molecule_chembl_id |
structure |
assay_type |
relation |
values |
units |
mol_wt |
smiles |
organism |
assay_chembl_id |
bao_label |
CHEMBL3699289 |
|
IC50 |
= |
0.03 |
nM |
425.42 |
[C-]#[N+]c1cnc2c(Nc3nc(C)n(C)n3)nc(Nc3ccc4c(c3)c(C#N)nn4C)nn12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699235 |
OBDepict
N
N
H
N
Cl
N
N
N
OH
NH
N
N
|
IC50 |
= |
0.07 |
nM |
435.88 |
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CCC(O)C2)c1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699234 |
OBDepict
N
N
N
CH
3
N
H
N
N
N
NH
N
N
|
IC50 |
= |
0.09 |
nM |
370.38 |
Cn1nc(C#N)c2cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)ccc21 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699295 |
OBDepict
N
N
H
Cl
OH
N
N
N
NH
N
N
|
IC50 |
= |
0.11 |
nM |
380.8 |
N#Cc1cc(CO)c(Cl)c(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699252 |
OBDepict
N
N
H
N
Cl
N
N
N
N
NH
N
N
S
O
O
CH
3
|
IC50 |
= |
0.11 |
nM |
553.05 |
CS(=O)(=O)C1CCN(C2CN(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)C2)C1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699237 |
OBDepict
N
N
H
N
H
Cl
N
N
N
N
NH
O
N
N
|
IC50 |
= |
0.11 |
nM |
450.89 |
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(NN2CCOCC2)c1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699282 |
OBDepict
CH
3
N
H
N
N
N
N
H
N
+
N
_
C
Cl
N
N
H
HO
H
N
H
O
O
H
3
C
|
IC50 |
= |
0.13 |
nM |
510.95 |
[C-]#[N+]c1cnc2c(NCC)nc(Nc3cc(C#N)cc(N4CC[C@H](NC(=O)OC)[C@@H](O)C4)c3Cl)nn12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699244 |
OBDepict
N
HN
N
Cl
N
N
N
HN
NH
N
N
S
O
O
|
IC50 |
= |
0.15 |
nM |
567.08 |
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CCC(NC3CCS(=O)(=O)C3)CC2)c1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699266 |
OBDepict
N
NH
Cl
N
N
N
N
HN
N
O
H
3
C
N
|
IC50 |
= |
0.16 |
nM |
475.94 |
CC(=O)N1CCC(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)CC1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699294 |
OBDepict
N
N
H
Cl
CH
2
N
N
N
NH
N
N
|
IC50 |
= |
0.16 |
nM |
376.81 |
C=Cc1cc(C#N)cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c1Cl |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699238 |
OBDepict
N
N
H
N
Cl
N
N
N
N
NH
N
N
O
|
IC50 |
= |
0.2 |
nM |
504.99 |
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CCN(C3CCOC3)CC2)c1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699292 |
OBDepict
H
3
C
NH
N
N
N
N
H
N
N
N
N
N
N
OH
H
3
C
H
|
IC50 |
= |
0.21 |
nM |
485.56 |
CCNc1nc(Nc2ccc3c(c2)c(C#N)nn3C2CCN(C[C@@H](C)O)CC2)nn2c(C#N)cnc12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699278 |
OBDepict
N
N
H
N
Cl
N
N
N
N
F
NH
N
+
N
_
C
O
|
IC50 |
= |
0.21 |
nM |
522.98 |
[C-]#[N+]c1cnc2c(NC3CC3)nc(Nc3cc(C#N)cc(N4CCN(C5COC5)CC(F)C4)c3Cl)nn12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699262 |
OBDepict
N
HN
Cl
N
N
N
N
NH
CH
3
N
N
|
IC50 |
= |
0.23 |
nM |
445.92 |
CN1CC=C(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)CC1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699296 |
OBDepict
H
3
C
HN
N
N
N
N
H
N
N
Cl
N
N
N
O
|
IC50 |
= |
0.23 |
nM |
478.95 |
CCNc1nc(Nc2cc(C#N)cc(N3CCN(C4COC4)CC3)c2Cl)nn2c(C#N)cnc12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699280 |
OBDepict
N
HN
Cl
N
N
N
N
NH
N
N
N
O
CH
3
|
IC50 |
= |
0.25 |
nM |
531.02 |
CC(=O)N1CC(N2CCC(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)C1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699259 |
OBDepict
N
NH
N
Cl
N
N
N
H
HO
NH
H
N
H
N
N
O
O
O
|
IC50 |
= |
0.26 |
nM |
564.99 |
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CC[C@@H](NC(=O)OC3COC3)[C@H](O)C2)c1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699255 |
OBDepict
N
N
H
N
Cl
N
N
N
N
NH
N
N
OH
|
IC50 |
= |
0.27 |
nM |
476.93 |
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CC(N3CC(O)C3)C2)c1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699256 |
OBDepict
CH
3
O
N
H
O
H
H
HO
N
Cl
N
H
N
N
N
N
NH
N
N
|
IC50 |
= |
0.27 |
nM |
522.96 |
COC(=O)N[C@@H]1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C[C@H]1O |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699291 |
OBDepict
H
3
C
NH
N
N
N
N
H
N
N
N
N
N
N
OH
H
3
C
H
|
IC50 |
= |
0.27 |
nM |
485.56 |
CCNc1nc(Nc2ccc3c(c2)c(C#N)nn3C2CCN(C[C@H](C)O)CC2)nn2c(C#N)cnc12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699267 |
OBDepict
N
N
H
Cl
N
N
N
N
NH
O
O
N
N
O
|
IC50 |
= |
0.27 |
nM |
533.98 |
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(C2CCN(C(=O)OC3COC3)CC2)c1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699239 |
OBDepict
N
HN
N
Cl
N
N
N
N
NH
N
N
OH
CH
3
H
|
IC50 |
= |
0.28 |
nM |
492.98 |
C[C@@H](O)CN1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)CC1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699253 |
OBDepict
H
3
C
O
N
N
Cl
N
H
N
N
N
N
HN
N
N
|
IC50 |
= |
0.31 |
nM |
504.99 |
COC1CCN(C2CN(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)C2)C1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699257 |
OBDepict
CH
3
O
N
H
O
H
H
HO
N
Cl
N
H
N
N
N
N
NH
N
N
|
IC50 |
= |
0.35 |
nM |
522.96 |
COC(=O)N[C@H]1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C[C@@H]1O |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699277 |
OBDepict
CH
3
O
N
H
O
H
H
F
N
Cl
N
H
N
N
N
N
NH
N
N
|
IC50 |
= |
0.45 |
nM |
524.95 |
COC(=O)N[C@@H]1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C[C@@H]1F |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699269 |
OBDepict
N
N
N
N
N
H
N
N
H
Cl
N
F
F
N
N
CH
3
|
IC50 |
= |
0.47 |
nM |
529.0 |
CN1CC(N2CCN(c3cc(C(F)F)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)C1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699258 |
OBDepict
CH
3
O
O
N
H
O
H
H
HO
N
Cl
N
H
N
N
N
N
NH
N
N
|
IC50 |
= |
0.49 |
nM |
567.01 |
COCCOC(=O)N[C@@H]1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C[C@H]1O |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699254 |
OBDepict
H
3
C
O
N
H
O
H
N
H
CH
3
N
Cl
N
H
N
N
N
N
HN
N
N
|
IC50 |
= |
0.49 |
nM |
562.04 |
COC(=O)N[C@@H]1CN(C2CN(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)C2)C[C@H]1C |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699286 |
OBDepict
H
3
C
N
H
N
N
N
HN
N
N
Cl
N
N
H
O
H
N
O
|
IC50 |
= |
0.52 |
nM |
535.01 |
CCNc1nc(Nc2cc(C#N)cc(N3CC[C@@H]4[C@@H](C3)OCCN4C3COC3)c2Cl)nn2c(C#N)cnc12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699250 |
OBDepict
N
HN
N
Cl
N
N
N
HN
NH
N
N
H
H
OH
|
IC50 |
= |
0.54 |
nM |
519.01 |
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CCC(N[C@H]3C[C@@H](O)C3)CC2)c1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699285 |
OBDepict
CH
3
N
H
N
N
N
N
H
N
+
N
_
C
Cl
N
N
N
H
OH
H
3
C
H
|
IC50 |
= |
0.61 |
nM |
494.99 |
[C-]#[N+]c1cnc2c(NCC)nc(Nc3cc(C#N)cc(N4CCC(NC[C@@H](C)O)CC4)c3Cl)nn12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699287 |
OBDepict
N
N
H
N
F
N
N
N
N
NH
N
+
N
_
C
N
CH
3
|
IC50 |
= |
0.61 |
nM |
487.55 |
[C-]#[N+]c1cnc2c(NC3CC3)nc(Nc3cc(C#N)cc(N4CC(N5CCN(C)CC5)C4)c3F)nn12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699242 |
OBDepict
N
HN
N
Cl
N
N
N
HN
N
H
N
+
N
_
C
F
F
|
IC50 |
= |
0.7 |
nM |
538.99 |
[C-]#[N+]c1cnc2c(NC3CC3)nc(Nc3cc(C#N)cc(N4CCC(NC5CC(F)(F)C5)CC4)c3Cl)nn12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699303 |
OBDepict
H
3
C
N
H
N
N
N
HN
N
N
Cl
N
N
N
F
F
|
IC50 |
= |
0.74 |
nM |
486.92 |
CCNc1nc(Nc2cc(C#N)cc(N3CCN(CC(F)F)CC3)c2Cl)nn2c(C#N)cnc12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699274 |
OBDepict
N
N
N
N
N
H
N
N
H
Cl
N
F
F
N
H
3
C
O
|
IC50 |
= |
0.75 |
nM |
529.98 |
CC1(N2CCN(c3cc(C(F)F)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)COC1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699284 |
OBDepict
CH
3
N
H
N
N
N
N
H
N
+
N
_
C
Cl
N
HN
|
IC50 |
= |
0.76 |
nM |
421.9 |
[C-]#[N+]c1cnc2c(NCC)nc(Nc3cc(C#N)cc(C4CCNCC4)c3Cl)nn12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699264 |
OBDepict
HO
HO
N
Cl
N
H
N
N
N
N
HN
N
N
|
IC50 |
= |
0.76 |
nM |
548.05 |
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(C2CCN(C3CC(CO)(CO)C3)CC2)c1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699297 |
OBDepict
N
N
H
N
H
Cl
N
N
N
N
HN
N
N
O
|
IC50 |
= |
0.82 |
nM |
504.99 |
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(NC2CCN(C3COC3)CC2)c1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699236 |
OBDepict
N
HN
N
Cl
N
N
N
NH
N
N
CH
3
N
|
IC50 |
= |
0.87 |
nM |
460.93 |
CN1CC2(C1)CN(c1cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c1Cl)C2 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699240 |
OBDepict
CH
3
O
N
O
N
N
Cl
N
H
N
N
N
N
NH
N
N
|
IC50 |
= |
0.93 |
nM |
576.07 |
COC(=O)N1CCC(N2CCN(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)CC1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699293 |
OBDepict
CH
3
N
H
N
N
N
N
H
N
N
N
N
N
N
O
|
IC50 |
= |
0.94 |
nM |
483.54 |
CCNc1nc(Nc2ccc3c(c2)c(C#N)nn3C2CCN(C3COC3)CC2)nn2c(C#N)cnc12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699241 |
OBDepict
N
NH
N
Cl
N
N
N
N
HN
N
N
S
O
O
CH
3
|
IC50 |
= |
0.99 |
nM |
541.04 |
CS(=O)(=O)CCN1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)CC1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699268 |
OBDepict
CH
3
O
N
H
O
H
N
H
O
CH
3
Cl
N
H
F
F
N
N
N
NH
N
N
|
IC50 |
= |
1.17 |
nM |
547.95 |
COC(=O)N[C@H]1CN(c2cc(C(F)F)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)C[C@H]1OC |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699300 |
OBDepict
N
F
N
H
O
N
N
N
NH
N
CH
3
CH
3
N
H
3
C
H
3
C
N
CH
3
|
IC50 |
= |
1.43 |
nM |
503.59 |
CN1C(C)(C)CC(Oc2cc(F)c(C#N)cc2Nc2nc(NC3CC3)c3ncc(C#N)n3n2)CC1(C)C |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699245 |
OBDepict
N
N
H
N
Cl
N
N
N
HN
N
H
N
N
N
|
IC50 |
= |
1.53 |
nM |
528.02 |
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CCC(NC3CC(C#N)C3)CC2)c1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699251 |
OBDepict
CH
3
O
N
H
O
H
N
H
H
3
C
N
Cl
N
H
N
N
N
N
NH
N
N
|
IC50 |
= |
1.61 |
nM |
590.09 |
COC(=O)N[C@@H]1CN(C2CCN(c3cc(C#N)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)C[C@@H]1C |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699265 |
OBDepict
N
N
H
Cl
N
N
N
N
NH
N
N
F
F
F
|
IC50 |
= |
2.05 |
nM |
529.96 |
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(C2CCN(CCC(F)(F)F)CC2)c1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3681206 |
OBDepict
CH
3
O
N
N
N
N
H
O
N
H
2
N
H
O
|
IC50 |
= |
2.2 |
nM |
354.37 |
COc1cc(-c2cc(C(=O)N[C@H]3CCOC3)c3c(N)ncnn23)ccn1 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3699290 |
OBDepict
_
C
+
N
N
N
N
N
H
N
N
H
N
N
N
CH
3
CH
3
N
N
N
OH
H
3
C
H
|
IC50 |
= |
2.47 |
nM |
469.47 |
[C-]#[N+]c1cnc2c(Nc3nc(C)n(C)n3)nc(Nc3ccc4c(c3)c(C#N)nn4C[C@@H](C)O)nn12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3681201 |
OBDepict
H
3
C
O
N
N
N
N
H
O
N
NH
2
H
N
O
NH
2
|
IC50 |
= |
2.5 |
nM |
450.5 |
COc1cc(-c2cc(C(=O)N[C@@H]3CCCN(C(=O)C4(N)CC4)C3)c3c(N)ncnn23)ccn1 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3681202 |
OBDepict
H
3
C
O
N
N
N
N
H
O
N
H
2
N
H
H
N
H
O
OH
CH
3
H
3
C
|
IC50 |
= |
2.7 |
nM |
467.53 |
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@H](NC(=O)C(C)(C)O)CC3)c3c(N)ncnn23)ccn1 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3116050 |
OBDepict
F
N
N
N
H
CH
3
H
N
N
HN
N
H
N
N
CH
3
|
IC50 |
= |
2.7 |
nM |
353.37 |
C[C@H](Nc1nc(Nc2cn(C)cn2)c2cc[nH]c2n1)c1ncc(F)cn1 |
Homo sapiens |
CHEMBL3118226 |
single protein format |
CHEMBL3699302 |
OBDepict
N
F
HN
O
N
N
N
N
H
N
HN
N
|
IC50 |
= |
2.75 |
nM |
433.45 |
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(OC2CCNCC2)cc1F |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3681194 |
OBDepict
CH
3
O
N
H
O
N
H
O
N
NH
2
N
N
N
O
H
3
C
|
IC50 |
= |
2.8 |
nM |
453.5 |
CCOC(=O)NC1CCC(NC(=O)c2cc(-c3ccnc(OC)c3)n3ncnc(N)c23)CC1 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3699281 |
OBDepict
CH
3
N
H
N
N
N
N
H
N
+
N
_
C
Cl
N
N
H
HO
H
N
H
O
O
H
3
C
|
IC50 |
= |
2.95 |
nM |
510.95 |
[C-]#[N+]c1cnc2c(NCC)nc(Nc3cc(C#N)cc(N4CC[C@@H](NC(=O)OC)[C@H](O)C4)c3Cl)nn12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699275 |
OBDepict
N
N
N
N
N
H
N
NH
Cl
N
F
F
O
|
IC50 |
= |
3.01 |
nM |
514.97 |
N#Cc1cnc2c(NC3CC3)nc(Nc3cc(C(F)F)cc(N4CCC(C5COC5)CC4)c3Cl)nn12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3681204 |
OBDepict
H
3
C
O
N
N
N
N
H
O
N
NH
2
H
H
OH
|
IC50 |
= |
3.2 |
nM |
396.45 |
COc1cc(-c2cc(C(=O)NC[C@H]3CC[C@H](O)CC3)c3c(N)ncnn23)ccn1 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3699272 |
OBDepict
N
N
N
N
N
H
N
NH
Cl
N
F
F
N
N
O
|
IC50 |
= |
3.21 |
nM |
540.97 |
N#Cc1cnc2c(NC3CC3)nc(Nc3cc(C(F)F)cc(N4CCN(C5(C#N)COC5)CC4)c3Cl)nn12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3681203 |
OBDepict
OH
H
H
N
H
O
N
NH
2
N
N
N
O
H
3
C
|
IC50 |
= |
3.4 |
nM |
396.45 |
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@@H](CO)CC3)c3c(N)ncnn23)ccn1 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3681200 |
OBDepict
H
2
N
N
H
O
H
H
N
H
O
N
H
2
N
N
N
N
O
CH
3
|
IC50 |
= |
3.6 |
nM |
478.56 |
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@H](NC(=O)C4(CN)CC4)CC3)c3c(N)ncnn23)ccn1 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3681205 |
OBDepict
H
3
C
O
N
N
N
N
H
O
N
NH
2
H
H
O
OH
|
IC50 |
= |
3.6 |
nM |
410.43 |
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@H](C(=O)O)CC3)c3c(N)ncnn23)ccn1 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3681208 |
OBDepict
H
3
C
O
N
N
N
N
H
O
N
H
2
N
H
H
N
H
O
H
3
C
H
3
C
N
|
IC50 |
= |
3.7 |
nM |
534.67 |
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@H](NC(=O)C(C)(C)CN4CCCC4)CC3)c3c(N)ncnn23)ccn1 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3681207 |
OBDepict
H
3
C
N
N
H
O
H
H
N
H
O
N
H
2
N
N
N
N
O
CH
3
|
IC50 |
= |
3.9 |
nM |
520.64 |
CCN1CCCC1CNC(=O)[C@H]1CC[C@H](NC(=O)c2cc(-c3ccnc(OC)c3)n3ncnc(N)c23)CC1 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3699288 |
OBDepict
CH
3
N
H
N
N
N
N
H
N
+
N
_
C
Cl
N
F
F
N
O
|
IC50 |
= |
4.53 |
nM |
503.95 |
[C-]#[N+]c1cnc2c(NCC)nc(Nc3cc(C(F)F)cc(N4CCN(C5COC5)CC4)c3Cl)nn12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3760043 |
OBDepict
H
3
C
O
N
H
O
N
S
N
O
OH
|
IC50 |
= |
4.6 |
nM |
355.38 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)nc3)s2)cc1 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL3699271 |
OBDepict
N
N
N
N
HN
N
HN
Cl
N
F
F
N
N
CH
3
|
IC50 |
= |
4.72 |
nM |
543.03 |
CN1CC(CN2CCN(c3cc(C(F)F)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)CC2)C1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699304 |
OBDepict
_
C
+
N
N
N
N
N
H
N
NH
N
Cl
N
N
|
IC50 |
= |
5.1 |
nM |
352.75 |
[C-]#[N+]c1cnc2c(NC3CC3)nc(Nc3nc(C#N)ncc3Cl)nn12 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699270 |
OBDepict
H
3
C
O
N
N
Cl
N
H
F
F
N
N
N
HN
N
N
|
IC50 |
= |
5.96 |
nM |
515.96 |
COC1CN(C2CN(c3cc(C(F)F)cc(Nc4nc(NC5CC5)c5ncc(C#N)n5n4)c3Cl)C2)C1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3759871 |
OBDepict
H
3
C
O
N
H
O
N
S
O
O
OH
F
|
IC50 |
= |
8.8 |
nM |
478.5 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccccc3F)s2)cc1 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL3758606 |
OBDepict
H
3
C
O
N
H
O
N
S
O
O
OH
N
|
IC50 |
= |
9.5 |
nM |
461.5 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccccn3)s2)cc1 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL3758317 |
OBDepict
H
3
C
O
N
H
O
N
S
N
N
O
OH
|
IC50 |
= |
9.6 |
nM |
356.36 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)nn3)s2)cc1 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL3759512 |
OBDepict
H
3
C
O
N
H
O
N
S
O
O
OH
Cl
|
IC50 |
= |
9.8 |
nM |
494.96 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccccc3Cl)s2)cc1 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL3758519 |
OBDepict
H
3
C
O
N
H
O
N
S
O
O
OH
|
IC50 |
= |
10.0 |
nM |
446.48 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3Oc3ccccc3)s2)cc1 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL3759755 |
OBDepict
H
3
C
O
N
H
O
N
S
N
O
OH
|
IC50 |
= |
10.0 |
nM |
355.38 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cn3)s2)cc1 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL3759349 |
OBDepict
H
3
C
O
N
H
O
N
S
O
O
OH
N
|
IC50 |
= |
11.0 |
nM |
485.52 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccccc3C#N)s2)cc1 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL1230165 |
OBDepict
Cl
N
H
N
N
O
HO
|
IC50 |
= |
11.0 |
nM |
349.78 |
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL3760009 |
OBDepict
H
3
C
O
N
H
O
N
S
O
O
OH
|
IC50 |
= |
11.0 |
nM |
474.54 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCCc3ccccc3)s2)cc1 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL3760064 |
OBDepict
H
3
C
O
N
H
O
N
S
O
O
OH
|
IC50 |
= |
12.0 |
nM |
460.51 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3COc3ccccc3)s2)cc1 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL3758270 |
OBDepict
H
3
C
O
N
H
O
N
S
O
O
OH
|
IC50 |
= |
12.0 |
nM |
460.51 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccccc3)s2)cc1 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL3758895 |
OBDepict
H
3
C
O
N
H
O
N
S
O
O
OH
O
CH
3
|
IC50 |
= |
13.0 |
nM |
490.54 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccccc3OC)s2)cc1 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL3758777 |
OBDepict
H
3
C
O
N
H
O
N
S
O
O
OH
Br
|
IC50 |
= |
14.0 |
nM |
539.41 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccccc3Br)s2)cc1 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL3699243 |
OBDepict
N
HN
N
Cl
N
N
N
NH
N
H
N
N
CH
3
CH
3
|
IC50 |
= |
15.53 |
nM |
491.0 |
CC(C)NC1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)CC1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699299 |
OBDepict
N
O
N
H
F
N
N
N
CH
3
H
3
C
NH
CH
3
CH
3
NH
N
N
|
IC50 |
= |
16.04 |
nM |
489.56 |
CC1(C)CC(Oc2cc(F)c(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)cc2C#N)CC(C)(C)N1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3759193 |
OBDepict
H
3
C
O
N
H
O
N
S
O
O
OH
Cl
|
IC50 |
= |
19.0 |
nM |
494.96 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3OCc3ccc(Cl)cc3)s2)cc1 |
Homo sapiens |
CHEMBL3760461 |
single protein format |
CHEMBL3699298 |
OBDepict
N
O
N
H
F
N
N
N
CH
3
H
3
C
N
CH
3
CH
3
NH
CH
3
N
N
|
IC50 |
= |
19.71 |
nM |
503.59 |
CN1C(C)(C)CC(Oc2cc(F)c(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)cc2C#N)CC1(C)C |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699246 |
OBDepict
N
N
H
N
Cl
N
N
N
NH
N
H
N
N
F
F
F
|
IC50 |
= |
20.89 |
nM |
530.95 |
N#Cc1cc(Nc2nc(NC3CC3)c3ncc(C#N)n3n2)c(Cl)c(N2CCC(NCC(F)(F)F)CC2)c1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL3699249 |
OBDepict
CH
3
O
N
H
N
Cl
N
H
N
N
N
N
NH
N
N
|
IC50 |
= |
24.95 |
nM |
507.0 |
COCCNC1CCN(c2cc(C#N)cc(Nc3nc(NC4CC4)c4ncc(C#N)n4n3)c2Cl)CC1 |
Homo sapiens |
CHEMBL3707628 |
single protein format |
CHEMBL1928903 |
OBDepict
HO
O
S
N
N
H
Br
Br
Br
Br
|
Ki |
= |
35.0 |
nM |
537.85 |
O=C(O)CCSc1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1 |
Homo sapiens |
CHEMBL1930611 |
assay format |
CHEMBL223082 |
OBDepict
HO
O
S
N
N
H
Br
Br
Br
Br
|
Ki |
= |
37.0 |
nM |
523.83 |
O=C(O)CSc1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1 |
Homo sapiens |
CHEMBL1930611 |
assay format |
CHEMBL4793819 |
OBDepict
OH
O
N
N
O
O
N
CH
3
CH
3
CH
3
N
OH
O
HO
|
IC50 |
= |
38.0 |
nM |
458.47 |
CC(C)(C)OC(=O)N(CCOCCO)c1ccn2ncc(-c3ccc(C(=O)O)c(O)c3)c2n1 |
Homo sapiens |
CHEMBL4710113 |
cell-based format |
CHEMBL2087023 |
OBDepict
H
3
C
O
N
H
O
N
S
O
OH
|
IC50 |
= |
46.0 |
nM |
354.39 |
COc1ccc(C(=O)Nc2ncc(-c3ccc(C(=O)O)cc3)s2)cc1 |
Homo sapiens |
CHEMBL2092254 |
assay format |
CHEMBL3681193 |
OBDepict
F
N
N
N
N
H
O
N
H
2
N
H
H
HO
|
IC50 |
= |
50.0 |
nM |
370.39 |
Nc1ncnn2c(-c3ccnc(F)c3)cc(C(=O)N[C@H]3CC[C@H](O)CC3)c12 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3681199 |
OBDepict
CH
3
O
N
N
N
N
H
O
N
NH
2
H
H
N
H
O
HO
CH
3
CH
3
|
IC50 |
= |
50.0 |
nM |
481.56 |
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@H](NC(=O)CC(C)(C)O)CC3)c3c(N)ncnn23)ccn1 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3681222 |
OBDepict
O
N
H
N
NH
2
N
N
N
N
|
IC50 |
= |
50.0 |
nM |
359.39 |
Nc1ncnn2c(-c3ccncc3)cc(C(=O)NCCc3ccccn3)c12 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3681209 |
OBDepict
CH
3
O
N
N
N
N
H
O
N
NH
2
H
H
O
CH
3
CH
3
CH
3
|
IC50 |
= |
50.0 |
nM |
452.56 |
COc1cc(-c2cc(C(=O)N[C@H]3CC[C@H](OCC(C)(C)C)CC3)c3c(N)ncnn23)ccn1 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3681220 |
OBDepict
O
N
H
N
H
NH
2
N
N
H
OH
N
|
IC50 |
= |
50.0 |
nM |
352.4 |
Nc1ncnn2c(-c3ccncc3)cc(C(=O)N[C@H]3CC[C@@H](O)CC3)c12 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3681197 |
OBDepict
CH
3
N
H
O
N
H
O
N
NH
2
N
N
N
|
IC50 |
= |
50.0 |
nM |
393.45 |
CC(=O)NC1CCC(NC(=O)c2cc(-c3ccncc3)n3ncnc(N)c23)CC1 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3681210 |
OBDepict
CH
3
N
O
N
NH
2
N
N
N
|
IC50 |
= |
50.0 |
nM |
336.4 |
CC1CCN(C(=O)c2cc(-c3ccncc3)n3ncnc(N)c23)CC1 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3681198 |
OBDepict
O
N
H
N
H
2
N
N
N
O
N
|
IC50 |
= |
60.0 |
nM |
338.37 |
Nc1ncnn2c(-c3ccncc3)cc(C(=O)NC3CCOCC3)c12 |
Homo sapiens |
CHEMBL3707831 |
single protein format |
CHEMBL3681221 |
OBDepict
O
O
N
H
CH
3
H
3
C
CH
3
N
H
O
N
NH
2
N
N
N
|
IC50 |
= |
60.0 |
nM |
439.52 |
CC(C)(C)OC(=O)NCCCCCNC(=O)c1cc(-c2ccncc2)n2ncnc(N)c12 |
Homo sapiens |
CHEMBL3707831 |
single protein format |