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P29323 | EPHB2_HUMAN | Ephrin type-B receptor 2 (EPHB2)

3D structures mapped by conservation among orthologs

[ Domain: "Galactose-binding domain-like" // Ephrin_lbd ]

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[ Domain: "SAM domain-like" // SAM_1 ]

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[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4859660 OBDepict NH 2 N F + N O NH O _ O IC50 = -25000.0 nM 378.36 Nc1ncc(-c2cccc([N+](=O)[O-])c2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804376 cell-based format
CHEMBL4860979 OBDepict F S N O O CH 3 N H 2 N O N H IC50 = -2000.0 nM 466.54 CN(C1CC1)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3ccc4c(c3)CCNC4=O)c2)c(F)c1 Homo sapiens CHEMBL4804376 cell-based format
CHEMBL566515 OBDepict H 3 C O N N N H 3 C N OH H 3 C O N O H IC50 = 1.2 nM 417.43 COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 Homo sapiens CHEMBL1046778 single protein format
CHEMBL4568087 OBDepict H 3 C N N N N N S N H O H H H 2 N IC50 = 2.9 nM 421.53 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479718 assay format
CHEMBL1421 OBDepict HO N N N N N H CH 3 N S N H O H 3 C Cl IC50 = 4.4 nM 488.02 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL1244584 single protein format
CHEMBL288441 OBDepict CH 3 O O N N H N N Cl O H 3 C Cl N CH 3 IC50 = 8.5 nM 530.46 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl Homo sapiens CHEMBL1244584 single protein format
CHEMBL4569508 OBDepict O N H S F F F N N N O N IC50 < 10.0 nM 529.59 O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 Homo sapiens CHEMBL4479718 assay format
CHEMBL1289494 OBDepict CH 3 O O H 3 C O N Cl N H NH O N O H 3 C IC50 = 17.5 nM 454.87 COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC Homo sapiens CHEMBL3429407 single protein format
CHEMBL3426225 OBDepict H 3 C N N N N NH 2 CH 3 N H O F F F N N CH 3 IC50 = 26.0 nM 576.63 CCn1nc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc2C)c2c(N)ncnc21 Homo sapiens CHEMBL3429877 single protein format
CHEMBL3426917 OBDepict O N H N H N Cl O H 3 C O N O O D D D D D D IC50 = 26.8 nM 460.91 [2H]C([2H])([2H])Oc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC([2H])([2H])[2H] Homo sapiens CHEMBL3429407 single protein format
CHEMBL4550702 OBDepict CH 3 N N N N N S NH O F F F IC50 = 36.0 nM 406.39 Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479718 assay format
CHEMBL445162 OBDepict Cl N H O O N N N H S O O CH 3 IC50 = 50.0 nM 418.86 CS(=O)(=O)c1cccc(Nc2nccc(Nc3c(Cl)ccc4c3OCO4)n2)c1 Homo sapiens CHEMBL932337 single protein format
CHEMBL4638981 OBDepict O N H H 3 C Cl N N N N N H N IC50 = 70.8 nM 507.99 Cc1ccc(C(=O)Nc2ccc(CN3Cc4cn[nH]c4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 Homo sapiens CHEMBL4605665 single protein format
CHEMBL1271376 OBDepict O NH N H N N Cl Cl H 3 C H 3 C CH 3 O NH 2 IC50 = 82.0 nM 460.37 CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)n(-c2cccc(CC(N)=O)c2)n1 Homo sapiens CHEMBL1274779 single protein format
CHEMBL4640297 OBDepict O N H CH 3 Cl N N N N HN N IC50 = 93.2 nM 524.03 Cc1ccc(C(=O)Nc2ccc(CN3CCC4C=NNC4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 Homo sapiens CHEMBL4605665 single protein format
CHEMBL103667 OBDepict O HN N H N N CH 3 CH 3 CH 3 O H 3 C N O IC50 = 160.0 nM 527.67 Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 Homo sapiens CHEMBL1932848 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 198.8 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL3820484 single protein format
CHEMBL3596879 OBDepict O N H HN N O O CH 3 CH 3 H 3 C N N N N CH 3 IC50 = 880.0 nM 433.47 Cn1cc(-c2cncc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C)on4)c3)n2)cn1 Homo sapiens CHEMBL3598607 single protein format