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P27986 | P85A_HUMAN | Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

3D structures mapped by conservation among orthologs

[ Domain: "GTPase activation domain, GAP" // RhoGAP ]

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[ Domain: "SH2" // SH2 ]

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[ Domain: "Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain" // PI3K_P85_iSH2 ]

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[ Domain: "SH3" // SH3_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL127907 OBDepict CH 3 O O CH 3 N N H N HO IC50 = 2.0 nM 297.31 COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC Homo sapiens CHEMBL936779 single protein format
CHEMBL3981126 OBDepict H 3 C N O CH 3 H 3 C O N N N F H H 3 C N H O NH O N IC50 = 103.0 nM 549.61 CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccncc4)c(F)c3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3953184 OBDepict H 3 C N O CH 3 H 3 C O N N N F H H 3 C HN O N H O N N H 3 C IC50 = 159.0 nM 552.61 CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4cn(C)cn4)c(F)c3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3945169 OBDepict H 3 C N O CH 3 H 3 C O N N N F H H 3 C N H O NH O N CH 3 IC50 = 174.0 nM 563.63 CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccnc(C)c4)c(F)c3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3922023 OBDepict CH N O N N N Cl N N H 2 N HO IC50 = 199.0 nM 533.98 C#Cc1cccc2nc(Cn3nc(-c4cccc(O)c4)c4c(N)ncnc43)n(Cc3ccccc3Cl)c(=O)c12 Homo sapiens CHEMBL3888355 single protein format
CHEMBL3982586 OBDepict CH 3 N O H 3 C CH 3 O N N N H CH 3 N H O HN O F IC50 = 213.0 nM 548.62 CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3972628 OBDepict H 3 C N O CH 3 H 3 C O N N N F H H 3 C N H O NH O N H 3 C IC50 = 321.0 nM 563.63 CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccc(C)nc4)c(F)c3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3947476 OBDepict H 3 C N O CH 3 H 3 C O N N N H H 3 C N H O NH O N IC50 = 372.0 nM 531.62 CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccccn4)cc3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3894827 OBDepict CH 3 N O H 3 C CH 3 O N N N H CH 3 N H O HN O O F F IC50 = 468.0 nM 596.63 CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4cccc(OC(F)F)c4)cc3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3943611 OBDepict O N H N H N N N N O O N CH 3 H 3 C CH 3 O IC50 = 472.0 nM 529.6 CN1CC(C)(C)Oc2nc(N3CC4CCC(C3)O4)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3908330 OBDepict CH 3 N O H 3 C CH 3 O N N N F H CH 3 N H O HN O CH 3 IC50 = 547.0 nM 486.55 CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)NC)c(F)c3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3892705 OBDepict H 3 C N O CH 3 H 3 C O N N N F H H 3 C HN O N H O N O IC50 = 561.0 nM 539.57 CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccon4)c(F)c3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3975008 OBDepict H 3 C N O CH 3 H 3 C O N N N H H 3 C N H O NH O F F IC50 = 570.0 nM 566.61 CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccc(F)cc4F)cc3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3903818 OBDepict CH 3 N O H 3 C CH 3 O N N N F H CH 3 N H O HN O N O CH 3 IC50 = 598.0 nM 579.63 CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccc(OC)nc4)c(F)c3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3958463 OBDepict H 3 C O N O H 3 C CH 3 O N N N H CH 3 NH O N H O N O IC50 = 604.0 nM 551.6 COCCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccon4)cc3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3902079 OBDepict CH 3 N O CH 3 CH 3 O N N N F H H 3 C N H O NH O N IC50 = 640.0 nM 549.61 CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4ccncc4)cc3F)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3957262 OBDepict H 3 C O N O H 3 C CH 3 O N N N H CH 3 NH O N H O N N CH 3 IC50 = 813.0 nM 564.65 COCCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4cnn(C)c4)cc3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3913302 OBDepict H 3 C N O CH 3 H 3 C O N N N F H H 3 C HN O N H O N O N H 3 C IC50 = 824.0 nM 554.58 CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4nnc(C)o4)c(F)c3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3965674 OBDepict CH 3 N O H 3 C CH 3 O N N N H CH 3 N H O HN O F O CH 3 IC50 = 991.0 nM 578.65 CCN1CC(C)(C)Oc2nc(N3CCOC[C@@H]3C)nc(-c3ccc(NC(=O)Nc4cc(OC)ccc4F)cc3)c2C1=O Homo sapiens CHEMBL3887224 single protein format
CHEMBL3652555 OBDepict CH 3 N O N N N N HN Cl S O O F F IC50 < 1000.0 nM 546.99 CN1CCC(Oc2ncnc3ccc(-c4cnc(Cl)c(NS(=O)(=O)c5ccc(F)cc5F)c4)nc23)CC1 Homo sapiens CHEMBL3705570 single protein format
CHEMBL3652554 OBDepict F F S HN O O Cl N N N N O O IC50 < 1000.0 nM 533.94 O=S(=O)(Nc1cc(-c2ccc3ncnc(OC4CCOCC4)c3n2)cnc1Cl)c1ccc(F)cc1F Homo sapiens CHEMBL3705570 single protein format