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P21860 | ERBB3_HUMAN | Receptor tyrosine-protein kinase erbB-3 (ERBB3)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: "Leucine-rich repeats" // GF_recep_IV,Recep_L_domain ]

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[ Domain: "Leucine-rich repeats" // Recep_L_domain ]

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[ Domain: "Growth factor receptor domain" // Furin-like ]

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[ Domain: "Growth factor receptor domain" // GF_recep_IV ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3883534 OBDepict H 2 C NH O O CH 3 N N H N Cl F IC50 = 1.0 nM 372.79 C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC Homo sapiens CHEMBL4178362 cell-based format
CHEMBL4228518 OBDepict CH 3 N CH 3 O N H N N N N S O F IC50 = 1.2 nM 508.62 CN(C)CCOc1ccc(Nc2ncc3nc(Sc4ccc(F)cc4)n(C4CCOCC4)c3n2)cc1 Homo sapiens CHEMBL4222845 single protein format
CHEMBL4225777 OBDepict CH 3 N CH 3 O N H N N N N S O IC50 = 1.7 nM 490.63 CN(C)CCOc1ccc(Nc2ncc3nc(Sc4ccccc4)n(C4CCOCC4)c3n2)cc1 Homo sapiens CHEMBL4222845 single protein format
CHEMBL4226676 OBDepict CH 3 N CH 3 N N H N N N N S O IC50 = 1.9 nM 529.71 CN(C)C1CCN(c2ccc(Nc3ncc4nc(Sc5ccccc5)n(C5CCOCC5)c4n3)cc2)CC1 Homo sapiens CHEMBL4222845 single protein format
CHEMBL3608429 OBDepict H 2 C HN O H N H F N N N H N N H 3 C CH 3 N N CH 3 IC50 = 2.0 nM 413.46 C=CC(=O)N[C@@H]1CN(c2nc(Nc3cnn(C)c3)c3ncn(C(C)C)c3n2)C[C@H]1F Homo sapiens CHEMBL4178362 cell-based format
CHEMBL4226151 OBDepict CH 3 N N N H N N N N S O IC50 = 2.0 nM 501.66 CN1CCN(c2ccc(Nc3ncc4nc(Sc5ccccc5)n(C5CCOCC5)c4n3)cc2)CC1 Homo sapiens CHEMBL4222845 single protein format
CHEMBL4216679 OBDepict H 2 C HN O H N H F N N NH N N H 3 C CH 3 N O N CH 3 H 3 C IC50 = 2.0 nM 443.49 C=CC(=O)N[C@@H]1CN(c2nc(Nc3cn(C)nc3OC)c3ncn(C(C)C)c3n2)C[C@H]1F Homo sapiens CHEMBL4178362 cell-based format
CHEMBL3353410 OBDepict CH 2 NH O N N H CH 3 O N N CH 3 N CH 3 CH 3 N H 3 C IC50 = 2.1 nM 499.62 C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C Homo sapiens CHEMBL4222845 single protein format
CHEMBL4225565 OBDepict CH 3 N N N H N N N N S H H HO IC50 = 2.4 nM 515.69 CN1CCN(c2ccc(Nc3ncc4nc(Sc5ccccc5)n([C@H]5CC[C@H](O)CC5)c4n3)cc2)CC1 Homo sapiens CHEMBL4222845 single protein format
CHEMBL4227084 OBDepict CH 3 N CH 3 O N H N N N N + S _ O O IC50 = 2.6 nM 506.63 CN(C)CCOc1ccc(Nc2ncc3nc([S+]([O-])c4ccccc4)n(C4CCOCC4)c3n2)cc1 Homo sapiens CHEMBL4222845 single protein format
CHEMBL2408045 OBDepict H 3 C NH O N O O CH 3 N NH N F Cl IC50 = 4.0 nM 473.94 CNC(=O)CN1CCC(Oc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC)CC1 Homo sapiens CHEMBL2412603 cell-based format
CHEMBL3989970 OBDepict CH 2 NH O H N H F N N HN N N CH 3 N O N H 3 C CH 3 IC50 = 4.0 nM 415.43 C=CC(=O)N[C@@H]1CN(c2nc(Nc3cn(C)nc3OC)c3ncn(C)c3n2)C[C@H]1F Homo sapiens CHEMBL4178362 cell-based format
CHEMBL4225951 OBDepict CH 3 N N N H N N N N + S _ O IC50 = 4.2 nM 501.66 CN1CCN(c2ccc(Nc3ncc4nc([S+]([O-])c5ccccc5)n(C5CCCC5)c4n3)cc2)CC1 Homo sapiens CHEMBL4222845 single protein format
CHEMBL4225306 OBDepict CH 3 N N N H N N N N S IC50 = 4.2 nM 485.66 CN1CCN(c2ccc(Nc3ncc4nc(Sc5ccccc5)n(C5CCCC5)c4n3)cc2)CC1 Homo sapiens CHEMBL4222845 single protein format
CHEMBL4226937 OBDepict CH 3 N CH 3 O N H N N N N S O F IC50 = 5.8 nM 508.62 CN(C)CCOc1ccc(Nc2ncc3nc(Sc4cccc(F)c4)n(C4CCOCC4)c3n2)cc1 Homo sapiens CHEMBL4222845 single protein format
CHEMBL3608432 OBDepict H 2 C HN O H N H F N N NH N N H 3 C CH 3 N H 3 C N CH 3 IC50 = 9.0 nM 427.49 C=CC(=O)N[C@@H]1CN(c2nc(Nc3cn(C)nc3C)c3ncn(C(C)C)c3n2)C[C@H]1F Homo sapiens CHEMBL4178362 cell-based format
CHEMBL553 OBDepict CH 3 O O O N N H N O CH 3 CH IC50 = 10.0 nM 393.44 C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1 Homo sapiens CHEMBL4178362 cell-based format
CHEMBL4288300 OBDepict CH 3 O N H N N NH O O H 3 C H 3 C IC50 = 18.0 nM 352.39 COc1cccc(Nc2cc(Nc3cc(OC)ccc3OC)ncn2)c1 Homo sapiens CHEMBL4267259 assay format
CHEMBL3786098 OBDepict H 3 C O H N H O O CH 2 N NH N Cl N H N N H 3 C IC50 = 21.0 nM 431.88 C=CC(=O)N1C[C@H](COc2nc(Nc3cnn(C)c3)nc3[nH]cc(Cl)c23)[C@@H](OC)C1 Homo sapiens CHEMBL4178362 cell-based format
CHEMBL4282460 OBDepict O NH N N N H O OH Cl IC50 = 21.0 nM 334.76 O=C(O)CCCC(=O)Nc1cc(Nc2cccc(Cl)c2)ncn1 Homo sapiens CHEMBL4267259 assay format
CHEMBL4283970 OBDepict O NH N N N O OH O IC50 = 27.0 nM 294.31 O=C(O)CCCC(=O)Nc1cc(N2CCOCC2)ncn1 Homo sapiens CHEMBL4267259 assay format
CHEMBL4294156 OBDepict CH 3 O N H N N NH O O OH IC50 = 31.0 nM 330.34 COc1cccc(Nc2cc(NC(=O)CCCC(=O)O)ncn2)c1 Homo sapiens CHEMBL4267259 assay format
CHEMBL4206501 OBDepict CH 2 NH O N N H CH 3 O N CH 3 N CH 3 CH 3 N N H 3 C IC50 = 36.0 nM 499.62 C=CC(=O)Nc1cc(Nc2ccnc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C Homo sapiens CHEMBL4178362 cell-based format
CHEMBL3545308 OBDepict CH 2 NH O NH N N N H F F F O CH 3 N N O H 3 C IC50 = 46.0 nM 555.56 C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3OC)ncc2C(F)(F)F)c1 Homo sapiens CHEMBL4178362 cell-based format
CHEMBL4283823 OBDepict CH 3 O N H N N NH O IC50 = 60.0 nM 320.35 COc1ccc(Nc2cc(NC(=O)c3ccccc3)ncn2)cc1 Homo sapiens CHEMBL4267259 assay format
CHEMBL4290750 OBDepict CH 3 O O N H N N NH O O OH IC50 = 69.0 nM 372.38 CCOC(=O)c1ccc(Nc2cc(NC(=O)CCCC(=O)O)ncn2)cc1 Homo sapiens CHEMBL4267259 assay format
CHEMBL1379917 OBDepict F NH O N N N O IC50 = 96.0 nM 302.31 O=C(Nc1cc(N2CCOCC2)ncn1)c1ccc(F)cc1 Homo sapiens CHEMBL4267259 assay format
CHEMBL4293690 OBDepict CH 3 O HN O N CH 3 N N H N N CH 3 IC50 = 167.0 nM 420.52 COc1ccc(OC)c(Nc2cc(Nc3ccc(N4CCN(C)CC4)cc3)ncn2)c1 Homo sapiens CHEMBL4267259 assay format
CHEMBL4283097 OBDepict H 3 C O N H O H 3 C N N N H S IC50 = 167.0 nM 356.45 COc1ccc(OC)c(Nc2cc(NCCc3cccs3)ncn2)c1 Homo sapiens CHEMBL4267259 assay format
CHEMBL4278997 OBDepict O NH N N N H O OH IC50 = 183.0 nM 300.32 O=C(O)CCCC(=O)Nc1cc(Nc2ccccc2)ncn1 Homo sapiens CHEMBL4267259 assay format
CHEMBL4280395 OBDepict CH 3 O NH O H 3 C N N N H F IC50 = 230.0 nM 340.36 COc1ccc(OC)c(Nc2cc(Nc3ccc(F)cc3)ncn2)c1 Homo sapiens CHEMBL4267259 assay format
CHEMBL4288262 OBDepict Cl NH N N N H N Cl IC50 = 236.0 nM 332.19 Clc1ccc(Nc2cc(Nc3cccc(Cl)n3)ncn2)cc1 Homo sapiens CHEMBL4267259 assay format
CHEMBL4276965 OBDepict CH 3 O N H O N CH 3 N N H S O O NH 2 IC50 = 619.0 nM 401.45 COc1ccc(OC)c(Nc2cc(Nc3ccc(S(N)(=O)=O)cc3)ncn2)c1 Homo sapiens CHEMBL4267259 assay format
CHEMBL4287629 OBDepict OH O NH O N N N H Cl IC50 = 825.0 nM 320.74 O=C(O)CCC(=O)Nc1cc(Nc2ccc(Cl)cc2)ncn1 Homo sapiens CHEMBL4267259 assay format