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P27448 | MARK3_HUMAN | MAP/microtubule affinity-regulating kinase 3 (MARK3)

3D structures mapped by conservation among orthologs

[ Domain: "RuvA-C, UBA, CRAL/TRIO-N, HBS1" // UBA_MELK ]

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[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4868141 OBDepict H 2 N N O O HN NH S O O IC50 = -22700.0 nM 532.67 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2OC2CCCCC2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804427 cell-based format
CHEMBL4565845 OBDepict CH 3 N N N N N CH 3 S NH O H H H 2 N F F IC50 < 0.25 nM 471.54 Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(-c3cnn(C)c3)cnc12 Homo sapiens CHEMBL4479676 assay format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 0.438 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328485 single protein format
CHEMBL3648448 OBDepict F N N N S N H O H NH 2 F F IC50 = 0.5 nM 471.51 N[C@@H]1CCCC(F)(F)C1NC(=O)c1cc(-c2cnc3cc(-c4ccc(F)cc4)cnn23)cs1 Homo sapiens CHEMBL3705161 single protein format
CHEMBL4568087 OBDepict H 3 C N N N N N S N H O H H H 2 N IC50 <= 0.5 nM 421.53 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479676 assay format
CHEMBL4569508 OBDepict O N H S F F F N N N O N IC50 = 1.0 nM 529.59 O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 Homo sapiens CHEMBL4479676 assay format
CHEMBL4532781 OBDepict H 3 C N N N N N S N H O H H H 2 N IC50 = 1.0 nM 421.53 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@H]5N)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479676 assay format
CHEMBL3884319 OBDepict HO H N N O CH 3 H 3 C N NH IC50 = 1.2 nM 386.45 CC1(C)C(=O)N([C@H]2CCc3c(O)cccc32)c2nc(Nc3ccccc3)ncc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL4550486 OBDepict H 3 C N N N N N H 3 C S HN O H H H 2 N IC50 = 1.3 nM 435.56 Cc1sc(C(=O)N[C@@H]2CCCC[C@@H]2N)cc1-c1cnn2cc(-c3cnn(C)c3)cnc12 Homo sapiens CHEMBL4479676 assay format
CHEMBL4528550 OBDepict CH 3 N N N N N S N H O H H H 2 N IC50 = 2.0 nM 407.5 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCC[C@@H]5N)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479676 assay format
CHEMBL4552799 OBDepict O N H S H CH 3 H NH 2 F F N N N IC50 = 2.4 nM 391.45 Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cccnc12 Homo sapiens CHEMBL4479676 assay format
CHEMBL4562217 OBDepict CH 3 N N N N N S N H O H H H 2 N IC50 = 3.0 nM 407.5 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCC[C@H]5N)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479676 assay format
CHEMBL4593028 OBDepict CH 3 O O N N N S NH O F F F IC50 = 5.0 nM 476.48 COCCOc1ccc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cc1 Homo sapiens CHEMBL4479676 assay format
CHEMBL4552628 OBDepict Cl N N N H 3 C S N H O H H H 2 N F F IC50 = 5.0 nM 425.89 Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12 Homo sapiens CHEMBL4479676 assay format
CHEMBL4550702 OBDepict CH 3 N N N N N S NH O F F F IC50 = 6.0 nM 406.39 Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479676 assay format
CHEMBL4571737 OBDepict HO N H O S N N N N N CH 3 IC50 = 9.0 nM 408.49 Cn1cc(-c2cnc3c(-c4csc(C(=O)NC(CO)C5CC5)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479676 assay format
CHEMBL4579339 OBDepict H 3 C N N N N N S N H O H H HO IC50 = 9.0 nM 422.51 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5O)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479676 assay format
CHEMBL3883979 OBDepict H 2 N H N N O CH 3 H 3 C N NH IC50 = 10.0 nM 385.47 CC1(C)C(=O)N([C@H]2CCc3c(N)cccc32)c2nc(Nc3ccccc3)ncc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL4569165 OBDepict CH 3 N N N N N S NH O H 2 N F F F IC50 = 10.0 nM 449.46 Cn1cc(-c2cnc3c(-c4csc(C(=O)NCCC(N)C(F)(F)F)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479676 assay format
CHEMBL4543195 OBDepict CH 3 N N N N N S N H O H H HO IC50 = 10.0 nM 408.49 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCC[C@H]5O)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479676 assay format
CHEMBL3884318 OBDepict HO N CH 3 H N O CH 3 H 3 C N NH N IC50 = 10.0 nM 375.43 C[C@@H](c1cccc(O)c1)N1C(=O)C(C)(C)c2cnc(Nc3cccnc3)nc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL2207198 OBDepict O HN HN N N N H N O IC50 = 12.0 nM 450.59 O=C(NCCCNc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1C1CC1)C1CCC1 Homo sapiens CHEMBL2213803 single protein format
CHEMBL4547786 OBDepict CH 3 N N N N N S HN O F F F IC50 = 13.0 nM 406.39 Cn1cnc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)c1 Homo sapiens CHEMBL4479676 assay format
CHEMBL3884535 OBDepict O N H 3 C H 3 C N N HN N NH IC50 = 14.0 nM 420.56 CC1(C)C(=O)N(C2CCCCC2)c2nc(Nc3cccc(N4CCNCC4)c3)ncc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL4578265 OBDepict F F H 2 N N H O S N N N N N CH 3 IC50 = 15.0 nM 431.47 Cn1cc(-c2cnc3c(-c4csc(C(=O)NCCC(N)C(F)F)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479676 assay format
CHEMBL4557345 OBDepict O N H S F F F N N N O IC50 = 15.0 nM 444.44 O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc5c(c4)OCC5)cnc23)cs1 Homo sapiens CHEMBL4479676 assay format
CHEMBL3648449 OBDepict O N H S H NH 2 F F N N N IC50 = 15.0 nM 377.42 N[C@H]1CCCC(F)(F)C1NC(=O)c1cc(-c2cnc3cccnn23)cs1 Homo sapiens CHEMBL3705161 single protein format
CHEMBL3884344 OBDepict O N H 3 C H 3 C N H N NH N H S O O CH 3 IC50 = 19.0 nM 463.56 CC1(C)C(=O)N([C@H]2CCc3c(NS(C)(=O)=O)cccc32)c2nc(Nc3ccccc3)ncc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL3648447 OBDepict O N H S CH 3 H NH 2 F F N N N IC50 = 20.0 nM 391.45 Cc1sc(C(=O)NC2[C@H](N)CCCC2(F)F)cc1-c1cnc2cccnn12 Homo sapiens CHEMBL3705161 single protein format
CHEMBL2207208 OBDepict O N H HN N N N H N N H 3 C IC50 = 20.0 nM 369.47 Cn1cc(Nc2ncc(C3CC3)c(NCCCNC(=O)C3CCC3)n2)cn1 Homo sapiens CHEMBL2213803 single protein format
CHEMBL4589674 OBDepict F H 2 N HN O S N N N N N CH 3 IC50 = 22.0 nM 413.48 Cn1cc(-c2cnc3c(-c4csc(C(=O)NCCC(N)CF)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479676 assay format
CHEMBL4544609 OBDepict H 3 C N N N N N S N H O H H HO IC50 = 24.0 nM 422.51 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@H]5O)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479676 assay format
CHEMBL3883433 OBDepict O N CH 3 H 3 C N H N NH N IC50 = 27.0 nM 371.44 CC1(C)C(=O)N([C@H]2CCc3ccccc32)c2nc(Nc3cccnc3)ncc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL3884884 OBDepict O N CH 3 CH 3 N H 3 C H N HN N IC50 = 37.0 nM 359.43 C[C@@H](c1ccccc1)N1C(=O)C(C)(C)c2cnc(Nc3cccnc3)nc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL4526375 OBDepict O N H S F F F N N N O IC50 = 38.0 nM 442.42 O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc5ccoc5c4)cnc23)cs1 Homo sapiens CHEMBL4479676 assay format
CHEMBL4588200 OBDepict CH 3 N N N N N S N H O H H HO IC50 = 43.0 nM 408.49 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCC[C@@H]5O)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479676 assay format
CHEMBL3885080 OBDepict CH 3 N H 3 C H N O N N H N IC50 = 60.0 nM 309.37 CC[C@H](C)N1C(=O)C2(CC2)c2cnc(Nc3cccnc3)nc21 Homo sapiens CHEMBL3876478 single protein format
CHEMBL3884179 OBDepict F N CH 3 H N O CH 3 H 3 C N NH N IC50 = 62.0 nM 377.42 C[C@@H](c1ccc(F)cc1)N1C(=O)C(C)(C)c2cnc(Nc3cccnc3)nc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL4550262 OBDepict O NH S F F F N N N N IC50 = 70.0 nM 403.39 O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4cccnc4)cnc23)cs1 Homo sapiens CHEMBL4479676 assay format
CHEMBL4541288 OBDepict O N H S F F F N N N N H 3 C IC50 = 74.0 nM 455.47 Cn1ccc2ccc(-c3cnc4c(-c5csc(C(=O)NCC(F)(F)F)c5)cnn4c3)cc21 Homo sapiens CHEMBL4479676 assay format
CHEMBL3884116 OBDepict H 3 C N CH 3 H N O H 3 C CH 3 N N H N N N H H 3 C IC50 = 80.0 nM 391.48 CC[C@H](C)N1C(=O)C(C)(C)c2cnc(Nc3ccc(-c4nnc(C)[nH]4)cc3)nc21 Homo sapiens CHEMBL3876478 single protein format
CHEMBL3883412 OBDepict H 3 C H 3 C N H 3 C H N O CH 3 CH 3 N N H IC50 = 80.0 nM 324.43 CC(C)[C@H](C)N1C(=O)C(C)(C)c2cnc(Nc3ccccc3)nc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL4514812 OBDepict H N N N N N S N H O F F F IC50 = 99.0 nM 392.37 O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4cn[nH]c4)cnc23)cs1 Homo sapiens CHEMBL4479676 assay format
CHEMBL3884253 OBDepict H 3 C N H 3 C H N O CH 3 CH 3 N N H N IC50 = 117.0 nM 311.39 CC[C@H](C)N1C(=O)C(C)(C)c2cnc(Nc3cccnc3)nc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL3885363 OBDepict CH 3 N H 3 C H N O CH 3 CH 3 N N H S O O CH 3 IC50 = 120.0 nM 388.49 CC[C@H](C)N1C(=O)C(C)(C)c2cnc(Nc3ccc(S(C)(=O)=O)cc3)nc21 Homo sapiens CHEMBL3876478 single protein format
CHEMBL4556844 OBDepict H 3 C NH O S N N N N N H 3 C IC50 = 129.0 nM 352.42 CCNC(=O)c1cc(-c2cnn3cc(-c4cnn(C)c4)cnc23)cs1 Homo sapiens CHEMBL4479676 assay format
CHEMBL4561857 OBDepict H 3 C N N N N N H 3 C S HN O H H H 2 N F F IC50 = 130.0 nM 471.54 Cc1sc(C(=O)N[C@H]2CCCC(F)(F)[C@H]2N)cc1-c1cnn2cc(-c3cnn(C)c3)cnc12 Homo sapiens CHEMBL4479676 assay format
CHEMBL3648450 OBDepict H 3 C S N N H O N N H NH 2 F F CH 3 IC50 = 140.0 nM 419.5 CCc1sc(C(=O)NC2[C@H](N)CCCC2(F)F)cc1-c1cnc2cc(C)cnn12 Homo sapiens CHEMBL3705161 single protein format
CHEMBL590109 OBDepict H 2 N N N N NH 2 N N S H IC50 = 210.0 nM 425.52 NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 Homo sapiens CHEMBL1072662 single protein format
CHEMBL3883637 OBDepict O N H 3 C CH 3 N N HN IC50 = 226.0 nM 322.41 CC1(C)C(=O)N(C2CCCC2)c2nc(Nc3ccccc3)ncc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL3883802 OBDepict O N H 3 C CH 3 N N HN IC50 = 304.0 nM 336.44 CC1(C)C(=O)N(C2CCCCC2)c2nc(Nc3ccccc3)ncc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL3883548 OBDepict O N H 3 C CH 3 N N HN N IC50 = 346.0 nM 337.43 CC1(C)C(=O)N(C2CCCCC2)c2nc(Nc3cccnc3)ncc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL3885175 OBDepict CH 3 N H 3 C N O H 3 C H 3 C N N H IC50 = 627.0 nM 296.37 CC(C)N1C(=O)C(C)(C)c2cnc(Nc3ccccc3)nc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL3648446 OBDepict O N H S N Cl H H 2 N F F N N IC50 = 720.0 nM 411.87 N[C@H]1CCCC(F)(F)C1NC(=O)c1nc(-c2cnc3ccccn23)c(Cl)s1 Homo sapiens CHEMBL3705161 single protein format
CHEMBL3883766 OBDepict H 3 C N H 3 C H N O CH 3 CH 3 N N H N IC50 = 738.0 nM 311.39 CC[C@@H](C)N1C(=O)C(C)(C)c2cnc(Nc3cccnc3)nc21 Homo sapiens CHEMBL3876023 single protein format
CHEMBL3885232 OBDepict O N H 3 C CH 3 CH 3 N N N H N HN IC50 = 850.0 nM 352.44 CN1C(=O)C(C)(C)c2cnc(Nc3cccc(N4CCNCC4)c3)nc21 Homo sapiens CHEMBL3876023 single protein format