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P22455 | FGFR4_HUMAN | Fibroblast growth factor receptor 4 (FGFR4)

3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_2 ]

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[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3953504 OBDepict O N N N CH 3 N H O O CH 3 N S N H 3 C CH 3 IC50 < 0.1 nM 466.57 CC(=O)N(C)Cc1cc2c(nc1C=O)N(C(=O)Nc1cc(SC(C)C)c(C#N)cn1)CCC2 Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3948579 OBDepict H 3 C O NH N HN N N O N O N O S IC50 = 0.1 nM 509.59 COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCSCC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3912731 OBDepict O N N NH O N N N H Cl S O O H 3 C H 3 C IC50 = 0.2 nM 515.0 CC(C)S(=O)(=O)c1ccccc1Nc1nc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1Cl Homo sapiens CHEMBL3888056 cell-based format
CHEMBL4786195 OBDepict CH 3 O O N HN N N O N O N O H N CH 3 H 3 C IC50 = 0.2 nM 521.58 COCCOc1cc(NC(=O)N2CCCc3cc(CN4C[C@H](N(C)C)CC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL3968338 OBDepict CH 3 O O H 3 C H N N H N N O N O N O O H CH 3 IC50 = 0.2 nM 508.54 COC[C@@H](C)Oc1cc(NC(=O)N2CCCc3cc(CN4C(=O)OC[C@@H]4C)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3912896 OBDepict CH 3 O N H N N H N N O N O N O O IC50 = 0.2 nM 465.47 COCCNc1cc(NC(=O)N2CCCc3cc(N4CCOC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3915180 OBDepict N N O HN O N O N O IC50 = 0.3 nM 393.4 N#Cc1cnc(NC(=O)N2CCCc3ccc(C=O)nc32)cc1OCC1CCO1 Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3924363 OBDepict OH N O H 3 C N O N HN O N O N CH 3 CH 3 IC50 = 0.3 nM 466.5 CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)CO)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3946444 OBDepict H 3 C O NH N HN N N O N O N CH 3 O O H 3 C IC50 = 0.3 nM 495.54 COCCNc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)COC)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3938786 OBDepict H 3 C O NH N HN N N O N O N O H H 3 C O IC50 = 0.3 nM 507.55 COCCNc1cc(NC(=O)N2CCCc3cc(CN4C(=O)COC[C@@H]4C)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3968334 OBDepict H 3 C O NH N HN N N O N O N O O IC50 = 0.4 nM 493.52 COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL4796410 OBDepict O N N N CH 3 N H O O CH 3 N NH N H 3 C CH 3 IC50 = 0.4 nM 449.52 CC(=O)N(C)Cc1cc2c(nc1C=O)N(C(=O)Nc1cc(NC(C)C)c(C#N)cn1)CCC2 Homo sapiens CHEMBL4723314 cell-based format
CHEMBL4744686 OBDepict H 2 C NH O N H CH 3 N N N N H Cl Cl O O CH 3 CH 3 IC50 = 0.4 nM 551.43 C=CC(=O)Nc1cccc(C)c1Nc1cc(-c2cccnc2Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL4703347 single protein format
CHEMBL3922033 OBDepict O N N N H 3 C HN O O H 3 C N N H N O F F F IC50 = 0.4 nM 519.48 CC(=O)N(C)Cc1cc2c(nc1C=O)N(C(=O)Nc1cc(NCCOC(F)(F)F)c(C#N)cn1)CCC2 Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3975745 OBDepict O N N N CH 3 N H O O N N CH 3 H 3 C O N CH 3 CH 3 IC50 = 0.4 nM 493.57 CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)CN(C)C)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3701239 OBDepict CH N O H N N N N H 2 N O O H 3 C CH 3 IC50 = 0.5 nM 416.44 C#CC(=O)N1CC[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL3707934 single protein format
CHEMBL4754106 OBDepict CH 3 O O N HN N N O N O N O H N CH 3 H 3 C IC50 = 0.6 nM 521.58 COCCOc1cc(NC(=O)N2CCCc3cc(CN4C[C@@H](N(C)C)CC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL4110949 OBDepict H 3 C O NH N HN N N O N O N O H H 3 C O IC50 = 0.6 nM 507.55 COCCNc1cc(NC(=O)N2CCCc3cc(CN4C(=O)COC[C@H]4C)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL4111721 OBDepict H 3 C O O H 3 C H N HN N N O N O N O N H 3 C IC50 = 0.6 nM 521.58 COC[C@@H](C)Oc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3955196 OBDepict CH 3 O N H N NH N N O N H CH 3 O N O N H 3 C IC50 = 0.6 nM 520.59 COCCNc1cc(NC(=O)N2c3nc(C=O)c(CN4CCN(C)CC4=O)cc3CC[C@@H]2C)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL4764394 OBDepict O N N N NH O O N O N CH 3 H 3 C IC50 = 0.7 nM 462.51 CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN4CCCC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL3959971 OBDepict N N O N H O N O N O IC50 = 0.7 nM 393.4 N#Cc1cnc(NC(=O)N2CCCc3ccc(C=O)nc32)cc1OC1CCOC1 Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3973588 OBDepict O N N N H O N O N H 3 C CH 3 IC50 = 0.7 nM 365.39 CC(C)Oc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3940110 OBDepict O N N N NH O H CH 3 O N N H 3 C O N H 3 C CH 3 IC50 = 0.7 nM 505.58 CC(C)Oc1cc(NC(=O)N2c3nc(C=O)c(CN4CCN(C)CC4=O)cc3CC[C@@H]2C)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3948578 OBDepict O N N N HN O O N N H 3 C N H N CH 3 CH 3 IC50 = 0.7 nM 490.57 CC(C)Nc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3924265 OBDepict O N N N HN O O N N H 3 C O N CH 3 CH 3 IC50 = 0.7 nM 491.55 CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL4758832 OBDepict O N N N S H 3 C HN O O O H 3 C N O N CH 3 CH 3 IC50 = 0.8 nM 486.55 CC(C)Oc1cc(NC(=O)N2CCCc3cc(CN(C)S(C)(=O)=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL4107472 OBDepict CH 3 O NH N HN N N O N O N O H OH IC50 = 0.8 nM 493.52 COCCNc1cc(NC(=O)N2CCCc3cc(CN4CC[C@@H](O)C4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3927056 OBDepict Cl HO O N N H N N O N O OH IC50 = 0.8 nM 459.89 N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1OCC(O)CCCl Homo sapiens CHEMBL3888056 cell-based format
CHEMBL4115011 OBDepict N N N H N H H H H N O OH H N O OH IC50 = 0.8 nM 476.54 N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1N[C@@H]1[C@H]2CC[C@H](C2)[C@@H]1CO Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3935951 OBDepict CH 3 O NH N HN N N O N O N O H OH IC50 = 0.9 nM 493.52 COCCNc1cc(NC(=O)N2CCCc3cc(CN4CC[C@H](O)C4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL4791610 OBDepict CH 3 O O N N H N N O N O N CH 3 O N H 3 C CH 3 IC50 = 0.9 nM 509.57 COCCOc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)CN(C)C)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL4742811 OBDepict H 3 C O NH N HN N N O N O F F IC50 = 0.9 nM 430.42 COCCNc1cc(NC(=O)N2CCCc3cc(C(F)F)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL4745780 OBDepict CH 3 O HN N N H N N O N O N O CH 3 CH 3 IC50 = 0.9 nM 479.54 CCN(Cc1cc2c(nc1C=O)N(C(=O)Nc1cc(NCCOC)c(C#N)cn1)CCC2)C(C)=O Homo sapiens CHEMBL4723314 cell-based format
CHEMBL4745615 OBDepict CH 3 O O N HN N N O N O N O H N H 3 C CH 3 IC50 = 0.9 nM 521.58 COCCOc1cc(NC(=O)N2CCCc3cc(CN4CC[C@H](N(C)C)C4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL3959290 OBDepict CH 2 N H O NH O N H 3 C N N CH 3 N H O Cl Cl O O H 3 C H 3 C IC50 < 1.0 nM 547.4 C=CC(=O)Nc1cccc(OC)c1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL4439119 OBDepict O N N N HN O O O N N H N H H O CH 3 IC50 = 1.0 nM 533.59 CO[C@@H]1CCC[C@H]1Nc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4339977 single protein format
CHEMBL4457168 OBDepict O N N N NH O O H O N H 3 C HN N H O IC50 = 1.0 nM 519.56 CO[C@@H]1CCN(Cc2cc3c(nc2C=O)N(C(=O)Nc2cc(N[C@@H]4CCOC4)c(C#N)cn2)CCC3)C1=O Homo sapiens CHEMBL4339977 single protein format
CHEMBL3940039 OBDepict O N N O NH O N O N CH 3 H 3 C IC50 = 1.0 nM 435.48 CC(C)Oc1cc(NC(=O)N2CCCc3cc(C4CCOC4)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3958828 OBDepict CH 2 N H O NH Cl N N N CH 3 N H O Cl Cl O O H 3 C H 3 C IC50 < 1.0 nM 551.82 C=CC(=O)Nc1cccc(Cl)c1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3927803 OBDepict OH N CH 3 HN N H O N CH 2 N N CH 3 N H O Cl Cl O O H 3 C H 3 C IC50 < 1.0 nM 590.47 C=CC(=O)Nc1cc(N(C)CCO)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3922336 OBDepict CH 2 HN O N H N N N N H O N Cl Cl O O H 3 C CH 3 IC50 < 1.0 nM 594.46 C=CC(=O)Nc1ccccc1Nc1cc(N(Cc2cccnc2)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3910442 OBDepict CH 2 N H O NH F N N N CH 3 N H O Cl Cl O O H 3 C H 3 C IC50 < 1.0 nM 535.36 C=CC(=O)Nc1cccc(F)c1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3940348 OBDepict CH 2 N H O NH HO CH 3 N N N CH 3 N H O Cl Cl O O H 3 C H 3 C IC50 < 1.0 nM 561.43 C=CC(=O)Nc1cc(C(C)O)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3957874 OBDepict CH 2 N H O NH N N H 3 C CH 3 N N CH 3 N H O Cl Cl O O H 3 C H 3 C IC50 < 1.0 nM 574.47 C=CC(=O)Nc1cc(CN(C)C)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3932109 OBDepict CH 2 N H O NH O CH 3 N CH 3 N N CH 3 N H O Cl Cl O O H 3 C H 3 C IC50 < 1.0 nM 575.45 C=CC(=O)Nc1cc(C(C)OC)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3892342 OBDepict HC NH O NH N N N CH 3 N H O Cl Cl O O H 3 C H 3 C IC50 < 1.0 nM 515.36 C#CC(=O)Nc1ccccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3937272 OBDepict CH 2 HN O N H N N CH 3 CH 3 N N CH 3 N H O Cl Cl O O H 3 C CH 3 IC50 < 1.0 nM 588.5 C=CC(=O)Nc1cc(CCN(C)C)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3961994 OBDepict CH 2 N H O NH N N N CH 3 N H O Cl Cl O O H 3 C H 3 C IC50 < 1.0 nM 517.37 C=CC(=O)Nc1ccccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3981394 OBDepict CH 2 HN O N H N N N N H O N Cl Cl H 3 C CH 3 O O H 3 C CH 3 IC50 < 1.0 nM 588.5 C=CC(=O)Nc1ccccc1Nc1cc(N(CCCN(C)C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3900286 OBDepict CH 3 O NH N H O N H 2 C N N CH 3 NH O Cl Cl O O H 3 C H 3 C IC50 < 1.0 nM 561.43 C=CC(=O)Nc1cc(COC)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3913504 OBDepict CH 2 HN O N H N O N H 3 C CH 3 N N CH 3 N H O Cl Cl O O H 3 C CH 3 IC50 < 1.0 nM 588.45 C=CC(=O)Nc1cc(C(=O)N(C)C)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3959844 OBDepict CH 2 N H O NH HO N N N CH 3 N H O Cl Cl O O H 3 C H 3 C IC50 < 1.0 nM 547.4 C=CC(=O)Nc1cc(CO)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3967008 OBDepict HO O NH N H O N H 2 C N N H 3 C N H O Cl Cl O O CH 3 CH 3 IC50 < 1.0 nM 577.43 C=CC(=O)Nc1cc(OCCO)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3960125 OBDepict CH 2 HN O N H N N N N H O N Cl Cl O O H 3 C CH 3 IC50 < 1.0 nM 594.46 C=CC(=O)Nc1ccccc1Nc1cc(N(Cc2ccccn2)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3898484 OBDepict CH 2 HN O N H N N N N H 3 C CH 3 CH 3 N H O Cl Cl O O H 3 C CH 3 IC50 < 1.0 nM 588.5 C=CC(=O)Nc1ccc(CCN(C)C)cc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3926533 OBDepict CH 2 HN O N H N N N NH O O N Cl Cl H 3 C O O H 3 C H 3 C IC50 < 1.0 nM 598.45 C=CC(=O)Nc1ccccc1Nc1cc(N(Cc2cc(C)no2)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3956014 OBDepict CH 2 N H O NH H 3 C N N N CH 3 N H O Cl Cl O O H 3 C H 3 C IC50 < 1.0 nM 531.4 C=CC(=O)Nc1cccc(C)c1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3912538 OBDepict CH 2 HN O N H N N N N H O Cl Cl N O O H 3 C CH 3 IC50 < 1.0 nM 594.46 C=CC(=O)Nc1ccccc1Nc1cc(N(Cc2ccncc2)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3921678 OBDepict CH 2 N H O NH H 2 N CH 3 N N N CH 3 N H O Cl Cl O O H 3 C H 3 C IC50 < 1.0 nM 560.44 C=CC(=O)Nc1cc(C(C)N)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3915751 OBDepict CH 3 O O NH N H O N H 2 C N N CH 3 NH O Cl Cl O O H 3 C H 3 C IC50 < 1.0 nM 591.45 C=CC(=O)Nc1cc(OCCOC)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3889496 OBDepict CH 3 N N HN N H O N CH 2 N N CH 3 N H O Cl Cl IC50 < 1.0 nM 569.5 C=CC(=O)Nc1cc(N2CCN(CC)CC2)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)cccc2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL4756889 OBDepict O N N N NH O O CH 3 CH 3 CH 3 N O N CH 3 H 3 C IC50 = 1.1 nM 478.55 CC(=O)N(Cc1cc2c(nc1C=O)N(C(=O)Nc1cc(OC(C)C)c(C#N)cn1)CCC2)C(C)C Homo sapiens CHEMBL4723314 cell-based format
CHEMBL3896282 OBDepict O N N N H O N O N H 3 C CH 3 IC50 = 1.1 nM 351.37 CC(C)Oc1cc(NC(=O)N2CCc3ccc(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3945836 OBDepict CH 3 O N H N N H N N O N O N N IC50 = 1.1 nM 446.47 COCCNc1cc(NC(=O)N2CCCc3cc(-n4ccnc4)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3891494 OBDepict N N O NH O N O N O IC50 = 1.1 nM 407.43 N#Cc1cnc(NC(=O)N2CCCc3ccc(C=O)nc32)cc1OCC1CCCO1 Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3978835 OBDepict OH NH N NH N N O N O N O N H 3 C IC50 = 1.2 nM 492.54 CN1CCN(Cc2cc3c(nc2C=O)N(C(=O)Nc2cc(NCCO)c(C#N)cn2)CCC3)C(=O)C1 Homo sapiens CHEMBL3888056 cell-based format
CHEMBL4784921 OBDepict H 3 C O NH N HN N N O N O N CH 3 O CH 3 H 3 C IC50 = 1.2 nM 493.57 COCCNc1cc(NC(=O)N2CCCc3cc(CN(C)C(=O)C(C)C)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL3951896 OBDepict N N O HN O N O N O IC50 = 1.2 nM 421.46 N#Cc1cnc(NC(=O)N2CCCc3ccc(C=O)nc32)cc1OCC1CCCCO1 Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3940572 OBDepict N N N N H N O CH 3 OH N O IC50 = 1.2 nM 420.47 CC1(O)CCN(c2cc(NC(=O)N3CCCc4ccc(C=O)nc43)ncc2C#N)CC1 Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3904238 OBDepict H 3 C O NH N HN N N O N O N O S O O IC50 = 1.2 nM 541.59 COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCS(=O)(=O)CC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL4764678 OBDepict H 3 C O O N HN N N O N O N F F F IC50 = 1.2 nM 546.55 COCCOc1cc(NC(=O)N2CCCc3cc(C4CCN(CC(F)(F)F)CC4)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL4518346 OBDepict CH 3 O NH N HN N N O N O N O H O H 3 C IC50 = 1.2 nM 507.55 COCCNc1cc(NC(=O)N2CCCc3cc(CN4CC[C@@H](OC)C4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4339977 single protein format
CHEMBL3913839 OBDepict H 3 C O NH N HN N N O N O N F F IC50 = 1.2 nM 527.58 COCCNc1cc(NC(=O)N2CCCc3cc(C4CCN(CC(F)F)CC4)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3908044 OBDepict H 3 C O O N N H N N O N O IC50 = 1.3 nM 381.39 COCCOc1cc(NC(=O)N2CCCc3ccc(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL4533697 OBDepict H 3 C O O H 3 C H N HN N N O N O N O O IC50 = 1.3 nM 508.54 COC[C@@H](C)Oc1cc(NC(=O)N2CCCc3cc(CN4CCOCC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4339977 single protein format
CHEMBL4778828 OBDepict H 3 C O O N HN N N O N O N N O H 3 C IC50 = 1.3 nM 507.55 COCCOc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)C(=O)C4)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL4562284 OBDepict O N N N NH O O O N NH N H O IC50 = 1.3 nM 519.56 N#Cc1cnc(NC(=O)N2CCCc3cc(CN4CCCCOC4=O)c(C=O)nc32)cc1N[C@@H]1CCOC1 Homo sapiens CHEMBL4339977 single protein format
CHEMBL4759211 OBDepict CH 3 O HN N N H N N O N O N CH 3 O CH 3 IC50 = 1.3 nM 465.51 COCCNc1cc(NC(=O)N2CCCc3cc(CN(C)C(C)=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL4862576 OBDepict CH 3 O O N CH 3 N N H N O CH 3 CH 3 N N H 3 C IC50 = 1.4 nM 462.55 COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)c(=O)n3c2)c1 Homo sapiens CHEMBL4838118 single protein format
CHEMBL4789692 OBDepict CH 3 O O N NH N N O N O N O H 3 C CH 3 N CH 3 IC50 = 1.4 nM 535.61 COCCOc1cc(NC(=O)N2CCCc3cc(CN4C(=O)CN(C)CC4(C)C)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL3974651 OBDepict H 3 C O NH N HN N N O N O N O HN IC50 = 1.4 nM 492.54 COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCNCC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL4532389 OBDepict O N N N NH O O O N NH N H O IC50 = 1.4 nM 519.56 N#Cc1cnc(NC(=O)N2CCCc3cc(CN4CCCCOC4=O)c(C=O)nc32)cc1N[C@H]1CCOC1 Homo sapiens CHEMBL4339977 single protein format
CHEMBL4758510 OBDepict H 3 C O NH H 3 C H N HN N N O N O N O N H 3 C IC50 = 1.5 nM 520.59 COC[C@@H](C)Nc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL4475216 OBDepict H 3 C O NH H 3 C H N HN N N O N O N O O IC50 = 1.5 nM 521.58 COC[C@@H](C)Nc1cc(NC(=O)N2CCCc3cc(CN4CCCCOC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4339977 single protein format
CHEMBL4752511 OBDepict CH 3 O O N HN N N O N O N O H N H 3 C CH 3 IC50 = 1.6 nM 521.58 COCCOc1cc(NC(=O)N2CCCc3cc(CN4CC[C@@H](N(C)C)C4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL4446965 OBDepict CH 3 O NH N HN N N O N O N O H O H 3 C IC50 = 1.7 nM 507.55 COCCNc1cc(NC(=O)N2CCCc3cc(CN4CC[C@H](OC)C4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4339977 single protein format
CHEMBL3964682 OBDepict O N N HO N H O N N H N O IC50 = 1.7 nM 422.45 N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1NC1CCOC1 Homo sapiens CHEMBL3888056 cell-based format
CHEMBL4438578 OBDepict CH 3 O S H 3 C N H 2 N N N N S O O H 2 C IC50 = 1.7 nM 455.57 C=CS(=O)(=O)N1CC(n2cc(-c3cc4cc(C)cc(OC)c4s3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL4382840 single protein format
CHEMBL3701266 OBDepict CH 2 N O N N N H 2 N O O H 3 C CH 3 IC50 = 1.7 nM 405.46 C=CC(=O)N1CC(N2C=C(C#Cc3cc(OC)cc(OC)c3)C3C(N)=NC=NC32)C1 Homo sapiens CHEMBL3707934 single protein format
CHEMBL3986875 OBDepict N N NH HN N O O N O OH IC50 = 1.8 nM 450.5 N#Cc1cnc(NC(=O)N2CCCc3cc(CO)c(C=O)nc32)cc1NCC1CCCOC1 Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3923150 OBDepict O N N N NH O N N O CH 3 O N CH 3 H 3 C IC50 = 1.9 nM 505.58 CC(=O)N1CCN(Cc2cc3c(nc2C=O)N(C(=O)Nc2cc(OC(C)C)c(C#N)cn2)CCC3)CC1 Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3931083 OBDepict H 3 C O NH N HN N N O N O N O N HO H 3 C IC50 = 1.9 nM 522.57 COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)C(O)C4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3908979 OBDepict H 3 C O NH N HN N N O N O N O N H 3 C IC50 = 1.9 nM 506.57 COCCNc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3944778 OBDepict O N N N HN O O N N CH 3 HN N IC50 = 1.9 nM 514.59 CN1CCN(Cc2cc3c(nc2C=O)N(C(=O)Nc2cc(NC45CC(C4)C5)c(C#N)cn2)CCC3)C(=O)C1 Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3960759 OBDepict H 3 C O NH N HN N N O N O N O H 3 C N H 3 C CH 3 IC50 = 2.0 nM 522.61 COCCNc1cc(NC(=O)N2CCCc3cc(CN(CCN(C)C)C(C)=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format
CHEMBL3948664 OBDepict H 3 C N N NH N H O N H 2 C N N H 3 C N H O Cl O O CH 3 CH 3 IC50 = 2.0 nM 595.1 C=CC(=O)Nc1cc(N2CCN(CC)CC2)ccc1Nc1cc(N(C)C(=O)Nc2cc(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL3967316 OBDepict CH 2 HN O N H N N N N H O Cl Cl O O H 3 C CH 3 IC50 = 2.0 nM 593.47 C=CC(=O)Nc1ccccc1Nc1cc(N(Cc2ccccc2)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1 Homo sapiens CHEMBL3889129 single protein format
CHEMBL4781882 OBDepict CH 3 O O N NH N N O N O Br IC50 = 2.0 nM 460.29 COCCOc1cc(NC(=O)N2CCCc3cc(Br)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL4723314 cell-based format
CHEMBL3973674 OBDepict H 3 C O O N HN N N O N O N O N H 3 C IC50 = 2.0 nM 507.55 COCCOc1cc(NC(=O)N2CCCc3cc(CN4CCN(C)CC4=O)c(C=O)nc32)ncc1C#N Homo sapiens CHEMBL3888056 cell-based format