P29350 | PTN6_HUMAN | Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)
3D structures mapped by conservation among orthologs
[ Domain: "(Phosphotyrosine protein) phosphatases II" // Y_phosphatase ]
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[ Domain: "SH2" // SH2 ]
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[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
IC50 table
| molecule_chembl_id | structure | assay_type | relation | values | units | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4750435 | IC50 | = | 130.0 | nM | 488.5 | COc1ccc(-n2cc(-c3ccc4ccc(=O)oc4c3)c3cc(-c4ccc(C(=O)O)cc4)cnc32)cc1 | Homo sapiens | CHEMBL4712043 | single protein format | |
| CHEMBL1650889 | IC50 | = | 335.0 | nM | 562.58 | COc1ccc(-c2oc3cc(O)c(C(=O)O)cc3c2-c2cn(CCCC(=O)Nc3cccc4ccccc34)nn2)cc1 | Homo sapiens | CHEMBL1664680 | single protein format | |
| CHEMBL472004 | IC50 | = | 355.0 | nM | 459.46 | O=S(=O)(O)c1ccc2cc(/N=N/c3cc(S(=O)(=O)O)c4cccnc4c3O)ccc2c1 | Homo sapiens | CHEMBL3707579 | single protein format | |
| CHEMBL1650891 | IC50 | = | 378.0 | nM | 581.03 | Cc1ccc(-c2oc3cc(O)c(C(=O)O)cc3c2-c2cn(CCCC(=O)Nc3ccc(Cl)c4ccccc34)nn2)cc1 | Homo sapiens | CHEMBL1664680 | single protein format | |
| CHEMBL1650892 | IC50 | = | 408.0 | nM | 546.58 | Cc1ccc(-c2oc3cc(O)c(C(=O)O)cc3c2-c2cn(CCCC(=O)Nc3cccc4ccccc34)nn2)cc1 | Homo sapiens | CHEMBL1664680 | single protein format | |
| CHEMBL1650893 | IC50 | = | 486.0 | nM | 583.63 | COc1ccc2nc(NC(=O)CCCn3cc(-c4c(-c5cccc(C)c5)oc5cc(O)c(C(=O)O)cc45)nn3)sc2c1 | Homo sapiens | CHEMBL1664680 | single protein format | |
| CHEMBL2316908 | IC50 | = | 760.0 | nM | 446.46 | O=C(O)c1cc2c(C#Cc3ccc(Oc4ccccc4)cc3)c(-c3ccccc3)oc2cc1O | Homo sapiens | CHEMBL2317718 | assay format | |
| CHEMBL2396718 | IC50 | = | 910.0 | nM | 503.94 | CCCNC(=O)COc1ccc(-c2oc3cc(O)c(C(=O)O)cc3c2C#Cc2cccc(Cl)c2)cc1 | Homo sapiens | CHEMBL2401201 | single protein format |