2CCN(CC)CC2)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL571913 OBDepict CH 3 O N O N H N N N O N O HN CH 3 IC50 = 100.0 nM 481.56 CCCOCCn1c(=O)c(NCC(=O)N2CCNCC2)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL569265 OBDepict CH 3 O N O N H N N N O N O O CH 3 IC50 = 114.0 nM 482.54 CCCOCCn1c(=O)c(NCC(=O)N2CCOCC2)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL567255 OBDepict CH 3 O N O N N NH N OH O H 3 C IC50 = 114.0 nM 399.45 CCCOCCn1c(=O)c(NCCO)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL571912 OBDepict H 3 C O N O N N HN N NH O H 3 C O CH 3 IC50 = 115.0 nM 426.48 CCCOCCn1c(=O)c(NCC(=O)NC)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL583835 OBDepict H 3 C O N O N N HN N HO O CH 3 IC50 = 124.0 nM 413.48 CCCOCCn1c(=O)c(NCCCO)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL567229 OBDepict H 3 C O N O N HN N N N CH 3 H 3 C O CH 3 IC50 = 261.0 nM 426.52 CCCOCCn1c(=O)c(NCCN(C)C)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL567252 OBDepict H 3 C O N O HN N N NH N O HO CH 3 IC50 = 272.0 nM 442.52 CCCOCCn1c(=O)c(NCCNCCO)nc2cnc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL566819 OBDepict H 3 C O N O N N HN N O H 2 N O CH 3 IC50 = 398.0 nM 412.45 CCCOCCn1c(=O)c(NCC(N)=O)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL565331 OBDepict H 3 C O N O N N HN N N O CH 3 H 3 C O CH 3 IC50 = 398.0 nM 440.5 CCCOCCn1c(=O)c(NCC(=O)N(C)C)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format
CHEMBL565518 OBDepict H 3 C O N O N N HN N O HO O CH 3 IC50 = 576.0 nM 413.43 CCCOCCn1c(=O)c(NCC(=O)O)nc2ncc(-c3ccc(OC)nc3)cc21 Homo sapiens CHEMBL1042745 single protein format