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P25440 | BRD2_HUMAN | Bromodomain-containing protein 2 (BRD2)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4228445 OBDepict CH 3 HN O N N NH N H N N H 3 C O H 3 C CH 3 N CH 3 O Ki = 0.27 nM 500.56 CCn1nc(C2CC2)cc1Nc1nc(C(=O)NC)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 Homo sapiens CHEMBL4219277 assay format
CHEMBL4208129 OBDepict H N O N N H 3 C N S O O CH 3 Ki = 0.48 nM 420.49 Cn1cc2c3c(c[nH]c3c1=O)CN(c1ccccn1)c1ccc(CS(C)(=O)=O)cc1-2 Homo sapiens CHEMBL4194904 single protein format
CHEMBL3987016 OBDepict CH 3 S N H O O O N H 3 C N F O H F Ki = 1.0 nM 459.47 CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 Homo sapiens CHEMBL4020255 single protein format
CHEMBL4555209 OBDepict CH 3 N N S N O CH 3 N N Ki = 1.7 nM 401.5 Cc1nnc2n1-c1sc(C#Cc3cnn(C)c3)c(Cc3ccccc3)c1COC2 Homo sapiens CHEMBL4382970 single protein format
CHEMBL4217457 OBDepict F F N N H N O S H 3 C O O CH 3 Ki = 2.5 nM 455.49 Cn1cc2c3c(c[nH]c3c1=O)CN(c1ccc(F)cc1F)c1ccc(CS(C)(=O)=O)cc1-2 Homo sapiens CHEMBL4194904 single protein format
CHEMBL4215988 OBDepict F N N CH 3 N O S H O O CH 3 Ki = 2.6 nM 437.5 Cn1cc2c3c(c[nH]c(=O)c31)-c1cc(CS(C)(=O)=O)ccc1N(c1ccc(F)cc1)C2 Homo sapiens CHEMBL4194904 single protein format
CHEMBL4780530 OBDepict Cl N H CH 3 N N N CH 3 N H 2 N IC50 = 3.0 nM 416.92 Cc1nnc2n1-c1ccc(-c3ccc(N)nc3)cc1N(c1ccc(Cl)cc1)C[C@H]2C Homo sapiens CHEMBL4716995 single protein format
CHEMBL4555209 OBDepict CH 3 N N S N O CH 3 N N IC50 = 3.5 nM 401.5 Cc1nnc2n1-c1sc(C#Cc3cnn(C)c3)c(Cc3ccccc3)c1COC2 Homo sapiens CHEMBL4382970 single protein format
CHEMBL4228445 OBDepict CH 3 HN O N N NH N H N N H 3 C O H 3 C CH 3 N CH 3 O IC50 = 3.9 nM 500.56 CCn1nc(C2CC2)cc1Nc1nc(C(=O)NC)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 Homo sapiens CHEMBL4219277 assay format
CHEMBL4297454 OBDepict CH 3 N H O N H O N CH 3 O HO CH 3 CH 3 CH 3 CH 3 F Ki = 4.6 nM 491.56 CCNC(=O)c1cc2c(-c3cc(C(C)(C)O)ccc3Oc3c(C)cc(F)cc3C)cn(C)c(=O)c2[nH]1 Homo sapiens CHEMBL4346371 single protein format
CHEMBL4165389 OBDepict Cl N N N N N N CH 3 N N H IC50 = 6.0 nM 378.83 Cc1nnn2c1-c1ccc(-c3nn[nH]n3)cc1N(c1ccc(Cl)cc1)CC2 Homo sapiens CHEMBL4144031 assay format
CHEMBL3895413 OBDepict CH 3 O N H 3 C N H N O H NH 2 IC50 = 6.6 nM 402.5 Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCC[C@H](N)C1)C(=O)N2 Homo sapiens CHEMBL3888742 single protein format
CHEMBL2017291 OBDepict H 3 C O N N CH 3 N H 3 C O N H O CH 3 H N Ki = 9.0 nM 415.45 COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n([C@H](C)c3ccccn3)c12 Homo sapiens CHEMBL3584941 cell-based format
CHEMBL3903717 OBDepict CH 3 O N H 3 C N H N O H OH IC50 = 9.6 nM 403.48 Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCC[C@H](O)C1)C(=O)N2 Homo sapiens CHEMBL3888742 single protein format
CHEMBL3581661 OBDepict H 3 C O N H 3 C N H 3 C O H N N CH 3 N H Ki = 11.1 nM 413.48 COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C4CC4)n[nH]c3C)c12 Homo sapiens CHEMBL3584941 cell-based format
CHEMBL3650967 OBDepict Cl H N N O H 3 C N N N CH 3 N CH 3 N IC50 = 12.0 nM 433.9 Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3n1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3581662 OBDepict CH 3 O N CH 3 N CH 3 O H N N N H 3 C H Ki = 12.2 nM 463.54 CCc1[nH]nc(-c2ccccc2)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 Homo sapiens CHEMBL3584941 cell-based format
CHEMBL1957266 OBDepict O O H N H 3 C CH 3 H 3 C N N N CH 3 S H 3 C CH 3 Cl Ki = 13.2 nM 457.0 Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2 Homo sapiens CHEMBL3584941 cell-based format
CHEMBL4063051 OBDepict O H 3 C N H O NH S O O H 3 C Ki = 14.0 nM 410.5 Cc1[nH]c(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2c1C(=O)CCC2 Homo sapiens CHEMBL4038422 single protein format
CHEMBL3650949 OBDepict Cl H N O H 3 C N N N H 3 C H 3 C H 3 C CH 3 O IC50 = 14.0 nM 410.91 Cc1nn(C(C)C)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650952 OBDepict CH 3 N N H N O N Cl CH 3 N CH 3 N IC50 = 14.0 nM 446.94 CCc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650899 OBDepict Cl H N O H 3 C N N N CH 3 CH 3 O IC50 = 15.0 nM 408.89 Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3654324 OBDepict OH N N H N O N Cl CH 3 N H 3 C N IC50 = 16.0 nM 448.91 Cc1cc(N2C(=O)c3c(c(CO)nn3C3CC3)[C@H]2c2ccc(Cl)cc2)cn2c(C)nnc12 Homo sapiens CHEMBL3707600 single protein format
CHEMBL3654293 OBDepict H 3 C N N CH 3 O N N F CH 3 H 3 C O Cl IC50 = 16.0 nM 414.87 CCn1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1F Homo sapiens CHEMBL3707600 single protein format
CHEMBL4577491 OBDepict H 2 N O O N H O H N N N N CH 3 S H 3 C CH 3 Cl IC50 = 16.0 nM 531.08 Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCN)c1nnc(C)n1-2 Homo sapiens CHEMBL4312045 single protein format
CHEMBL3581647 OBDepict O NH H N N N N CH 3 S HO CH 3 CH 3 Cl Ki = 16.6 nM 492.0 Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1ccc(O)cc1)c1nnc(C)n1-2 Homo sapiens CHEMBL3584941 cell-based format
CHEMBL3650901 OBDepict Cl H N O H 3 C N N N CH 3 Cl O IC50 = 17.0 nM 429.31 Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(Cl)c(=O)n(C)c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3654323 OBDepict Cl H N O H 3 C N N N H H 3 C N H 3 C N IC50 = 17.0 nM 392.85 Cc1n[nH]c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3895277 OBDepict H 3 C O N CH 3 N H OH O S IC50 = 18.0 nM 326.38 Cc1noc(C)c1-c1ccc2c(c1)C(O)(c1ccsc1)C(=O)N2 Homo sapiens CHEMBL3888742 single protein format
CHEMBL3650955 OBDepict Cl N N O H 3 C N N CH 3 N N CH 3 N IC50 = 18.0 nM 433.9 Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnn(C)c3n1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650964 OBDepict Cl H N O H 3 C N N N CH 3 N CH 3 N IC50 = 19.0 nM 432.92 Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3654318 OBDepict Cl N H 3 C N N N O N CH 3 N N F F IC50 = 20.0 nM 469.88 Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C(F)F)n3n1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3654322 OBDepict Cl H N O N N N H 3 C CH 3 N CH 3 N IC50 = 20.0 nM 432.92 Cc1cc(N2C(=O)c3c(c(C4CC4)nn3C)[C@H]2c2ccc(Cl)cc2)cn2c(C)nnc12 Homo sapiens CHEMBL3707600 single protein format
CHEMBL3581660 OBDepict H 3 C O N CH 3 O H 3 C N N H N N CH 3 CH 3 H Ki = 21.0 nM 415.5 CCc1n[nH]c(CC)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 Homo sapiens CHEMBL3584941 cell-based format
CHEMBL3654321 OBDepict H 3 C O N N H N O N Cl NH 2 N CH 3 N IC50 = 23.0 nM 463.93 COCc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(N)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3910920 OBDepict HO NH CH 3 H O N H CH 3 N CH 3 O IC50 = 24.0 nM 377.44 Cc1noc(C)c1-c1ccc2c(c1)C(N[C@H](C)CO)(c1ccccc1)C(=O)N2 Homo sapiens CHEMBL3888742 single protein format
CHEMBL3650933 OBDepict Cl N O H 3 C N N CH 3 N N CH 3 N IC50 = 24.0 nM 432.92 Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnn(C)c3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL4752543 OBDepict CH 3 O S N H O O N H CH 3 H 3 C O IC50 = 24.0 nM 358.42 COc1ccccc1S(=O)(=O)Nc1ccc2c(c1)C(=C(C)C)C(=O)N2 Homo sapiens CHEMBL4710396 single protein format
CHEMBL3650940 OBDepict Cl N O H 3 C N N N CH 3 CH 3 O IC50 = 25.0 nM 422.92 Cc1nn(C2CCC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650918 OBDepict CH 3 N N N O N Cl CH 3 CH 3 O IC50 = 26.0 nM 422.92 CCc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3786012 OBDepict F F O N S H O O H 3 C H 3 C HN O Ki = 27.0 nM 432.45 Cc1[nH]c(-c2cc(S(C)(=O)=O)ccc2Oc2ccc(F)cc2F)c2c1C(=O)NCC2 Homo sapiens CHEMBL4038422 single protein format
CHEMBL3650954 OBDepict CH 3 O N N N H 3 C O N N CH 3 N N H 3 C N Cl IC50 = 27.0 nM 500.95 COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnn(C)c3n1)C2c1ccc(Cl)cc1 Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650937 OBDepict Cl N O H 3 C N N N CH 3 N N H 3 C N H 3 C N IC50 = 28.0 nM 472.94 Cc1nn(-c2ccnn2C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3654313 OBDepict Cl F H N O H 3 C N N N CH 3 N CH 3 N IC50 = 28.0 nM 450.91 Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650945 OBDepict CH 3 O N N O N N CH 3 H 3 C O N H N CH 3 CH 3 O Cl IC50 = 28.0 nM 506.95 COc1ncc(-n2nc(C)c3c2C(=O)N(c2cc(C)c(=O)n(C)c2)[C@@H]3c2ccc(Cl)cc2)c(OC)n1 Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650938 OBDepict Cl N O H 3 C N N N CH 3 N CH 3 N IC50 = 29.0 nM 432.92 Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL1738926 OBDepict O HN O H N N N N CH 3 IC50 = 29.9 nM 423.48 Cc1nnc2n1-c1ccccc1C(c1ccccc1)=N[C@H]2NC(=O)OCc1ccccc1 Homo sapiens CHEMBL1958571 single protein format
CHEMBL2153434 OBDepict O N H O N N N N CH 3 IC50 = 29.9 nM 423.48 Cc1nnc2n1-c1ccccc1C(c1ccccc1)=NC2NC(=O)OCc1ccccc1 Homo sapiens CHEMBL2156117 single protein format
CHEMBL3650973 OBDepict CH 3 O N N N H 3 C O N H N CH 3 CH 3 O Cl IC50 = 30.0 nM 475.94 COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)[C@@H]2c1ccc(Cl)cc1 Homo sapiens CHEMBL3707600 single protein format
CHEMBL2177300 OBDepict Cl NH H H CH 3 N O H 3 C O OH IC50 = 30.0 nM 434.92 CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C Homo sapiens CHEMBL4182256 single protein format
CHEMBL3650919 OBDepict CH 3 N N N O N Cl CH 3 N CH 3 N IC50 = 31.0 nM 446.94 CCc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3910409 OBDepict H 3 C O N CH 3 N H HN O HO CH 3 H IC50 = 32.0 nM 383.49 Cc1noc(C)c1-c1ccc2c(c1)C(NC[C@@H](C)O)(C1CCCCC1)C(=O)N2 Homo sapiens CHEMBL3888742 single protein format
CHEMBL3650970 OBDepict Cl H N O H 3 C N N N H 3 C N N H 3 C N H 3 C N IC50 = 32.0 nM 472.94 Cc1nn(-c2ccnn2C)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650956 OBDepict CH 3 O N N N H 3 C O N N N CH 3 N H 3 C N Cl IC50 = 32.0 nM 500.95 COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3n1)C2c1ccc(Cl)cc1 Homo sapiens CHEMBL3707600 single protein format
CHEMBL1232461 OBDepict CH 3 HN O H N N N N H 3 C O Cl H 3 C IC50 = 32.5 nM 423.9 CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc21 Homo sapiens CHEMBL1958571 single protein format
CHEMBL3654320 OBDepict CH 3 N H N N N N N H 3 C O H N N H 3 C Cl IC50 = 33.0 nM 448.92 CNc1cc(N2C(=O)c3c(c(C)nn3C3CC3)[C@H]2c2ccc(Cl)cc2)nn2c(C)nnc12 Homo sapiens CHEMBL3707600 single protein format
CHEMBL4168815 OBDepict Cl N N N N CH 3 N H 2 N IC50 = 33.0 nM 402.89 Cc1nnn2c1-c1ccc(-c3ccc(N)nc3)cc1N(c1ccc(Cl)cc1)CC2 Homo sapiens CHEMBL4144031 assay format
CHEMBL3650962 OBDepict Cl N O N N N CH 3 N N CH 3 N H 3 C N IC50 = 34.0 nM 498.98 Cc1cc(N2C(=O)c3c(c(C4CC4)nn3-c3ccnn3C)C2c2ccc(Cl)cc2)cn2c(C)nnc12 Homo sapiens CHEMBL3707600 single protein format
CHEMBL4161767 OBDepict Cl N N N N O NH 2 CH 3 IC50 = 34.0 nM 353.81 Cc1nnn2c1-c1ccc(C(N)=O)cc1N(c1ccc(Cl)cc1)CC2 Homo sapiens CHEMBL4144031 assay format
CHEMBL4177080 OBDepict Cl N N N N N CH 3 N H IC50 = 35.0 nM 376.85 Cc1nnn2c1-c1ccc(-c3cc[nH]n3)cc1N(c1ccc(Cl)cc1)CC2 Homo sapiens CHEMBL4144031 assay format
CHEMBL3650959 OBDepict Cl N N O H 3 C N N N CH 3 N N H 3 C N H 3 C N IC50 = 35.0 nM 473.93 Cc1nn(-c2ccnn2C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3n1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650961 OBDepict H 3 C N N CH 3 O N N CH 3 N H 3 C N Cl IC50 = 36.0 nM 420.9 CCn1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1 Homo sapiens CHEMBL3707600 single protein format
CHEMBL3654326 OBDepict Cl N O H 3 C N N N CH 3 N O N H 3 C N H 3 C CH 3 IC50 = 36.0 nM 463.93 Cc1nn(C(=O)N(C)C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650932 OBDepict CH 3 N N N O N Cl O CH 3 N CH 3 N IC50 = 37.0 nM 462.94 CCc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(OC)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650917 OBDepict CH 3 N N N O N Cl CH 3 H 3 C O IC50 = 37.0 nM 422.92 CCc1c2c(nn1C1CC1)C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 Homo sapiens CHEMBL3707600 single protein format
CHEMBL4170756 OBDepict Cl N H CH 3 N N N CH 3 IC50 = 38.0 nM 324.82 Cc1nnn2c1-c1ccccc1N(c1ccc(Cl)cc1)C[C@H]2C Homo sapiens CHEMBL4144031 assay format
CHEMBL3654290 OBDepict H 3 C O N N H N O N Cl CH 3 CH 3 O IC50 = 39.0 nM 438.92 COCc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL4743540 OBDepict CH 3 O S N H O O N H CH 3 H 3 C O Br IC50 = 39.0 nM 437.32 COc1ccc(Br)cc1S(=O)(=O)Nc1ccc2c(c1)C(=C(C)C)C(=O)N2 Homo sapiens CHEMBL4710396 single protein format
CHEMBL4798353 OBDepict H 3 C CH 3 O N H N H S O O Br IC50 = 40.0 nM 407.29 CC(C)=C1C(=O)Nc2ccc(NS(=O)(=O)c3ccccc3Br)cc21 Homo sapiens CHEMBL4710396 single protein format
CHEMBL3654312 OBDepict Cl F H N O H 3 C N N N H 3 C H 3 C CH 3 N H 3 C N IC50 = 40.0 nM 452.92 Cc1nn(C(C)C)c2c1[C@@H](c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650974 OBDepict Cl N O N N N H 3 C CH 3 N CH 3 N IC50 = 40.0 nM 432.92 Cc1cc(N2C(=O)c3c(c(C4CC4)nn3C)C2c2ccc(Cl)cc2)cn2c(C)nnc12 Homo sapiens CHEMBL3707600 single protein format
CHEMBL3654311 OBDepict F F H N O H 3 C N N N CH 3 N CH 3 N IC50 = 41.0 nM 434.45 Cc1nn(C2CC2)c2c1[C@@H](c1ccc(F)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650920 OBDepict CH 3 O N N N H 3 C O N N CH 3 CH 3 O Cl IC50 = 41.0 nM 475.94 COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 Homo sapiens CHEMBL3707600 single protein format
CHEMBL3654325 OBDepict Cl H N O H 3 C N N N H 3 C N H 3 C N OH H F F F IC50 = 42.0 nM 504.9 Cc1nn(C[C@H](O)C(F)(F)F)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650916 OBDepict CH 3 O N N O N N CH 3 H 3 C CH 3 O N N H 3 C Cl N CH 3 N IC50 = 43.0 nM 559.03 COc1ncc(-n2nc3c(c2C(C)C)C(c2ccc(Cl)cc2)N(c2cc(C)c4nnc(C)n4c2)C3=O)c(OC)n1 Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650946 OBDepict CH 3 O N N N H 3 C O N N CH 3 N H 3 C N Cl IC50 = 43.0 nM 499.96 COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1 Homo sapiens CHEMBL3707600 single protein format
CHEMBL4167362 OBDepict Cl N N N N N H O H 3 C S O O CH 3 IC50 = 44.0 nM 431.91 Cc1nnn2c1-c1ccc(C(=O)NS(C)(=O)=O)cc1N(c1ccc(Cl)cc1)CC2 Homo sapiens CHEMBL4144031 assay format
CHEMBL3650939 OBDepict Cl N O N CH 3 N N CH 3 N H 3 C N IC50 = 45.0 nM 432.92 Cc1cc(N2C(=O)c3nn(C4CC4)c(C)c3C2c2ccc(Cl)cc2)cn2c(C)nnc12 Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650976 OBDepict OH N N N O N Cl CH 3 N H 3 C N IC50 = 46.0 nM 448.91 Cc1cc(N2C(=O)c3c(c(CO)nn3C3CC3)C2c2ccc(Cl)cc2)cn2c(C)nnc12 Homo sapiens CHEMBL3707600 single protein format
CHEMBL3654307 OBDepict CH 3 O N N N H 3 C O N N F CH 3 N H 3 C N Cl IC50 = 47.0 nM 517.95 COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1F Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650874 OBDepict Cl H N O N CH 3 N N CH 3 H 3 C O IC50 = 48.0 nM 408.89 Cc1cc(N2C(=O)c3nn(C4CC4)c(C)c3[C@H]2c2ccc(Cl)cc2)cn(C)c1=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650960 OBDepict H 3 C N N H 3 C O N N CH 3 Cl N H 3 C N IC50 = 48.0 nM 420.9 CCn1nc2c(c1C)C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650890 OBDepict Cl N O N N N H 3 C Cl CH 3 CH 3 O IC50 = 49.0 nM 417.3 CC(C)n1ncc2c1C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 Homo sapiens CHEMBL3707600 single protein format
CHEMBL4162832 OBDepict Cl N N N N N H O CH 3 CH 3 H IC50 = 51.0 nM 457.97 Cc1nnn2c1-c1ccc(C(=O)N[C@@H](C)c3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 Homo sapiens CHEMBL4144031 assay format
CHEMBL3929288 OBDepict O OH O N H H 3 C N CH 3 O IC50 = 52.0 nM 340.38 Cc1noc(C)c1-c1ccc2c(c1)C(O)(C1CCCCC1=O)C(=O)N2 Homo sapiens CHEMBL3888742 single protein format
CHEMBL3650934 OBDepict H 3 C O N N O N CH 3 N CH 3 H 3 C O Cl IC50 = 52.0 nM 440.93 CCc1nn(CCOC)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3654315 OBDepict H 3 C N N CH 3 O N H N F CH 3 N H 3 C N Cl IC50 = 53.0 nM 438.89 CCn1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)[C@@H]2c1ccc(Cl)cc1F Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650975 OBDepict H 3 C O N N N O N Cl CH 3 N CH 3 N IC50 = 53.0 nM 462.94 COCc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL4173305 OBDepict Cl N N N N CH 3 N CH 3 IC50 = 53.0 nM 401.9 Cc1ccc(-c2ccc3c(c2)N(c2ccc(Cl)cc2)CCn2nnc(C)c2-3)cn1 Homo sapiens CHEMBL4144031 assay format
CHEMBL4159455 OBDepict Cl N H CH 3 N N N CH 3 IC50 = 53.0 nM 324.82 Cc1nnn2c1-c1ccccc1N(c1ccc(Cl)cc1)C[C@@H]2C Homo sapiens CHEMBL4144031 assay format
CHEMBL4174587 OBDepict Cl N N N N N H O H 3 C S O O IC50 = 54.0 nM 493.98 Cc1nnn2c1-c1ccc(C(=O)NS(=O)(=O)c3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 Homo sapiens CHEMBL4144031 assay format
CHEMBL3955162 OBDepict H 3 C O N CH 3 N H NH 2 O IC50 = 55.0 nM 319.36 Cc1noc(C)c1-c1ccc2c(c1)C(N)(c1ccccc1)C(=O)N2 Homo sapiens CHEMBL3888742 single protein format
CHEMBL4173105 OBDepict N N N CH 3 N N Cl IC50 = 56.0 nM 335.8 Cc1nnn2c1-c1ccc(C#N)cc1N(c1ccc(Cl)cc1)CC2 Homo sapiens CHEMBL4144031 assay format
CHEMBL1232461 OBDepict CH 3 HN O H N N N N H 3 C O Cl H 3 C Ki = 56.8 nM 423.9 CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc21 Homo sapiens CHEMBL3584941 cell-based format
CHEMBL3650888 OBDepict Cl N O N N N H 3 C H 3 C CH 3 H 3 C O IC50 = 57.0 nM 396.88 Cc1cc(N2C(=O)c3c(cnn3C(C)C)C2c2ccc(Cl)cc2)cn(C)c1=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL4228904 OBDepict CH 3 HN O N N N H O CH 3 H 3 C N CH 3 O Ki = 57.3 nM 351.37 CNC(=O)c1ncc2c(n1)[nH]c1cc(-c3c(C)noc3C)c(OC)cc12 Homo sapiens CHEMBL4219277 assay format
CHEMBL3654285 OBDepict H 3 C O N O N N H 3 C O N N H 3 C N CH 3 N Cl IC50 = 59.0 nM 519.99 CCOC(=O)N1CC(n2nc(C)c3c2C(=O)N(c2cc(C)c4nnc(C)n4c2)C3c2ccc(Cl)cc2)C1 Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650928 OBDepict HO N N CH 3 O N CH 3 Cl O H 3 C N IC50 = 59.0 nM 450.93 CCc1c2c(nn1CCO)C(=O)N(c1cc(C)c3onc(C)c3c1)C2c1ccc(Cl)cc1 Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650936 OBDepict H 3 C N N N N O H 3 C N N Cl CH 3 H 3 C O IC50 = 60.0 nM 462.94 CCc1nn(-c2ccnn2C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O Homo sapiens CHEMBL3707600 single protein format
CHEMBL3650921 OBDepict CH 3 O N N N H 3 C O N N CH 3 Cl O Cl IC50 = 60.0 nM 496.35 COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 Homo sapiens CHEMBL3707600 single protein format