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P36896 | ACV1B_HUMAN | Activin receptor type-1B (ACVR1B)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3260567 OBDepict H 3 C N N H N N H N N N F IC50 = 13.0 nM 399.43 Cc1cccc(-c2[nH]c(CNc3ccccc3F)nc2-c2ccc3ncnn3c2)n1 Homo sapiens CHEMBL3269163 single protein format
CHEMBL1829511 OBDepict CH 3 N CH 3 O N N N N H N IC50 = 18.0 nM 400.49 CN(C)CCCOc1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cn1 Homo sapiens CHEMBL1831614 cell-based format
CHEMBL492634 OBDepict H 3 C N N H N N N O NH 2 IC50 = 23.0 nM 420.48 Cc1cccc(-c2[nH]c(Cc3cccc(C(N)=O)c3)nc2-c2ccc3nccnc3c2)n1 Homo sapiens CHEMBL3269163 single protein format
CHEMBL3818173 OBDepict O N H N NH Cl O N O IC50 = 31.0 nM 332.75 O=C(Nc1cc(Nc2c(Cl)cnc3c2OCO3)ccn1)C1CC1 Homo sapiens CHEMBL3820166 assay format
CHEMBL424676 OBDepict CH 3 N H 3 C O N N N H N IC50 = 46.0 nM 385.47 CN(C)CCOc1ccc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cc1 Homo sapiens CHEMBL1831614 cell-based format
CHEMBL2024684 OBDepict H 3 C N N N N O N CH 3 IC50 = 59.0 nM 317.35 Cc1cccc(-n2nccc2-c2ccc3ncn(C)c(=O)c3c2)n1 Homo sapiens CHEMBL2026331 single protein format
CHEMBL226838 OBDepict H 3 C N N N H CH 3 CH 3 CH 3 O O IC50 = 70.0 nM 335.41 Cc1cccc(-c2[nH]c(C(C)(C)C)nc2-c2ccc3c(c2)OCO3)n1 Homo sapiens CHEMBL3269163 single protein format
CHEMBL4280731 OBDepict H 3 C NH O N N H N N O D D D IC50 < 100.0 nM 362.41 [2H]C([2H])([2H])Oc1ccc(-c2c(-c3ccnc(NC(C)=O)c3)[nH]c3cccnc23)nc1 Homo sapiens CHEMBL4270435 single protein format
CHEMBL4284170 OBDepict H 3 C NH O N N H N N F F IC50 < 100.0 nM 379.37 CC(=O)Nc1cc(-c2[nH]c3cccnc3c2-c2cccc(C(F)F)n2)ccn1 Homo sapiens CHEMBL4270435 single protein format
CHEMBL1829512 OBDepict CH 3 N N N N N N H N IC50 = 108.0 nM 397.49 CN1CCN(c2ccc(-c3cc(-c4c[nH]nc4-c4ccccn4)ccn3)cn2)CC1 Homo sapiens CHEMBL1831614 cell-based format
CHEMBL6250 OBDepict OH O N N H N O O IC50 = 158.0 nM 385.38 O=C(O)c1ccc(-c2nc(-c3ccc4c(c3)OCO4)c(-c3ccccn3)[nH]2)cc1 Homo sapiens CHEMBL4817029 single protein format
CHEMBL4550702 OBDepict CH 3 N N N N N S NH O F F F IC50 = 170.0 nM 406.39 Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479694 assay format
CHEMBL2385596 OBDepict CH 3 N N N N N N IC50 = 183.0 nM 420.52 CN1CCN(c2ccc(-c3cnc4c(-c5ccnc6ccccc56)cnn4c3)cc2)CC1 Homo sapiens CHEMBL2390523 single protein format
CHEMBL4742906 OBDepict CH 3 N N N NH HN IC50 = 192.0 nM 419.53 Cc1cc(-c2cnc3cc(-c4ccc(C5CNCCN5)cc4)ccn23)c2ccccc2n1 Homo sapiens CHEMBL4727756 single protein format
CHEMBL2364611 OBDepict CH 3 N N N N O NH 2 IC50 = 199.0 nM 369.43 Cc1cccc(-c2nn3c(c2-c2ccnc4ccc(C(N)=O)cc24)CCC3)n1 Homo sapiens CHEMBL3269163 single protein format
CHEMBL4569508 OBDepict O N H S F F F N N N O N IC50 = 200.0 nM 529.59 O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 Homo sapiens CHEMBL4479694 assay format
CHEMBL1828640 OBDepict H N N N N N N CH 3 IC50 = 224.0 nM 302.34 Cn1cc(-c2cc(-c3c[nH]nc3-c3ccccn3)ccn2)cn1 Homo sapiens CHEMBL1831614 cell-based format
CHEMBL513147 OBDepict HN N N N N N IC50 = 297.0 nM 406.49 c1ccc2c(-c3cnn4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1 Homo sapiens CHEMBL4328307 single protein format
CHEMBL2385582 OBDepict O N N N N N IC50 = 326.0 nM 407.48 c1ccc2c(-c3cnn4cc(-c5ccc(N6CCOCC6)cc5)cnc34)ccnc2c1 Homo sapiens CHEMBL2390523 single protein format
CHEMBL4778971 OBDepict F F N N H 3 C N N H N H IC50 = 390.0 nM 455.51 Cc1cc(-c2cnc3cc(-c4ccc(C5CNCCN5)cc4)ccn23)c2cc(F)cc(F)c2n1 Homo sapiens CHEMBL4727756 single protein format
CHEMBL4740381 OBDepict CH 3 N N N N HN IC50 = 464.0 nM 419.53 Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2ccccc2n1 Homo sapiens CHEMBL4727756 single protein format
CHEMBL4788859 OBDepict F N N H 3 C N N HN IC50 = 568.7 nM 437.52 Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2cc(F)ccc2n1 Homo sapiens CHEMBL4727756 single protein format
CHEMBL4786529 OBDepict F F N N H 3 C N N HN IC50 = 596.1 nM 455.51 Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2cc(F)cc(F)c2n1 Homo sapiens CHEMBL4727756 single protein format
CHEMBL4568087 OBDepict H 3 C N N N N N S N H O H H H 2 N IC50 = 730.0 nM 421.53 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479694 assay format
CHEMBL1829504 OBDepict H N N N N N N IC50 = 882.0 nM 288.31 c1ccc(-c2n[nH]cc2-c2ccnc(-n3cccn3)c2)nc1 Homo sapiens CHEMBL1831614 cell-based format
CHEMBL1829505 OBDepict H N N N N N N IC50 = 956.0 nM 288.31 c1ccc(-c2n[nH]cc2-c2ccnc(-n3ccnc3)c2)nc1 Homo sapiens CHEMBL1831614 cell-based format