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P39748 | FEN1_HUMAN | Flap endonuclease 1 (FEN1)

3D structures mapped by conservation among orthologs

[ Domain: "SAM domain-like" // 5_3_exonuc_1 ]

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[ Domain: "PIN domain-like" // XPG_I ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL181962 OBDepict NH 2 O N O N S HO O IC50 = 0.003 nM 393.42 NC(=O)c1ccc(-c2cccc(Cn3c(=O)n(O)c(=O)c4sccc43)c2)cc1 Homo sapiens CHEMBL827838 single protein format
CHEMBL182077 OBDepict H 3 C NH O N O N S OH O IC50 = 0.004 nM 407.45 CC(=O)Nc1cccc(-c2cccc(Cn3c(=O)n(O)c(=O)c4sccc43)c2)c1 Homo sapiens CHEMBL827838 single protein format
CHEMBL362842 OBDepict H N S O N OH O IC50 = 0.009 nM 238.27 O=c1[nH]c2sc3c(c2c(=O)n1O)CCCC3 Homo sapiens CHEMBL827838 single protein format
CHEMBL361962 OBDepict O N N OH H O S S O O IC50 = 0.01 nM 324.34 O=c1[nH]c2c(S(=O)(=O)c3ccccc3)csc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL361546 OBDepict OH N O N O S O O IC50 = 0.011 nM 332.34 O=c1c2sccc2n(CC2COc3ccccc3O2)c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL361011 OBDepict O N N H OH O S IC50 = 0.012 nM 260.27 O=c1[nH]c2c(-c3ccccc3)csc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL183792 OBDepict H 3 C S O N N OH H O IC50 = 0.014 nM 198.2 Cc1csc2[nH]c(=O)n(O)c(=O)c12 Homo sapiens CHEMBL827838 single protein format
CHEMBL182687 OBDepict Cl N O N H OH O IC50 = 0.014 nM 212.59 O=c1[nH]c2cccc(Cl)c2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL182519 OBDepict CH 3 O O O N S O N HO H 3 C O IC50 = 0.018 nM 362.36 COc1cc(Cn2c(=O)n(O)c(=O)c3c(C)csc32)cc2c1OCO2 Homo sapiens CHEMBL827838 single protein format
CHEMBL364591 OBDepict O N N H OH O O IC50 = 0.023 nM 320.3 O=c1[nH]c2c(-c3ccc(-c4ccccc4)cc3)coc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL361350 OBDepict OH N O O N H S IC50 = 0.025 nM 184.18 O=c1[nH]c2sccc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL181709 OBDepict CH 3 S N O N OH O IC50 = 0.028 nM 288.33 Cc1csc2c1c(=O)n(O)c(=O)n2Cc1ccccc1 Homo sapiens CHEMBL827838 single protein format
CHEMBL185325 OBDepict H 3 C O O N H O N O OH IC50 = 0.031 nM 274.23 COc1cccc(-c2coc3c(=O)n(O)c(=O)[nH]c23)c1 Homo sapiens CHEMBL827838 single protein format
CHEMBL359747 OBDepict CH 3 O O N H O N O HO IC50 = 0.034 nM 274.23 COc1ccc(-c2coc3c(=O)n(O)c(=O)[nH]c23)cc1 Homo sapiens CHEMBL827838 single protein format
CHEMBL362205 OBDepict CH 3 O N O N S OH O H 3 C IC50 = 0.035 nM 304.33 COc1ccc(-n2c(=O)n(O)c(=O)c3c(C)csc32)cc1 Homo sapiens CHEMBL827838 single protein format
CHEMBL183133 OBDepict O N N H HO O O IC50 = 0.038 nM 258.23 O=c1[nH]c2c(Cc3ccccc3)coc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL359533 OBDepict H N O N S HO O IC50 = 0.043 nM 234.24 O=c1[nH]c2c(sc3ccccc32)c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL185322 OBDepict Br N O N OH S O IC50 = 0.072 nM 353.2 O=c1c2sccc2n(Cc2cccc(Br)c2)c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL180566 OBDepict Br O N H O N O OH IC50 = 0.076 nM 323.1 O=c1[nH]c2c(-c3ccc(Br)cc3)coc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL183852 OBDepict H N O N OH O IC50 = 0.079 nM 178.15 O=c1[nH]c2ccccc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL182381 OBDepict CH 3 O N H O N O HO IC50 = 0.082 nM 258.23 Cc1ccc(-c2coc3c(=O)n(O)c(=O)[nH]c23)cc1 Homo sapiens CHEMBL827838 single protein format
CHEMBL360615 OBDepict H N O N S HO O CH 3 CH 3 CH 3 IC50 = 0.135 nM 240.28 CC(C)(C)c1cc2[nH]c(=O)n(O)c(=O)c2s1 Homo sapiens CHEMBL827838 single protein format
CHEMBL183539 OBDepict O N N H OH O O IC50 = 0.143 nM 244.21 O=c1[nH]c2c(-c3ccccc3)coc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL183062 OBDepict H N O N S OH O IC50 = 0.146 nM 260.27 O=c1[nH]c2cc(-c3ccccc3)sc2c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL182974 OBDepict OH N O N O S IC50 = 0.23 nM 274.3 O=c1c2ccsc2n(Cc2ccccc2)c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL181766 OBDepict H N O N O HO O IC50 = 0.285 nM 218.17 O=c1[nH]c2c(oc3ccccc32)c(=O)n1O Homo sapiens CHEMBL827838 single protein format
CHEMBL181637 OBDepict CH 3 S N O N CH 3 HO O IC50 = 0.338 nM 212.23 Cc1csc2c1c(=O)n(O)c(=O)n2C Homo sapiens CHEMBL827838 single protein format
CHEMBL181907 OBDepict NH 2 O N O N CH 3 S OH O IC50 = 1.08 nM 407.45 Cc1csc2c(=O)n(O)c(=O)n(Cc3cccc(-c4ccc(C(N)=O)cc4)c3)c12 Homo sapiens CHEMBL827838 single protein format
CHEMBL3617199 OBDepict CH 3 NH O N H O N O OH IC50 = 38.0 nM 235.2 CC(=O)Nc1cccc2c(=O)n(O)c(=O)[nH]c12 Homo sapiens CHEMBL3619485 single protein format
CHEMBL182748 OBDepict CH 3 O Cl O O O HO IC50 = 190.0 nM 332.74 COc1ccc(-c2ccc(Cl)c(C(=O)CC(=O)C(=O)O)c2)cc1 Homo sapiens CHEMBL829355 single protein format
CHEMBL3617197 OBDepict O N N H OH O N H IC50 = 230.0 nM 269.26 O=c1[nH]c2cc(Nc3ccccc3)ccc2c(=O)n1O Homo sapiens CHEMBL3619485 single protein format
CHEMBL1207029 OBDepict HO N O O IC50 = 300.0 nM 213.19 O=C1c2cccc3cccc(c23)C(=O)N1O Homo sapiens CHEMBL3619485 single protein format
CHEMBL188067 OBDepict OH O O O Cl IC50 = 330.0 nM 302.71 O=C(O)C(=O)CC(=O)c1cc(-c2ccccc2)ccc1Cl Homo sapiens CHEMBL829355 single protein format
CHEMBL183257 OBDepict Cl Cl O O O OH IC50 = 410.0 nM 337.16 O=C(O)C(=O)CC(=O)c1ccc(-c2ccc(Cl)cc2)cc1Cl Homo sapiens CHEMBL829355 single protein format
CHEMBL182756 OBDepict HO O O O S O F F F IC50 = 440.0 nM 358.29 O=C(O)C(=O)CC(=O)c1ccc(-c2ccc(OC(F)(F)F)cc2)s1 Homo sapiens CHEMBL829355 single protein format
CHEMBL361960 OBDepict O S O O OH F Cl IC50 = 570.0 nM 326.73 O=C(O)C(=O)CC(=O)c1ccc(-c2ccc(Cl)c(F)c2)s1 Homo sapiens CHEMBL829355 single protein format
CHEMBL3617203 OBDepict O N OH N O H IC50 = 630.0 nM 204.19 O=c1cc(-c2ccccc2)[nH]c(=O)n1O Homo sapiens CHEMBL3619485 single protein format
CHEMBL1415852 OBDepict OH N O O Cl IC50 = 700.0 nM 247.64 O=C1c2cccc3c(Cl)ccc(c23)C(=O)N1O Homo sapiens CHEMBL3619485 single protein format