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P35499 | SCN4A_HUMAN | Sodium channel protein type 4 subunit alpha (SCN4A)

3D structures mapped by conservation among orthologs

[ Domain: "EF-hand" // EF-hand_7_6 ]

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[ Domain: "Voltage-gated ion channels" // Ion_trans ]

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[ Domain: "Voltage gated calcium channel IQ domain" // IQ_like ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3617050 OBDepict OH N H O O N NH N H H H N H N O N HO OH HN O O H S H O O HO HO IC50 = 0.062 nM 552.48 N=C1N[C@@]23[C@H]([C@H]4NC(=N)N2C[C@](OS(=O)(=O)O)(C[C@H]2[C@@H](CO)CON2C4=O)C3(O)O)N1COC(=O)NO Homo sapiens CHEMBL3618798 cell-based format
CHEMBL38401 OBDepict F F O N N O H 2 N Ki = 25.0 nM 315.28 NC(=O)n1ccc(-c2ccc(Oc3ccc(F)cc3F)cc2)n1 Homo sapiens CHEMBL805351 cell-based format
CHEMBL507974 OBDepict HO OH H O H O H OH H OH N H H OH N H OH H 2 N IC50 = 25.0 nM 319.27 NC1=N[C@H](O)[C@H]2[C@H]3O[C@]4(O)O[C@@H]([C@@H](O)[C@@]2(N1)[C@@H]4O)[C@]3(O)CO Homo sapiens CHEMBL3880175 single protein format
CHEMBL501134 OBDepict HN N H HN H N H NH OH HO O NH O H 2 N IC50 = 30.0 nM 299.29 N=C1N[C@H]2[C@H](COC(N)=O)NC(=N)N3CCC(O)(O)[C@]23N1 Homo sapiens CHEMBL3887478 single protein format
CHEMBL37316 OBDepict _ O + N O O N N O H 2 N Ki = 31.0 nM 324.3 NC(=O)n1ccc(-c2ccc(Oc3ccc([N+](=O)[O-])cc3)cc2)n1 Homo sapiens CHEMBL805351 cell-based format
CHEMBL289425 OBDepict F O N N O NH 2 Ki = 31.0 nM 297.29 NC(=O)n1ccc(-c2ccc(Oc3ccc(F)cc3)cc2)n1 Homo sapiens CHEMBL805351 cell-based format
CHEMBL37263 OBDepict NH 2 N O N O Ki = 35.0 nM 279.3 NC(=O)n1ccc(-c2ccc(Oc3ccccc3)cc2)n1 Homo sapiens CHEMBL805351 cell-based format
CHEMBL3983577 OBDepict NH NH N H H N H N H OH OH O HN N O IC50 = 100.0 nM 353.38 N=C1N[C@H]2[C@H](COC(=O)N3CCCC3)NC(=N)N3CCC(O)(O)[C@]23N1 Homo sapiens CHEMBL3887478 single protein format
CHEMBL38488 OBDepict CH 3 HN N O N O F Ki = 150.0 nM 311.32 CNC(=O)n1ccc(-c2ccc(Oc3ccc(F)cc3)cc2)n1 Homo sapiens CHEMBL805351 cell-based format
CHEMBL3977689 OBDepict CH 3 N H CH 3 O O H NH H N H NH N HN HN OH HO IC50 = 175.0 nM 341.37 CC(C)NC(=O)OC[C@@H]1NC(=N)N2CCC(O)(O)[C@@]23NC(=N)N[C@@H]13 Homo sapiens CHEMBL3887478 single protein format
CHEMBL287833 OBDepict NH 2 HN O N O F Ki = 180.0 nM 273.27 NC(=O)N/N=C/c1ccc(Oc2ccc(F)cc2)cc1 Homo sapiens CHEMBL805351 cell-based format
CHEMBL38031 OBDepict F O N N H Ki = 200.0 nM 254.26 Fc1ccc(Oc2ccc(-c3cc[nH]n3)cc2)cc1 Homo sapiens CHEMBL805351 cell-based format
CHEMBL41864 OBDepict H N N O Ki = 240.0 nM 236.27 c1ccc(Oc2ccc(-c3cc[nH]n3)cc2)cc1 Homo sapiens CHEMBL805351 cell-based format
CHEMBL289421 OBDepict F O N N N O CH 3 H 3 C Ki = 340.0 nM 325.34 CN(C)C(=O)n1ccc(-c2ccc(Oc3ccc(F)cc3)cc2)n1 Homo sapiens CHEMBL805351 cell-based format
CHEMBL1813048 OBDepict CH 3 NH O CH 3 HN N N N N O O F F F IC50 = 400.0 nM 516.52 CC(=O)Nc1cccc(Nc2ncnc(N3CCC(OCc4ccc(OC(F)(F)F)cc4)CC3)n2)c1C Homo sapiens CHEMBL1816276 cell-based format
CHEMBL38970 OBDepict F O N N CH 3 Ki = 690.0 nM 268.29 Cn1ccc(-c2ccc(Oc3ccc(F)cc3)cc2)n1 Homo sapiens CHEMBL805351 cell-based format
CHEMBL3896454 OBDepict NH NH N H H N H N H OH OH O HN N H O IC50 = 700.0 nM 381.44 N=C1N[C@H]2[C@H](COC(=O)NC3CCCCC3)NC(=N)N3CCC(O)(O)[C@]23N1 Homo sapiens CHEMBL3887478 single protein format