HOME LIGAND hPROTEOME OTHERS DOCUMENT

P26639 | SYTC_HUMAN | "Threonine--tRNA ligase 1, cytoplasmic" (TARS1)

3D structures mapped by conservation among orthologs

[ Domain: "Ubiquitin-like" // TGS ]

download pymol session

[ Domain: "Class II aaRS and biotin synthetases" // tRNA-synt_2b ]

download pymol session

[ Domain: "Anticodon-binding domain of Class II aaRS" // HGTP_anticodon ]

download pymol session

[ Domain: pdbs with more than 2 multi-domains ]

download pymol session



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL2311920 OBDepict Cl N N NH 2 S N H O O O NH 2 H OH H 3 C H Ki = 1.2 nM 435.89 C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1cccc(-c2ccc3c(N)nc(Cl)nc3c2)c1 Homo sapiens CHEMBL2317882 single protein format
CHEMBL2311926 OBDepict O N H NH 2 H S HO CH 3 H O O N N N H Ki = 1.8 nM 425.47 C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1ccc2ccc(-c3ncnc4[nH]ccc34)cc2c1 Homo sapiens CHEMBL2317882 single protein format
CHEMBL2311924 OBDepict O HN H 2 N H S OH CH 3 H O O N N H 2 N Ki = 3.0 nM 401.45 C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1ccc2ccc(-c3cc(N)ncn3)cc2c1 Homo sapiens CHEMBL2317882 single protein format
CHEMBL2311918 OBDepict NH 2 N N S N H O O O NH 2 H OH H 3 C H Ki = 3.3 nM 401.45 C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1cccc(-c2ccc3c(N)ncnc3c2)c1 Homo sapiens CHEMBL2317882 single protein format
CHEMBL2311925 OBDepict O HN H 2 N H S OH CH 3 H O O N N H 2 N Ki = 4.1 nM 377.43 C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)/C=C/c1cccc(-c2cc(N)ncn2)c1 Homo sapiens CHEMBL2317882 single protein format
CHEMBL2311927 OBDepict O N H NH 2 H S HO CH 3 H N O O N N N H Ki = 5.2 nM 430.49 C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)N1CCc2ccc(-c3ncnc4[nH]ccc34)cc2C1 Homo sapiens CHEMBL2317882 single protein format
CHEMBL2311919 OBDepict NH 2 N N NH 2 S N H O O O NH 2 H OH H 3 C H Ki = 10.1 nM 416.46 C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1cccc(-c2ccc3c(N)nc(N)nc3c2)c1 Homo sapiens CHEMBL2317882 single protein format
CHEMBL2311917 OBDepict NH 2 N N N N H O H OH H H HO O S N H O O O H 2 N H OH CH 3 H Ki = 13.4 nM 447.43 C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)OC[C@@H]1O[C@H](n2cnc3c(N)ncnc32)[C@@H](O)[C@H]1O Homo sapiens CHEMBL2317882 single protein format
CHEMBL1163068 OBDepict NH 2 N N N N H O H OH H H HO O S N H O O O H 2 N H OH CH 3 H IC50 = 15.0 nM 447.43 C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O Homo sapiens CHEMBL816522 single protein format
CHEMBL2316966 OBDepict H 3 C HO H NH 2 H HN O S O O N N H 2 N Ki = 32.0 nM 391.45 CC[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)/C=C/c1cccc(-c2cc(N)ncn2)c1 Homo sapiens CHEMBL2317882 single protein format
CHEMBL2311921 OBDepict H 3 C N N NH 2 S NH O O O H 2 N H OH H 3 C H Ki = 72.0 nM 415.48 Cc1nc(N)c2ccc(-c3cccc(S(=O)(=O)NC(=O)[C@@H](N)[C@@H](C)O)c3)cc2n1 Homo sapiens CHEMBL2317882 single protein format
CHEMBL2311928 OBDepict O N H S N H O O O NH 2 H HO CH 3 H Ki = 91.0 nM 389.43 C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1cccc(-c2ccc3c(c2)CNC3=O)c1 Homo sapiens CHEMBL2317882 single protein format
CHEMBL2316963 OBDepict Cl N N NH 2 N H NH O H 2 N H HO CH 3 H Ki = 399.0 nM 386.84 C[C@@H](O)[C@H](N)C(=O)NNc1cccc(-c2ccc3c(N)nc(Cl)nc3c2)c1 Homo sapiens CHEMBL2317882 single protein format
CHEMBL2311922 OBDepict Cl N NH 2 S N H O O O NH 2 H OH H 3 C H Ki = 463.0 nM 434.91 C[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)c1cccc(-c2ccc3c(N)nc(Cl)cc3c2)c1 Homo sapiens CHEMBL2317882 single protein format
CHEMBL2316967 OBDepict O HN H 2 N H S HO H O O N N H 2 N CH 3 CH 3 Ki = 601.0 nM 405.48 CC(C)[C@@H](O)[C@H](N)C(=O)NS(=O)(=O)/C=C/c1cccc(-c2cc(N)ncn2)c1 Homo sapiens CHEMBL2317882 single protein format
CHEMBL2316962 OBDepict Cl N N NH 2 NH O H 2 N H HO CH 3 H Ki = 935.0 nM 385.86 C[C@@H](O)[C@H](N)C(=O)NCc1cccc(-c2ccc3c(N)nc(Cl)nc3c2)c1 Homo sapiens CHEMBL2317882 single protein format