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P36888 | FLT3_HUMAN | Receptor-type tyrosine-protein kinase FLT3 (FLT3)

3D structures mapped by conservation among orthologs

[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_12 ]

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[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set ]

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[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_11 ]

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[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_13 ]

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[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4744130 OBDepict O N H NH N O F CH 3 CH 3 H 3 C O N N H N IC50 = 0.015 nM 410.41 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4nc[nH]c34)c(F)c2)no1 Homo sapiens CHEMBL4701738 cell-based format
CHEMBL4790915 OBDepict CH 3 O O N CH 3 O F N H N H O N O H 3 C CH 3 H 3 C IC50 = 0.072 nM 480.5 COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3F)c2cc1OC Homo sapiens CHEMBL4701738 cell-based format
CHEMBL4086149 OBDepict H 3 C S N N HN N N H NH O N N H 3 C IC50 = 0.101 nM 476.61 CCc1cc2c(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)ncnc2s1 Homo sapiens CHEMBL4059187 single protein format
CHEMBL3612622 OBDepict Cl N N N N S O O CH 3 + N O _ O IC50 = 0.123 nM 417.83 Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)n1ccc(-c2cnn3ccc(Cl)nc23)c1 Homo sapiens CHEMBL3615646 single protein format
CHEMBL4092761 OBDepict CH 3 N CH 3 N H O N N N H H N N N H IC50 = 0.13 nM 404.48 CCN(CC)Cc1ccc(NC(=O)c2n[nH]cc2Nc2ncnc3[nH]ccc23)cc1 Homo sapiens CHEMBL4059187 single protein format
CHEMBL3612511 OBDepict Cl N N N HN S O O CH 3 + N O _ O IC50 = 0.166 nM 395.83 Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)NCCc1cnn2ccc(Cl)nc12 Homo sapiens CHEMBL3615646 single protein format
CHEMBL4078261 OBDepict CH 3 N N N H O N N HN H N N H 3 C S IC50 = 0.167 nM 462.58 Cc1csc2ncnc(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)c12 Homo sapiens CHEMBL4059187 single protein format
CHEMBL3612513 OBDepict N S H 3 C N O O CH 3 N N N Cl IC50 = 0.177 nM 389.87 Cc1ccc(C#N)cc1S(=O)(=O)N(C)CCc1cnn2ccc(Cl)nc12 Homo sapiens CHEMBL3615646 single protein format
CHEMBL4163870 OBDepict H N N N H N H O N H 3 C N N HN IC50 = 0.19 nM 418.51 Cc1nc2c(c(Nc3c[nH]nc3C(=O)Nc3ccc(N4CCNCC4)cc3)n1)CCC2 Homo sapiens CHEMBL4155885 single protein format
CHEMBL3237712 OBDepict CH 3 O N N N H N N N N CH 3 CH 3 H N H H 3 C IC50 = 0.2 nM 514.68 COc1nc(Nc2ncc3c4ccncc4n([C@H]4CC[C@H](C)CC4)c3n2)ccc1N1CCC(N(C)C)CC1 Homo sapiens CHEMBL3240326 single protein format
CHEMBL1173107 OBDepict O HN N H N H O N H CH 3 H 3 C O HO IC50 = 0.2 nM 416.44 Cc1[nH]c(/C=C2C(=O)Nc3cc(NC(=O)Nc4ccccc4)ccc32)c(C)c1C(=O)O Homo sapiens CHEMBL1176709 single protein format
CHEMBL3612507 OBDepict N N N N N N S H 3 C O O CH 3 + N O _ O IC50 = 0.212 nM 399.39 Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnn2ccc(C#N)nc12 Homo sapiens CHEMBL3615646 single protein format
CHEMBL4077071 OBDepict CH 3 N N N H O N N N H H N N N H IC50 = 0.27 nM 431.5 CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1 Homo sapiens CHEMBL4059187 single protein format
CHEMBL4749639 OBDepict O N H NH N O F H 3 C H 3 C CH 3 O N N N H IC50 = 0.292 nM 410.41 CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]ncc34)c(F)c2)no1 Homo sapiens CHEMBL4701738 cell-based format
CHEMBL3288854 OBDepict H 3 C N N N H O H 3 C CH 3 N H O HN F Ki < 0.3 nM 425.51 Cc1[nH]c(/C=C2C(=O)Nc3ccc(F)cc32)c(C)c1NC(=O)CCN1CCN(C)CC1 Homo sapiens CHEMBL3296757 single protein format
CHEMBL4515413 OBDepict O N F F F N N N H N N H N H 3 C IC50 = 0.3 nM 509.54 Cc1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ccn1 Homo sapiens CHEMBL4380524 cell-based format
CHEMBL3237706 OBDepict H H 3 C H N N N N N H N N HN IC50 = 0.3 nM 442.57 C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)nc4)nc32)CC1 Homo sapiens CHEMBL3240326 single protein format
CHEMBL1171837 OBDepict H 3 C N N F F F N H O CH 3 N N N IC50 = 0.3 nM 532.57 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 Homo sapiens CHEMBL3225231 cell-based format
CHEMBL4101635 OBDepict H 3 C N N N H O N N NH H N N S IC50 = 0.32 nM 462.58 CN1CCCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4sccc34)cc2)CC1 Homo sapiens CHEMBL4059187 single protein format
CHEMBL4475689 OBDepict CH 3 N N N H N H N S IC50 = 0.327 nM 339.47 CN1CCN(c2ccc(Nc3cc(-c4cccs4)n[nH]3)cc2)CC1 Homo sapiens CHEMBL4353138 single protein format
CHEMBL4104057 OBDepict H N N HN NH O N N S N N H IC50 = 0.34 nM 434.53 O=C(Nc1ccc(CN2CCNCC2)cc1)c1n[nH]cc1Nc1ncnc2sccc12 Homo sapiens CHEMBL4059187 single protein format
CHEMBL3687210 OBDepict CH 3 N N NH O NH 2 N H H H HO H 3 C N N H 3 C CH 3 IC50 = 0.34 nM 495.67 CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C(C)C)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL3687202 OBDepict CH 3 N N NH O NH 2 N H H H HO H 3 C N N N H 3 C IC50 = 0.35 nM 550.75 CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL3687222 OBDepict CH 3 N NH N O NH 2 N H O F N N H 3 C IC50 = 0.36 nM 457.55 CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)c(F)c2)nc1NC1CCOCC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL4461418 OBDepict HO O O OH CH 3 N NH N O NH 2 N H O F N N H 3 C IC50 = 0.36 nM 573.63 CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)c(F)c2)nc1NC1CCOCC1.O=C(O)/C=C/C(=O)O Homo sapiens CHEMBL4418514 assay format
CHEMBL3687215 OBDepict CH 3 N NH N O NH 2 N H O H 3 C N N N H 3 C IC50 = 0.36 nM 536.73 CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCOCC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL3687212 OBDepict CH 3 N N NH O NH 2 N H H CH 3 HO H 3 C N N N H 3 C IC50 = 0.37 nM 564.78 CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@](C)(O)CC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL3687225 OBDepict CH 3 N NH N O NH 2 N H O H 3 C N N N H 3 C IC50 = 0.37 nM 536.73 CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCOCC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL3612512 OBDepict Cl N N N N S H 3 C O O CH 3 + N O _ O IC50 = 0.374 nM 409.86 Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)CCc1cnn2ccc(Cl)nc12 Homo sapiens CHEMBL3615646 single protein format
CHEMBL4073053 OBDepict CH 3 N N N H O N N HN H N N S H 3 C IC50 = 0.384 nM 462.58 Cc1cc2c(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)ncnc2s1 Homo sapiens CHEMBL4059187 single protein format
CHEMBL3687207 OBDepict CH 3 N N NH O NH 2 N H H CH 3 HO H 3 C N N N H 3 C IC50 = 0.39 nM 564.78 CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@@](C)(O)CC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL4870188 OBDepict CH 3 N O N NH N N N H N Ki = 0.4 nM 427.51 CC(=O)N1CCCN(c2cccc(Nc3nccc(-c4c[nH]c5ncccc45)n3)c2)CC1 Homo sapiens CHEMBL4815226 single protein format
CHEMBL3301622 OBDepict CH 3 O N N H N N N HN O H 2 N CH 3 N H 3 C O IC50 = 0.41 nM 552.72 CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL4075720 OBDepict CH 3 N N N H O N N NH H N N S IC50 = 0.438 nM 448.56 CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4sccc34)cc2)CC1 Homo sapiens CHEMBL4059187 single protein format
CHEMBL4441604 OBDepict HO O O OH CH 3 N N NH O NH 2 N H H H HO N N H 3 C IC50 = 0.44 nM 569.66 CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1.O=C(O)/C=C/C(=O)O Homo sapiens CHEMBL4418514 assay format
CHEMBL3687191 OBDepict CH 3 N N NH O NH 2 N H H H HO N N H 3 C IC50 = 0.44 nM 453.59 CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL3687195 OBDepict CH 3 N N N H N N HN O NH 2 H CH 3 H 3 C H OH IC50 = 0.46 nM 467.62 CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL4454732 OBDepict H 3 C N N N H N N NH O H 2 N H CH 3 CH 3 H HO HO O O HO IC50 = 0.46 nM 583.69 CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1.O=C(O)/C=C/C(=O)O Homo sapiens CHEMBL4418514 assay format
CHEMBL4061686 OBDepict CH 3 N N N H O N N NH H N S N IC50 = 0.47 nM 448.56 CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4ccsc34)cc2)CC1 Homo sapiens CHEMBL4059187 single protein format
CHEMBL4172223 OBDepict O HN N N NH H N N Cl N S NH IC50 = 0.47 nM 454.95 O=C(Nc1ccc(N2CCNCC2)cc1)c1n[nH]cc1Nc1nc(Cl)nc2sccc12 Homo sapiens CHEMBL4155885 single protein format
CHEMBL3917983 OBDepict NH 2 O N O H 3 C N N F H HN H 3 C H 3 C IC50 = 0.48 nM 447.51 Cc1cc(F)c2[nH]ccc2c1-c1nc(C(N)=O)c(-c2ccc(N3CCNC(C)(C)C3)cc2)o1 Homo sapiens CHEMBL3887269 single protein format
CHEMBL3687223 OBDepict CH 3 O N N H N N N H 3 C NH O NH 2 CH 3 CH 3 O IC50 = 0.49 nM 483.62 COc1cc(Nc2nc(NC3CCOCC3)c(C(C)C)nc2C(N)=O)ccc1N1CCN(C)CC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL4438727 OBDepict HO O O HO CH 3 O N N H N N N H 3 C NH O NH 2 CH 3 CH 3 O IC50 = 0.49 nM 599.69 COc1cc(Nc2nc(NC3CCOCC3)c(C(C)C)nc2C(N)=O)ccc1N1CCN(C)CC1.O=C(O)/C=C/C(=O)O Homo sapiens CHEMBL4418514 assay format
CHEMBL1173411 OBDepict CH 3 O N H N H O N H O N H CH 3 O HO IC50 = 0.5 nM 432.44 COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=Cc2[nH]cc(C(=O)O)c2C)cc1 Homo sapiens CHEMBL1176709 single protein format
CHEMBL3329684 OBDepict CH 3 O F N H O N H O N H O N H CH 3 H 3 C N H O N IC50 = 0.5 nM 588.64 COc1ccc(C(=O)NC(=O)Nc2ccc3c(c2)NC(=O)/C3=Cc2[nH]c(C)c(C(=O)NCCN3CCCC3)c2C)c(F)c1 Homo sapiens CHEMBL3380434 single protein format
CHEMBL3687220 OBDepict CH 3 N NH N O NH 2 N H O N N N H 3 C IC50 = 0.51 nM 522.7 CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1NC1CCOCC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL3687194 OBDepict CH 3 N N NH O NH 2 N H H H HO N N N H 3 C IC50 = 0.51 nM 536.73 CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL3687224 OBDepict H 3 C N N N H N N NH O H 2 N CH 3 CH 3 O IC50 = 0.52 nM 453.59 CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1NC1CCOCC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL4591953 OBDepict CH 3 N N N H N N HN O NH 2 CH 3 H 3 C O HO O O HO IC50 = 0.52 nM 569.66 CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1NC1CCOCC1.O=C(O)/C=C/C(=O)O Homo sapiens CHEMBL4418514 assay format
CHEMBL3884839 OBDepict H 3 C O N N NH N N O Cl HN O H 2 C IC50 = 0.54 nM 414.85 C=CC(=O)Nc1ccccc1Oc1nc(Nc2cnn(CCOC)c2)ncc1Cl Homo sapiens CHEMBL4118530 single protein format
CHEMBL3945870 OBDepict H 2 N O N O H 3 C N N H HN H 3 C H 3 C IC50 = 0.55 nM 429.52 Cc1c[nH]c2cccc(-c3nc(C(N)=O)c(-c4ccc(N5CCNC(C)(C)C5)cc4)o3)c12 Homo sapiens CHEMBL3887269 single protein format
CHEMBL3687221 OBDepict H 3 C N N N N H N N NH O H 2 N CH 3 CH 3 O IC50 = 0.56 nM 536.73 CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1NC1CCOCC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL4093755 OBDepict CH 3 N N N H O N N HN H N N S H 3 C H 3 C IC50 = 0.576 nM 476.61 Cc1sc2ncnc(Nc3c[nH]nc3C(=O)Nc3ccc(CN4CCN(C)CC4)cc3)c2c1C Homo sapiens CHEMBL4059187 single protein format
CHEMBL4088753 OBDepict H N N NH HN O N N N O IC50 = 0.588 nM 429.48 O=C(Nc1ccc(CN2CCOCC2)cc1)c1n[nH]cc1Nc1ncnc2ccccc12 Homo sapiens CHEMBL4059187 single protein format
CHEMBL4868092 OBDepict O N H NH N H 3 C H O N H F IC50 = 0.6 nM 396.47 Cc1c(NC(=O)CCNC2CCCC2)c[nH]c1/C=C1C(=O)Nc2ccc(F)cc21 Homo sapiens CHEMBL4823733 single protein format
CHEMBL3237718 OBDepict CH 3 O N N N H N N HN N O H N H H 3 C IC50 = 0.6 nM 540.67 COc1nc(Nc2ncc3c4ccncc4n([C@H]4CC[C@H](C)CC4)c3n2)ccc1N1CCC2(CCC(=O)N2)CC1 Homo sapiens CHEMBL3240326 single protein format
CHEMBL2032155 OBDepict OH O F F F NH 2 N N O N N N HN IC50 = 0.6 nM 551.53 Nc1ncc(-c2cnn(C3CCNCC3)c2)cc1-c1nc2cccc(-c3ccccn3)c2o1.O=C(O)C(F)(F)F Homo sapiens CHEMBL2034188 single protein format
CHEMBL3237711 OBDepict H 3 C N H 3 C N F N NH N N N H N H H 3 C IC50 = 0.6 nM 502.64 CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nc2F)CC1 Homo sapiens CHEMBL3240326 single protein format
CHEMBL4164331 OBDepict O N H N N N H H N N CH 3 N S HN IC50 = 0.62 nM 434.53 Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(N3CCNCC3)cc2)c2ccsc2n1 Homo sapiens CHEMBL4155885 single protein format
CHEMBL4077074 OBDepict H N N HN NH O N N S N O IC50 = 0.623 nM 435.51 O=C(Nc1ccc(CN2CCOCC2)cc1)c1n[nH]cc1Nc1ncnc2sccc12 Homo sapiens CHEMBL4059187 single protein format
CHEMBL3884960 OBDepict CH 2 NH O O N Cl N N H N N H 3 C IC50 = 0.63 nM 464.96 C=CC(=O)Nc1ccccc1Oc1nc(Nc2ccc(N3CCN(C)CC3)cc2)ncc1Cl Homo sapiens CHEMBL4118530 single protein format
CHEMBL4175865 OBDepict CH 3 N N NH O N N HN H N CH 3 N S IC50 = 0.65 nM 462.58 Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(CN3CCN(C)CC3)cc2)c2ccsc2n1 Homo sapiens CHEMBL4155885 single protein format
CHEMBL3684989 OBDepict HO N O N N H N N N N IC50 = 0.65 nM 443.51 O=C(CO)N1CCc2nc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)ccc2C1 Homo sapiens CHEMBL3705970 single protein format
CHEMBL4171138 OBDepict H N N N H N H O N H 3 C N S H 3 C CH 3 N O IC50 = 0.66 nM 491.62 Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(CN3CCOCC3)cc2)c2cc(C(C)C)sc2n1 Homo sapiens CHEMBL4155885 single protein format
CHEMBL4159478 OBDepict H N N NH N H O N H 3 C N N NH IC50 = 0.66 nM 432.53 Cc1nc2c(c(Nc3c[nH]nc3C(=O)Nc3ccc(N4CCNCC4)cc3)n1)CCCC2 Homo sapiens CHEMBL4155885 single protein format
CHEMBL3957869 OBDepict CH 3 N H N O O NH 2 N HN CH 3 H 3 C IC50 = 0.67 nM 443.55 CCc1ccc(-c2nc(C(N)=O)c(-c3ccc(N4CCNC(C)(C)C4)cc3)o2)c2cc[nH]c12 Homo sapiens CHEMBL3887269 single protein format
CHEMBL1172837 OBDepict O NH N H N H O N H IC50 = 0.7 nM 420.47 O=C(Nc1ccc(-c2ccccc2)cc1)Nc1ccc2c(c1)NC(=O)/C2=Cc1ccc[nH]1 Homo sapiens CHEMBL1176709 single protein format
CHEMBL3687217 OBDepict CH 3 N N N CH 3 N H N N NH O H 2 N Cl H H HO IC50 = 0.72 nM 557.14 Cc1cc(Nc2nc(N[C@H]3CC[C@H](O)CC3)c(Cl)nc2C(N)=O)ccc1N1CCC(N2CCN(C)CC2)CC1 Homo sapiens CHEMBL3706339 single protein format
CHEMBL4790597 OBDepict O HN N N H 3 C O CH 3 H N H 3 C O IC50 = 0.73 nM 554.65 CN(C(=O)c1ccccc1)[C@H]1C[C@]2(C)O[C@](C)(C1)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O Homo sapiens CHEMBL4686308 single protein format
CHEMBL4160544 OBDepict CH 3 N N NH O N N HN H N CH 3 N S H 3 C CH 3 IC50 = 0.73 nM 504.66 Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(CN3CCN(C)CC3)cc2)c2cc(C(C)C)sc2n1 Homo sapiens CHEMBL4155885 single protein format
CHEMBL3612503 OBDepict H 3 C N N N N N S H 3 C O O CH 3 + N O _ O IC50 = 0.762 nM 388.41 Cc1ccn2ncc(/C=N/N(C)S(=O)(=O)c3cc([N+](=O)[O-])ccc3C)c2n1 Homo sapiens CHEMBL3615646 single protein format
CHEMBL3970921 OBDepict NH 2 O N O H 3 C N N H HN H 3 C H 3 C IC50 = 0.77 nM 429.52 Cc1ccc2[nH]ccc2c1-c1nc(C(N)=O)c(-c2ccc(N3CCNC(C)(C)C3)cc2)o1 Homo sapiens CHEMBL3887269 single protein format
CHEMBL4571743 OBDepict CH 3 N N N H N H N S Cl IC50 = 0.7991 nM 373.91 CN1CCN(c2ccc(Nc3cc(-c4cc(Cl)cs4)n[nH]3)cc2)CC1 Homo sapiens CHEMBL4353138 single protein format
CHEMBL4864449 OBDepict CH 3 N O N N H N N N H N Ki = 0.8 nM 413.49 CC(=O)N1CCN(c2ccc(Nc3nccc(-c4c[nH]c5ncccc45)n3)cc2)CC1 Homo sapiens CHEMBL4815226 single protein format
CHEMBL3326006 OBDepict CH 3 N H N N N H H OH N N H 3 C IC50 = 0.8 nM 476.67 CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL3363337 single protein format
CHEMBL1172887 OBDepict O N H NH N H O O N H IC50 = 0.8 nM 436.47 O=C(Nc1ccc(Oc2ccccc2)cc1)Nc1ccc2c(c1)NC(=O)/C2=Cc1ccc[nH]1 Homo sapiens CHEMBL1176709 single protein format
CHEMBL3932362 OBDepict NH 2 O N O N N F H NH CH 3 CH 3 IC50 = 0.821 nM 433.49 CC1(C)CN(c2ccc(-c3oc(-c4ccc(F)c5[nH]ccc45)nc3C(N)=O)cc2)CCN1 Homo sapiens CHEMBL3887269 single protein format
CHEMBL2086760 OBDepict CH 3 N N H N H O N N H Cl IC50 = 0.85 nM 447.97 CCN1CCC(Nc2ccc3c(c2)C(=C(c2ccc(Cl)cc2)c2ncc[nH]2)C(=O)N3)CC1 Homo sapiens CHEMBL2089889 single protein format
CHEMBL4791998 OBDepict F N H O HN N O N NH ClH IC50 = 0.87 nM 443.91 Cl.O=C1Nc2ccc(F)cc2/C1=C1/Nc2ccccc2/C1=NOCCN1CCNCC1 Homo sapiens CHEMBL4768775 assay format
CHEMBL3923418 OBDepict CH 3 O N H N O O NH 2 N HN CH 3 H 3 C IC50 = 0.89 nM 445.52 COc1ccc(-c2nc(C(N)=O)c(-c3ccc(N4CCNC(C)(C)C4)cc3)o2)c2cc[nH]c12 Homo sapiens CHEMBL3887269 single protein format
CHEMBL4284541 OBDepict H 3 C NH N N N H H OH N N CH 3 IC50 = 0.9 nM 502.71 CCCCNc1ncc2c(-c3ccc(C4(N5CCN(C)CC5)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 Homo sapiens CHEMBL4276335 single protein format
CHEMBL1172815 OBDepict O HN N H N H CH 3 O N H IC50 = 0.9 nM 358.4 Cc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=Cc2ccc[nH]2)cc1 Homo sapiens CHEMBL1176709 single protein format
CHEMBL4160930 OBDepict CH 3 N N HN O N N NH H N H 3 C N S IC50 = 0.95 nM 448.56 Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(N3CCN(C)CC3)cc2)c2ccsc2n1 Homo sapiens CHEMBL4155885 single protein format
CHEMBL4059849 OBDepict H N N HN N H O N Cl N N O IC50 = 0.958 nM 463.93 O=C(Nc1ccc(CN2CCOCC2)cc1)c1n[nH]cc1Nc1nc(Cl)nc2ccccc12 Homo sapiens CHEMBL4059187 single protein format
CHEMBL3959866 OBDepict NH 2 O N O N N Cl H NH CH 3 CH 3 IC50 = 0.97 nM 449.94 CC1(C)CN(c2ccc(-c3oc(-c4ccc(Cl)c5[nH]ccc45)nc3C(N)=O)cc2)CCN1 Homo sapiens CHEMBL3887269 single protein format
CHEMBL4212560 OBDepict NH 2 NH N N N H N N N O IC50 = 1.0 nM 464.62 NCCCCNc1nc(Nc2ccc(CN3CCOCC3)cc2)c2ncn(C3CCCC3)c2n1 Homo sapiens CHEMBL4183761 cell-based format
CHEMBL1271480 OBDepict O N H N N N O N O IC50 < 1.0 nM 417.47 O=c1ccc(-c2cnn3cc(-c4ccc(OCCN5CCOCC5)cc4)cnc23)c[nH]1 Homo sapiens CHEMBL1272382 single protein format
CHEMBL478629 OBDepict N O N N N N IC50 < 1.0 nM 399.5 c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1 Homo sapiens CHEMBL1272382 single protein format
CHEMBL2071201 OBDepict H 3 C N N N H N N NH Br H H H O NH 2 H IC50 = 1.0 nM 404.27 Cn1cc(Nc2ncc(Br)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)cn1 Homo sapiens CHEMBL2073510 single protein format
CHEMBL256893 OBDepict CH 3 N N N H N N N O O H 2 N IC50 = 1.0 nM 509.61 CN1CCN(Cc2ccc(Nc3ncc4c(=O)c(C(N)=O)cn(-c5ccc6c(c5)CCC6)c4n3)cc2)CC1 Homo sapiens CHEMBL951153 single protein format
CHEMBL4867869 OBDepict CH 3 N O N NH N N N N H Ki = 1.0 nM 427.51 CC(=O)N1CCCN(c2cccc(Nc3nccc(-c4n[nH]c5ccccc45)n3)c2)CC1 Homo sapiens CHEMBL4815226 single protein format
CHEMBL1835746 OBDepict CH 3 O N H N N N H 2 N N N N H N H 3 C H 3 C Ki = 1.0 nM 369.43 COc1ccccc1Nc1nc(N)n(-c2cc(NCCN(C)C)ncn2)n1 Homo sapiens CHEMBL1840408 single protein format
CHEMBL4871011 OBDepict H 3 C N O N HN N N N N CH 3 Ki = 1.0 nM 441.54 CC(=O)N1CCCN(c2cccc(Nc3nccc(-c4cnc5n(C)cccc4-5)n3)c2)CC1 Homo sapiens CHEMBL4815226 single protein format
CHEMBL1835868 OBDepict CH 3 N N H N N N NH 2 N Ki < 1.0 nM 349.44 CN1CCC(c2cccc(Nc3nc(N)n(-c4ccccn4)n3)c2)CC1 Homo sapiens CHEMBL1840408 single protein format
CHEMBL1271533 OBDepict NH 2 N N N N O N O IC50 = 1.0 nM 416.49 Nc1cc(-c2cnn3cc(-c4ccc(OCCN5CCOCC5)cc4)cnc23)ccn1 Homo sapiens CHEMBL1272382 single protein format
CHEMBL235008 OBDepict H 3 C O N NH 2 N N N N N H O O IC50 = 1.0 nM 447.5 CO/N=C/c1c(N)ncnc1N1CCN(C(=O)Nc2ccc(Oc3ccccc3)cc2)CC1 Homo sapiens CHEMBL897762 single protein format
CHEMBL324153 OBDepict O N O N N N N IC50 = 1.0 nM 401.47 c1cc(-c2cnn3cc(-c4ccc(OCCN5CCOCC5)cc4)cnc23)ccn1 Homo sapiens CHEMBL1272382 single protein format
CHEMBL3237719 OBDepict HO N O N N H N N N H N H CH 3 IC50 = 1.0 nM 471.57 C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(C(=O)CO)C5)nc32)CC1 Homo sapiens CHEMBL3240326 single protein format
CHEMBL4451595 OBDepict O N F F F N N N H N N H N N CH 3 CH 3 IC50 = 1.0 nM 538.58 CN(C)c1cc(-c2ccc3nc(Nc4cc(CN5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ccn1 Homo sapiens CHEMBL4380524 cell-based format
CHEMBL3237708 OBDepict NH 2 N N N H N N N H N H H 3 C IC50 = 1.0 nM 456.6 C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc(N5CCC(N)CC5)cn4)nc32)CC1 Homo sapiens CHEMBL3240326 single protein format