molecule_chembl_id |
structure |
assay_type |
relation |
values |
units |
mol_wt |
smiles |
organism |
assay_chembl_id |
bao_label |
CHEMBL4552275 |
|
Ki |
= |
0.0835 |
nM |
573.47 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Br)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4450864 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
Br
|
Ki |
= |
0.137 |
nM |
573.47 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5Br)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4464522 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
Br
|
Ki |
= |
0.148 |
nM |
587.5 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Br)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4540206 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
Br
|
Ki |
= |
0.153 |
nM |
587.5 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Br)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL486478 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
F
F
F
|
Ki |
= |
0.157 |
nM |
562.57 |
CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C(F)(F)F)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL3121728 |
OBDepict
Cl
N
N
O
N
N
H
N
CH
3
O
N
O
CH
3
|
Ki |
= |
0.17 |
nM |
523.04 |
Cn1c(=O)c2[nH]c(-c3ccc(OCCCN4CCN(Cc5ccccc5Cl)CC4)cc3)nc2n(C)c1=O |
Homo sapiens |
CHEMBL3123572 |
cell-based format |
CHEMBL483261 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
Cl
|
Ki |
= |
0.215 |
nM |
529.02 |
CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL4463929 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
O
Cl
CH
3
|
Ki |
= |
0.215 |
nM |
559.05 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)c(OC)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4466625 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
Br
|
Ki |
= |
0.234 |
nM |
573.47 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5cccc(Br)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4567785 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
N
+
N
_
N
|
Ki |
= |
0.244 |
nM |
549.62 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(N=[N+]=[N-])cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL519390 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
F
F
F
|
Ki |
= |
0.281 |
nM |
562.57 |
CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C(F)(F)F)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL486479 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
F
F
F
|
Ki |
= |
0.303 |
nM |
576.6 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C(F)(F)F)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL4460114 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
Cl
|
Ki |
= |
0.342 |
nM |
529.02 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4530074 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
Cl
O
H
3
C
|
Ki |
= |
0.352 |
nM |
559.05 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)c(Cl)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL482436 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
Cl
|
Ki |
= |
0.393 |
nM |
543.05 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL4440526 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
CH
3
|
Ki |
= |
0.397 |
nM |
522.63 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4441276 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
Cl
|
Ki |
= |
0.403 |
nM |
529.02 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5Cl)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL483487 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
Cl
|
Ki |
= |
0.406 |
nM |
515.0 |
CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL485862 |
OBDepict
CH
3
HN
O
N
H
N
N
N
H
N
O
N
|
Ki |
= |
0.41 |
nM |
525.66 |
CC(=O)NCCNc1nc(-c2ccccc2)nc2[nH]c(C(=O)N3CCN(CCCc4ccccc4)CC3)cc12 |
Homo sapiens |
CHEMBL947856 |
single protein format |
CHEMBL4454417 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
OH
Cl
|
Ki |
= |
0.421 |
nM |
545.02 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)c(O)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4443090 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
CH
3
|
Ki |
= |
0.432 |
nM |
508.6 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5C)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL484900 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
F
|
Ki |
= |
0.446 |
nM |
526.59 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL519253 |
OBDepict
CH
N
O
O
N
N
H
H
N
S
N
O
O
N
Cl
|
Ki |
= |
0.473 |
nM |
524.99 |
C#CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL3786849 |
OBDepict
CH
3
N
H
O
HN
N
N
N
N
H
N
O
N
|
Ki |
= |
0.5 |
nM |
526.65 |
CC(=O)NCCNc1nc(-c2ccccc2)nc2nc(C(=O)N3CCN(CCCc4ccccc4)CC3)[nH]c12 |
Homo sapiens |
CHEMBL3791363 |
cell-based format |
CHEMBL483688 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
Cl
|
Ki |
= |
0.553 |
nM |
529.02 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL520830 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
F
|
Ki |
= |
0.595 |
nM |
526.59 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL1672631 |
OBDepict
O
N
H
N
N
F
F
N
|
Ki |
= |
0.6 |
nM |
352.34 |
O=C(Nc1cnc(-c2ccncc2F)c(-c2ccccc2F)n1)C1CC1 |
Homo sapiens |
CHEMBL1679071 |
cell-based format |
CHEMBL482638 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
Cl
|
Ki |
= |
0.61 |
nM |
529.02 |
CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL4456096 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
O
CH
3
|
Ki |
= |
0.616 |
nM |
524.6 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5cccc(OC)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4464175 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
O
F
H
3
C
|
Ki |
= |
0.629 |
nM |
556.62 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)c(OC)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4466765 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
F
|
Ki |
= |
0.632 |
nM |
512.57 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5cccc(F)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4572369 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
|
Ki |
= |
0.643 |
nM |
494.58 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccccc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4471205 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
F
|
Ki |
= |
0.644 |
nM |
512.57 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(F)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL484899 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
F
|
Ki |
= |
0.695 |
nM |
512.57 |
CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(F)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL4464738 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
CH
3
|
Ki |
= |
0.706 |
nM |
508.6 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(C)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL483688 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
Cl
|
IC50 |
= |
0.739 |
nM |
529.02 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4189485 |
cell-based format |
CHEMBL486688 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
F
F
F
|
Ki |
= |
0.775 |
nM |
576.6 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(C(F)(F)F)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL483469 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
Cl
|
Ki |
= |
0.782 |
nM |
543.05 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(Cl)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL513681 |
OBDepict
O
N
H
O
S
N
H
N
CH
3
O
N
O
CH
3
|
Ki |
= |
0.8 |
nM |
410.46 |
Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccsc4)cc3)cc2n(C)c1=O |
Homo sapiens |
CHEMBL976198 |
cell-based format |
CHEMBL518972 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
H
3
C
|
Ki |
= |
0.858 |
nM |
522.63 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL483065 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
O
O
|
Ki |
= |
0.875 |
nM |
538.59 |
CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL4453324 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
F
O
H
3
C
|
Ki |
= |
0.894 |
nM |
556.62 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)c(F)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4068507 |
OBDepict
H
3
C
N
N
O
N
N
H
O
H
3
C
N
N
N
O
N
F
F
F
|
Ki |
= |
0.9 |
nM |
572.59 |
CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5ccc(C(F)(F)F)cc5)CC4)c3)nc2n(CCC)c1=O |
Homo sapiens |
CHEMBL3995074 |
cell-based format |
CHEMBL482855 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
O
H
3
C
|
Ki |
= |
0.944 |
nM |
538.63 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL437309 |
OBDepict
Br
N
N
S
O
O
N
H
N
CH
3
O
N
O
CH
3
|
IC50 |
= |
1.0 |
nM |
572.49 |
Cn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Br)cc5)CC4)cc3)cc2n(C)c1=O |
Homo sapiens |
CHEMBL864807 |
cell-based format |
CHEMBL1081812 |
OBDepict
O
N
H
N
O
N
|
Ki |
= |
1.0 |
nM |
305.34 |
O=C(Nc1ccc(-c2ccncc2)c(-c2ccco2)n1)C1CC1 |
Homo sapiens |
CHEMBL1102041 |
cell-based format |
CHEMBL456125 |
OBDepict
H
3
C
N
O
N
HO
N
H
O
H
3
C
O
N
H
O
Br
|
Ki |
= |
1.0 |
nM |
555.43 |
CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)c(O)c2n(CCC)c1=O |
Homo sapiens |
CHEMBL1036747 |
cell-based format |
CHEMBL1079804 |
OBDepict
O
N
H
N
O
F
N
|
Ki |
= |
1.0 |
nM |
323.33 |
O=C(Nc1ccc(-c2ccncc2F)c(-c2ccco2)n1)C1CC1 |
Homo sapiens |
CHEMBL1102041 |
cell-based format |
CHEMBL1080513 |
OBDepict
O
N
N
H
H
O
N
O
N
N
|
Ki |
= |
1.0 |
nM |
307.27 |
O=c1[nH]c(=O)c2cc(-c3ccncn3)c(-c3ccco3)nc2[nH]1 |
Homo sapiens |
CHEMBL1100686 |
cell-based format |
CHEMBL3121726 |
OBDepict
H
N
N
N
O
N
H
3
C
CH
3
O
O
|
Ki |
= |
1.0 |
nM |
340.38 |
Cn1c(=O)c2[nH]c(-c3ccc(OC4CCCC4)cc3)nc2n(C)c1=O |
Homo sapiens |
CHEMBL3123572 |
cell-based format |
CHEMBL4095766 |
OBDepict
CH
3
N
N
O
N
N
H
O
H
3
C
O
N
O
F
F
F
|
Ki |
= |
1.0 |
nM |
569.58 |
CCCn1c(=O)c2[nH]c(-c3ccc(OCC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)cc3)nc2n(CCC)c1=O |
Homo sapiens |
CHEMBL3995074 |
cell-based format |
CHEMBL1672623 |
OBDepict
O
N
H
N
N
F
N
|
Ki |
= |
1.0 |
nM |
334.35 |
O=C(Nc1cnc(-c2ccncc2)c(-c2ccccc2F)n1)C1CC1 |
Homo sapiens |
CHEMBL1679071 |
cell-based format |
CHEMBL4083317 |
OBDepict
CH
3
N
N
O
N
N
H
O
H
3
C
N
N
N
O
F
F
F
|
Ki |
= |
1.0 |
nM |
543.55 |
CCCn1c(=O)c2[nH]c(-c3cnn(CC4CC(=O)N(c5ccc(C(F)(F)F)cc5)C4)c3)nc2n(CCC)c1=O |
Homo sapiens |
CHEMBL3995074 |
cell-based format |
CHEMBL208824 |
OBDepict
H
N
N
N
CH
3
N
N
O
N
O
H
3
C
F
F
F
|
Ki |
= |
1.0 |
nM |
404.35 |
Cn1c(=O)c2nc(-c3cnn(Cc4cccc(C(F)(F)F)c4)c3)[nH]c2n(C)c1=O |
Homo sapiens |
CHEMBL870844 |
cell-based format |
CHEMBL200779 |
OBDepict
CH
3
N
N
O
N
H
N
O
CH
3
N
N
O
N
N
|
Ki |
= |
1.0 |
nM |
460.5 |
CCCn1c(=O)c2nc(-c3cnn(Cc4nc(-c5ccccc5)no4)c3)[nH]c2n(CCC)c1=O |
Homo sapiens |
CHEMBL871361 |
cell-based format |
CHEMBL4467573 |
OBDepict
CH
3
N
O
N
O
H
N
N
H
S
N
O
O
N
F
O
H
3
C
|
Ki |
= |
1.02 |
nM |
556.62 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cc(F)cc(OC)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL3121727 |
OBDepict
H
N
N
N
O
N
CH
3
CH
3
O
O
N
N
|
Ki |
= |
1.05 |
nM |
380.41 |
Cn1c(=O)c2[nH]c(-c3ccc(OCCCn4ccnc4)cc3)nc2n(C)c1=O |
Homo sapiens |
CHEMBL3123572 |
cell-based format |
CHEMBL4215606 |
OBDepict
CH
3
N
O
N
O
N
N
S
N
O
O
N
Cl
|
IC50 |
= |
1.06 |
nM |
541.03 |
CCCN1C(=O)N=C2N=C(c3ccc(S(=O)(=O)N4CCN(Cc5ccc(Cl)cc5)CC4)cc3)N=C2C1=O |
Homo sapiens |
CHEMBL4189485 |
cell-based format |
CHEMBL486893 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
O
O
|
Ki |
= |
1.06 |
nM |
552.61 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc6c(c5)OCO6)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL519813 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
|
Ki |
= |
1.15 |
nM |
494.58 |
CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccccc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL482648 |
OBDepict
H
3
C
O
N
N
S
O
O
N
N
H
N
H
O
N
O
CH
3
|
Ki |
= |
1.19 |
nM |
524.6 |
CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL416417 |
OBDepict
CH
3
N
O
O
N
N
H
N
H
O
N
H
O
HO
|
Ki |
= |
1.2 |
nM |
387.4 |
CCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)NCCO)cc3)nc2c1=O |
Homo sapiens |
CHEMBL642011 |
single protein format |
CHEMBL37726 |
OBDepict
CH
3
N
O
O
N
N
H
N
H
O
N
O
N
O
CH
3
|
Ki |
= |
1.2 |
nM |
532.6 |
CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccccc5OC)CC4)cc3)nc2c1=O |
Homo sapiens |
CHEMBL642011 |
single protein format |
CHEMBL490262 |
OBDepict
H
3
C
N
O
O
N
N
CH
3
H
O
N
H
O
HO
|
Ki |
= |
1.2 |
nM |
400.44 |
CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)NCCO)cc3)cc2n(C)c1=O |
Homo sapiens |
CHEMBL947856 |
single protein format |
CHEMBL4092455 |
OBDepict
CH
3
N
N
O
N
N
H
O
H
3
C
N
N
HO
N
O
F
F
F
|
Ki |
= |
1.2 |
nM |
573.58 |
CCCn1c(=O)c2[nH]c(-c3cnn(CC(O)C4CC(=O)N(c5cccc(C(F)(F)F)c5)C4)c3)nc2n(CCC)c1=O |
Homo sapiens |
CHEMBL3995074 |
cell-based format |
CHEMBL4556744 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
F
O
H
3
C
|
Ki |
= |
1.24 |
nM |
542.59 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)c(F)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL520297 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
F
|
Ki |
= |
1.27 |
nM |
512.57 |
CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(F)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL4437222 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
O
H
3
C
|
Ki |
= |
1.28 |
nM |
538.63 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5cccc(OC)c5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4087158 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
N
N
F
F
F
|
Ki |
= |
1.3 |
nM |
442.4 |
CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4ccc(C(F)(F)F)cc4)c3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4021342 |
cell-based format |
CHEMBL38304 |
OBDepict
CH
3
N
O
O
N
N
H
N
H
O
N
O
N
|
Ki |
= |
1.3 |
nM |
516.6 |
CCCCn1c(=O)[nH]c2[nH]c(-c3ccc(OCC(=O)N4CCN(Cc5ccccc5)CC4)cc3)nc2c1=O |
Homo sapiens |
CHEMBL642011 |
single protein format |
CHEMBL3121723 |
OBDepict
H
N
N
N
O
N
H
3
C
CH
3
O
O
N
O
|
Ki |
= |
1.34 |
nM |
385.42 |
Cn1c(=O)c2[nH]c(-c3ccc(OCCN4CCOCC4)cc3)nc2n(C)c1=O |
Homo sapiens |
CHEMBL3123572 |
cell-based format |
CHEMBL592891 |
OBDepict
CH
3
N
O
N
N
N
O
CH
3
CH
3
O
NH
O
O
H
3
C
|
Ki |
= |
1.39 |
nM |
517.59 |
CCCn1c(=O)c2c(nc(-c3ccc(OCC(=O)Nc4ccc(C(C)=O)cc4)cc3)n2C)n(CCC)c1=O |
Homo sapiens |
CHEMBL1066997 |
single protein format |
CHEMBL4088514 |
OBDepict
CH
3
N
N
O
N
N
H
O
H
3
C
N
N
F
F
F
|
Ki |
= |
1.5 |
nM |
484.48 |
CCCn1c(=O)c2[nH]c(-c3cnn(CC#Cc4ccc(C(F)(F)F)cc4)c3)nc2n(CCC)c1=O |
Homo sapiens |
CHEMBL4021342 |
cell-based format |
CHEMBL260051 |
OBDepict
H
3
C
N
O
N
N
H
O
H
3
C
O
N
O
N
Cl
|
Ki |
= |
1.5 |
nM |
564.09 |
CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5cccc(Cl)c5)CC4)cc3)cc2n(CCC)c1=O |
Homo sapiens |
CHEMBL939997 |
cell-based format |
CHEMBL4095843 |
OBDepict
H
3
C
N
N
O
N
N
H
O
H
3
C
N
N
N
O
N
F
F
F
|
Ki |
= |
1.5 |
nM |
572.59 |
CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5cccc(C(F)(F)F)c5)CC4)c3)nc2n(CCC)c1=O |
Homo sapiens |
CHEMBL3995074 |
cell-based format |
CHEMBL520617 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
H
3
C
|
Ki |
= |
1.58 |
nM |
508.6 |
CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(Cc5ccc(C)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL4079273 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
N
N
F
|
Ki |
= |
1.6 |
nM |
392.39 |
CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4ccc(F)cc4)c3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4021342 |
cell-based format |
CHEMBL4059779 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
N
N
O
F
F
F
|
Ki |
= |
1.6 |
nM |
458.4 |
CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4ccc(OC(F)(F)F)cc4)c3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4021342 |
cell-based format |
CHEMBL4473749 |
OBDepict
CH
3
N
O
N
O
H
N
N
H
S
N
O
O
H
3
C
|
Ki |
= |
1.69 |
nM |
467.55 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N(C)CCc4ccccc4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL466035 |
OBDepict
CH
3
N
O
N
N
H
O
H
3
C
O
N
H
O
N
O
|
Ki |
= |
1.7 |
nM |
451.48 |
CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccon4)cc3)cc2n(CCC)c1=O |
Homo sapiens |
CHEMBL976198 |
cell-based format |
CHEMBL4080171 |
OBDepict
H
3
C
N
N
O
N
N
H
O
H
3
C
N
N
N
O
N
Cl
F
|
Ki |
= |
1.8 |
nM |
557.03 |
CCCn1c(=O)c2[nH]c(-c3cnn(CC(=O)N4CCN(c5ccc(F)c(Cl)c5)CC4)c3)nc2n(CCC)c1=O |
Homo sapiens |
CHEMBL3995074 |
cell-based format |
CHEMBL4537196 |
OBDepict
CH
3
N
O
O
N
N
H
3
C
H
N
S
N
O
O
N
Cl
|
Ki |
= |
1.91 |
nM |
543.05 |
CCCn1c(=O)c2[nH]c(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5)CC4)cc3)nc2n(C)c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL4461478 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
F
Cl
|
Ki |
= |
1.91 |
nM |
547.01 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(Cl)cc5F)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4346832 |
cell-based format |
CHEMBL273807 |
OBDepict
H
3
C
N
N
O
N
N
H
O
H
3
C
O
N
H
O
N
|
Ki |
= |
1.97 |
nM |
486.53 |
CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)nc2n(CCC)c1=O |
Homo sapiens |
CHEMBL645971 |
single protein format |
CHEMBL3121724 |
OBDepict
H
N
N
N
O
N
H
3
C
CH
3
O
O
N
|
Ki |
= |
1.97 |
nM |
369.43 |
Cn1c(=O)c2[nH]c(-c3ccc(OCCN4CCCC4)cc3)nc2n(C)c1=O |
Homo sapiens |
CHEMBL3123572 |
cell-based format |
CHEMBL486481 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
S
N
O
O
N
O
H
3
C
|
Ki |
= |
1.99 |
nM |
524.6 |
CCCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O |
Homo sapiens |
CHEMBL948832 |
cell-based format |
CHEMBL512276 |
OBDepict
H
3
C
N
O
N
N
H
O
H
3
C
O
N
H
O
F
|
Ki |
= |
2.0 |
nM |
478.52 |
CCCn1c(=O)c2[nH]c(-c3ccc(COC(=O)Nc4ccc(F)cc4)cc3)cc2n(CCC)c1=O |
Homo sapiens |
CHEMBL976198 |
cell-based format |
CHEMBL1082028 |
OBDepict
O
N
H
N
F
N
|
Ki |
= |
2.0 |
nM |
333.37 |
O=C(Nc1ccc(-c2ccncc2)c(-c2ccccc2F)n1)C1CC1 |
Homo sapiens |
CHEMBL1102041 |
cell-based format |
CHEMBL412112 |
OBDepict
H
3
C
N
O
N
N
CH
3
H
O
O
N
O
N
F
F
F
|
Ki |
= |
2.0 |
nM |
569.58 |
CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCN(c5ccc(C(F)(F)F)cc5)CC4)cc3)cc21 |
Homo sapiens |
CHEMBL939997 |
cell-based format |
CHEMBL1672633 |
OBDepict
O
N
H
N
N
O
N
F
N
|
Ki |
= |
2.0 |
nM |
325.3 |
O=C(Nc1cnc(-c2ccncc2F)c(-c2cnco2)n1)C1CC1 |
Homo sapiens |
CHEMBL1679071 |
cell-based format |
CHEMBL408266 |
OBDepict
CH
3
N
O
O
N
N
CH
3
H
N
N
N
|
Ki |
= |
2.0 |
nM |
350.38 |
CCn1c(=O)c2[nH]c(-c3cnn(Cc4ccccc4)c3)nc2n(C)c1=O |
Homo sapiens |
CHEMBL933586 |
cell-based format |
CHEMBL260692 |
OBDepict
CH
3
N
N
O
O
H
3
C
N
H
N
CH
3
O
N
O
H
3
C
|
Ki |
= |
2.0 |
nM |
501.59 |
Cc1ccc(N2CCN(C(=O)C(C)Oc3ccc(-c4cc5c([nH]4)c(=O)n(C)c(=O)n5C)cc3)CC2)cc1 |
Homo sapiens |
CHEMBL939997 |
cell-based format |
CHEMBL1076587 |
OBDepict
O
N
H
N
F
N
|
Ki |
= |
2.0 |
nM |
333.37 |
O=C(Nc1ccc(-c2ccncc2)c(-c2cccc(F)c2)n1)C1CC1 |
Homo sapiens |
CHEMBL1102041 |
cell-based format |
CHEMBL469136 |
OBDepict
O
N
O
N
H
N
CH
3
O
N
O
H
3
C
|
Ki |
= |
2.1 |
nM |
444.49 |
Cn1c(=O)c2[nH]c(-c3ccc(COC(=O)N4CCc5ccccc5C4)cc3)cc2n(C)c1=O |
Homo sapiens |
CHEMBL976198 |
cell-based format |
CHEMBL1672611 |
OBDepict
O
N
H
N
N
O
N
|
Ki |
= |
2.2 |
nM |
306.33 |
O=C(Nc1cnc(-c2ccncc2)c(-c2ccco2)n1)C1CC1 |
Homo sapiens |
CHEMBL1679071 |
cell-based format |
CHEMBL201145 |
OBDepict
H
3
C
N
O
N
N
H
O
H
3
C
O
N
H
O
Br
|
Ki |
= |
2.2 |
nM |
539.43 |
CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(Br)cc4)cc3)cc2n(CCC)c1=O |
Homo sapiens |
CHEMBL1036747 |
cell-based format |
CHEMBL4105001 |
OBDepict
CH
3
N
O
O
N
N
H
H
N
N
N
F
F
F
|
Ki |
= |
2.2 |
nM |
442.4 |
CCCn1c(=O)[nH]c2nc(-c3cnn(CC#Cc4cccc(C(F)(F)F)c4)c3)[nH]c2c1=O |
Homo sapiens |
CHEMBL4021342 |
cell-based format |
CHEMBL1672619 |
OBDepict
O
N
H
N
N
O
H
3
C
N
|
Ki |
= |
2.2 |
nM |
320.35 |
Cc1ccc(-c2nc(NC(=O)C3CC3)cnc2-c2ccncc2)o1 |
Homo sapiens |
CHEMBL1679071 |
cell-based format |
CHEMBL4569909 |
OBDepict
CH
3
O
N
S
O
N
H
3
C
O
N
H
3
C
N
H
|
IC50 |
= |
2.4 |
nM |
438.55 |
COCCn1c(=O)n(CCc2ccccc2)c(=O)c2c(C)c(Cc3nc[nH]c3C)sc21 |
Homo sapiens |
CHEMBL4422945 |
cell-based format |
CHEMBL259857 |
OBDepict
CH
3
N
O
N
N
H
3
C
H
O
O
N
O
|
Ki |
= |
2.5 |
nM |
500.6 |
CCCn1c(=O)n(C)c(=O)c2[nH]c(-c3ccc(OCC(=O)N4CCC(c5ccccc5)CC4)cc3)cc21 |
Homo sapiens |
CHEMBL939997 |
cell-based format |