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P21802 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2)

3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set ]

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[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4870179 OBDepict CH 3 O F O N CH 3 F O N H 3 C N N H IC50 = 0.15 nM 374.35 COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1F Homo sapiens CHEMBL4810138 single protein format
CHEMBL4862576 OBDepict CH 3 O O N CH 3 N N H N O CH 3 CH 3 N N H 3 C IC50 = 0.2 nM 462.55 COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)c(=O)n3c2)c1 Homo sapiens CHEMBL4838031 cell-based format
CHEMBL3800526 OBDepict CH 3 O O CH 3 N H N HN N N N N IC50 = 0.2 nM 513.65 COc1cc(CCc2cc(Nc3ncnc4cc(N5CCN6CCCCC6C5)ccc34)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3798625 OBDepict CH 3 O O CH 3 N H N HN N N N H CH 3 N H H 3 C H 3 C IC50 = 0.2 nM 501.64 COc1cc(CCc2cc(Nc3ncnc4cc(N5C[C@H](C)N(C)[C@H](C)C5)ccc34)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3701266 OBDepict CH 2 N O N N N H 2 N O O H 3 C CH 3 IC50 < 0.3 nM 405.46 C=CC(=O)N1CC(N2C=C(C#Cc3cc(OC)cc(OC)c3)C3C(N)=NC=NC32)C1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3797507 OBDepict H 3 C N N N N N H N N H Cl Cl O O CH 3 H 3 C IC50 = 0.3 nM 556.5 CCN1CCN(c2ccc3c(Nc4cc(CCc5c(Cl)c(OC)cc(OC)c5Cl)[nH]n4)ncnc3c2)CC1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL4862823 OBDepict CH 3 O F O N CH 3 Cl O N H 3 C N N H IC50 = 0.3 nM 390.8 COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1F Homo sapiens CHEMBL4810138 single protein format
CHEMBL3701278 OBDepict H 3 C O O H N H N O CH 2 N N H 2 N O O H 3 C CH 3 IC50 < 0.3 nM 475.51 C=CC(=O)N1C[C@@H](n2cc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C[C@H]1C(=O)OC Homo sapiens CHEMBL3705582 single protein format
CHEMBL4091628 OBDepict CH 3 N N F F F HN O Cl N N O IC50 = 0.3 nM 598.07 CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(C#Cc4cncc(N5CCOCC5)c4)c3)cc2C(F)(F)F)CC1 Homo sapiens CHEMBL4002766 single protein format
CHEMBL3797845 OBDepict CH 3 O O CH 3 N H N HN N N N N H 3 C CH 3 IC50 = 0.3 nM 501.64 COc1cc(CCc2cc(Nc3ncnc4cc(N5CCC(N(C)C)CC5)ccc34)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3701258 OBDepict CH 2 N O H N N N H 2 N O O CH 3 CH 3 IC50 = 0.4 nM 417.47 C=CC(=O)N1CC[C@H](n2cc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3797594 OBDepict CH 3 O O CH 3 N H N HN N N N N H 3 C H 3 C IC50 = 0.4 nM 487.61 COc1cc(CCc2cc(Nc3ncnc4cc(N5CCC(N(C)C)C5)ccc34)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3798342 OBDepict CH 3 O O CH 3 N H N NH N N N O IC50 = 0.4 nM 460.54 COc1cc(CCc2cc(Nc3ncnc4cc(N5CCOCC5)ccc34)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3701256 OBDepict CH H N H N O N H 2 C N N H 2 N O O H 3 C CH 3 IC50 = 0.4 nM 442.48 C#C[C@@H]1C[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)CN1C(=O)C=C Homo sapiens CHEMBL3705582 single protein format
CHEMBL4294625 OBDepict OH O O N N H O CH 3 N N H O N HO IC50 = 0.5 nM 573.65 CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(C5CCN(CCO)CC5)cc4)c3)c(OCCO)cc21 Homo sapiens CHEMBL4271733 assay format
CHEMBL3797416 OBDepict H 3 C N N N N H N H 3 C N N H O O CH 3 CH 3 IC50 = 0.5 nM 515.66 CCc1nc(Nc2cc(CCc3cc(OC)cc(OC)c3)[nH]n2)c2ccc(N3CCN(CC)CC3)cc2n1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL4297522 OBDepict CH 3 N O N N N F F H O O N H 3 C H 3 C O IC50 = 0.5 nM 487.51 CCN1C(=O)N(c2c(F)c(OC)cc(OC)c2F)Cc2cnc3[nH]c(CN4CCOCC4)cc3c21 Homo sapiens CHEMBL4838112 single protein format
CHEMBL3799426 OBDepict CH 3 O O CH 3 N H N N H N N N N IC50 = 0.6 nM 513.65 COc1cc(CCc2cc(Nc3ncnc4cc(N5CCN(C6CCC6)CC5)ccc34)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3799403 OBDepict CH 3 O O CH 3 N H N HN N N N N H 3 C CH 3 IC50 = 0.6 nM 501.64 COc1cc(CCc2cc(Nc3ncnc4cc(N5CCN(C(C)C)CC5)ccc34)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3701268 OBDepict H 3 C O O H 3 C N H 2 N N N N O N IC50 = 0.6 nM 486.58 COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CN4CCCC4)C3)c3ncnc(N)c23)cc(OC)c1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3799611 OBDepict CH 3 N N N N H N CH 3 N N H O O CH 3 H 3 C IC50 = 0.6 nM 501.64 CCN1CCN(c2ccc3c(Nc4cc(CCc5cc(OC)cc(OC)c5)[nH]n4)nc(C)nc3c2)CC1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3799093 OBDepict CH 3 N N N N H N Cl N N H O O CH 3 H 3 C IC50 = 0.6 nM 522.05 CCN1CCN(c2ccc3c(Nc4cc(CCc5cc(OC)cc(OC)c5)[nH]n4)nc(Cl)nc3c2)CC1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3798940 OBDepict CH 3 O N N N N N H N N H O O CH 3 H 3 C IC50 = 0.7 nM 517.63 COCCN1CCN(c2ccc3c(Nc4cc(CCc5cc(OC)cc(OC)c5)[nH]n4)ncnc3c2)CC1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3797998 OBDepict H 3 C O O H 3 C N H N NH N N N N CH 3 IC50 = 0.7 nM 487.61 COc1cc(CCc2cc(Nc3ncnc4cc(N5CCCN(C)CC5)ccc34)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL4447359 OBDepict H 3 C O N N N H O N N H N Cl Cl O O H 3 C CH 3 IC50 = 0.7 nM 585.49 COCCN1CCN(c2ccc(C(=O)Nc3n[nH]c4nc(-c5c(Cl)c(OC)cc(OC)c5Cl)ccc34)cc2)CC1 Homo sapiens CHEMBL4426417 single protein format
CHEMBL3799885 OBDepict CH 3 N N HN N N N H N H 3 C O O CH 3 CH 3 IC50 = 0.7 nM 529.69 CCCc1nc(Nc2cc(CCc3cc(OC)cc(OC)c3)[nH]n2)c2ccc(N3CCN(CC)CC3)cc2n1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3798997 OBDepict CH 3 N N N N N H N N H O O CH 3 H 3 C IC50 = 0.8 nM 487.61 CCN1CCN(c2ccc3c(Nc4cc(CCc5cc(OC)cc(OC)c5)[nH]n4)ncnc3c2)CC1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL4475243 OBDepict CH 2 N O H N N S N H 2 N O H 3 C CH 3 IC50 = 0.8 nM 433.54 C=CC(=O)N1CC[C@H](n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL4382846 single protein format
CHEMBL3800072 OBDepict CH 3 O O CH 3 N H N HN N N N H 3 C IC50 = 0.8 nM 472.59 COc1cc(CCc2cc(Nc3ncnc4cc(C5CCN(C)CC5)ccc34)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3798911 OBDepict CH 3 O O CH 3 N H N HN N N N HN H 3 C H 3 C IC50 = 0.9 nM 487.61 COc1cc(CCc2cc(Nc3ncnc4cc(N5CCNC(C)(C)C5)ccc34)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3798532 OBDepict CH 3 O O N N N H N N H O O CH 3 H 3 C IC50 = 0.9 nM 449.51 COCCOc1ccc2c(Nc3cc(CCc4cc(OC)cc(OC)c4)[nH]n3)ncnc2c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL1852688 OBDepict CH 3 N N N H N N N CH 3 N H O Cl Cl O O H 3 C H 3 C IC50 = 1.0 nM 560.49 CCN1CCN(c2ccc(Nc3cc(N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)ncn3)cc2)CC1 Homo sapiens CHEMBL3998328 single protein format
CHEMBL3701275 OBDepict H 3 C O O H 3 C N H 2 N N N N O N H OH IC50 = 1.0 nM 502.58 COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CN4CC[C@@H](O)C4)C3)c3ncnc(N)c23)cc(OC)c1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3799354 OBDepict CH 3 O O CH 3 N H N HN N N N N H 3 C IC50 = 1.0 nM 473.58 COc1cc(CCc2cc(Nc3ncnc4cc(N5CCN(C)CC5)ccc34)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3701267 OBDepict H 3 C O O H 3 C N H 2 N N N N O N CH 3 H 3 C IC50 = 1.0 nM 460.54 COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CN(C)C)C3)c3ncnc(N)c23)cc(OC)c1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL4863146 OBDepict CH 3 O Cl O N CH 3 Cl O N H 3 C N N H IC50 = 1.0 nM 407.26 COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1Cl Homo sapiens CHEMBL4810138 single protein format
CHEMBL495727 OBDepict O NH NH N N H N N H N O IC50 = 1.0 nM 381.44 O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 Homo sapiens CHEMBL1009900 single protein format
CHEMBL3701241 OBDepict CH 2 N O N N N N H 2 N O O H 3 C CH 3 IC50 = 1.1 nM 404.43 C=CC(=O)N1CC(n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL4467025 OBDepict H 2 C N H O N N O O N H 2 N N CH 3 H Cl IC50 = 1.1 nM 460.88 C=CC(=O)Nc1ccc(-n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(Cl)cc3c2C)cc1 Homo sapiens CHEMBL4313068 single protein format
CHEMBL3701239 OBDepict CH N O H N N N N H 2 N O O H 3 C CH 3 IC50 = 1.1 nM 416.44 C#CC(=O)N1CC[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3701238 OBDepict CH 2 N O H N N N N H 2 N O O CH 3 CH 3 IC50 = 1.1 nM 418.46 C=CC(=O)N1CC[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3701271 OBDepict CH 3 N H 3 C N O N N N H 2 N O O H 3 C H 3 C IC50 = 1.2 nM 488.59 CCN(CC)C/C=C/C(=O)N1CC(n2cc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3800415 OBDepict CH 3 N N N N H N N H O O CH 3 H 3 C IC50 = 1.2 nM 486.62 CCN1CCN(c2ccc3c(Nc4cc(CCc5cc(OC)cc(OC)c5)[nH]n4)nccc3c2)CC1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3701242 OBDepict HO N O N N N N NH 2 O O CH 3 H 3 C IC50 = 1.2 nM 432.44 COc1cc(C#Cc2nn(C3CN(C(=O)C#CCO)C3)c3ncnc(N)c23)cc(OC)c1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL4763773 OBDepict CH 3 O N N H N N N N H 3 C F F O O CH 3 CH 3 IC50 = 1.2 nM 582.7 COc1cc(Nc2ncc(CCc3c(F)c(OC)cc(OC)c3F)cn2)ccc1N1CCC(N2CCN(C)CC2)CC1 Homo sapiens CHEMBL4724603 assay format
CHEMBL3701279 OBDepict CH 2 N O H H N N O N N N H 2 N O O H 3 C H 3 C IC50 = 1.2 nM 485.5 C=CC(=O)N1C[C@@H](n2cc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C[C@H]1c1nnco1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL4068509 OBDepict CH 2 N O N N N O HN N CH 3 Cl Cl O O CH 3 CH 3 Ki = 1.3 nM 561.47 C=CC(=O)N1CCN(CCCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)CC1 Homo sapiens CHEMBL4013895 single protein format
CHEMBL4068509 OBDepict CH 2 N O N N N O HN N CH 3 Cl Cl O O CH 3 CH 3 IC50 = 1.3 nM 561.47 C=CC(=O)N1CCN(CCCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)CC1 Homo sapiens CHEMBL4013817 single protein format
CHEMBL3800352 OBDepict H 3 C O O H 3 C N H N NH N N N H N O IC50 = 1.3 nM 503.61 COc1cc(CCc2cc(Nc3ncnc4cc(NCCN5CCOCC5)ccc34)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL1171837 OBDepict H 3 C N N F F F N H O CH 3 N N N IC50 = 1.3 nM 532.57 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 Homo sapiens CHEMBL4002766 single protein format
CHEMBL4847441 OBDepict CH 3 O O N CH 3 Cl O N H 3 C N N H IC50 = 1.4 nM 372.81 COc1cc(OC)c(Cl)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1 Homo sapiens CHEMBL4810138 single protein format
CHEMBL4863224 OBDepict CH 3 O O N CH 3 F O N H 3 C N N H IC50 = 1.4 nM 356.36 COc1cc(OC)c(F)c(N2Cc3cnc4[nH]ccc4c3N(C)C2=O)c1 Homo sapiens CHEMBL4810138 single protein format
CHEMBL1784637 OBDepict HO N N F F F N H O CH 3 N N CH 3 N H O CH 3 IC50 = 1.5 nM 582.63 CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C Homo sapiens CHEMBL1785581 single protein format
CHEMBL3701270 OBDepict H 3 C O O H 3 C N H 2 N N N N O N H CH 3 CH 3 IC50 = 1.5 nM 474.57 COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CNC(C)C)C3)c3ncnc(N)c23)cc(OC)c1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL4446835 OBDepict H 2 C N H O N N O O N H 2 N N CH 3 H H 3 C IC50 = 1.5 nM 440.46 C=CC(=O)Nc1ccc(-n2nc3c(=O)[nH]nc(N)c3c2-c2oc3ccc(C)cc3c2C)cc1 Homo sapiens CHEMBL4313068 single protein format
CHEMBL3701272 OBDepict CH 3 O N H 3 C N O N N N H 2 N O O H 3 C H 3 C IC50 = 1.5 nM 504.59 COCCN(C)C/C=C/C(=O)N1CC(n2cc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL4062877 OBDepict OH HN H N HO F N H 3 C N H IC50 = 1.6 nM 454.51 Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(F)ccc3O)cc12 Homo sapiens CHEMBL4018626 single protein format
CHEMBL4092354 OBDepict CH 3 HN N N N N O N Cl Cl O O O CH 3 CH 3 N H 3 C CH 3 IC50 = 1.62 nM 578.5 CNc1ncc2c(n1)N(C1CCN(C(=O)/C=C/CN(C)C)CC1)C(=O)N(c1c(Cl)c(OC)cc(OC)c1Cl)C2 Homo sapiens CHEMBL4043778 assay format
CHEMBL4463714 OBDepict CH 3 N CH 3 N H O N N O O N NH 2 N H 3 C H CH 3 IC50 = 1.9 nM 497.56 Cc1ccc2oc(-c3c4c(N)n[nH]c(=O)c4nn3-c3ccc(NC(=O)/C=C/CN(C)C)cc3)c(C)c2c1 Homo sapiens CHEMBL4313068 single protein format
CHEMBL2071201 OBDepict H 3 C N N N H N N NH Br H H H O NH 2 H IC50 = 2.0 nM 404.27 Cn1cc(Nc2ncc(Br)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)cn1 Homo sapiens CHEMBL2072345 single protein format
CHEMBL3827178 OBDepict H 3 C N N N N H N N H O CH 3 H Cl Cl N IC50 = 2.0 nM 522.44 C[C@@H](Oc1ccc2[nH]nc(-c3nc4cc(N5CCN(C)CC5)ccc4[nH]3)c2c1)c1c(Cl)cncc1Cl Homo sapiens CHEMBL3830172 single protein format
CHEMBL4067871 OBDepict OH N H H N OH Cl N IC50 = 2.0 nM 467.96 OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(-c2ccc3cnccc3c2)c1)c1ccccc1 Homo sapiens CHEMBL4018626 single protein format
CHEMBL4448252 OBDepict H 3 C N CH 3 N H O N N O O N H 2 N N CH 3 H Br IC50 = 2.0 nM 562.43 Cc1c(-c2c3c(N)n[nH]c(=O)c3nn2-c2ccc(NC(=O)/C=C/CN(C)C)cc2)oc2ccc(Br)cc12 Homo sapiens CHEMBL4313068 single protein format
CHEMBL4105407 OBDepict H 3 C N N N H O N N H F F O H 3 C IC50 = 2.0 nM 491.54 CCN1CCN(c2ccc(C(=O)Nc3n[nH]c4cc(-c5c(F)ccc(OC)c5F)ccc34)cc2)CC1 Homo sapiens CHEMBL4056996 single protein format
CHEMBL4086560 OBDepict CH 3 O F F N H N N H O N N H 3 C IC50 = 2.0 nM 491.54 COc1ccc(F)c(-c2ccc3c(NC(=O)c4ccc(N5CCCN(C)CC5)cc4)n[nH]c3c2)c1F Homo sapiens CHEMBL4056996 single protein format
CHEMBL3701262 OBDepict H 3 C O O H 3 C N H 2 N N N H N O HO CH 3 CH 3 IC50 = 2.0 nM 473.53 COc1cc(C#Cc2cn([C@H]3CCN(C(=O)C#CC(C)(C)O)C3)c3ncnc(N)c23)cc(OC)c1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3701243 OBDepict H 3 C O O H 3 C N N H 2 N N N N O N CH 3 H 3 C IC50 = 2.2 nM 461.53 COc1cc(C#Cc2nn(C3CN(C(=O)/C=C/CN(C)C)C3)c3ncnc(N)c23)cc(OC)c1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3701273 OBDepict H 3 C O O H 3 C N H 2 N N N N O N OH IC50 = 2.3 nM 516.6 COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CN4CCC(O)CC4)C3)c3ncnc(N)c23)cc(OC)c1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3701237 OBDepict CH 2 N O N N N N H 2 N O O H 3 C CH 3 IC50 = 2.4 nM 418.46 C=CC(=O)N1CCC(n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3545376 OBDepict CH 3 O O N CH 3 N H N N CH 3 CH 3 N N H 3 C IC50 = 2.5 nM 446.56 COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1 Homo sapiens CHEMBL4400599 single protein format
CHEMBL3701269 OBDepict H 3 C O O H 3 C N N N N O N IC50 = 2.5 nM 457.53 COc1cc(C#Cc2cn(C3CN(C(=O)/C=C/CN4CCC4)C3)c3ncncc23)cc(OC)c1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL4076118 OBDepict OH HN H N HO F N CH 3 N H IC50 = 2.5 nM 454.51 Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cccc(F)c3O)cc12 Homo sapiens CHEMBL4018626 single protein format
CHEMBL3828009 OBDepict HO N N N N H O CH 3 H Cl Cl N IC50 = 2.6 nM 444.32 C[C@@H](Oc1ccc2[nH]nc(/C=C/c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl Homo sapiens CHEMBL4400591 single protein format
CHEMBL3798924 OBDepict CH 3 O N H N N N H N N H O O CH 3 H 3 C IC50 = 2.7 nM 448.53 COCCNc1ccc2c(Nc3cc(CCc4cc(OC)cc(OC)c4)[nH]n3)ncnc2c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3701249 OBDepict H 3 C O O H 3 C N N H 2 N N N N O N H 3 C CH 3 CH 3 IC50 = 2.7 nM 489.58 COc1cc(C#Cc2nn(C3CN(C(=O)/C=C/CN(C)C(C)C)C3)c3ncnc(N)c23)cc(OC)c1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL4074407 OBDepict HO NH H N OH F N CH 3 N F H IC50 = 2.8 nM 472.5 Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(F)c(F)cc3O)cc12 Homo sapiens CHEMBL4018626 single protein format
CHEMBL4104460 OBDepict H 3 C O F F N H N N H O N N O CH 3 IC50 = 2.9 nM 505.53 COc1ccc(F)c(-c2ccc3c(NC(=O)c4ccc(N5CCN(C(C)=O)CC5)cc4)n[nH]c3c2)c1F Homo sapiens CHEMBL4056996 single protein format
CHEMBL3701245 OBDepict CH 3 N H 3 C N O N N N N H 2 N O O H 3 C H 3 C IC50 = 3.0 nM 475.55 CCN(C)C/C=C/C(=O)N1CC(n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL4073545 OBDepict OH HN H N HO N CH 3 N H IC50 = 3.0 nM 436.52 Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3ccccc3O)cc12 Homo sapiens CHEMBL4018626 single protein format
CHEMBL3797268 OBDepict CH 3 O O CH 3 N H N N H N N IC50 = 3.2 nM 375.43 COc1cc(CCc2cc(Nc3ncnc4ccccc34)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3348846 OBDepict CH 3 O O CH 3 N H N HN O N H CH 3 HN H H 3 C IC50 = 3.2 nM 463.58 COc1cc(CCc2cc(NC(=O)c3ccc(N4C[C@H](C)N[C@H](C)C4)cc3)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3404249 single protein format
CHEMBL3701259 OBDepict H 3 C O O H 3 C N H 2 N N N H N O N IC50 = 3.2 nM 500.6 COc1cc(C#Cc2cn([C@H]3CCN(C(=O)/C=C/CN4CCCC4)C3)c3ncnc(N)c23)cc(OC)c1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3676315 OBDepict O N N NH 2 N H O N N H CH 3 N O IC50 = 3.2 nM 485.55 Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(OCCN6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 Homo sapiens CHEMBL3705409 assay format
CHEMBL3701250 OBDepict H 3 C O O H 3 C N N H 2 N N N N O N IC50 = 3.3 nM 501.59 COc1cc(C#Cc2nn(C3CN(C(=O)/C=C/CN4CCCCC4)C3)c3ncnc(N)c23)cc(OC)c1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL4077448 OBDepict OH HN H N HO F F N H 3 C N H IC50 = 3.4 nM 472.5 Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(F)cc(F)c3O)cc12 Homo sapiens CHEMBL4018626 single protein format
CHEMBL3681278 OBDepict O N N NH 2 N H N N N H CH 3 O IC50 = 3.6 nM 455.52 Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(CN6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 Homo sapiens CHEMBL3861871 single protein format
CHEMBL3681294 OBDepict F N N H O O N NH 2 N N N H CH 3 IC50 = 3.6 nM 475.53 Cc1nc2cc(-n3ncc(C(=O)c4cc5c([nH]4)=CC(CN4CCOCC4)C(F)C=5)c3N)ccc2[nH]1 Homo sapiens CHEMBL3705409 assay format
CHEMBL3701254 OBDepict OH H N N O N CH 2 N N H 2 N O O H 3 C CH 3 IC50 = 3.7 nM 448.48 C=CC(=O)N1CC(n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C[C@H]1CO Homo sapiens CHEMBL3705582 single protein format
CHEMBL3701246 OBDepict H 3 C O O H 3 C N N H 2 N N N N O N H IC50 = 3.8 nM 487.56 COc1cc(C#Cc2nn(C3CN(C(=O)/C=C/CNC4CCC4)C3)c3ncnc(N)c23)cc(OC)c1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3701244 OBDepict H 3 C O O H 3 C N N H 2 N N N N O N H CH 3 CH 3 IC50 = 3.8 nM 475.55 COc1cc(C#Cc2nn(C3CN(C(=O)/C=C/CNC(C)C)C3)c3ncnc(N)c23)cc(OC)c1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3797238 OBDepict CH 3 O O CH 3 N H N NH N N O CH 3 IC50 = 3.9 nM 405.46 COc1cc(CCc2cc(Nc3ncnc4c(OC)cccc34)n[nH]2)cc(OC)c1 Homo sapiens CHEMBL3803146 single protein format
CHEMBL3681303 OBDepict CH 3 O Cl N H O N NH 2 N N N H H 3 C IC50 = 4.0 nM 420.86 COc1cc2[nH]c(C(=O)c3cnn(-c4ccc5[nH]c(C)nc5c4)c3N)cc2cc1Cl Homo sapiens CHEMBL3705409 assay format
CHEMBL4076610 OBDepict CH 3 N N N H O N N H F O CH 3 IC50 = 4.0 nM 473.55 CCN1CCN(c2ccc(C(=O)Nc3n[nH]c4cc(-c5cccc(OC)c5F)ccc34)cc2)CC1 Homo sapiens CHEMBL4056996 single protein format
CHEMBL3681284 OBDepict O N N NH 2 N H N N N H CH 3 O IC50 = 4.0 nM 441.5 Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(N6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 Homo sapiens CHEMBL3705409 assay format
CHEMBL4096740 OBDepict CH 3 O F F N H N N H O N N H 3 C IC50 < 4.1 nM 477.52 COc1ccc(F)c(-c2ccc3c(NC(=O)c4ccc(N5CCN(C)CC5)cc4)n[nH]c3c2)c1F Homo sapiens CHEMBL4056996 single protein format
CHEMBL3701247 OBDepict CH 3 N H 3 C N O N N N N H 2 N O O H 3 C H 3 C IC50 = 4.1 nM 489.58 CCN(CC)C/C=C/C(=O)N1CC(n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL3705582 single protein format
CHEMBL3984621 OBDepict HO N Cl N H 2 N O N H N O IC50 = 4.2 nM 451.91 Nc1c(C(=O)c2cc3cc(CN4CCOCC4)ccc3[nH]2)cnn1-c1cc(O)ccc1Cl Homo sapiens CHEMBL3861871 single protein format
CHEMBL3676316 OBDepict O N N NH 2 N H O N N H CH 3 O IC50 = 4.3 nM 456.51 Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(OC6CCOCC6)cc5[nH]4)c3N)ccc2[nH]1 Homo sapiens CHEMBL3705409 assay format
CHEMBL3676328 OBDepict O N N NH 2 N H N N N H CH 3 H H 3 C O IC50 = 4.3 nM 469.55 Cc1nc2cc(-n3ncc(C(=O)c4cc5ccc(CN6CCOC[C@@H]6C)cc5[nH]4)c3N)ccc2[nH]1 Homo sapiens CHEMBL3705409 assay format
CHEMBL3701261 OBDepict CH 3 N O H N N N H 2 N O O H 3 C CH 3 IC50 = 4.3 nM 429.48 CC#CC(=O)N1CC[C@H](n2cc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL3705582 single protein format