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P19438 | TNR1A_HUMAN | Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

3D structures mapped by conservation among orthologs

[ Domain: "DEATH domain" // Death ]

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[ Domain: "TNF receptor-like" // TNFR_c6_2 ]

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[ Domain: "TNF receptor-like" // TNFR_c6_1 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL359346 OBDepict H 3 C N O S N O H 3 C N CH 3 IC50 = 130.0 nM 341.44 CCN1C(=O)C(=Cc2cn(C)c3ccccc23)C(=O)N(CC)C1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL357092 OBDepict CH 3 N S S O S N CH 3 N F F F IC50 = 140.0 nM 403.48 CCN1C(=O)/C(=C/c2ccc(-c3cc(C(F)(F)F)nn3C)s2)SC1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL150292 OBDepict CH 2 N O N S H 3 C O O H 3 C H 3 C IC50 = 210.0 nM 316.38 C=CCN1C(=O)n2c(c(C)c3c(OC)cc(OC)cc32)C1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL356012 OBDepict CH 2 N S N S H 3 C O O H 3 C H 3 C IC50 = 210.0 nM 332.45 C=CCN1C(=S)c2c(C)c3c(OC)cc(OC)cc3n2C1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL356830 OBDepict CH 2 N S N O O O H 3 C H 3 C IC50 = 280.0 nM 302.36 C=CCN1C(=O)c2cc3c(OC)cc(OC)cc3n2C1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL151203 OBDepict H 3 C O O O N H 3 C S N O CH 3 IC50 = 280.0 nM 320.37 CCN1C(=O)c2cc3c(OC)cc(OCOC)cc3n2C1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL150886 OBDepict CH 3 N S S O O S O O H 3 C IC50 = 300.0 nM 379.48 CCN1C(=O)/C(=C/c2ccc(-c3ccsc3C(=O)OC)o2)SC1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL423208 OBDepict CH 3 O O N O N S N H 3 C IC50 = 310.0 nM 367.43 CCN1C(=O)c2cc3c(OC)cc(OCc4ccccn4)cc3n2C1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL146955 OBDepict H 3 C N S S O O F F F IC50 = 320.0 nM 383.42 CCN1C(=O)/C(=C/c2ccc(-c3ccccc3C(F)(F)F)o2)SC1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL151686 OBDepict CH 3 O O N O N S O O H 3 C CH 3 CH 3 H 3 C IC50 = 390.0 nM 390.46 CCN1C(=O)c2cc3c(OC)cc(OCC(=O)OC(C)(C)C)cc3n2C1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL150992 OBDepict H 3 C N O S N O CH 3 N H O IC50 = 400.0 nM 433.53 CCN1C(=O)C(=Cc2c[nH]c3ccc(OCc4ccccc4)cc23)C(=O)N(CC)C1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL359348 OBDepict CH 3 N O S N O CH 3 N H H 3 C IC50 = 600.0 nM 341.44 CCN1C(=O)C(=Cc2c[nH]c3c(C)cccc23)C(=O)N(CC)C1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL345772 OBDepict CH 2 N O N S O O H 3 C H 3 C IC50 = 610.0 nM 302.36 C=CCN1C(=O)n2c(cc3c(OC)cc(OC)cc32)C1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL355913 OBDepict CH 3 O O N CH 3 S N O N O IC50 = 670.0 nM 389.48 COc1cc(OC)c2cc3n(c2c1)C(=S)N(CCCN1CCOCC1)C3=O Homo sapiens CHEMBL817776 single protein format
CHEMBL4213787 OBDepict Cl Cl S N N H O N H O N IC50 = 770.0 nM 393.25 O=C(NNC(=O)c1csc(-c2ccc(Cl)cc2Cl)n1)c1ccccn1 Homo sapiens CHEMBL4195488 cell-based format
CHEMBL151752 OBDepict CH 2 N S N O O O H 3 C O H 3 C H 3 C IC50 = 780.0 nM 332.38 C=CCN1C(=O)c2cc3c(OC)c(OC)c(OC)cc3n2C1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL347715 OBDepict O N O N S H 3 C N H H 3 C IC50 = 790.0 nM 451.55 Cc1ccccc1N1C(=O)C(=Cc2c[nH]c3ccccc23)C(=O)N(c2ccccc2C)C1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL151578 OBDepict CH 3 O O N CH 3 S N O H 3 C IC50 = 1000.0 nM 290.34 CCN1C(=O)c2cc3c(OC)cc(OC)cc3n2C1=S Homo sapiens CHEMBL817776 single protein format
CHEMBL345500 OBDepict H 3 C N O S N O H 3 C N H IC50 = 1000.0 nM 327.41 CCN1C(=O)C(=Cc2c[nH]c3ccccc23)C(=O)N(CC)C1=S Homo sapiens CHEMBL817776 single protein format