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P17706 | PTN2_HUMAN | Tyrosine-protein phosphatase non-receptor type 2 (PTPN2)

3D structures mapped by conservation among orthologs

[ Domain: "(Phosphotyrosine protein) phosphatases II" // Y_phosphatase ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL267759 OBDepict F P F O OH HO N N N IC50 = 24.0 nM 595.59 O=P(O)(O)C(F)(F)c1ccc(CC(Cc2ccc(-c3ccccc3)cc2)(c2ccccc2)n2nnc3ccccc32)cc1 Homo sapiens CHEMBL805116 cell-based format
CHEMBL253500 OBDepict O NH S O O N H N N S H O O F IC50 = 24.0 nM 596.71 O=C1CC(c2ccc(CC(NS(=O)(=O)c3cccc(F)c3)c3ncc(CCCc4ccccc4)[nH]3)cc2)S(=O)(=O)N1 Homo sapiens CHEMBL927698 single protein format
CHEMBL248291 OBDepict O HN S O O H H 3 C HN H N N S H O O IC50 = 25.0 nM 524.62 Cc1cc(C[C@H](NS(=O)(=O)c2ccccc2)c2nc3ccccc3[nH]2)ccc1[C@@H]1CC(=O)NS1(=O)=O Homo sapiens CHEMBL1071697 single protein format
CHEMBL243942 OBDepict OH O O Br S O HO N H CH 3 CH 3 H 3 C CH 3 Ki = 26.0 nM 510.45 CC1(C)CC(Nc2cccc(-c3sc(C(=O)O)c(OCC(=O)O)c3Br)c2)CC(C)(C)C1 Homo sapiens CHEMBL896127 single protein format
CHEMBL428589 OBDepict O NH S O O N H N N H S O O F H F IC50 = 38.0 nM 588.66 O=C1CC(c2ccc(CC(NS(=O)(=O)c3cccc(F)c3)C3=NC[C@@H](Cc4ccccc4F)N3)cc2)S(=O)(=O)N1 Homo sapiens CHEMBL927698 single protein format
CHEMBL436933 OBDepict O NH S O O N H N N S H O O F F F IC50 = 43.0 nM 578.59 O=C1CC(c2ccc(CC(NS(=O)(=O)c3cccc(C(F)(F)F)c3)c3nc4ccccc4[nH]3)cc2)S(=O)(=O)N1 Homo sapiens CHEMBL927698 single protein format
CHEMBL416145 OBDepict F P F O OH OH N N N IC50 = 49.0 nM 545.53 O=P(O)(O)C(F)(F)c1ccc(CC(C/C=C/c2ccccc2)(c2ccccc2)n2nnc3ccccc32)cc1 Homo sapiens CHEMBL805116 cell-based format
CHEMBL403577 OBDepict O NH S O O N H N N H S O O F H IC50 = 68.0 nM 584.7 O=C1CC(c2ccc(CC(NS(=O)(=O)c3cccc(F)c3)C3=NC[C@@H](CCc4ccccc4)N3)cc2)S(=O)(=O)N1 Homo sapiens CHEMBL927698 single protein format
CHEMBL9321 OBDepict F P F O OH OH N N N IC50 = 72.0 nM 547.54 O=P(O)(O)C(F)(F)c1ccc(CC(CCCc2ccccc2)(c2ccccc2)n2nnc3ccccc32)cc1 Homo sapiens CHEMBL805116 cell-based format
CHEMBL253282 OBDepict O NH S O O N H N N S H O O F IC50 = 90.0 nM 554.63 O=C1CC(c2ccc(CC(NS(=O)(=O)c3cccc(F)c3)c3ncc(-c4ccccc4)[nH]3)cc2)S(=O)(=O)N1 Homo sapiens CHEMBL927698 single protein format
CHEMBL9339 OBDepict Br N N N P F F O OH HO IC50 = 92.0 nM 598.38 O=P(O)(O)C(F)(F)c1ccc(CC(Cc2ccc(Br)cc2)(c2ccccc2)n2nnc3ccccc32)cc1 Homo sapiens CHEMBL805116 cell-based format
CHEMBL403746 OBDepict O NH S O O N H N N S H O O F IC50 = 100.0 nM 582.68 O=C1CC(c2ccc(CC(NS(=O)(=O)c3cccc(F)c3)c3ncc(CCc4ccccc4)[nH]3)cc2)S(=O)(=O)N1 Homo sapiens CHEMBL927698 single protein format
CHEMBL259628 OBDepict N Br P F F O OH HO IC50 = 120.0 nM 362.07 N#Cc1ccc2cc(Br)c(C(F)(F)P(=O)(O)O)cc2c1 Homo sapiens CHEMBL1071697 single protein format
CHEMBL8758 OBDepict O Br P F F O HO OH IC50 = 120.0 nM 495.26 O=C(c1ccccc1)C(Cc1ccc(C(F)(F)P(=O)(O)O)c(Br)c1)c1ccccc1 Homo sapiens CHEMBL1071697 single protein format
CHEMBL382311 OBDepict H N H O NH 2 O N H H O H 3 C H S O O HN O IC50 = 135.0 nM 486.55 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc([C@@H]2CC(=O)NS2(=O)=O)cc1)C(N)=O Homo sapiens CHEMBL881785 cell-based format
CHEMBL253475 OBDepict O NH S O O N H N N H S O O F H IC50 = 140.0 nM 570.67 O=C1CC(c2ccc(CC(NS(=O)(=O)c3cccc(F)c3)C3=NC[C@@H](Cc4ccccc4)N3)cc2)S(=O)(=O)N1 Homo sapiens CHEMBL927698 single protein format
CHEMBL592245 OBDepict O HN N S O O H 3 C HN H N N S H O O IC50 = 150.0 nM 525.61 Cc1cc(C[C@H](NS(=O)(=O)c2ccccc2)c2nc3ccccc3[nH]2)ccc1N1CC(=O)NS1(=O)=O Homo sapiens CHEMBL1071697 single protein format
CHEMBL3911307 OBDepict CH 3 NH O N H O H 2 N O HN O CH 3 P F F O OH HO IC50 = 160.0 nM 596.57 CCc1ccc(C(=O)NCCCCC(NC(=O)C(Cc2ccc(C(F)(F)P(=O)(O)O)cc2)NC(C)=O)C(N)=O)cc1 Homo sapiens CHEMBL3887770 single protein format
CHEMBL3818451 OBDepict H 3 C N H O N H H S O O CH 3 O N H O O NH 2 O OH Ki = 160.0 nM 572.64 CCCCCNC(=O)[C@H](Cc1ccc(C(=O)C(=O)Nc2ccccc2C(=O)O)c(/C=C/C(N)=O)c1)NS(C)(=O)=O Homo sapiens CHEMBL3819930 single protein format
CHEMBL215335 OBDepict OH O O Br S O OH HN O O OH Ki = 180.0 nM 458.24 O=C(O)COc1c(C(=O)O)sc(-c2ccc(NC(=O)CC(=O)O)cc2)c1Br Homo sapiens CHEMBL854225 single protein format
CHEMBL607027 OBDepict O NH S O O H F HN H N N H N S IC50 = 250.0 nM 521.6 O=C1C[C@@H](c2ccc(C[C@H](Nc3nc4ccccc4s3)c3nc4ccccc4[nH]3)cc2F)S(=O)(=O)N1 Homo sapiens CHEMBL1071697 single protein format
CHEMBL404319 OBDepict O NH S O O N H N N S H O O F IC50 = 270.0 nM 568.65 O=C1CC(c2ccc(CC(NS(=O)(=O)c3cccc(F)c3)c3ncc(Cc4ccccc4)[nH]3)cc2)S(=O)(=O)N1 Homo sapiens CHEMBL927698 single protein format
CHEMBL254513 OBDepict O NH S O O N H N N S H O O F F F IC50 = 270.0 nM 528.53 O=C1CC(c2ccc(CC(NS(=O)(=O)c3cccc(C(F)(F)F)c3)c3ncc[nH]3)cc2)S(=O)(=O)N1 Homo sapiens CHEMBL927698 single protein format
CHEMBL267245 OBDepict O O N N N P F F O OH OH IC50 = 290.0 nM 563.5 O=C(OCc1ccccc1)C(Cc1ccc(C(F)(F)P(=O)(O)O)cc1)(c1ccccc1)n1nnc2ccccc21 Homo sapiens CHEMBL805116 cell-based format
CHEMBL213758 OBDepict HO O O S Br O HO Ki = 320.0 nM 357.18 O=C(O)COc1c(C(=O)O)sc(-c2ccccc2)c1Br Homo sapiens CHEMBL854225 single protein format
CHEMBL556636 OBDepict O NH O S S H CH 3 H 3 C O HO IC50 = 321.3 nM 409.57 CC1(C)SCC(CCCCC(=O)Nc2ccc3c(c2)CO[C@H](C(=O)O)C3)S1 Homo sapiens CHEMBL1053999 single protein format
CHEMBL564699 OBDepict O NH S O H S O HO CH 3 H 3 C IC50 = 322.7 nM 409.57 CC1(C)SCC(CCCCC(=O)Nc2ccc3c(c2)C[C@@H](C(=O)O)OC3)S1 Homo sapiens CHEMBL1053999 single protein format
CHEMBL1242552 OBDepict _ O + N O S N O O HO IC50 = 348.0 nM 416.41 O=C(O)c1cccc2c1oc1ccc(-c3csc(-c4ccc([N+](=O)[O-])cc4)n3)cc12 Homo sapiens CHEMBL1248461 single protein format
CHEMBL549372 OBDepict O NH S S O CH 3 H 3 C H O HO IC50 = 403.3 nM 381.52 CC1(C)SCC(CCC(=O)Nc2ccc3c(c2)CO[C@H](C(=O)O)C3)S1 Homo sapiens CHEMBL1053999 single protein format
CHEMBL4871707 OBDepict CH 3 + N N CH 3 F F F _ I IC50 = 410.0 nM 482.29 Cc1cccc(Cc2c3cccn3c3ccc(C(F)(F)F)cc3[n+]2C)c1.[I-] Homo sapiens CHEMBL4813844 assay format
CHEMBL253065 OBDepict O NH S O O N H N N H S O O F F F H H 3 C IC50 = 420.0 nM 544.58 C[C@@H]1CN=C(C(Cc2ccc(C3CC(=O)NS3(=O)=O)cc2)NS(=O)(=O)c2cccc(C(F)(F)F)c2)N1 Homo sapiens CHEMBL927698 single protein format
CHEMBL556076 OBDepict O HN S S H 3 C CH 3 O H O OH IC50 = 436.7 nM 381.52 CC1(C)SCC(CCC(=O)Nc2ccc3c(c2)C[C@@H](C(=O)O)OC3)S1 Homo sapiens CHEMBL1053999 single protein format
CHEMBL55274 OBDepict CH 3 N O N H O OH NH O O OH O H 3 C + N O _ O Ki = 450.0 nM 576.56 CCc1cc(CC(NC(C)=O)C(=O)NCc2ccc([N+](=O)[O-])cc2)ccc1N(C(=O)C(=O)O)c1ccccc1C(=O)O Homo sapiens CHEMBL767806 single protein format
CHEMBL508831 OBDepict OH O O H CH 3 H 3 C H CH 3 H H 3 C CH 3 H H 3 C CH 3 O HO IC50 = 470.0 nM 590.85 CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](OCc6ccc(C(=O)O)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 Homo sapiens CHEMBL963011 single protein format
CHEMBL506556 OBDepict OH O O H CH 3 H 3 C H CH 3 H H 3 C CH 3 H H 3 C CH 3 O HO IC50 = 490.0 nM 590.85 CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](OCc6cccc(C(=O)O)c6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 Homo sapiens CHEMBL963011 single protein format
CHEMBL4865928 OBDepict CH 3 N CH 3 N IC50 = 500.0 nM 198.27 CC1c2cccn2-c2ccccc2N1C Homo sapiens CHEMBL4813844 assay format
CHEMBL401833 OBDepict O NH S O O N H N H N S O O F F F IC50 = 500.0 nM 530.55 O=C1CC(c2ccc(CC(NS(=O)(=O)c3cccc(C(F)(F)F)c3)C3=NCCN3)cc2)S(=O)(=O)N1 Homo sapiens CHEMBL927698 single protein format
CHEMBL550662 OBDepict O N H S O H O OH IC50 = 550.3 nM 345.42 O=C(CCCc1cccs1)Nc1ccc2c(c1)CO[C@H](C(=O)O)C2 Homo sapiens CHEMBL1053999 single protein format
CHEMBL577144 OBDepict OH O HN O S O HO H O O N S O O Ki = 600.0 nM 466.45 O=C(O)C(=O)Nc1sc2c(c1C(=O)O)CCO[C@H]2COC1=NS(=O)(=O)c2ccccc21 Homo sapiens CHEMBL1050896 single protein format
CHEMBL501267 OBDepict HO O H H 3 C CH 3 CH 3 CH 3 H CH 3 H CH 3 H 3 C H HO IC50 = 630.0 nM 596.98 CC1(C)CC[C@]2(CCCCCCCCCCC(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 Homo sapiens CHEMBL963011 single protein format
CHEMBL253066 OBDepict O NH S O O N H N N H S O O F F F H H 3 C IC50 = 670.0 nM 544.58 C[C@H]1CN=C(C(Cc2ccc(C3CC(=O)NS3(=O)=O)cc2)NS(=O)(=O)c2cccc(C(F)(F)F)c2)N1 Homo sapiens CHEMBL927698 single protein format
CHEMBL570779 OBDepict O N H S O H O HO IC50 = 677.7 nM 345.42 O=C(CCCc1cccs1)Nc1ccc2c(c1)C[C@@H](C(=O)O)OC2 Homo sapiens CHEMBL1053999 single protein format
CHEMBL89067 OBDepict CH 3 S N + S _ O N N H O CH 3 H 3 C IC50 = 680.0 nM 361.49 CSc1ccnc(C[S+]([O-])c2nc3cc(OC(C)C)ccc3[nH]2)c1 Homo sapiens CHEMBL981142 single protein format
CHEMBL214378 OBDepict HO O O Br S O HO N H O N Ki = 680.0 nM 477.29 O=C(O)COc1c(C(=O)O)sc(-c2ccc(NC(=O)c3cccnc3)cc2)c1Br Homo sapiens CHEMBL854225 single protein format
CHEMBL1242457 OBDepict H 2 N S N O O HO IC50 = 693.0 nM 386.43 Nc1ccc(-c2nc(-c3ccc4oc5c(C(=O)O)cccc5c4c3)cs2)cc1 Homo sapiens CHEMBL1248461 single protein format
CHEMBL3098852 OBDepict HO O N N S O O IC50 = 700.0 nM 534.64 O=C(O)c1ccc(CN2C(=O)/C(=C/c3ccc(OCCc4ccccc4)cc3)S/C2=Nc2ccccc2)cc1 Homo sapiens CHEMBL3102580 assay format
CHEMBL253268 OBDepict O NH S O O N H N N H S O O F F F H 3 C H 3 C IC50 = 700.0 nM 558.6 CC1(C)CN=C(C(Cc2ccc(C3CC(=O)NS3(=O)=O)cc2)NS(=O)(=O)c2cccc(C(F)(F)F)c2)N1 Homo sapiens CHEMBL927698 single protein format
CHEMBL139393 OBDepict O N H O HO S O OH NH Ki = 710.0 nM 270.27 O=C(O)C(=O)Nc1sc2c(c1C(=O)O)CCNC2 Homo sapiens CHEMBL869792 single protein format
CHEMBL1242458 OBDepict H 3 C S N O O HO IC50 = 730.0 nM 385.44 Cc1ccc(-c2nc(-c3ccc4oc5c(C(=O)O)cccc5c4c3)cs2)cc1 Homo sapiens CHEMBL1248461 single protein format
CHEMBL445491 OBDepict HO O H H 3 C CH 3 CH 3 CH 3 H CH 3 H CH 3 H 3 C H HO IC50 = 790.0 nM 568.93 CC1(C)CC[C@]2(CCCCCCCCC(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 Homo sapiens CHEMBL963011 single protein format
CHEMBL1241469 OBDepict HO O S N O O HO IC50 = 794.0 nM 441.46 O=C(O)/C=C/c1cccc(-c2nc(-c3ccc4oc5c(C(=O)O)cccc5c4c3)cs2)c1 Homo sapiens CHEMBL1248461 single protein format
CHEMBL3098857 OBDepict HO O N N S O F O IC50 = 800.0 nM 538.6 O=C(O)c1ccc(CN2C(=O)/C(=C/c3ccc(OCc4ccccc4)c(F)c3)S/C2=Nc2ccccc2)cc1 Homo sapiens CHEMBL3102580 assay format
CHEMBL464276 OBDepict CH 3 CH 3 CH 3 H O HO O CH 3 O IC50 = 800.0 nM 398.54 CC1=C(O)/C(=C/[C@@H](C)CCC/C(C)=C/CC/C(C)=C/CCc2ccoc2)OC1=O Homo sapiens CHEMBL3997392 assay format
CHEMBL504291 OBDepict OH O H H 3 C CH 3 CH 3 CH 3 H CH 3 H CH 3 H 3 C H HO IC50 = 850.0 nM 540.87 CC1(C)CC[C@]2(CCCCCCC(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 Homo sapiens CHEMBL963011 single protein format
CHEMBL55799 OBDepict CH 3 NH O HN O CH 3 N CH 3 O O OH O HO Ki = 900.0 nM 511.58 CCCCCNC(=O)C(Cc1ccc(N(C(=O)C(=O)O)c2ccccc2C(=O)O)c(CC)c1)NC(C)=O Homo sapiens CHEMBL767806 single protein format
CHEMBL1242363 OBDepict H 3 C N CH 3 S N O O OH IC50 = 961.0 nM 414.49 CN(C)c1ccc(-c2nc(-c3ccc4oc5c(C(=O)O)cccc5c4c3)cs2)cc1 Homo sapiens CHEMBL1248461 single protein format
CHEMBL1242827 OBDepict OH O S N O O OH IC50 = 983.0 nM 441.46 O=C(O)/C=C/c1ccc(-c2nc(-c3ccc4oc5c(C(=O)O)cccc5c4c3)cs2)cc1 Homo sapiens CHEMBL1248461 single protein format
CHEMBL379196 OBDepict HO O O Br S O OH N CH 3 CH 3 Ki = 1000.0 nM 400.25 CN(C)c1ccc(-c2sc(C(=O)O)c(OCC(=O)O)c2Br)cc1 Homo sapiens CHEMBL854225 single protein format