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P30530 | UFO_HUMAN | Tyrosine-protein kinase receptor UFO (AXL)

3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_4 ]

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[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_5 ]

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[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4858468 OBDepict F N O N H O O N CH 3 H 2 N N N IC50 = 0.1 nM 552.61 Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4871361 OBDepict F N O H 3 C CH 3 N H O F F N H NH 2 N N IC50 < 0.2 nM 518.5 CC(C)n1cc(C(=O)Nc2cc(F)c(-c3c[nH]c4ncnc(N)c34)cc2F)c(=O)c(-c2ccc(F)cc2)c1 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4855261 OBDepict Cl N O N H O O N CH 3 H 2 N N N IC50 = 0.2 nM 569.07 Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(Cl)cc4)c3=O)cc2)c2c(N)ncnc21 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4860162 OBDepict F N O N H O O N H H 2 N N N IC50 = 0.2 nM 538.58 Nc1ncnc2[nH]cc(-c3ccc(NC(=O)c4cn(CC5CCOCC5)cc(-c5ccc(F)cc5)c4=O)cc3)c12 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4877502 OBDepict F N O N H O O F N CH 3 H 2 N N N IC50 = 0.2 nM 570.6 Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)c(F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4869472 OBDepict F N O N H O O F F N H H 2 N N N IC50 = 0.4 nM 574.56 Nc1ncnc2[nH]cc(-c3cc(F)c(NC(=O)c4cn(CC5CCOCC5)cc(-c5ccc(F)cc5)c4=O)cc3F)c12 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4875762 OBDepict F N O H 3 C CH 3 N H O N H 3 C NH 2 N N IC50 = 0.4 nM 496.55 CC(C)n1cc(C(=O)Nc2ccc(-c3cn(C)c4ncnc(N)c34)cc2)c(=O)c(-c2ccc(F)cc2)c1 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4476226 OBDepict H 3 C N O N N H N N N F F F N S H 3 C O O H 3 C IC50 < 0.5 nM 589.64 CC(=O)N1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(N4Cc5cccc(N(C)S(C)(=O)=O)c5C4)n3)cc2)CC1 Homo sapiens CHEMBL4326591 cell-based format
CHEMBL4845677 OBDepict F N O N H O N O H 3 C CH 3 N H 3 C NH 2 N N IC50 = 0.5 nM 539.57 CN(C)C(=O)Cn1cc(C(=O)Nc2ccc(-c3cn(C)c4ncnc(N)c34)cc2)c(=O)c(-c2ccc(F)cc2)c1 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4873311 OBDepict F N O N H O O F F N CH 3 H 2 N N N IC50 = 0.5 nM 588.59 Cn1cc(-c2cc(F)c(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnc21 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4516515 OBDepict H 3 C N N H N N HN O H 2 N CH 3 O IC50 = 0.7 nM 506.7 CCc1nc(C(N)=O)c(Nc2ccc3c(c2)CCN(C2CCC(CC)C2)CC3)nc1NC1CCOCC1 Homo sapiens CHEMBL4424132 single protein format
CHEMBL3301622 OBDepict CH 3 O N N H N N N HN O H 2 N CH 3 N H 3 C O IC50 = 0.73 nM 552.72 CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 Homo sapiens CHEMBL4360650 assay format
CHEMBL4277499 OBDepict F N O NH O F O N N N H IC50 = 0.77 nM 459.41 O=C(Nc1ccc(Oc2ccnc3[nH]cnc23)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4264825 assay format
CHEMBL4866647 OBDepict F N O N H O O F N CH 3 H 2 N N N IC50 = 0.8 nM 570.6 Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnc21 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4851553 OBDepict F F N O N H O O N H 3 C NH 2 N N IC50 = 0.8 nM 570.6 Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4F)c3=O)cc2)c2c(N)ncnc21 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4871310 OBDepict F N O O N N H O CH 3 H 3 C F O N N N H 3 C IC50 = 0.8 nM 558.55 CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cnn(C)c4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4823577 single protein format
CHEMBL4845957 OBDepict O N H N N O NH O N O N CH 3 H 3 C O F IC50 = 0.85 nM 544.54 CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)C4CC4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4822425 single protein format
CHEMBL4873571 OBDepict O N H N O F NH O N O N CH 3 H 3 C O F IC50 = 0.9 nM 561.55 CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4823577 single protein format
CHEMBL4445940 OBDepict CH 3 N S O O H 3 C N N N N H F F F N O IC50 = 0.94 nM 548.59 CN(c1cccc2c1CN(c1nc(Nc3ccc(N4CCOCC4)cc3)ncc1C(F)(F)F)C2)S(C)(=O)=O Homo sapiens CHEMBL4326591 cell-based format
CHEMBL4871620 OBDepict O N H N O O N H 3 C NH 2 N N IC50 = 1.0 nM 534.62 Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccccc4)c3=O)cc2)c2c(N)ncnc21 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4062894 OBDepict O NH N N H S N N H N H N S O O CH 3 IC50 = 1.0 nM 515.67 CS(=O)(=O)N1CCC[C@H](c2csc(-c3cc(N4CCNCC4)ccc3NC(=O)c3ncc[nH]3)n2)C1 Homo sapiens CHEMBL4001907 single protein format
CHEMBL4855494 OBDepict F N O N H O O N CH 3 H 2 N N N IC50 = 1.1 nM 538.58 Cn1cc(-c2ccc(NC(=O)c3cn(C4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 Homo sapiens CHEMBL4838186 single protein format
CHEMBL460702 OBDepict CH 3 O N N H O O F F O Cl N NH 2 IC50 = 1.1 nM 512.9 CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 Homo sapiens CHEMBL959563 single protein format
CHEMBL4753082 OBDepict H 3 C O N N H O O F F O Cl N NH 2 IC50 = 1.1 nM 498.87 COc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 Homo sapiens CHEMBL4686591 single protein format
CHEMBL4524568 OBDepict CH 3 N HN N O NH 2 N H O N IC50 = 1.2 nM 478.64 CCc1nc(C(N)=O)c(Nc2ccc3c(c2)CCN(C2CCCC2)CC3)nc1NC1CCOCC1 Homo sapiens CHEMBL4424132 single protein format
CHEMBL4865357 OBDepict F N O N H O O N CH 3 H 2 N N N IC50 = 1.2 nM 538.58 Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCCO4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 Homo sapiens CHEMBL4838186 single protein format
CHEMBL2036807 OBDepict H N N H NH 2 N N H N N NH IC50 = 1.4 nM 524.72 N[C@H]1CC[C@H](Cn2nc(-c3ccc(N4CCNCC4)cc3)c3cnc(NCCCc4ccccc4)nc32)CC1 Homo sapiens CHEMBL2037931 single protein format
CHEMBL4576727 OBDepict CH 3 N HN N O NH 2 N H O N IC50 = 1.6 nM 478.64 CCc1nc(C(N)=O)c(Nc2ccc3c(c2)CCC(N2CCCC2)CC3)nc1NC1CCOCC1 Homo sapiens CHEMBL4424132 single protein format
CHEMBL4861161 OBDepict F N O O N N H O H 3 C CH 3 F O N HN N O IC50 = 1.7 nM 590.59 CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)N4CCCC4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4823577 single protein format
CHEMBL4090103 OBDepict CH 3 N H 3 C O HN S N O N N H H N S O O H 3 C IC50 = 1.8 nM 518.67 CN(C)CCOc1ccc(NC(=O)c2ncc[nH]2)c(-c2nc([C@H]3CCCN(S(C)(=O)=O)C3)cs2)c1 Homo sapiens CHEMBL4001907 single protein format
CHEMBL4864971 OBDepict H 3 C N N N H 2 N N H O N O O F IC50 = 1.8 nM 580.66 CCCn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4858048 OBDepict F N O O N N H O H 3 C CH 3 O N N N CH 3 IC50 = 1.9 nM 540.56 CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cnn(C)c4)c3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4823577 single protein format
CHEMBL3545307 OBDepict F N CH 3 O N H O F O N N N N H 3 C H IC50 = 2.0 nM 552.54 Cc1ccc(C(=O)Nc2ccc(Oc3cc4cnn(C)c4cc3-c3cn[nH]c3)c(F)c2)c(=O)n1-c1ccc(F)cc1 Homo sapiens CHEMBL3811325 cell-based format
CHEMBL4105249 OBDepict Cl N N N CH 3 S N NH 2 N N H O N IC50 = 2.0 nM 470.99 Cc1csc2c(-n3nc(Nc4ccc(OCCN5CCCC5)cc4)nc3N)nc(Cl)nc12 Homo sapiens CHEMBL4057778 assay format
CHEMBL4867664 OBDepict F N O O N N H O H 3 C CH 3 O N N N H N O IC50 = 2.0 nM 559.56 CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N4CCC4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4822425 single protein format
CHEMBL4849099 OBDepict F N O O N N H O H 3 C CH 3 O N N HN N O IC50 = 2.1 nM 573.58 CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N4CCCC4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4822425 single protein format
CHEMBL4094158 OBDepict O NH N N H S N N H O O N S O O CH 3 IC50 = 2.2 nM 518.62 CS(=O)(=O)N1CCO[C@H](c2csc(-c3cc(N4CCOCC4)ccc3NC(=O)c3ncc[nH]3)n2)C1 Homo sapiens CHEMBL4001907 single protein format
CHEMBL4849955 OBDepict F N O N H O N CH 3 H 2 N N N IC50 = 2.3 nM 550.64 Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCCCC4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4578043 OBDepict H 3 C N NH N O H 2 N N H O N N H IC50 = 2.5 nM 519.69 CCc1nc(C(N)=O)c(Nc2ccc3c(c2)CCC(N2CC4CNCC4C2)CC3)nc1NC1CCOCC1 Homo sapiens CHEMBL4424132 single protein format
CHEMBL4878216 OBDepict F N O O N N H O H 3 C CH 3 F O N N N O IC50 = 2.7 nM 588.57 CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CN(C(=O)C3CC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4824951 single protein format
CHEMBL4863290 OBDepict F N O O N N H O CH 3 H 3 C F F O N N N H 3 C IC50 = 2.75 nM 576.54 CC(C)n1cc(C(=O)Nc2cc(F)c(Oc3ccnc(-c4cnn(C)c4)c3)cc2F)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4823577 single protein format
CHEMBL4090562 OBDepict Cl N N N N NH 2 N N H N N IC50 = 3.0 nM 516.05 Nc1nc(Nc2ccc(N3CCN(C4CC5CCC4C5)CC3)cc2)nn1-c1ncnc2ccc(Cl)cc12 Homo sapiens CHEMBL4057778 assay format
CHEMBL2143592 OBDepict H N NH O O F F O Cl N NH 2 IC50 < 3.0 nM 468.85 Nc1nccc(Oc2ccc(NC(=O)c3c[nH]cc(-c4ccc(F)cc4)c3=O)cc2F)c1Cl Homo sapiens CHEMBL3767452 single protein format
CHEMBL4064955 OBDepict F N N N N NH 2 N N H O N IC50 = 3.0 nM 434.48 Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2ccc(F)cc12 Homo sapiens CHEMBL4057778 assay format
CHEMBL4087395 OBDepict Cl N N N N NH 2 N N H O N IC50 = 3.0 nM 450.93 Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2ccc(Cl)cc12 Homo sapiens CHEMBL4057778 assay format
CHEMBL4853092 OBDepict F N O N H O O N CH 3 H 2 N N N IC50 = 3.0 nM 552.61 Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4cccc(F)c4)c3=O)cc2)c2c(N)ncnc21 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4869458 OBDepict F N O O N N H O CH 3 H 3 C F O N N N H IC50 = 3.1 nM 544.52 CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cn[nH]c4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4823577 single protein format
CHEMBL4066616 OBDepict O NH N N H S N N H O N S O O CH 3 IC50 = 3.4 nM 516.65 CS(=O)(=O)N1CCC[C@H](c2csc(-c3cc(N4CCOCC4)ccc3NC(=O)c3ncc[nH]3)n2)C1 Homo sapiens CHEMBL4001907 single protein format
CHEMBL4864028 OBDepict HO N N H O N N O N H O N O N CH 3 H 3 C O F IC50 = 3.5 nM 575.56 CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N4CC(O)C4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4822425 single protein format
CHEMBL2036805 OBDepict H N N H NH 2 N N H N N N NH IC50 = 3.7 nM 525.71 N[C@H]1CC[C@H](Cn2nc(-c3ccc(N4CCNCC4)nc3)c3cnc(NCCCc4ccccc4)nc32)CC1 Homo sapiens CHEMBL2037931 single protein format
CHEMBL4847126 OBDepict F N O N H O O Cl N CH 3 H 2 N N N IC50 = 3.7 nM 587.06 Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)c(Cl)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4864676 OBDepict F N O O N N H O CH 3 H 3 C F F O N N N H 3 C IC50 = 3.7 nM 576.54 CC(C)n1cc(C(=O)Nc2cc(F)c(Oc3ccnc(-c4cnn(C)c4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4823577 single protein format
CHEMBL4856684 OBDepict F N O N H O O CH 3 N H 3 C NH 2 N N IC50 = 4.0 nM 566.64 Cc1cc(-c2cn(C)c3ncnc(N)c23)ccc1NC(=O)c1cn(CC2CCOCC2)cc(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4838186 single protein format
CHEMBL2036806 OBDepict H 3 C N H N N N N H N H H 2 N NH IC50 = 4.0 nM 462.65 CCCCNc1ncc2c(-c3ccc(N4CCNCC4)cc3)nn(C[C@H]3CC[C@H](N)CC3)c2n1 Homo sapiens CHEMBL2037931 single protein format
CHEMBL4571241 OBDepict CH 3 N O CH 3 H 3 C NH O F O N N O CH 3 O H 3 C IC50 = 4.0 nM 542.57 CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4cc(OC)c(OC)cc34)c(F)c1)c(C)n2C Homo sapiens CHEMBL4426892 single protein format
CHEMBL4078564 OBDepict H 2 N N N N NH N S N O N IC50 = 4.0 nM 472.58 Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2c1sc1ccccc12 Homo sapiens CHEMBL4057778 assay format
CHEMBL3964573 OBDepict CH 3 N N N N N NH H H 2 N O HN IC50 = 4.2 nM 560.79 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCCNC(=O)[C@@H](N)CCCC4)cc2)CC1 Homo sapiens CHEMBL3865273 single protein format
CHEMBL4519811 OBDepict CH 3 N NH N O NH 2 N H O N N H 3 C IC50 = 4.5 nM 507.68 CCc1nc(C(N)=O)c(Nc2ccc3c(c2)CCN(C2CCN(C)CC2)CC3)nc1NC1CCOCC1 Homo sapiens CHEMBL4424132 single protein format
CHEMBL4445646 OBDepict CH 3 N S O O CH 3 N N N NH F F F O O IC50 = 4.5 nM 507.49 CN(c1cccc2c1CN(c1nc(Nc3ccc4c(c3)OCO4)ncc1C(F)(F)F)C2)S(C)(=O)=O Homo sapiens CHEMBL4326591 cell-based format
CHEMBL4857746 OBDepict NH 2 N N N N H N N H N IC50 = 4.8 nM 506.66 Nc1nc(Nc2ccc3c(c2)CC[C@H](N2CCCC2)CC3)nn1-c1cc2c(nn1)-c1ccccc1CCC2 Homo sapiens CHEMBL4823577 single protein format
CHEMBL4846125 OBDepict F N O O N N H O H 3 C CH 3 F F O N N N CH 3 IC50 = 4.9 nM 576.54 CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cnn(C)c4)c3)c(F)c2F)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4823577 single protein format
CHEMBL3920222 OBDepict O N H H 3 C N O N CH 3 O N O HO H 3 C CH 3 IC50 = 5.0 nM 538.6 Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)cc2)c(=O)n(-c2ccccc2)n1C Homo sapiens CHEMBL3887258 single protein format
CHEMBL4858746 OBDepict H 3 C N N H O O F N H 3 C NH 2 N N IC50 = 5.0 nM 468.49 Cn1cc(C(=O)Nc2ccc(-c3cn(C)c4ncnc(N)c34)cc2)c(=O)c(-c2ccc(F)cc2)c1 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4846616 OBDepict F N O N H O O N CH 3 H 2 N N N CH 3 IC50 = 5.1 nM 566.64 Cc1nc(N)c2c(-c3ccc(NC(=O)c4cn(CC5CCOCC5)cc(-c5ccc(F)cc5)c4=O)cc3)cn(C)c2n1 Homo sapiens CHEMBL4838186 single protein format
CHEMBL4867669 OBDepict F N O O N N H O CH 3 H 3 C F O N N N H 3 C IC50 = 5.5 nM 558.55 CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cnn(C)c4)c3)cc2F)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4823577 single protein format
CHEMBL4855681 OBDepict CH 3 NH O N O F N H O N O N H 3 C CH 3 O F IC50 = 5.8 nM 549.53 CCC(=O)Nc1cc(Oc2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)ccn1 Homo sapiens CHEMBL4823577 single protein format
CHEMBL2158230 OBDepict N N N H N H O N N O IC50 = 6.0 nM 488.64 N#Cc1cnc(C(=O)Nc2ccc(C3CCN(CCN4CCOCC4)CC3)cc2C2=CCCCC2)[nH]1 Homo sapiens CHEMBL2161434 single protein format
CHEMBL4513513 OBDepict CH 3 N O CH 3 H 3 C N H O F O N N N H IC50 = 6.0 nM 547.59 CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c1)c(C)n2C Homo sapiens CHEMBL4426892 single protein format
CHEMBL4868163 OBDepict H 3 C N H N N H O N N O NH O N O N CH 3 H 3 C O F IC50 = 6.4 nM 588.6 CNC1CN(C(=O)Nc2cc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3)ncn2)C1 Homo sapiens CHEMBL4822425 single protein format
CHEMBL254702 OBDepict N N H N H O N N CH 3 N H 3 C IC50 = 6.4 nM 406.53 CC1CCN(c2cc(N3CCN(C)CC3)ccc2NC(=O)c2cc(C#N)c[nH]2)CC1 Homo sapiens CHEMBL927242 single protein format
CHEMBL4870149 OBDepict CH 3 N N N O F N H O N O N H 3 C CH 3 O F IC50 = 6.6 nM 548.55 CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(C)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4824951 single protein format
CHEMBL4856526 OBDepict H 3 C N H O N O F HN O N O N H 3 C CH 3 O F IC50 = 6.7 nM 535.51 CC(=O)Nc1cc(Oc2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)ccn1 Homo sapiens CHEMBL4823577 single protein format
CHEMBL2105717 OBDepict CH 3 O O CH 3 O N N H O HN O F IC50 = 7.0 nM 501.51 COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC Homo sapiens CHEMBL3766485 single protein format
CHEMBL4102842 OBDepict Cl N N N N NH 2 N N H O N IC50 = 7.0 nM 450.93 Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nc(Cl)nc2ccccc12 Homo sapiens CHEMBL4057778 assay format
CHEMBL4856234 OBDepict O N H N O F N H O N O N CH 3 H 3 C O F IC50 = 8.0 nM 575.57 CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CCC4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4823577 single protein format
CHEMBL4584949 OBDepict O N H N O F NH N N O CH 3 F IC50 = 8.2 nM 539.54 Cn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)nccc21 Homo sapiens CHEMBL4376515 cell-based format
CHEMBL4581972 OBDepict CH 3 N N H N O NH 2 NH O N IC50 = 8.3 nM 450.59 CCc1nc(C(N)=O)c(Nc2ccc3c(c2)CCN(C2CC2)CC3)nc1NC1CCOCC1 Homo sapiens CHEMBL4424132 single protein format
CHEMBL4875876 OBDepict F N O O N N H O H 3 C CH 3 O N N N H 3 C IC50 = 8.7 nM 540.56 CC(C)n1cc(C(=O)Nc2ccc(Oc3ccncc3-c3cnn(C)c3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4823577 single protein format
CHEMBL4851321 OBDepict CH 3 N O N N H O O F O N N N H 3 C IC50 = 8.8 nM 526.53 CCn1cc(C(=O)Nc2ccc(Oc3ccncc3-c3cnn(C)c3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4823577 single protein format
CHEMBL4068447 OBDepict Cl N N N H 3 C S N NH 2 N N H N N IC50 = 9.0 nM 536.11 Cc1csc2c(-n3nc(Nc4ccc(N5CCN(C6CC7CCC6C7)CC5)cc4)nc3N)nc(Cl)nc12 Homo sapiens CHEMBL4057778 assay format
CHEMBL535 OBDepict H 3 C N CH 3 HN O H 3 C CH 3 N H O N H F IC50 = 9.0 nM 398.48 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2C(=O)Nc3ccc(F)cc32)c1C Homo sapiens CHEMBL3811326 assay format
CHEMBL4059790 OBDepict CH 3 O O CH 3 N N N N NH 2 N N H Cl N N IC50 = 9.0 nM 576.11 COc1cc2ncnc(-n3nc(Nc4ccc(N5CCN(C6CC7CCC6C7)CC5)c(Cl)c4)nc3N)c2cc1OC Homo sapiens CHEMBL4057778 assay format
CHEMBL3967759 OBDepict OH N N N H N N N CH 3 IC50 = 9.3 nM 518.75 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCCC(O)CCCC4)cc2)CC1 Homo sapiens CHEMBL3865273 single protein format
CHEMBL4095789 OBDepict F N N N N NH 2 N N H N N IC50 = 10.0 nM 499.6 Nc1nc(Nc2ccc(N3CCN(C4CC5CCC4C5)CC3)cc2)nn1-c1ncnc2ccc(F)cc12 Homo sapiens CHEMBL4057778 assay format
CHEMBL3810063 OBDepict F N N O CH 3 H 3 C NH O F O N N H IC50 = 10.0 nM 551.55 Cc1c(C(=O)Nc2ccc(Oc3ccnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)n(-c2ccc(F)cc2)n1C Homo sapiens CHEMBL3811326 assay format
CHEMBL4529955 OBDepict CH 3 N HN N O NH 2 N H O N O H 2 N IC50 = 10.3 nM 493.61 CCc1nc(C(N)=O)c(Nc2ccc3c(c2)CCN(C(=O)C2(N)CC2)CC3)nc1NC1CCOCC1 Homo sapiens CHEMBL4424132 single protein format
CHEMBL4846678 OBDepict F N O O N HN O H 3 C CH 3 F O N N N IC50 = 10.5 nM 584.58 CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cnn(C5CC5)c4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4823577 single protein format
CHEMBL3984441 OBDepict F O N H O N H 3 C N O N H 3 C O HO CH 3 CH 3 IC50 = 11.0 nM 556.59 Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C Homo sapiens CHEMBL3887258 single protein format
CHEMBL3892515 OBDepict CH 3 N N N N N N H H H 2 N O NH IC50 = 11.0 nM 532.74 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCNC(=O)[C@@H](N)CCCC4)cc2)CC1 Homo sapiens CHEMBL3865273 single protein format
CHEMBL4794496 OBDepict H 3 C O O H 3 C N O N F N H N N O H F IC50 = 11.0 nM 553.53 COc1cc2ncnc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)c2cc1OC Homo sapiens CHEMBL4774503 single protein format
CHEMBL4873958 OBDepict CH 3 N CH 3 N H O N O N H O N O N CH 3 CH 3 O F IC50 = 11.0 nM 560.59 CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)CN(C)C)c3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O Homo sapiens CHEMBL4822425 single protein format
CHEMBL2036804 OBDepict H 3 C N H N N N N H N N H H 2 N NH IC50 = 12.0 nM 463.63 CCCCNc1ncc2c(-c3ccc(N4CCNCC4)nc3)nn(C[C@H]3CC[C@H](N)CC3)c2n1 Homo sapiens CHEMBL2037931 single protein format
CHEMBL1908842 OBDepict N N N H N H O N O N H 3 C CH 3 IC50 = 12.0 nM 460.58 CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 Homo sapiens CHEMBL2161434 single protein format
CHEMBL4856142 OBDepict F N O O N H N H O O N N N CH 3 IC50 = 13.0 nM 498.47 Cn1cc(-c2cnccc2Oc2ccc(NC(=O)c3c[nH]c(=O)n(-c4ccc(F)cc4)c3=O)cc2)cn1 Homo sapiens CHEMBL4823577 single protein format
CHEMBL4218175 OBDepict CH 3 N H N N N N N N H 3 C IC50 = 13.0 nM 405.55 CNc1ncc2c(-c3ccc(N4CCN(C)CC4)cc3)nn(CC3CCCC3)c2n1 Homo sapiens CHEMBL4188972 assay format
CHEMBL3809489 OBDepict NH 2 N N N N H N N H N IC50 = 14.0 nM 506.66 Nc1nc(Nc2ccc3c(c2)CC[C@@H](N2CCCC2)CC3)nn1-c1cc2c(nn1)-c1ccccc1CCC2 Homo sapiens CHEMBL3811333 single protein format
CHEMBL3326006 OBDepict CH 3 N H N N N H H OH N N H 3 C IC50 = 14.0 nM 476.67 CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL3363356 single protein format
CHEMBL4086420 OBDepict NH 2 N N N N H N N O N IC50 = 14.0 nM 406.49 Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2c1CCC2 Homo sapiens CHEMBL4057778 assay format
CHEMBL3910520 OBDepict OH N N N H N N N CH 3 IC50 = 14.0 nM 490.7 CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCC(O)CCC4)cc2)CC1 Homo sapiens CHEMBL3865273 single protein format
CHEMBL2023349 OBDepict NH 2 N N N N H N N N IC50 = 14.0 nM 506.66 Nc1nc(Nc2ccc3c(c2)CCC(N2CCCC2)CC3)nn1-c1cc2c(nn1)-c1ccccc1CCC2 Homo sapiens CHEMBL2027232 single protein format