P30531 | SC6A1_HUMAN | Sodium- and chloride-dependent GABA transporter 1 (SLC6A1)
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
IC50 table
| molecule_chembl_id | structure | assay_type | relation | values | units | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL277498 | IC50 | = | 10.1 | nM | 129.16 | O=C(O)C1CCCNC1 | Homo sapiens | CHEMBL881972 | single protein format | |
| CHEMBL1695 | IC50 | = | 49.0 | nM | 412.02 | Cc1ccsc1C(=CCCN1CCC[C@@H](C(=O)O)C1)c1sccc1C.Cl | Homo sapiens | CHEMBL2417030 | cell-based format | |
| CHEMBL1027 | IC50 | = | 70.0 | nM | 375.56 | Cc1ccsc1C(=CCCN1CCC[C@@H](C(=O)O)C1)c1sccc1C | Homo sapiens | CHEMBL806333 | single protein format | |
| CHEMBL77626 | IC50 | = | 130.0 | nM | 335.45 | O=C(O)[C@@H]1CCCN(CCC=C(c2ccccc2)c2ccccc2)C1 | Homo sapiens | CHEMBL806333 | single protein format | |
| CHEMBL103623 | IC50 | = | 200.0 | nM | 333.43 | O=C(O)C1=CCCN(CCC=C(c2ccccc2)c2ccccc2)C1 | Homo sapiens | CHEMBL1166723 | single protein format | |
| CHEMBL38686 | IC50 | = | 200.0 | nM | 335.45 | O=C(O)C1CCCN(CCC=C(c2ccccc2)c2ccccc2)C1 | Homo sapiens | CHEMBL1166723 | single protein format | |
| CHEMBL77287 | IC50 | = | 260.0 | nM | 473.41 | O=C(O)C1=CCCN(CCOC(c2ccc(C(F)(F)F)cc2)c2ccc(C(F)(F)F)cc2)C1 | Homo sapiens | CHEMBL806333 | single protein format | |
| CHEMBL556819 | IC50 | = | 340.0 | nM | 596.21 | Cl.O=C(O)[C@@H]1CCCN(CCC=C(c2sccc2COc2ccccc2)c2sccc2COc2ccccc2)C1 | Homo sapiens | CHEMBL862288 | single protein format | |
| CHEMBL559211 | IC50 | = | 650.0 | nM | 596.21 | Cl.O=C(O)C1CCCCN1CCC=C(c1sccc1COc1ccccc1)c1sccc1COc1ccccc1 | Homo sapiens | CHEMBL862288 | single protein format |