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P36507 | MP2K2_HUMAN | Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4855730 OBDepict F NH S N O O H 2 N O HN IC50 = -79800.0 nM 452.51 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804412 cell-based format
CHEMBL4855542 OBDepict NH 2 N S N O NH IC50 = -36700.0 nM 372.45 Nc1ncc(-c2cccc3ncsc23)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804412 cell-based format
CHEMBL4860979 OBDepict F S N O O CH 3 N H 2 N O N H IC50 = -23700.0 nM 466.54 CN(C1CC1)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3ccc4c(c3)CCNC4=O)c2)c(F)c1 Homo sapiens CHEMBL4804412 cell-based format
CHEMBL4859660 OBDepict NH 2 N F + N O NH O _ O IC50 = -13500.0 nM 378.36 Nc1ncc(-c2cccc([N+](=O)[O-])c2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804412 cell-based format
CHEMBL4867931 OBDepict H 3 C O N H S N O O H 2 N O HN IC50 = -5700.0 nM 464.55 COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(-c2ccc3c(c2)CCNC3=O)c1 Homo sapiens CHEMBL4804412 cell-based format
CHEMBL2012519 OBDepict CH 3 O OH O O H HO H CH 3 H HO O IC50 = 15.0 nM 364.39 COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)C(=O)/C=CC[C@H](C)OC2=O Homo sapiens CHEMBL1656376 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 37.4 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328488 single protein format
CHEMBL34704 OBDepict N S NH 2 S NH 2 N NH 2 NH 2 IC50 = 60.0 nM 380.5 N#CC(=C(/N)Sc1ccccc1N)/C(C#N)=C(N)Sc1ccccc1N Homo sapiens CHEMBL714048 single protein format
CHEMBL3753341 OBDepict NH 2 N N N N N O H 3 C CH 3 IC50 = 82.0 nM 284.32 CC(C)n1nc(-c2cc(C3CC3)on2)c2c(N)ncnc21 Homo sapiens CHEMBL3757134 single protein format
CHEMBL507361 OBDepict OH OH H O N H O N H F F F I IC50 = 110.0 nM 482.2 O=C(NOC[C@H](O)CO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F Homo sapiens CHEMBL4324547 assay format
CHEMBL4099337 OBDepict CH 3 O OH O O H HO H CH 3 H HO O IC50 = 186.7 nM 366.41 COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)C(=O)CCC[C@H](C)OC2=O Homo sapiens CHEMBL3998825 single protein format
CHEMBL261237 OBDepict N S H 2 N F F F H 2 N IC50 = 220.0 nM 335.35 N#C/C(=C(/N)Sc1ccc(N)cc1)c1ccccc1C(F)(F)F Homo sapiens CHEMBL936811 single protein format
CHEMBL2006765 OBDepict CH 3 HN O N H N N HN N H F F F IC50 = 391.0 nM 392.39 CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 Homo sapiens CHEMBL4007727 single protein format
CHEMBL583679 OBDepict O NH N H 3 C H O H 3 C CH 3 H 3 C N O N H H 3 C O Ki = 670.0 nM 476.58 C[C@H](c1ccccc1)N(CC(=O)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)NC(=O)N1C)C(=O)C(C)(C)C Homo sapiens CHEMBL1050774 cell-based format
CHEMBL571823 OBDepict O HN N O CH 3 CH 3 H 3 C N O NH H 3 C O Ki = 710.0 nM 462.55 CN1C(=O)NC(=O)[C@@]12Cc1ccc(NC(=O)CN(Cc3ccccc3)C(=O)C(C)(C)C)cc1C2 Homo sapiens CHEMBL1050774 cell-based format