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P19525 | E2AK2_HUMAN | "Interferon-induced, double-stranded RNA-activated protein kinase" (EIF2AK2)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: "dsRNA-binding domain-like" // dsrm ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4859660 OBDepict NH 2 N F + N O NH O _ O IC50 = -36700.0 nM 378.36 Nc1ncc(-c2cccc([N+](=O)[O-])c2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804478 cell-based format
CHEMBL4855542 OBDepict NH 2 N S N O NH IC50 = -21700.0 nM 372.45 Nc1ncc(-c2cccc3ncsc23)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804478 cell-based format
CHEMBL4867931 OBDepict H 3 C O N H S N O O H 2 N O HN IC50 = -11100.0 nM 464.55 COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(-c2ccc3c(c2)CCNC3=O)c1 Homo sapiens CHEMBL4804478 cell-based format
CHEMBL4868141 OBDepict H 2 N N O O HN NH S O O IC50 = -7600.0 nM 532.67 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2OC2CCCCC2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804478 cell-based format
CHEMBL4860979 OBDepict F S N O O CH 3 N H 2 N O N H IC50 = -800.0 nM 466.54 CN(C1CC1)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3ccc4c(c3)CCNC4=O)c2)c(F)c1 Homo sapiens CHEMBL4804478 cell-based format
CHEMBL2441346 OBDepict O N N N CH 3 F CH 3 N H 3 C NH 2 N N IC50 = 99.0 nM 419.46 Cc1cc(C)n(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1 Homo sapiens CHEMBL2443946 single protein format
CHEMBL416056 OBDepict CH 3 O O HO CH 3 O N H N N H O IC50 < 100.0 nM 467.48 COC(=O)[C@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL1805140 single protein format
CHEMBL413188 OBDepict O N H O N N H N IC50 < 100.0 nM 276.26 O=C1NC(=O)c2c1c1c3ccccc3[nH]c1n1cncc21 Homo sapiens CHEMBL1805140 single protein format
CHEMBL1802727 OBDepict HO OH O N N H O HN IC50 < 100.0 nM 365.39 O=C1Nc2ccccc2/C1=C1/Nc2ccccc2/C1=NOCCC(O)CO Homo sapiens CHEMBL1805140 single protein format
CHEMBL126077 OBDepict O N N H OH N H IC50 < 100.0 nM 277.28 O=Nc1c(-c2c(O)[nH]c3ccccc23)[nH]c2ccccc12 Homo sapiens CHEMBL1805140 single protein format
CHEMBL1802629 OBDepict H N CH 3 N N HN N IC50 = 100.0 nM 301.35 Cc1[nH]c2ccccc2c1-c1ccnc(Nc2cccnc2)n1 Homo sapiens CHEMBL1805140 single protein format
CHEMBL1802782 OBDepict CH 3 N N N H N N CH 3 N H Cl IC50 = 100.0 nM 432.96 Cc1[nH]c2ccc(Cl)cc2c1-c1ccnc(Nc2ccc(N3CCN(C)CC3)cc2)n1 Homo sapiens CHEMBL1805140 single protein format
CHEMBL1182777 OBDepict HO O N N O IC50 < 100.0 nM 314.3 O=C(O)c1ccc2c3c1cccc3c(=O)n1c3ccccc3nc21 Homo sapiens CHEMBL1805140 single protein format
CHEMBL191384 OBDepict N S NH N N HN N IC50 < 100.0 nM 372.46 N#C/C(=C1/Nc2ccccc2S1)c1ccnc(NCCc2cccnc2)n1 Homo sapiens CHEMBL1805140 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 < 100.0 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL1805140 single protein format
CHEMBL1802778 OBDepict F HN N N H 3 C N H IC50 = 150.0 nM 318.36 Cc1[nH]c2ccccc2c1-c1ccnc(Nc2ccc(F)cc2)n1 Homo sapiens CHEMBL1805140 single protein format
CHEMBL4281823 OBDepict CH 3 N N N NH 2 N O O F F F IC50 = 210.0 nM 481.48 CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261425 single protein format
CHEMBL257167 OBDepict NH 2 N H O S O H 2 N F IC50 = 250.0 nM 279.3 NC(=O)Nc1sc(-c2ccc(F)cc2)cc1C(N)=O Homo sapiens CHEMBL1805140 single protein format
CHEMBL200381 OBDepict N N NH N NH Cl F N IC50 = 250.0 nM 404.84 N#Cc1cnc2cnc(NCc3cccnc3)cc2c1Nc1ccc(F)c(Cl)c1 Homo sapiens CHEMBL1805140 single protein format
CHEMBL2171122 OBDepict Cl N O N H 3 C NH 2 N N IC50 = 291.0 nM 417.9 Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(Cl)c2)c2c(N)ncnc21 Homo sapiens CHEMBL2172951 single protein format
CHEMBL1802769 OBDepict Cl HN N N H 3 C N H IC50 = 300.0 nM 334.81 Cc1[nH]c2ccccc2c1-c1ccnc(Nc2cccc(Cl)c2)n1 Homo sapiens CHEMBL1805140 single protein format
CHEMBL2441342 OBDepict O N N F F F F N CH 3 H 2 N N N IC50 = 359.0 nM 470.43 Cn1cc(-c2ccc3c(c2F)CCN3C(=O)Cc2cccc(C(F)(F)F)n2)c2c(N)ncnc21 Homo sapiens CHEMBL2443946 single protein format
CHEMBL409450 OBDepict HO N N H O HN Br IC50 = 600.0 nM 356.18 O=C1Nc2cc(Br)ccc2/C1=C1/Nc2ccccc2/C1=NO Homo sapiens CHEMBL1805140 single protein format
CHEMBL1802630 OBDepict Cl HN N N H 3 C N H IC50 = 600.0 nM 334.81 Cc1[nH]c2ccccc2c1-c1ccnc(Nc2ccc(Cl)cc2)n1 Homo sapiens CHEMBL1805140 single protein format
CHEMBL2171124 OBDepict O N F F F N CH 3 H 2 N N N IC50 = 696.0 nM 451.45 Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(C(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL2172951 single protein format
CHEMBL1802486 OBDepict O N H N N O IC50 = 750.0 nM 379.42 O=C1NCc2c1c1c3ccccc3n3c1c1c2c2ccccc2n1C1CCC3O1 Homo sapiens CHEMBL1805140 single protein format
CHEMBL2441340 OBDepict O N N F CH 3 N H 3 C NH 2 N N IC50 = 905.0 nM 416.46 Cc1cccc(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1 Homo sapiens CHEMBL2443946 single protein format
CHEMBL2171132 OBDepict O N S H 2 N N N N CH 3 IC50 = 978.0 nM 465.58 Cn1cc(-c2cnc(N)c3c(-c4ccc5c(c4)CCN5C(=O)Cc4ccccc4)csc23)cn1 Homo sapiens CHEMBL2172951 single protein format