HOME LIGAND hPROTEOME OTHERS DOCUMENT

P40337 | VHL_HUMAN | von Hippel-Lindau disease tumor suppressor (VHL)

3D structures mapped by conservation among orthologs

[ Domain: "Prealbumin-like" // VHL ]

download pymol session

[ Domain: "SOCS box-like" // VHL_C ]

download pymol session



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4225537 OBDepict H N H H 3 C H 3 C CH 3 N O O H H HO NH O N S H 3 C N IC50 = 88.0 nM 523.66 Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(C#N)CC2)C(C)(C)C)cc1 Homo sapiens CHEMBL4620018 single protein format
CHEMBL3683782 OBDepict N N N O N H N CH 3 IC50 = 180.0 nM 277.29 Cc1ccnc(-n2[nH]cc(-c3ccc(C#N)nc3)c2=O)c1 Homo sapiens CHEMBL3705901 single protein format
CHEMBL3344081 OBDepict CH 3 N H O H H 3 C H 3 C CH 3 N O H H OH NH O S H 3 C N IC50 = 185.0 nM 472.61 CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C Homo sapiens CHEMBL4620018 single protein format
CHEMBL3683779 OBDepict H N N N O N IC50 = 430.0 nM 238.25 O=c1c(-c2cccnc2)c[nH]n1-c1ccccn1 Homo sapiens CHEMBL3705901 single protein format
CHEMBL3683785 OBDepict O N H N N N H O N IC50 = 700.0 nM 385.43 O=C(Cc1ccccc1)NCc1ccnc(-n2[nH]cc(-c3cccnc3)c2=O)c1 Homo sapiens CHEMBL3705901 single protein format
CHEMBL3683781 OBDepict H 3 C N N O N H N IC50 = 760.0 nM 252.28 Cc1ncccc1-c1c[nH]n(-c2ccccn2)c1=O Homo sapiens CHEMBL3705901 single protein format
CHEMBL3683780 OBDepict OH N N N H O N IC50 = 860.0 nM 268.28 O=c1c(-c2cccnc2)c[nH]n1-c1ccc(CO)cn1 Homo sapiens CHEMBL3705901 single protein format
CHEMBL3260851 OBDepict O N H H N H HO O CH 3 H 2 N S H 3 C N IC50 = 900.0 nM 450.56 Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)c2cccc(N)c2C)cc1 Homo sapiens CHEMBL4396993 single protein format