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P17252 | KPCA_HUMAN | Protein kinase C alpha type (PRKCA)

3D structures mapped by conservation among orthologs

[ Domain: "C2 domain" // C2_2 ]

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[ Domain: "Cysteine-rich domain" // C1_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3970090 OBDepict NH 2 N N HN O N N F N N N H 3 C H 2 N F F IC50 = 0.13 nM 542.57 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(N4CCC(F)(F)CC4)ncc3F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3980746 OBDepict NH 2 N N NH O N H 2 N N N F F F O IC50 = 0.13 nM 542.57 Nc1ncc(-c2cc(N3CCOCC3)ccc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3951893 OBDepict NH 2 N N N H O N H 2 N N N H F F F IC50 = 0.13 nM 496.5 Nc1ncc(-c2cccc3[nH]c(C(F)(F)F)cc23)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3966595 OBDepict H 2 N N N HN O N NH 2 N N N O IC50 = 0.13 nM 525.62 Nc1ncc(-c2nc(N3CCOCC3)cc3ccccc23)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3958917 OBDepict H 2 N N N HN O N NH 2 N N N N F O IC50 = 0.13 nM 544.6 Nc1ncc(-c2nc(N3CCOCC3)nc3ccc(F)cc23)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3966643 OBDepict NH 2 N N NH O N H 2 N N N N F F F O IC50 = 0.13 nM 543.55 Nc1ncc(-c2nc(N3CCOCC3)ccc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3892099 OBDepict O HN N NH 2 N N N N N H 3 C H 2 N O IC50 = 0.13 nM 539.64 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(N4CCOCC4)cc4ccccc34)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3969856 OBDepict NH 2 N N N H O N NH 2 N N CH 3 H IC50 = 0.13 nM 442.53 Cc1cc2c(-c3cnc(N)c(C(=O)Nc4ncccc4N4CCC(N)CC4)n3)cccc2[nH]1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3984009 OBDepict O HN N NH 2 N N N N N N H 3 C H 2 N O IC50 = 0.13 nM 540.63 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(N4CCOCC4)nc4ccccc34)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3893533 OBDepict H 2 N N N HN O N NH 2 N N F F F O IC50 = 0.13 nM 542.57 Nc1ncc(-c2cc(N3CCOCC3)cc(C(F)(F)F)c2)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3984070 OBDepict NH 2 N N NH O N H 2 N N N N N F F F O IC50 = 0.13 nM 544.54 Nc1ncc(-c2nc(N3CCOCC3)ncc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3957715 OBDepict NH 2 N N N H O N H 2 N N N N H IC50 = 0.13 nM 429.49 Nc1ncc(-c2cccc3[nH]ncc23)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3983009 OBDepict NH 2 N N N H O N NH 2 N N H 3 C IC50 = 0.13 nM 442.53 Cn1ccc2c(-c3cnc(N)c(C(=O)Nc4ncccc4N4CCC(N)CC4)n3)cccc21 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3932204 OBDepict NH 2 N N NH O N H 2 N N N O IC50 = 0.13 nM 474.57 Nc1ncc(-c2cccc(N3CCOCC3)c2)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3895998 OBDepict NH 2 N NH N O N H 2 N N F IC50 = 0.13 nM 407.45 Nc1ncc(-c2ccccc2F)nc1C(=O)Nc1cnccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3963605 OBDepict H 2 N N HN N O N NH 2 N IC50 = 0.13 nM 389.46 Nc1ncc(-c2ccccc2)nc1C(=O)Nc1cnccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3958761 OBDepict O HN N NH 2 N N N N N F F F H 3 C H 2 N O IC50 = 0.13 nM 555.57 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(C4=CCOCC4)ncc3C(F)(F)F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3982497 OBDepict NH 2 N N N H O N H 2 N N N H IC50 = 0.13 nM 428.5 Nc1ncc(-c2cccc3[nH]ccc23)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3920517 OBDepict OH H 2 N N N NH O N NH 2 N N N F F F O IC50 = 0.13 nM 573.58 Nc1ncc(-c2nc(N3CCOCC3)ccc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)(CO)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3943147 OBDepict NH 2 N N N H O N H 2 N N N N F F F CH 3 H 3 C IC50 = 0.13 nM 501.52 CN(C)c1ccc(C(F)(F)F)c(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(N)CC3)n2)n1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL46094 OBDepict HO H OH H HO O H H O H 3 C H 3 C H CH 3 H CH 3 O Ki = 0.14 nM 452.55 CC1=CC23C(=O)[C@@H](C=C(CO)[C@@H](O)[C@]2(O)[C@H]1OC(=O)c1ccccc1)[C@H]1[C@@H](C[C@H]3C)C1(C)C Homo sapiens CHEMBL822646 single protein format
CHEMBL3945647 OBDepict O NH N H 2 N N N N N F N N CH 3 NH 2 O IC50 = 0.14 nM 508.56 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(N4CCOCC4)ncc3F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3943813 OBDepict H 2 N N HN O N NH 2 N IC50 = 0.15 nM 388.48 Nc1ncc(-c2ccccc2)nc1C(=O)Nc1ccccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3987185 OBDepict CH 3 O NH 2 N N N H O N NH 2 N N O F F F IC50 = 0.16 nM 532.53 CCOCC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3ncccc3OC(F)(F)F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3970893 OBDepict NH 2 N N HN O N N N F F F O H 3 C H 2 N IC50 = 0.17 nM 556.59 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3cc(N4CCOCC4)ccc3C(F)(F)F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3976541 OBDepict NH 2 N N NH O N H 2 N N N N O IC50 = 0.19 nM 475.56 Nc1ncc(-c2cccc(N3CCOCC3)n2)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3942619 OBDepict CH 3 O N N H 2 N NH O N N NH 2 IC50 = 0.19 nM 419.49 COc1ccc(-c2cnc(N)c(C(=O)Nc3cnccc3N3CCC(N)CC3)n2)cc1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL27768 OBDepict CH 3 O O H H H 3 C O OH CH 3 CH 3 H H H O OH H 3 C O CH 3 HO Ki = 0.2 nM 504.62 CCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@H]23)[C@@H]2C(C)(C)[C@]12OC(=O)CCC Homo sapiens CHEMBL766516 single protein format
CHEMBL3957149 OBDepict H 2 N N N N H O N H 2 N N N N F F F IC50 = 0.2 nM 513.53 Nc1ncc(-c2nc(N3CCC3)ccc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3901073 OBDepict HO H 2 N N N HN O N H 2 N N N O F F F IC50 = 0.22 nM 504.47 Nc1ncc(-c2ncccc2OC(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)(CO)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL4115475 OBDepict H 2 N N N NH O N N N N F F F H O H O H H 2 N IC50 = 0.24 nM 571.56 Nc1ncc(-c2nc(N3CCOCC3)ccc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1C[C@@H]2CO[C@H](C1)[C@H]2N Homo sapiens CHEMBL3889158 single protein format
CHEMBL3960459 OBDepict H 2 N N N N H O N N O N F F F H F H H 2 N IC50 = 0.25 nM 492.44 Nc1ncc(-c2ncccc2OC(F)(F)F)nc1C(=O)Nc1ncccc1N1CC[C@@H](N)[C@@H](F)C1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3912038 OBDepict OH NH 2 N N NH O N NH 2 N N N O IC50 = 0.25 nM 555.64 Nc1ncc(-c2cc3ccccc3c(N3CCOCC3)n2)nc1C(=O)Nc1ncccc1N1CCC(N)(CO)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3915489 OBDepict NH 2 N N NH O N H 2 N N N O F F F IC50 = 0.25 nM 474.45 Nc1ncc(-c2ncccc2OC(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL2148106 OBDepict H 3 C O H OH H 3 C H H O H CH 3 O H O CH 3 H 3 C HO O H H 3 C O O H OH H 3 C H Ki = 0.26 nM 592.73 CO[C@@H](CC[C@H](C)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C)c1cccc(O)c1 Homo sapiens CHEMBL2148237 single protein format
CHEMBL4109540 OBDepict OH HN CH 3 H N N F F F N H 2 N NH O N N CH 3 NH 2 IC50 = 0.26 nM 545.57 C[C@H](CO)Nc1ccc(C(F)(F)F)c(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(C)(N)CC3)n2)n1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3967547 OBDepict NH 2 N N N H O N NH 2 N N N N N H 3 C IC50 = 0.27 nM 445.49 Cn1ncc2c(-c3cnc(N)c(C(=O)Nc4ncccc4N4CCC(N)CC4)n3)ncnc21 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3975977 OBDepict NH 2 N N NH O N H 2 N N N N N O IC50 = 0.29 nM 476.55 Nc1ncc(-c2ccnc(N3CCOCC3)n2)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3893839 OBDepict O HN N NH 2 N N N N N N F F F H 3 C H 2 N O IC50 = 0.3 nM 558.57 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(N4CCOCC4)ncc3C(F)(F)F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3946659 OBDepict F N H 2 N N HN O N NH 2 N N O F F F IC50 = 0.3 nM 492.44 Nc1ncc(-c2ncccc2OC(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)C(F)C1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3893246 OBDepict H 2 N N N N H O N N N N F F F H H 3 C O CH 3 H 2 N IC50 = 0.32 nM 571.61 C[C@H]1COCCN1c1ccc(C(F)(F)F)c(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(C)(N)CC3)n2)n1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3904204 OBDepict NH 2 N N N H O N H 2 N N N N F N H IC50 = 0.33 nM 448.47 Nc1ncc(-c2ncnc3[nH]cc(F)c23)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3950697 OBDepict NH 2 N N NH O N H 2 N N N F IC50 = 0.33 nM 408.44 Nc1ncc(-c2ncccc2F)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3907088 OBDepict NH 2 N N Cl N N H 2 N N H O N N H 3 C NH 2 IC50 = 0.35 nM 454.93 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(N)ncc3Cl)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3965722 OBDepict CH 3 O N NH 2 N N H O N NH 2 N N O F F F IC50 = 0.36 nM 504.47 COC1CN(c2cccnc2NC(=O)c2nc(-c3ncccc3OC(F)(F)F)cnc2N)CCC1N Homo sapiens CHEMBL3889158 single protein format
CHEMBL3942560 OBDepict N N N N H 2 N N H O N N H 3 C NH 2 IC50 = 0.4 nM 429.49 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3ncccc3C#N)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3937993 OBDepict NH 2 O N N F N N H 2 N N H O N N H 3 C NH 2 IC50 = 0.4 nM 466.48 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(C(N)=O)ncc3F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL2151411 OBDepict CH 3 N N N N O N H O N H H 3 C IC50 = 0.4 nM 452.52 Cc1cccc2c(C3=C(c4nc(N5CCN(C)CC5)nc5ccccc45)C(=O)NC3=O)c[nH]c12 Homo sapiens CHEMBL2156011 single protein format
CHEMBL3908251 OBDepict NH 2 N N NH O N N N F F F CH 3 NH 2 IC50 = 0.4 nM 512.54 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(C4CC4)ccc3C(F)(F)F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3909349 OBDepict H 2 N N N HN O N NH 2 N N N IC50 = 0.43 nM 445.53 Nc1ncc(-c2ncnc3c2CCCC3)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3909775 OBDepict NH 2 N N NH O N H 2 N N N F F F F F F IC50 = 0.46 nM 526.45 Nc1ncc(-c2nc(C(F)(F)F)ccc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3977690 OBDepict N N N N F F F N NH 2 N H O N N CH 3 H 2 N IC50 = 0.48 nM 498.47 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(C#N)ncc3C(F)(F)F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL285801 OBDepict CH 3 N H N H 3 C H H N H H 3 C CH 3 O OH Ki = 0.5 nM 413.61 CCCCCCCCc1ccc2c3c(c[nH]c13)C[C@@H](CO)NC(=O)[C@H](C(C)C)N2C Homo sapiens CHEMBL769617 assay format
CHEMBL4072879 OBDepict CH 3 HN Cl O N H O N H 3 C IC50 = 0.5 nM 429.91 CNCc1ccc2ccc(Cl)c(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c2c1 Homo sapiens CHEMBL4004540 single protein format
CHEMBL1996510 OBDepict O N H O N N N N H N H IC50 = 0.5 nM 424.46 O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1nc(N2CCNCC2)nc2ccccc12 Homo sapiens CHEMBL2156011 single protein format
CHEMBL4102228 OBDepict H 3 C N CH 3 Cl O N H O N H IC50 = 0.5 nM 429.91 CN(C)Cc1ccc2ccc(Cl)c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c2c1 Homo sapiens CHEMBL4004540 single protein format
CHEMBL3928145 OBDepict NH 2 N N HN O N N N N F F F H H O H NH 2 IC50 = 0.5 nM 569.59 Nc1ncc(-c2nc(N3CCOCC3)ccc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1C[C@@H]2CC[C@H](C1)[C@H]2N Homo sapiens CHEMBL3889158 single protein format
CHEMBL3921551 OBDepict O HN N NH 2 N N N N Cl F F F H 3 C H 2 N IC50 = 0.5 nM 506.92 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nccc(Cl)c3C(F)(F)F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3939304 OBDepict H 3 C O N N N F F F N NH 2 HN O N N H 3 C H 2 N IC50 = 0.51 nM 571.61 CC1CN(c2ccc(C(F)(F)F)c(-c3cnc(N)c(C(=O)Nc4ncccc4N4CCC(C)(N)CC4)n3)n2)CCO1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3928668 OBDepict N H 2 N N N N H O N NH 2 N N N O H 3 C IC50 = 0.53 nM 484.52 COc1ccnc(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(N)(CC#N)CC3)n2)c1C#N Homo sapiens CHEMBL3889158 single protein format
CHEMBL346228 OBDepict CH 3 O O H O H H 3 C H CH 3 CH 3 OH O H H OH H 3 C O H 3 C OH Ki = 0.54 nM 532.67 CCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@H]23)[C@@H]2C(C)(C)[C@]12OC(=O)CCCC Homo sapiens CHEMBL770276 single protein format
CHEMBL3891166 OBDepict H 3 C O F N N N NH 2 HN O N N H 3 C H 2 N IC50 = 0.55 nM 452.49 COc1ccnc(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(C)(N)CC3)n2)c1F Homo sapiens CHEMBL3889158 single protein format
CHEMBL3919379 OBDepict CH 3 N H 3 C N N F F F N NH 2 HN O N N H 3 C H 2 N IC50 = 0.55 nM 515.54 CN(C)c1ccc(C(F)(F)F)c(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(C)(N)CC3)n2)n1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3968875 OBDepict NH 2 N N HN O N N N N F F F O H 3 C H 2 N IC50 = 0.57 nM 557.58 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(N4CCOCC4)ccc3C(F)(F)F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3905583 OBDepict H 3 C NH 2 N N N H O N NH 2 N N O F F F IC50 = 0.6 nM 502.5 CCC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3ncccc3OC(F)(F)F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3919287 OBDepict N O N N F F F N NH 2 N H O N N CH 3 H 2 N IC50 = 0.6 nM 513.48 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nccc(OC(F)(F)F)c3C#N)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3981769 OBDepict CH 3 O N N F F F N H 2 N NH O N N CH 3 NH 2 IC50 = 0.63 nM 502.5 COc1ccc(C(F)(F)F)c(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(C)(N)CC3)n2)n1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3970381 OBDepict H 2 N N N HN O N N N F F F F F H 3 C H 2 N IC50 = 0.68 nM 562.55 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(C4CC(F)(F)C4)ccc3C(F)(F)F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3892736 OBDepict O HN N NH 2 N N N N Cl H 3 C H 2 N IC50 = 0.7 nM 438.92 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3ncccc3Cl)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3957649 OBDepict O N H N NH 2 N N N F N H IC50 = 0.8 nM 393.43 Nc1ncc(-c2ccccc2F)nc1C(=O)Nc1cnccc1N1CCNCC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3889877 OBDepict N N F F F N N NH 2 N H O N N H 3 C NH 2 IC50 = 0.8 nM 497.49 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nccc(C#N)c3C(F)(F)F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3924825 OBDepict NH 2 N N N H O N H 2 N N N N S IC50 = 0.84 nM 447.53 Nc1ncc(-c2ncnc3sccc23)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3922907 OBDepict HO HN N N F F F N H 2 N N H O N N H 3 C NH 2 IC50 = 0.84 nM 531.54 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(NCCO)ccc3C(F)(F)F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3928682 OBDepict OH NH 2 N N N H O N H 2 N N N N IC50 = 0.85 nM 445.49 N#Cc1cccnc1-c1cnc(N)c(C(=O)Nc2ncccc2N2CCC(N)(CO)CC2)n1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3975025 OBDepict H 3 C NH 2 N N N H O N NH 2 N N F IC50 = 0.86 nM 436.5 CCC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3ncccc3F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3919244 OBDepict CH 3 O NH 2 N N N H O N NH 2 N N F IC50 = 0.86 nM 452.49 COCC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3ncccc3F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3933423 OBDepict OH NH 2 N N NH O N NH 2 N N F IC50 = 0.88 nM 452.49 Nc1ncc(-c2ncccc2F)nc1C(=O)Nc1ncccc1N1CCC(N)(CCO)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL4113858 OBDepict H 2 N N N N H O N N N N F F F H H 3 C O CH 3 H 2 N IC50 = 0.89 nM 571.61 C[C@@H]1COCCN1c1ccc(C(F)(F)F)c(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(C)(N)CC3)n2)n1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3959314 OBDepict F N N N CH 3 N NH 2 HN O N N H 3 C H 2 N IC50 = 0.9 nM 487.54 Cc1nc(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(C)(N)CC3)n2)c2cc(F)ccc2n1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL568580 OBDepict CH 3 N N O N H O N H IC50 = 0.9 nM 436.52 CN1CCN(c2cc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3c2)CC1 Homo sapiens CHEMBL1040086 single protein format
CHEMBL3954062 OBDepict NH 2 N N HN O N N O N F F F H 3 C H 2 N IC50 = 0.9 nM 488.47 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3ncccc3OC(F)(F)F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3915095 OBDepict H 2 N N N N H O N N N N F F F O H 3 C H 2 N IC50 = 0.94 nM 583.62 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nc(N4C5CCC4COC5)ccc3C(F)(F)F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL2347053 OBDepict H N N + N O N H O _ O IC50 = 0.98 nM 332.32 O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-] Homo sapiens CHEMBL2350681 single protein format
CHEMBL3943631 OBDepict N F N N N NH 2 N H O N N CH 3 H 2 N IC50 = 0.99 nM 447.48 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nccc(C#N)c3F)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL4077967 OBDepict H 3 C N CH 3 Cl O N H O N H 3 C Ki = 1.0 nM 443.93 CN(C)Cc1ccc2ccc(Cl)c(C3=C(c4cn(C)c5ccccc45)C(=O)NC3=O)c2c1 Homo sapiens CHEMBL4004553 single protein format
CHEMBL2418196 OBDepict O O H O H OH H 3 C H H CH 3 O O O H CH 3 H 3 C CH 3 H HO H H 3 C OH Ki = 1.0 nM 562.7 C[C@@H](CCCc1cccc(O)c1)[C@H]1O[C@@]23C[C@H](OC(=O)C[C@H]([C@@H](C)O)OC(=O)C[C@](O)(O2)[C@H](C)CC3(C)C)[C@@H]1C Homo sapiens CHEMBL2421509 single protein format
CHEMBL3963597 OBDepict N O N N N NH 2 NH O N N CH 3 NH 2 IC50 = 1.0 nM 485.55 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3nccc(OC4CC4)c3C#N)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3914252 OBDepict H 2 N N N HN O N H 2 N N N S N O IC50 = 1.0 nM 481.59 Nc1ncc(-c2csc(N3CCOCC3)n2)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3933598 OBDepict H 3 C O N N N N NH 2 HN O N N H 3 C H 2 N IC50 = 1.0 nM 459.51 COc1ccnc(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(C)(N)CC3)n2)c1C#N Homo sapiens CHEMBL3889158 single protein format
CHEMBL2153750 OBDepict CH 3 N N N N O N H F O N H IC50 = 1.0 nM 456.48 CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3cc(F)ccc3n2)CC1 Homo sapiens CHEMBL2156011 single protein format
CHEMBL3912781 OBDepict CH 3 O F N N N NH 2 HN O N N H 3 C H 2 N IC50 = 1.1 nM 466.52 CCOc1ccnc(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(C)(N)CC3)n2)c1F Homo sapiens CHEMBL3889158 single protein format
CHEMBL108303 OBDepict H 3 C O O O H HO O H 3 C Ki = 1.202 nM 410.6 CCCCCCCC/C=C1CC([C@H](CO)OC(=O)CCCCCCCC)OC1=O Homo sapiens CHEMBL762305 single protein format
CHEMBL3967601 OBDepict CH 3 O N F F F N N H 2 N NH O N N CH 3 NH 2 IC50 = 1.3 nM 516.53 CCOc1ccnc(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(C)(N)CC3)n2)c1C(F)(F)F Homo sapiens CHEMBL3889158 single protein format
CHEMBL3890986 OBDepict NH 2 N N NH O N H 2 N N N F F F IC50 = 1.3 nM 458.45 Nc1ncc(-c2ncccc2C(F)(F)F)nc1C(=O)Nc1ncccc1N1CCC(N)CC1 Homo sapiens CHEMBL3889158 single protein format
CHEMBL3925357 OBDepict OH NH 2 N N N H O N H 2 N N N N O CH 3 IC50 = 1.3 nM 475.51 COc1ccnc(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(N)(CO)CC3)n2)c1C#N Homo sapiens CHEMBL3889158 single protein format
CHEMBL3899197 OBDepict H 3 C O N F F F N N NH 2 HN O N N H 3 C H 2 N IC50 = 1.3 nM 502.5 COc1ccnc(-c2cnc(N)c(C(=O)Nc3ncccc3N3CCC(C)(N)CC3)n2)c1C(F)(F)F Homo sapiens CHEMBL3889158 single protein format
CHEMBL2151415 OBDepict O N H O N N N N H 3 C N H IC50 = 1.4 nM 438.49 Cn1cc(C2=C(c3nc(N4CCNCC4)nc4ccccc34)C(=O)NC2=O)c2ccccc21 Homo sapiens CHEMBL2156011 single protein format
CHEMBL2153748 OBDepict CH 3 N N N O N H O N H IC50 = 1.4 nM 437.5 CN1CCN(c2cc3ccccc3c(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)n2)CC1 Homo sapiens CHEMBL2156011 single protein format
CHEMBL203524 OBDepict OH O O O O CH 3 CH 3 CH 3 H 3 C H 3 C H 3 C CH 3 Ki = 1.45 nM 382.54 CC(C)CC(C/C=C1/C[C@@](CO)(COC(=O)C(C)(C)C)OC1=O)CC(C)C Homo sapiens CHEMBL860607 single protein format
CHEMBL3916984 OBDepict F N N N N H 2 N N H O N N H 3 C NH 2 IC50 = 1.5 nM 473.52 CC1(N)CCN(c2cccnc2NC(=O)c2nc(-c3ncnc4ccc(F)cc34)cnc2N)CC1 Homo sapiens CHEMBL3889158 single protein format