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P41182 | BCL6_HUMAN | B-cell lymphoma 6 protein (BCL6)

3D structures mapped by conservation among orthologs

[ Domain: "POZ domain" // BTB ]

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[ Domain: "beta-beta-alpha zinc fingers" // zf-C2H2_16 ]

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[ Domain: "beta-beta-alpha zinc fingers" // zf-C2H2_15 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4090962 OBDepict OH H N H O N N H N N Cl O N H O IC50 = 1.5 nM 496.96 O=C1CCc2cc3cc(c2N1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 Homo sapiens CHEMBL4015778 assay format
CHEMBL4066850 OBDepict N N N N N N H H H O O HO O N H O IC50 = 1.7 nM 515.53 N#Cc1cnn2c3cc(nc12)N1C[C@H](C[C@H]1CC(=O)O)OC/C=C/COc1cc(cc2c1NC(=O)CC2)N3 Homo sapiens CHEMBL4015778 assay format
CHEMBL4093418 OBDepict N N N N N N H H H O OH O N H O IC50 = 2.4 nM 489.54 N#Cc1cnn2c3cc(nc12)N1C[C@H](C[C@H]1CO)OCCCCOc1cc(cc2c1NC(=O)CC2)N3 Homo sapiens CHEMBL4015778 assay format
CHEMBL4094351 OBDepict N N N N N N H H H O OH O N H O IC50 = 2.9 nM 487.52 N#Cc1cnn2c3cc(nc12)N1C[C@H](C[C@H]1CO)OC/C=C/COc1cc(cc2c1NC(=O)CC2)N3 Homo sapiens CHEMBL4015778 assay format
CHEMBL4795171 OBDepict H 3 C NH O O O N CH 3 N H O H 3 C N Cl N N H H 3 C H CH 3 IC50 = 3.0 nM 515.01 CNC(=O)COc1cc2cc(Nc3nc(N4C[C@@H](C)C[C@@H](C)C4)ncc3Cl)cc(OC)c2n(C)c1=O Homo sapiens CHEMBL4668330 cell-based format
CHEMBL4755229 OBDepict H 3 C NH O O O N CH 3 N H O H 3 C N Cl N N N O CH 3 H 3 C IC50 = 3.0 nM 558.04 CNC(=O)COc1cc2cc(Nc3nc(N4CCC(C(=O)N(C)C)CC4)ncc3Cl)cc(OC)c2n(C)c1=O Homo sapiens CHEMBL4668330 cell-based format
CHEMBL4101172 OBDepict OH H N H O N N H N N Cl O N H O IC50 = 3.3 nM 498.97 O=C1CCc2cc3cc(c2N1)OCCCCO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 Homo sapiens CHEMBL4015778 assay format
CHEMBL4063061 OBDepict HO H N H O N HN N N Cl O N CH 3 O IC50 = 4.9 nM 510.98 CN1C(=O)CCc2cc3cc(c21)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 Homo sapiens CHEMBL4015778 assay format
CHEMBL4062105 OBDepict HO H N H O N N H N N Cl O N O N IC50 = 9.9 nM 588.07 O=C1CCc2cc3cc(c2N1Cc1ccncc1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 Homo sapiens CHEMBL4015778 assay format
CHEMBL4064865 OBDepict HO H N H O N N H N N Cl O N O IC50 = 11.0 nM 587.08 O=C1CCc2cc3cc(c2N1Cc1ccccc1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 Homo sapiens CHEMBL4015778 assay format
CHEMBL4093431 OBDepict N N N N N N H H O O N H O IC50 = 15.0 nM 457.49 N#Cc1cnn2c3cc(nc12)N1CC[C@@H](C1)OC/C=C/COc1cc(cc2c1NC(=O)CC2)N3 Homo sapiens CHEMBL4015778 assay format
CHEMBL4085689 OBDepict N N N N N N H H O O N H O IC50 = 24.0 nM 459.51 N#Cc1cnn2c3cc(nc12)N1CC[C@@H](C1)OCCCCOc1cc(cc2c1NC(=O)CC2)N3 Homo sapiens CHEMBL4015778 assay format
CHEMBL4448503 OBDepict N N N N N HN CH 3 O N H CH 3 CH 3 O IC50 = 25.0 nM 445.53 C[C@@H]1CCCCN(C)c2cc(n3ncc(C#N)c3n2)Nc2cc3c(c(c2)O1)N(C)C(=O)CC3 Homo sapiens CHEMBL4336433 single protein format
CHEMBL4078747 OBDepict OH H N H O N N H N N Cl O N O IC50 = 36.0 nM 551.05 O=C1CCc2cc3cc(c2N1CC1CC1)OC/C=C/CO[C@H]1C[C@@H](CO)N(C1)c1cc(n2ncc(Cl)c2n1)N3 Homo sapiens CHEMBL4015778 assay format
CHEMBL4083173 OBDepict OH H N H O N N H N N O N H O IC50 = 55.0 nM 464.53 O=C1CCc2cc3cc(c2N1)OCCCCO[C@H]1C[C@@H](CO)N(C1)c1cc(n2nccc2n1)N3 Homo sapiens CHEMBL4015778 assay format
CHEMBL4559074 OBDepict HO N F F N N N H Cl N N H 3 C O OH H 3 C H 3 C IC50 = 86.0 nM 510.97 Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCC(F)(F)C(CO)C4)ncc3Cl)ccc21 Homo sapiens CHEMBL4345696 assay format
CHEMBL4574515 OBDepict Cl N NH N N N H 3 C CH 3 O H 3 C H 3 C N H 3 C O OH CH 3 CH 3 IC50 = 97.0 nM 503.05 Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CC(C)(C)OC(C)(C)C4)ncc3Cl)ccc21 Homo sapiens CHEMBL4345696 assay format
CHEMBL4465387 OBDepict OH N N N N H Cl N N CH 3 O HO CH 3 CH 3 IC50 = 130.0 nM 474.99 Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCCC(CO)C4)ncc3Cl)ccc21 Homo sapiens CHEMBL4345696 assay format
CHEMBL4476234 OBDepict Cl N N H N N N H H 3 C O H H 3 C N CH 3 O HO H 3 C CH 3 IC50 = 150.0 nM 474.99 C[C@H]1CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)C[C@@H](C)O1 Homo sapiens CHEMBL4345696 assay format
CHEMBL4646073 OBDepict CH 3 NH O O O N H 3 C NH O H 3 C N Cl N NH S O O F IC50 = 152.0 nM 591.02 CNC(=O)COc1cc2cc(Nc3nc(NCc4cccc(S(=O)(=O)F)c4)ncc3Cl)cc(OC)c2n(C)c1=O Homo sapiens CHEMBL4619130 cell-based format
CHEMBL4517433 OBDepict N N N N N N H H 3 C O N CH 3 O IC50 = 190.0 nM 431.5 CN1CCCCCOc2cc(cc3c2N(C)C(=O)CC3)Nc2cc1nc1c(C#N)cnn21 Homo sapiens CHEMBL4336433 single protein format
CHEMBL4458261 OBDepict CH 3 N H H 3 C H CH 3 N N N N H Cl N N H 3 C O OH CH 3 H 3 C IC50 = 190.0 nM 488.04 C[C@H]1CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)C[C@@H](C)N1C Homo sapiens CHEMBL4345696 assay format
CHEMBL4573672 OBDepict H 3 C O N F F N N NH Cl N N CH 3 O HO H 3 C H 3 C IC50 = 200.0 nM 525.0 COCC1CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)CCC1(F)F Homo sapiens CHEMBL4345696 assay format
CHEMBL4072708 OBDepict N N N N N HN H O N H O N H O IC50 = 210.0 nM 472.51 N#Cc1cnn2c3cc(nc12)N1CCC[C@@H]1CC(=O)NCCOc1cc(cc2c1NC(=O)CC2)N3 Homo sapiens CHEMBL4015778 assay format
CHEMBL4524719 OBDepict Cl N N H N N N N F F H 3 C O HO CH 3 CH 3 IC50 = 230.0 nM 506.99 Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4C5CCC4CC(F)(F)C5)ncc3Cl)ccc21 Homo sapiens CHEMBL4345696 assay format
CHEMBL4640734 OBDepict O HN N H N Cl N N H S O O F IC50 = 251.0 nM 447.88 O=C1Cc2cc(Nc3nc(NCc4cccc(S(=O)(=O)F)c4)ncc3Cl)ccc2N1 Homo sapiens CHEMBL4619130 cell-based format
CHEMBL4451702 OBDepict CH 3 N N CH 3 N N N H Cl N N H 3 C O OH CH 3 H 3 C IC50 = 260.0 nM 455.95 Cc1cc(C)n(-c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)n1 Homo sapiens CHEMBL4345696 assay format
CHEMBL4463841 OBDepict Cl N N H N N N O N CH 3 O OH CH 3 CH 3 IC50 = 270.0 nM 446.94 Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCOCC4)ncc3Cl)ccc21 Homo sapiens CHEMBL4345696 assay format
CHEMBL4587209 OBDepict Cl N NH N N N N F F H 3 C O OH CH 3 CH 3 IC50 = 310.0 nM 480.95 Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCC(F)(F)CC4)ncc3Cl)ccc21 Homo sapiens CHEMBL4345696 assay format
CHEMBL4439574 OBDepict CH 3 N F F N N HN Cl N N H 3 C O OH CH 3 CH 3 IC50 = 330.0 nM 494.97 CC1CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)CCC1(F)F Homo sapiens CHEMBL4345696 assay format
CHEMBL4061857 OBDepict N N N N N N H H O OH N H O IC50 = 350.0 nM 431.46 N#Cc1cnn2c(Nc3ccc4c(c3)CCC(=O)N4)cc(N3CCC[C@H]3CC(=O)O)nc12 Homo sapiens CHEMBL4015778 assay format
CHEMBL4644523 OBDepict CH 3 NH O O O N H 3 C NH O H 3 C N Cl N NH S O O H 3 C IC50 = 368.0 nM 587.06 CNC(=O)COc1cc2cc(Nc3nc(NCc4cccc(S(C)(=O)=O)c4)ncc3Cl)cc(OC)c2n(C)c1=O Homo sapiens CHEMBL4619130 cell-based format
CHEMBL4077836 OBDepict N N N N N N H H HO N H O IC50 = 370.0 nM 403.45 N#Cc1cnn2c(Nc3ccc4c(c3)CCC(=O)N4)cc(N3CCC[C@H]3CO)nc12 Homo sapiens CHEMBL4015778 assay format
CHEMBL4072699 OBDepict N N N N N NH H H O OH O IC50 = 390.0 nM 418.46 N#Cc1cnn2c3cc(nc12)N1C[C@H](C[C@H]1CO)OC/C=C/COc1cccc(c1)N3 Homo sapiens CHEMBL4015778 assay format
CHEMBL4466680 OBDepict N N N N HN Cl N N H 3 C O OH H 3 C H 3 C IC50 = 390.0 nM 469.98 Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCCC(C#N)C4)ncc3Cl)ccc21 Homo sapiens CHEMBL4345696 assay format
CHEMBL4482923 OBDepict Cl N NH N N N N F F F H 3 C O OH CH 3 CH 3 IC50 = 400.0 nM 512.96 Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCCC(C(F)(F)F)C4)ncc3Cl)ccc21 Homo sapiens CHEMBL4345696 assay format
CHEMBL4583696 OBDepict H 3 C N N N N N H Cl N N CH 3 O HO H 3 C CH 3 IC50 = 400.0 nM 441.92 Cc1ccn(-c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)n1 Homo sapiens CHEMBL4345696 assay format
CHEMBL4450499 OBDepict Cl N N H N N N CH 3 N N H 3 C O OH CH 3 H 3 C IC50 = 430.0 nM 441.92 Cc1ccnn1-c1ncc(Cl)c(Nc2ccc3c(c2)n(CCC(C)(C)O)c(=O)n3C)n1 Homo sapiens CHEMBL4345696 assay format
CHEMBL4538610 OBDepict H 3 C O N H HN O N S F N N H H 3 C HN H H 3 C IC50 = 470.0 nM 522.65 COc1cc(Nc2nc(N3C[C@H](C)N[C@H](C)C3)ncc2F)ccc1NC(=O)c1ccc(C2=CCCC2)s1 Homo sapiens CHEMBL4380816 cell-based format
CHEMBL4077392 OBDepict O N H NH N Cl N N H N IC50 = 480.0 nM 366.81 O=C1Cc2cc(Nc3nc(NCc4cccnc4)ncc3Cl)ccc2N1 Homo sapiens CHEMBL4052325 single protein format
CHEMBL4475529 OBDepict Cl N N H N N N CH 3 N N H 3 C O OH CH 3 H 3 C IC50 = 480.0 nM 441.92 Cn1ccnc1-c1ncc(Cl)c(Nc2ccc3c(c2)n(CCC(C)(C)O)c(=O)n3C)n1 Homo sapiens CHEMBL4345696 assay format
CHEMBL4456817 OBDepict H 3 C O N H HN O N S F N N O H H 3 C HN H H 3 C IC50 = 520.0 nM 522.61 COc1cc(Nc2nc(N3C[C@H](C)N[C@H](C)C3)ncc2F)ccc1NC(=O)c1ccc(-c2ccoc2)s1 Homo sapiens CHEMBL4380816 cell-based format
CHEMBL4445645 OBDepict Cl N N H N N N H H 3 C H H 3 C N F F CH 3 O HO H 3 C CH 3 IC50 = 520.0 nM 509.0 C[C@H]1CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)C[C@@H](C)C1(F)F Homo sapiens CHEMBL4345696 assay format
CHEMBL4061037 OBDepict N N N N N N H H HO N H O IC50 = 590.0 nM 403.45 N#Cc1cnn2c(Nc3ccc4c(c3)CCC(=O)N4)cc(N3CCC[C@@H]3CO)nc12 Homo sapiens CHEMBL4015778 assay format
CHEMBL4459012 OBDepict CH 3 N N N HN Cl N N H 3 C O OH CH 3 CH 3 IC50 = 640.0 nM 458.99 CC1CCCN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)C1 Homo sapiens CHEMBL4345696 assay format
CHEMBL4483413 OBDepict CH 3 S N N N H Cl N N H 3 C O OH H 3 C H 3 C IC50 = 680.0 nM 407.93 CSc1ncc(Cl)c(Nc2ccc3c(c2)n(CCC(C)(C)O)c(=O)n3C)n1 Homo sapiens CHEMBL4345696 assay format
CHEMBL4525209 OBDepict Cl N N H N N N N F F H 3 C O HO CH 3 CH 3 IC50 = 710.0 nM 506.99 Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CC5CCC(C4)C5(F)F)ncc3Cl)ccc21 Homo sapiens CHEMBL4345696 assay format
CHEMBL4548894 OBDepict Cl N N H N N N N N H 3 C O HO H 3 C H 3 C IC50 = 710.0 nM 427.9 Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(-n4cccn4)ncc3Cl)ccc21 Homo sapiens CHEMBL4345696 assay format
CHEMBL4547183 OBDepict Cl N N H N N N H CH 3 H CH 3 N H 3 C O OH CH 3 H 3 C IC50 = 760.0 nM 473.02 C[C@H]1C[C@@H](C)CN(c2ncc(Cl)c(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)n2)C1 Homo sapiens CHEMBL4345696 assay format
CHEMBL4446667 OBDepict H 3 C O Cl NH N F N N H CH 3 HN H H 3 C IC50 = 770.0 nM 365.84 COc1ccc(Nc2nc(N3C[C@H](C)N[C@H](C)C3)ncc2F)cc1Cl Homo sapiens CHEMBL4380816 cell-based format
CHEMBL4467613 OBDepict CH 3 N N H 3 C N N H Cl N N H 3 C O HO H 3 C CH 3 IC50 = 790.0 nM 454.96 Cc1cc(C)n(-c2cc(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)c(Cl)cn2)n1 Homo sapiens CHEMBL4345696 assay format
CHEMBL4530646 OBDepict OH HN N N N H F Cl O CH 3 IC50 = 860.0 nM 326.76 COc1ccc(Nc2nc(NCCCO)ncc2F)cc1Cl Homo sapiens CHEMBL4380816 cell-based format
CHEMBL4572689 OBDepict N N H Cl N N N H 3 C O HO CH 3 CH 3 IC50 = 860.0 nM 385.86 Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3ccnc(Cl)c3C#N)ccc21 Homo sapiens CHEMBL4345696 assay format
CHEMBL4445208 OBDepict CH 3 O Cl N H N F N NH N H 3 C IC50 = 890.0 nM 365.84 COc1ccc(Nc2nc(NC3CCN(C)CC3)ncc2F)cc1Cl Homo sapiens CHEMBL4380816 cell-based format
CHEMBL4475438 OBDepict Cl N N H N N H CH 3 O H H 3 C N CH 3 O HO H 3 C CH 3 IC50 = 930.0 nM 474.01 C[C@H]1CN(c2cc(Nc3ccc4c(c3)n(CCC(C)(C)O)c(=O)n4C)c(Cl)cn2)C[C@@H](C)O1 Homo sapiens CHEMBL4345696 assay format
CHEMBL4457011 OBDepict Cl N NH N N N N H 3 C O F F F OH CH 3 CH 3 IC50 = 960.0 nM 512.96 Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCC(C(F)(F)F)CC4)ncc3Cl)ccc21 Homo sapiens CHEMBL4345696 assay format
CHEMBL4527835 OBDepict H 3 C O Cl NH N F N N HN IC50 = 980.0 nM 337.79 COc1ccc(Nc2nc(N3CCNCC3)ncc2F)cc1Cl Homo sapiens CHEMBL4380816 cell-based format
CHEMBL4451202 OBDepict Cl N N H N N CH 3 O OH H 3 C H 3 C IC50 = 990.0 nM 360.85 Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3ccncc3Cl)ccc21 Homo sapiens CHEMBL4345696 assay format
CHEMBL4469177 OBDepict Cl N N H N N N N CH 3 O OH CH 3 CH 3 IC50 = 1000.0 nM 444.97 Cn1c(=O)n(CCC(C)(C)O)c2cc(Nc3nc(N4CCCCC4)ncc3Cl)ccc21 Homo sapiens CHEMBL4345696 assay format