HOME LIGAND hPROTEOME OTHERS DOCUMENT

P20701 | ITAL_HUMAN | Integrin alpha-L (ITGAL)

3D structures mapped by conservation among orthologs

[ Domain: "vWA-like" // VWA ]

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[ Domain: "Integrin alpha-L cytoplasmic domain" // Integrin_alpha ]

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[ Domain: "7-bladed" // FG-GAP_1st ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL1221918 OBDepict OH O N H H NH O O Cl Cl S OH HO IC50 = 1.4 nM 537.42 O=C(NC[C@H](NC(=O)c1c(Cl)cc(CCC(O)c2cccc(O)c2)cc1Cl)C(=O)O)c1cccs1 Homo sapiens CHEMBL1227566 single protein format
CHEMBL1094128 OBDepict N H N N CH 3 O N N S O Cl Cl O HO IC50 = 1.8 nM 592.46 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3cccc(C(=O)O)c3s1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL1098727 OBDepict N H N N H 3 C O N N O Cl Cl N N N H N IC50 = 1.8 nM 560.41 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(-c3nnn[nH]3)cn1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL1098726 OBDepict N H N N O N H 3 C N O Cl Cl O OH IC50 = 2.5 nM 536.38 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(C(=O)O)cn1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL337562 OBDepict OH O N O F F F S F F F O O IC50 = 3.0 nM 561.5 O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(C(F)(F)F)c2C(F)(F)F)CC1 Homo sapiens CHEMBL699110 single protein format
CHEMBL1094115 OBDepict N H N N CH 3 O N N O O HO Cl Cl IC50 = 3.6 nM 536.38 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1cc(C(=O)O)ccn1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL1094127 OBDepict N H N N H 3 C O N N O O Cl Cl O OH IC50 = 4.0 nM 576.4 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3cc(C(=O)O)ccc3o1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL1098437 OBDepict N H N N CH 3 O N N S O Cl Cl O HO IC50 = 4.4 nM 592.46 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3ccc(C(=O)O)cc3s1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL1095138 OBDepict N H N N CH 3 O N N O O Cl Cl O HO IC50 = 4.8 nM 576.4 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3cccc(C(=O)O)c3o1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL139349 OBDepict HO O N O Cl F F F S O O IC50 = 5.0 nM 527.95 O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(Cl)c2C(F)(F)F)CC1 Homo sapiens CHEMBL698471 single protein format
CHEMBL336789 OBDepict CH 3 O S F F F F F F N O O HO IC50 = 5.0 nM 533.49 COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCC(C(=O)O)CC2)c(C(F)(F)F)c1C(F)(F)F Homo sapiens CHEMBL872962 single protein format
CHEMBL343390 OBDepict OH O N O F F F S F F F N CH 3 IC50 = 5.0 nM 556.53 Cn1ccc2cc(Sc3ccc(/C=C/C(=O)N4CCC(C(=O)O)CC4)c(C(F)(F)F)c3C(F)(F)F)ccc21 Homo sapiens CHEMBL699115 single protein format
CHEMBL1096088 OBDepict N H N N CH 3 O N N S O O HO Cl Cl IC50 = 5.0 nM 542.4 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ncc(C(=O)O)s1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL138185 OBDepict HO O N O Cl Cl S N H 3 C IC50 = 6.0 nM 489.42 Cn1ccc2cc(Sc3ccc(/C=C/C(=O)N4CCC(C(=O)O)CC4)c(Cl)c3Cl)ccc21 Homo sapiens CHEMBL698476 single protein format
CHEMBL139068 OBDepict CH 3 O S Cl F F F N O O OH IC50 = 6.0 nM 499.94 COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCC(C(=O)O)CC2)c(C(F)(F)F)c1Cl Homo sapiens CHEMBL698472 single protein format
CHEMBL1095148 OBDepict N H N N CH 3 O N N O O Cl Cl O HO IC50 = 6.0 nM 576.4 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc3ccc(C(=O)O)cc3o1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL341999 OBDepict O N N Cl O CH 3 Cl S O O IC50 = 7.0 nM 493.41 CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(Cl)c2Cl)CC1 Homo sapiens CHEMBL699118 single protein format
CHEMBL139390 OBDepict HO O N O Cl Cl S O O IC50 = 7.0 nM 494.4 O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(Cl)c2Cl)CC1 Homo sapiens CHEMBL698477 single protein format
CHEMBL1098760 OBDepict N H N N CH 3 O N N O N O HO Cl Cl IC50 = 8.0 nM 537.36 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1cc(C(=O)O)ncn1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL423725 OBDepict CH 3 O S Cl F F F N O O IC50 = 8.0 nM 457.9 COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCOCC2)c(C(F)(F)F)c1Cl Homo sapiens CHEMBL698473 single protein format
CHEMBL140085 OBDepict H 3 C O S Cl Cl N O O OH IC50 = 8.0 nM 466.39 COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCC(C(=O)O)CC2)c(Cl)c1Cl Homo sapiens CHEMBL698474 single protein format
CHEMBL344897 OBDepict CH 3 O S Cl Cl N O O IC50 = 10.0 nM 424.35 COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCOCC2)c(Cl)c1Cl Homo sapiens CHEMBL699117 single protein format
CHEMBL337322 OBDepict OH O N O Cl Cl S CH 3 H 3 C IC50 = 10.0 nM 478.44 CC(C)c1ccccc1Sc1ccc(/C=C/C(=O)N2CCC(C(=O)O)CC2)c(Cl)c1Cl Homo sapiens CHEMBL698475 single protein format
CHEMBL1097733 OBDepict N H N N CH 3 O N N N O Cl Cl O HO IC50 = 11.0 nM 537.36 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ncc(C(=O)O)cn1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL1099103 OBDepict N H N N CH 3 O N N O CH 3 Cl Cl O OH IC50 = 11.0 nM 550.4 Cc1cc(N2C[C@@H](c3ccc(C#N)cc3)[C@]3(C2)C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)N3C)ncc1C(=O)O Homo sapiens CHEMBL1120946 cell-based format
CHEMBL1094753 OBDepict N H N N CH 3 O N O N Cl Cl N IC50 = 12.0 nM 517.38 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(C#N)nc1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL1098761 OBDepict N H N N O N CH 3 N O CH 3 Cl Cl O OH IC50 = 12.0 nM 550.4 Cc1nc(N2C[C@@H](c3ccc(C#N)cc3)[C@]3(C2)C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)N3C)ccc1C(=O)O Homo sapiens CHEMBL1120946 cell-based format
CHEMBL1096053 OBDepict N H N N O N H 3 C N O N Cl Cl O OH IC50 = 13.0 nM 537.36 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(C(=O)O)nn1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL214529 OBDepict N H N N CH 3 O N O S Cl Cl O OH IC50 = 18.0 nM 555.44 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(Cc1cc(C(=O)O)cs1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL1098071 OBDepict N H N N CH 3 O N N O N Cl Cl O HO IC50 = 19.0 nM 537.36 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1cnc(C(=O)O)cn1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL1094431 OBDepict N H N N CH 3 O N N N O O OH Cl Cl IC50 = 26.0 nM 537.36 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nccc(C(=O)O)n1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL136191 OBDepict O N O S F F F O O IC50 = 30.0 nM 451.47 O=C(/C=C/c1ccc(Sc2ccc3c(c2)OCCO3)c(C(F)(F)F)c1)N1CCOCC1 Homo sapiens CHEMBL699111 single protein format
CHEMBL275402 OBDepict O N N O CH 3 Cl S O O IC50 = 40.0 nM 458.97 CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(Cl)c2)CC1 Homo sapiens CHEMBL699112 single protein format
CHEMBL19677 OBDepict O N N O CH 3 + N S O _ O CH 3 H 3 C IC50 = 44.0 nM 453.56 CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccccc3C(C)C)c([N+](=O)[O-])c2)CC1 Homo sapiens CHEMBL699112 single protein format
CHEMBL102030 OBDepict OH O N O S F F F O O IC50 = 50.0 nM 493.5 O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(C(F)(F)F)c2)CC1 Homo sapiens CHEMBL699114 single protein format
CHEMBL138777 OBDepict O N N O CH 3 S F F F O O IC50 = 55.0 nM 492.52 CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(C(F)(F)F)c2)CC1 Homo sapiens CHEMBL699116 single protein format
CHEMBL1095137 OBDepict N H N N CH 3 O N O N O O HO Cl Cl IC50 = 58.0 nM 526.34 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1nc(C(=O)O)co1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL1096040 OBDepict N N H N O N H 3 C O N Cl Cl IC50 = 60.0 nM 516.39 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(C#N)cc1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120946 cell-based format
CHEMBL1222290 OBDepict Cl N H O Cl N H O O OH N H O O S IC50 = 69.0 nM 586.45 O=C(NC[C@H](NC(=O)c1c(Cl)cc2c(c1Cl)CCN(C(=O)c1cc3ccccc3o1)C2)C(=O)O)c1cccs1 Homo sapiens CHEMBL1227415 single protein format
CHEMBL1096039 OBDepict N H N N O N CH 3 N O Cl Cl N IC50 = 80.0 nM 517.38 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccc(C#N)cn1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120949 single protein format
CHEMBL343370 OBDepict CH 3 O S CH 3 H 3 C N O O IC50 = 90.0 nM 383.51 COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCOCC2)c(C)c1C Homo sapiens CHEMBL698478 single protein format
CHEMBL130110 OBDepict O N N O CH 3 + N S O _ O Cl Cl IC50 = 105.0 nM 480.37 CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3cccc(Cl)c3Cl)c([N+](=O)[O-])c2)CC1 Homo sapiens CHEMBL699103 single protein format
CHEMBL336265 OBDepict OH O N O F F S CH 3 H 3 C IC50 = 115.0 nM 447.55 CC(C)c1ccccc1SC1=CC=C(/C=C/C(=O)N2CCC(C(=O)O)CC2)C(F)C1F Homo sapiens CHEMBL699106 single protein format
CHEMBL538164 OBDepict O N N O CH 3 + N S O _ O O O IC50 = 139.0 nM 469.52 CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c([N+](=O)[O-])c2)CC1 Homo sapiens CHEMBL699107 single protein format
CHEMBL101416 OBDepict Cl Cl S Cl N O N O CH 3 IC50 = 140.0 nM 469.82 CC(=O)N1CCN(C(=O)/C=C/c2ccc(Sc3ccc(Cl)cc3Cl)c(Cl)c2)CC1 Homo sapiens CHEMBL699104 single protein format
CHEMBL1094116 OBDepict N H N N CH 3 O N O N O OH Cl Cl IC50 = 140.0 nM 536.38 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccnc(C(=O)O)c1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120949 single protein format
CHEMBL138860 OBDepict OH O N O Cl S O O IC50 = 145.0 nM 459.95 O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c(Cl)c2)CC1 Homo sapiens CHEMBL699109 single protein format
CHEMBL138987 OBDepict CH 3 O S Cl N O O IC50 = 150.0 nM 389.9 COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCOCC2)cc1Cl Homo sapiens CHEMBL699108 single protein format
CHEMBL455056 OBDepict H 3 C O O H 3 C CH 3 O OH H 3 C H H OH CH 3 CH 3 O H CH 3 H HO CH 3 H 3 C O IC50 = 180.0 nM 556.7 CC(=O)OC(C)(C)/C=C/C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C Homo sapiens CHEMBL1017447 cell-based format
CHEMBL1097384 OBDepict N H N N CH 3 O N N O Cl Cl IC50 = 200.0 nM 492.37 CN1C(=O)N(c2cc(Cl)cc(Cl)c2)C(=O)[C@]12CN(c1ccccn1)C[C@H]2c1ccc(C#N)cc1 Homo sapiens CHEMBL1120949 single protein format
CHEMBL1222021 OBDepict Cl N O Cl Cl HN O H O OH N H O S IC50 = 240.0 nM 580.88 O=C(NC[C@H](NC(=O)c1c(Cl)cc2c(c1Cl)CCN(C(=O)c1cccc(Cl)c1)C2)C(=O)O)c1cccs1 Homo sapiens CHEMBL1227415 single protein format
CHEMBL1222288 OBDepict O N O Cl Cl N H O H O OH HN O S IC50 = 260.0 nM 586.45 O=C(NC[C@H](NC(=O)c1c(Cl)cc2c(c1Cl)CCN(C(=O)c1ccc3ccoc3c1)C2)C(=O)O)c1cccs1 Homo sapiens CHEMBL1227415 single protein format
CHEMBL140234 OBDepict CH 3 O S F F F N O O HO IC50 = 265.0 nM 465.49 COc1ccccc1Sc1ccc(/C=C/C(=O)N2CCC(C(=O)O)CC2)c(C(F)(F)F)c1 Homo sapiens CHEMBL698468 single protein format
CHEMBL140361 OBDepict OH O N O S O O IC50 = 295.0 nM 475.57 O=C(O)C1CCN(C(=O)/C=C/c2ccc(Sc3ccc4c(c3)OCCO4)c3ccccc23)CC1 Homo sapiens CHEMBL698469 single protein format
CHEMBL507237 OBDepict H 3 C O O H 3 C CH 3 O OH H 3 C H H OH CH 3 CH 3 O H CH 3 H H HO CH 3 H 3 C O IC50 = 300.0 nM 558.71 CC(=O)OC(C)(C)/C=C/C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@H](C[C@H](O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C Homo sapiens CHEMBL1017447 cell-based format
CHEMBL1222022 OBDepict Cl N O Cl Cl HN O H O OH N H O S IC50 = 430.0 nM 580.88 O=C(NC[C@H](NC(=O)c1c(Cl)cc2c(c1Cl)CCN(C(=O)c1ccc(Cl)cc1)C2)C(=O)O)c1cccs1 Homo sapiens CHEMBL1227415 single protein format
CHEMBL1222132 OBDepict Cl N O Cl Cl N H O H O OH N H O IC50 = 550.0 nM 574.85 O=C(NC[C@H](NC(=O)c1c(Cl)cc2c(c1Cl)CCN(C(=O)c1ccc(Cl)cc1)C2)C(=O)O)c1ccccc1 Homo sapiens CHEMBL1227415 single protein format
CHEMBL1222289 OBDepict O N O Cl Cl N H O H O OH HN O S IC50 = 650.0 nM 588.47 O=C(NC[C@H](NC(=O)c1c(Cl)cc2c(c1Cl)CCN(C(=O)c1ccc3c(c1)OCC3)C2)C(=O)O)c1cccs1 Homo sapiens CHEMBL1227415 single protein format
CHEMBL387737 OBDepict HO O H CH 3 H 3 C CH 3 O H CH 3 CH 3 H H OH HO CH 3 O OH CH 3 H 3 C IC50 = 950.0 nM 514.66 CC(C)(O)/C=C/C(=O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC=C4[C@@H](C=C(O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C Homo sapiens CHEMBL1017447 cell-based format