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P38919 | IF4A3_HUMAN | Eukaryotic initiation factor 4A-III (EIF4A3)

3D structures mapped by conservation among orthologs

[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // DEAD ]

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[ Domain: "P-loop containing nucleoside triphosphate hydrolases" // Helicase_C_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4176393 OBDepict N O N H N O N O Cl Cl IC50 = 190.0 nM 557.44 N#Cc1cccc(-c2cc(C(=O)N3CCN(C(=O)c4ccc(Cl)cc4)C(c4ccc(Cl)cc4)C3)c[nH]c2=O)c1 Homo sapiens CHEMBL4140796 assay format
CHEMBL4073833 OBDepict N N N CH 3 N O N H O Cl Br IC50 = 260.0 nM 588.89 Cc1c(C(=O)N2CCN(C(=O)c3ccc(Br)cc3)[C@@H](c3ccc(Cl)cc3)C2)cnn1-c1cccc(C#N)c1 Homo sapiens CHEMBL4051066 assay format
CHEMBL4173010 OBDepict Cl H N N O O N H Br O IC50 = 290.0 nM 550.84 O=C(c1c[nH]c(=O)c2ccccc12)N1CCN(C(=O)c2ccc(Br)cc2)[C@@H](c2ccc(Cl)cc2)C1 Homo sapiens CHEMBL4140796 assay format
CHEMBL4172770 OBDepict Cl N N O O N H Cl O Cl IC50 = 290.0 nM 566.87 O=C(c1c[nH]c(=O)c(-c2cccc(Cl)c2)c1)N1CCN(C(=O)c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)C1 Homo sapiens CHEMBL4140796 assay format
CHEMBL4104965 OBDepict N N O N O N O Cl Br IC50 = 360.0 nM 575.85 N#Cc1cccc(-c2ncc(C(=O)N3CCN(C(=O)c4ccc(Br)cc4)C(c4ccc(Cl)cc4)C3)o2)c1 Homo sapiens CHEMBL4051066 assay format
CHEMBL4080736 OBDepict N N N O N O N O Cl Br IC50 = 390.0 nM 576.84 N#Cc1ccnc(-c2ncc(C(=O)N3CCN(C(=O)c4ccc(Br)cc4)C(c4ccc(Cl)cc4)C3)o2)c1 Homo sapiens CHEMBL4051066 assay format
CHEMBL4169616 OBDepict Cl N N O O N H Cl O IC50 = 410.0 nM 532.43 O=C(c1c[nH]c(=O)c(-c2ccccc2)c1)N1CCN(C(=O)c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)C1 Homo sapiens CHEMBL4140796 assay format
CHEMBL4164548 OBDepict Cl N N O O N H Cl O Cl IC50 = 420.0 nM 566.87 O=C(c1c[nH]c(=O)c(-c2ccccc2Cl)c1)N1CCN(C(=O)c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)C1 Homo sapiens CHEMBL4140796 assay format
CHEMBL4070102 OBDepict CH 3 CH 3 F Cl N H O HO Ki = 430.0 nM 255.68 CC(C)c1cc(Cl)c2cc(C(=O)O)[nH]c2c1F Homo sapiens CHEMBL4007301 assay format
CHEMBL4097260 OBDepict N N N CH 3 N O N O Cl Br IC50 = 580.0 nM 588.89 Cc1c(C(=O)N2CCN(C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)cc3)C2)cnn1-c1cccc(C#N)c1 Homo sapiens CHEMBL4051066 assay format
CHEMBL4087208 OBDepict N N O N O N O Cl Cl IC50 = 600.0 nM 531.4 N#Cc1cccc(-c2ncc(C(=O)N3CCN(C(=O)c4ccc(Cl)cc4)C(c4ccc(Cl)cc4)C3)o2)c1 Homo sapiens CHEMBL4051066 assay format
CHEMBL4070582 OBDepict Cl N N O O O N Br IC50 = 660.0 nM 550.84 O=C(c1cnc(-c2ccccc2)o1)N1CCN(C(=O)c2ccc(Br)cc2)C(c2ccc(Cl)cc2)C1 Homo sapiens CHEMBL4051066 assay format
CHEMBL4092418 OBDepict Cl N N O O N N Cl Br IC50 = 720.0 nM 558.26 O=C(c1cnn2cc(Br)ccc12)N1CCN(C(=O)c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)C1 Homo sapiens CHEMBL4051066 assay format
CHEMBL4071622 OBDepict Cl N N O O N N Cl Br IC50 = 830.0 nM 558.26 O=C(c1cnn2ccc(Br)cc12)N1CCN(C(=O)c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)C1 Homo sapiens CHEMBL4051066 assay format
CHEMBL4088472 OBDepict H 3 C O N N N O N O Cl Br IC50 = 920.0 nM 553.84 COc1ccc2c(C(=O)N3CCN(C(=O)c4ccc(Br)cc4)C(c4ccc(Cl)cc4)C3)cnn2c1 Homo sapiens CHEMBL4051066 assay format
CHEMBL4070102 OBDepict CH 3 CH 3 F Cl N H O HO IC50 = 970.0 nM 255.68 CC(C)c1cc(Cl)c2cc(C(=O)O)[nH]c2c1F Homo sapiens CHEMBL4007297 assay format