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P34947 | GRK5_HUMAN | G protein-coupled receptor kinase 5 (GRK5)

3D structures mapped by conservation among orthologs

[ Domain: "Regulator of G-protein signaling, RGS" // RGS ]

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[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4855542 OBDepict NH 2 N S N O NH IC50 = -12000.0 nM 372.45 Nc1ncc(-c2cccc3ncsc23)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804386 cell-based format
CHEMBL4786599 OBDepict Cl N H O H 3 C N CH 3 H O NH N H O CH 3 H F IC50 = 3.8 nM 508.98 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)Cc4ccc(F)cc4)cc32)c(C)c1NC(=O)CCl Homo sapiens CHEMBL4775829 assay format
CHEMBL4785430 OBDepict Br N H O CH 3 N H 3 C H O HN N H O H 3 C H IC50 = 8.6 nM 521.42 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1NC(=O)CBr Homo sapiens CHEMBL4775829 assay format
CHEMBL4877302 OBDepict CH 3 O N NH N N H N N H H 3 C O H 3 C Cl IC50 = 12.0 nM 438.92 CCc1cc(Nc2nc(NCc3ccc(Cl)cc3OC)nc3cccc(OC)c23)n[nH]1 Homo sapiens CHEMBL4810443 single protein format
CHEMBL4780266 OBDepict Br N H O H 3 C N CH 3 H O NH N H O CH 3 H F IC50 = 15.0 nM 553.43 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)Cc4ccc(F)cc4)cc32)c(C)c1NC(=O)CBr Homo sapiens CHEMBL4775829 assay format
CHEMBL4800665 OBDepict CH 3 N H 3 C NH O CH 3 N H 3 C H O HN N H O H 3 C H IC50 = 15.0 nM 527.67 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c1C Homo sapiens CHEMBL4775829 assay format
CHEMBL4786599 OBDepict Cl N H O H 3 C N CH 3 H O NH N H O CH 3 H F Ki = 19.0 nM 508.98 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)Cc4ccc(F)cc4)cc32)c(C)c1NC(=O)CCl Homo sapiens CHEMBL4775836 assay format
CHEMBL4782014 OBDepict HC HN O H 3 C N CH 3 H O NH N H O CH 3 H IC50 = 21.0 nM 466.54 C#CCNC(=O)c1c(C)[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c1C Homo sapiens CHEMBL4775829 assay format
CHEMBL4854871 OBDepict CH 3 O N N H N NH N N CH 3 H H N CH 3 F IC50 = 26.0 nM 407.45 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc3cccc(OC)c23)n[nH]1 Homo sapiens CHEMBL4810443 single protein format
CHEMBL4794078 OBDepict Cl NH O H 3 C N CH 3 H O N H N H O CH 3 H CH 3 IC50 = 29.0 nM 505.02 Cc1cccc(C[C@@H](C)NC(=O)c2ccc3c(c2)/C(=C/c2[nH]c(C)c(NC(=O)CCl)c2C)C(=O)N3)c1 Homo sapiens CHEMBL4775829 assay format
CHEMBL4781735 OBDepict CH 2 NH O CH 3 N H 3 C H O HN N H O H 3 C H IC50 = 48.0 nM 468.56 C=CCNC(=O)c1c(C)[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c1C Homo sapiens CHEMBL4775829 assay format
CHEMBL4847703 OBDepict CH 3 O N NH N N H N N H N H 3 C F IC50 = 51.0 nM 393.43 CCc1cc(Nc2nc(NCc3ccc(F)cn3)nc3cccc(OC)c23)n[nH]1 Homo sapiens CHEMBL4810443 single protein format
CHEMBL3093151 OBDepict H 2 N N N O N N N N H IC50 = 59.0 nM 429.53 Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2ccc(N3CCCC3)cc2o1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 73.3 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328436 single protein format
CHEMBL4787507 OBDepict Cl HO N H O H 3 C N CH 3 H O NH NH O CH 3 H IC50 = 80.0 nM 506.99 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1NC(=O)C(O)CCl Homo sapiens CHEMBL4775829 assay format
CHEMBL4779427 OBDepict Cl N H O H 3 C N CH 3 H O NH NH O H CH 3 H 3 C IC50 = 87.0 nM 519.05 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@@H](Cc4ccccc4)C(C)C)cc32)c(C)c1NC(=O)CCl Homo sapiens CHEMBL4775829 assay format
CHEMBL4786185 OBDepict HC HN O H 3 C N CH 3 H O NH N H O CH 3 H IC50 = 91.0 nM 480.57 C#CCCNC(=O)c1c(C)[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c1C Homo sapiens CHEMBL4775829 assay format
CHEMBL4786846 OBDepict Cl NH O H 3 C N CH 3 H O HN N H O O IC50 = 95.0 nM 519.0 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)NC4(Cc5ccccc5)COC4)cc32)c(C)c1NC(=O)CCl Homo sapiens CHEMBL4775829 assay format
CHEMBL3729453 OBDepict O NH NH N O NH 2 N Ki = 100.0 nM 297.32 NC(=O)c1cccc(NCC(=O)N/N=C/c2ccncc2)c1 Homo sapiens CHEMBL3734285 single protein format
CHEMBL3732018 OBDepict CH 3 O HN N H O N Cl Cl N Ki = 100.0 nM 353.21 COc1cccc(NCC(=O)N/N=C/c2c(Cl)cncc2Cl)c1 Homo sapiens CHEMBL3734285 single protein format
CHEMBL4799210 OBDepict Cl N H O H 3 C N CH 3 H O NH N H O CH 3 H Cl IC50 = 110.0 nM 525.44 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)Cc4ccc(Cl)cc4)cc32)c(C)c1NC(=O)CCl Homo sapiens CHEMBL4775829 assay format
CHEMBL4785430 OBDepict Br N H O CH 3 N H 3 C H O HN N H O H 3 C H Ki = 110.0 nM 521.42 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1NC(=O)CBr Homo sapiens CHEMBL4775836 assay format
CHEMBL3093260 OBDepict H 2 N N N O N N N N H IC50 = 120.0 nM 429.53 Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2cc(N3CCCC3)ccc2o1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL4784634 OBDepict Cl NH O H 3 C N CH 3 H O N H NH O IC50 = 130.0 nM 476.96 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)NCCc4ccccc4)cc32)c(C)c1NC(=O)CCl Homo sapiens CHEMBL4775829 assay format
CHEMBL4777196 OBDepict Cl N H O CH 3 N H 3 C H O HN N H O H 3 C H N IC50 = 130.0 nM 477.95 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccncc4)cc32)c(C)c1NC(=O)CCl Homo sapiens CHEMBL4775829 assay format
CHEMBL3093258 OBDepict NH 2 N N O N N N N H IC50 = 140.0 nM 443.56 Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2cc(N3CCCCC3)ccc2o1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL4798127 OBDepict Cl N H O H 3 C N CH 3 H O NH N H O CH 3 H Cl IC50 = 140.0 nM 525.44 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)Cc4cccc(Cl)c4)cc32)c(C)c1NC(=O)CCl Homo sapiens CHEMBL4775829 assay format
CHEMBL60254 OBDepict OH HN O H N H H O O OH HO O OH O HO IC50 = 160.0 nM 550.52 O=C(N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 Homo sapiens CHEMBL1106959 single protein format
CHEMBL2079205 OBDepict NH 2 N N O N N OH HN IC50 = 210.0 nM 452.52 Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2ccc(O)c(-c3ccccc3)c2o1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL4464632 OBDepict H 2 C N H O O N H H 3 C N N NH N H O NH 2 IC50 = 220.0 nM 443.47 C=CC(=O)Nc1ccc(Nc2nc(Nc3ccccc3C(N)=O)c3cc[nH]c3n2)c(OC)c1 Homo sapiens CHEMBL4411102 single protein format
CHEMBL4791260 OBDepict Cl N H O CH 3 N H 3 C H O HN N H O H 3 C H IC50 = 220.0 nM 476.96 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1NC(=O)CCl Homo sapiens CHEMBL4775829 assay format
CHEMBL4475305 OBDepict CH 3 O N H HN N N O HN N H N CH 3 CH 3 O NH 2 IC50 = 220.0 nM 500.56 COc1ccc(NC(=O)/C=C/CN(C)C)cc1Nc1nc(Nc2ccccc2C(N)=O)c2cc[nH]c2n1 Homo sapiens CHEMBL4411099 single protein format
CHEMBL4225427 OBDepict CH 3 O N N O N H O F NH O HN H 3 C HN O N N H IC50 = 260.0 nM 534.51 COCc1noc(CNC(=O)c2cc(C3NC(=O)NC(C)=C3C(=O)Nc3ccc4[nH]ncc4c3)ccc2F)n1 Homo sapiens CHEMBL4223319 single protein format
CHEMBL4786913 OBDepict N HN O H 3 C H 3 C H 3 C H 3 C N CH 3 H O NH N H O CH 3 H IC50 = 280.0 nM 535.65 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1NC(=O)/C(C#N)=C/C(C)(C)C Homo sapiens CHEMBL4775829 assay format
CHEMBL3093253 OBDepict O N H N N O NH 2 N O N IC50 = 360.0 nM 520.59 Nc1ncc(-c2cccc(C(=O)NCCN3CCOCC3)c2)cc1-c1nc2cccc(-c3ccccn3)c2o1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL4793010 OBDepict CH 3 N H 3 C N H O H 3 C N CH 3 H O NH NH O CH 3 H IC50 = 360.0 nM 511.63 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1NC(=O)/C=C/CN(C)C Homo sapiens CHEMBL4775829 assay format
CHEMBL4228779 OBDepict H 3 C O N N N H O F HN O NH CH 3 HN O N N H IC50 = 380.0 nM 518.51 CCc1nc(CNC(=O)c2cc(C3NC(=O)NC(C)=C3C(=O)Nc3ccc4[nH]ncc4c3)ccc2F)no1 Homo sapiens CHEMBL4223319 single protein format
CHEMBL3808660 OBDepict O N H HN CH 3 N H O F HN O N N N H IC50 = 380.0 nM 499.51 CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(F)c(C(=O)NCc3ccccn3)c2)NC(=O)N1 Homo sapiens CHEMBL3811362 single protein format
CHEMBL3093255 OBDepict CH 3 O OH O N NH 2 N N N HN IC50 = 450.0 nM 482.54 COc1ccc(-c2c(O)ccc3nc(-c4cc(-c5cnn(C6CCNCC6)c5)cnc4N)oc23)cc1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL4788756 OBDepict Cl N H O CH 3 N H 3 C H O HN N H O H 3 C H N IC50 = 450.0 nM 477.95 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccn4)cc32)c(C)c1NC(=O)CCl Homo sapiens CHEMBL4775829 assay format
CHEMBL3093145 OBDepict CH 3 N H N O NH 2 N N N HN IC50 = 500.0 nM 431.54 CCCCNc1ccc2oc(-c3cc(-c4cnn(C5CCNCC5)c4)cnc3N)nc2c1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL2079522 OBDepict NH 2 N O NH 2 N N N HN IC50 = 520.0 nM 375.44 Nc1ccc2oc(-c3cc(-c4cnn(C5CCNCC5)c4)cnc3N)nc2c1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL3093254 OBDepict H 2 N N N O N N HO N NH H N IC50 = 530.0 nM 492.54 Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2ccc(O)c(-c3ccc4cn[nH]c4c3)c2o1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL4456539 OBDepict CH 3 O N H N H N N O HN N H N CH 3 CH 3 O H 2 N IC50 = 570.0 nM 500.56 COc1cc(NC(=O)/C=C/CN(C)C)ccc1Nc1nc(Nc2ccccc2C(N)=O)c2cc[nH]c2n1 Homo sapiens CHEMBL4411099 single protein format
CHEMBL3093247 OBDepict F NH O O N H 2 N N N N NH IC50 = 640.0 nM 497.53 Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2ccc(NC(=O)c3ccc(F)cc3)cc2o1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL2078645 OBDepict H 3 C N H N O H 2 N N N N NH IC50 = 660.0 nM 389.46 CNc1ccc2oc(-c3cc(-c4cnn(C5CCNCC5)c4)cnc3N)nc2c1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL3093147 OBDepict CH 3 N H N O NH 2 N N N HN IC50 = 700.0 nM 417.52 CCCNc1ccc2oc(-c3cc(-c4cnn(C5CCNCC5)c4)cnc3N)nc2c1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL4796116 OBDepict O NH N H CH 3 H 3 C + N NH O O _ O CH 3 H IC50 = 730.0 nM 430.46 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1[N+](=O)[O-] Homo sapiens CHEMBL4775829 assay format
CHEMBL4796861 OBDepict CH 2 S N H O O CH 3 N H 3 C H O N H N H O CH 3 H IC50 = 740.0 nM 490.59 C=CS(=O)(=O)Nc1c(C)[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c1C Homo sapiens CHEMBL4775829 assay format
CHEMBL4791163 OBDepict O NH O H 3 C N CH 3 H O N H N H O CH 3 H IC50 = 740.0 nM 470.53 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1NC(=O)C1CO1 Homo sapiens CHEMBL4775829 assay format
CHEMBL4796154 OBDepict Cl NH O H 3 C N CH 3 H O N H N H O CH 3 H CH 3 IC50 = 780.0 nM 505.02 Cc1ccc(C[C@@H](C)NC(=O)c2ccc3c(c2)/C(=C/c2[nH]c(C)c(NC(=O)CCl)c2C)C(=O)N3)cc1 Homo sapiens CHEMBL4775829 assay format
CHEMBL3809100 OBDepict O N H HN CH 3 N H O F HN O N N H F IC50 = 800.0 nM 516.51 CC1=C(C(=O)Nc2ccc3[nH]ncc3c2)C(c2ccc(F)c(C(=O)NCc3cccc(F)c3)c2)NC(=O)N1 Homo sapiens CHEMBL3811362 single protein format
CHEMBL4782275 OBDepict H 2 C N H O H 3 C N CH 3 H O NH N H O CH 3 H IC50 = 810.0 nM 454.53 C=CC(=O)Nc1c(C)[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c1C Homo sapiens CHEMBL4775829 assay format
CHEMBL3093150 OBDepict H 2 N N N O N N N NH O IC50 = 810.0 nM 445.53 Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2ccc(N3CCOCC3)cc2o1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL535 OBDepict H 3 C N CH 3 HN O H 3 C CH 3 N H O N H F IC50 = 830.0 nM 398.48 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2C(=O)Nc3ccc(F)cc32)c1C Homo sapiens CHEMBL4775829 assay format
CHEMBL2079395 OBDepict NH 2 N O N N N OH CH 3 HN IC50 = 870.0 nM 390.45 Cc1cc2nc(-c3cc(-c4cnn(C5CCNCC5)c4)cnc3N)oc2cc1O Homo sapiens CHEMBL3096888 single protein format
CHEMBL3093244 OBDepict O N H N H O F N H 2 N N N N N H IC50 = 880.0 nM 512.55 Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2ccc(NC(=O)Nc3ccc(F)cc3)cc2o1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL2032290 OBDepict O HN HN S O O H 3 C O N H 2 N N N N NH IC50 = 880.0 nM 572.65 Cc1ccc(S(=O)(=O)NC(=O)Nc2ccc3nc(-c4cc(-c5cnn(C6CCNCC6)c5)cnc4N)oc3c2)cc1 Homo sapiens CHEMBL3096888 single protein format
CHEMBL3731472 OBDepict O NH NH N O Cl Cl N Ki = 1000.0 nM 415.28 O=C(CNc1cccc(Oc2ccccc2)c1)N/N=C/c1c(Cl)cncc1Cl Homo sapiens CHEMBL3734285 single protein format
CHEMBL3729247 OBDepict CH 3 HN O HN N H O N Cl Cl N Ki = 1000.0 nM 380.24 CNC(=O)c1cccc(NCC(=O)N/N=C/c2c(Cl)cncc2Cl)c1 Homo sapiens CHEMBL3734285 single protein format
CHEMBL3729970 OBDepict CH 3 S HN N H O N Cl Cl N Ki = 1000.0 nM 369.28 CSc1cccc(NCC(=O)N/N=C/c2c(Cl)cncc2Cl)c1 Homo sapiens CHEMBL3734285 single protein format
CHEMBL3730250 OBDepict O NH NH N F Cl Cl N Ki = 1000.0 nM 341.17 O=C(CNc1cccc(F)c1)N/N=C/c1c(Cl)cncc1Cl Homo sapiens CHEMBL3734285 single protein format
CHEMBL3732736 OBDepict O NH NH N Cl Cl Cl N Ki = 1000.0 nM 357.63 O=C(CNc1cccc(Cl)c1)N/N=C/c1c(Cl)cncc1Cl Homo sapiens CHEMBL3734285 single protein format
CHEMBL4791260 OBDepict Cl N H O CH 3 N H 3 C H O HN N H O H 3 C H Ki = 1000.0 nM 476.96 Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1NC(=O)CCl Homo sapiens CHEMBL4775836 assay format
CHEMBL3727997 OBDepict O NH NH N O Cl Cl N Ki = 1000.0 nM 429.31 O=C(CNc1cccc(OCc2ccccc2)c1)N/N=C/c1c(Cl)cncc1Cl Homo sapiens CHEMBL3734285 single protein format
CHEMBL3728662 OBDepict O NH NH N Cl Cl NH O N Ki = 1000.0 nM 442.31 O=C(CNc1cccc(C(=O)Nc2ccccc2)c1)N/N=C/c1c(Cl)cncc1Cl Homo sapiens CHEMBL3734285 single protein format
CHEMBL3729044 OBDepict CH 3 O N H HN O N CH 3 N Ki = 1000.0 nM 298.35 COc1cccc(NCC(=O)N/N=C(C)c2ccncc2)c1 Homo sapiens CHEMBL3734285 single protein format
CHEMBL3730555 OBDepict O NH NH N O N Ki = 1000.0 nM 360.42 O=C(CNc1cccc(OCc2ccccc2)c1)N/N=C/c1ccncc1 Homo sapiens CHEMBL3734285 single protein format
CHEMBL3728772 OBDepict CH 3 O HN N H O N N Ki = 1000.0 nM 284.32 COc1cccc(NCC(=O)N/N=C/c2ccncc2)c1 Homo sapiens CHEMBL3734285 single protein format
CHEMBL3730586 OBDepict O N H HN N S Cl Cl O O NH 2 N Ki = 1000.0 nM 402.26 NS(=O)(=O)c1cccc(NCC(=O)N/N=C/c2c(Cl)cncc2Cl)c1 Homo sapiens CHEMBL3734285 single protein format