P29322 | EPHA8_HUMAN | Ephrin type-A receptor 8 (EPHA8)
3D structures mapped by conservation among orthologs
[ Domain: "SAM domain-like" // SAM_1 ]
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[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // fn3 ]
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[ Domain: "Protein kinase" // Pkinase_Tyr ]
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[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
IC50 table
| molecule_chembl_id | structure | assay_type | relation | values | units | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4568087 | IC50 | = | 2.9 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479717 | assay format | |
| CHEMBL566515 | IC50 | = | 4.5 | nM | 417.43 | COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 | Homo sapiens | CHEMBL1046776 | single protein format | |
| CHEMBL4569508 | IC50 | = | 21.0 | nM | 529.59 | O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 | Homo sapiens | CHEMBL4479717 | assay format | |
| CHEMBL4550702 | IC50 | = | 29.0 | nM | 406.39 | Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479717 | assay format | |
| CHEMBL388978 | IC50 | = | 137.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328403 | single protein format | |
| CHEMBL4281823 | IC50 | = | 233.0 | nM | 481.48 | CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL4261409 | single protein format | |
| CHEMBL1916891 | IC50 | = | 434.0 | nM | 432.5 | Cc1ccccc1Nc1nc2cc(F)c(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 | Homo sapiens | CHEMBL1919258 | single protein format | |
| CHEMBL103667 | IC50 | < | 1000.0 | nM | 527.67 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Homo sapiens | CHEMBL4602918 | single protein format |