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P41240 | CSK_HUMAN | Tyrosine-protein kinase CSK (CSK)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: "SH2" // SH2 ]

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[ Domain: "SH3" // SH3_1 ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4859660 OBDepict NH 2 N F + N O NH O _ O IC50 = -4500.0 nM 378.36 Nc1ncc(-c2cccc([N+](=O)[O-])c2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804372 cell-based format
CHEMBL1421 OBDepict HO N N N N N H CH 3 N S N H O H 3 C Cl IC50 = 1.3 nM 488.02 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL4412234 single protein format
CHEMBL591325 OBDepict H 3 C N CH 3 O N H N N O H 2 N O IC50 = 1.7 nM 483.57 CN(C)CCOc1ccc2c(c1)CCn1nc(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c1N2 Homo sapiens CHEMBL1049479 single protein format
CHEMBL1873475 OBDepict CH 2 N O H N N N N H 2 N O IC50 = 2.2 nM 440.51 C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL3887546 single protein format
CHEMBL3647967 OBDepict CH 2 HN O H H N N N N H 2 N O IC50 = 2.4 nM 454.53 C=CC(=O)N[C@H]1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 Homo sapiens CHEMBL3887546 single protein format
CHEMBL4577049 OBDepict O N N H H 3 C H 3 C CH 3 N N N H O CH 3 N H O N N IC50 = 4.0 nM 592.7 Cc1cc(NC(=O)c2nn(C3CCN(C(=O)NC(C)(C)C)CC3)c3ccccc23)ccc1NC(=O)c1cnn2ccccc12 Homo sapiens CHEMBL4308764 single protein format
CHEMBL589630 OBDepict NH 2 O NH 2 N H O F F O IC50 = 4.5 nM 433.41 NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)[nH]c(C(=O)c2c(F)cccc2F)c1N Homo sapiens CHEMBL1049492 single protein format
CHEMBL4437906 OBDepict CH 3 NH N N CH 3 O H CH 3 N O N N N H O CH 3 H 3 C CH 3 IC50 = 8.0 nM 569.71 CCc1cc(NC(=O)c2nn(C3CCN(C(=O)NC(C)(C)C)CC3)c3ccccc23)ccc1-c1n[nH]c(=O)c(C)c1C Homo sapiens CHEMBL4308759 single protein format
CHEMBL4798527 OBDepict H 3 C N H N O N NH 2 N N H CH 3 F F F H HO IC50 = 9.0 nM 548.57 Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 Homo sapiens CHEMBL4766170 single protein format
CHEMBL1171837 OBDepict H 3 C N N F F F N H O CH 3 N N N IC50 = 12.7 nM 532.57 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 Homo sapiens CHEMBL4721775 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 14.3 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328378 single protein format
CHEMBL4483095 OBDepict O N N H H 3 C H 3 C CH 3 N N N H O N H O N N IC50 = 26.0 nM 578.68 CC(C)(C)NC(=O)N1CCC(n2nc(C(=O)Nc3ccc(NC(=O)c4cnn5ccccc45)cc3)c3ccccc32)CC1 Homo sapiens CHEMBL4308759 single protein format
CHEMBL47203 OBDepict H 3 C N N H H N N N NH 2 O IC50 = 41.0 nM 482.63 CN1CCN([C@H]2CC[C@@H](n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 Homo sapiens CHEMBL814626 single protein format
CHEMBL4469360 OBDepict CH 3 O N N N H O CH 3 N H O N N H 3 C IC50 = 42.0 nM 454.49 COc1ccc2c(C(=O)Nc3ccc(NC(=O)c4nn(C)c5ccccc45)cc3C)cnn2c1 Homo sapiens CHEMBL4308759 single protein format
CHEMBL288441 OBDepict CH 3 O O N N H N N Cl O H 3 C Cl N CH 3 IC50 = 63.0 nM 530.46 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl Homo sapiens CHEMBL1244342 single protein format
CHEMBL4591137 OBDepict CH 3 NH N N CH 3 O H N O N N N H O CH 3 H 3 C CH 3 IC50 = 70.0 nM 555.68 CCc1cc(NC(=O)c2nn(C3CCN(C(=O)NC(C)(C)C)CC3)c3ccccc23)ccc1-c1n[nH]c(=O)cc1C Homo sapiens CHEMBL4308759 single protein format
CHEMBL4555519 OBDepict O N N H CH 3 CH 3 CH 3 N N N H O Cl N N H O IC50 = 79.0 nM 548.05 CC(C)(C)NC(=O)N1CCC(n2nc(C(=O)Nc3ccc(-c4ccc(=O)[nH]n4)c(Cl)c3)c3ccccc32)CC1 Homo sapiens CHEMBL4308759 single protein format
CHEMBL4518970 OBDepict O N N H CH 3 CH 3 CH 3 N N N H O Cl N N CH 3 H O IC50 = 80.0 nM 562.07 Cc1cc(=O)[nH]nc1-c1ccc(NC(=O)c2nn(C3CCN(C(=O)NC(C)(C)C)CC3)c3ccccc23)cc1Cl Homo sapiens CHEMBL4308759 single protein format
CHEMBL1762530 OBDepict HO N CH 3 CH 3 N N N H N N O O IC50 = 80.0 nM 490.61 Cc1ccc(CO)cc1N(C)c1ccnc(Nc2cc(N3CCOCC3)cc(N3CCOCC3)c2)n1 Homo sapiens CHEMBL1763678 single protein format
CHEMBL4868141 OBDepict H 2 N N O O HN NH S O O IC50 = 100.0 nM 532.67 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2OC2CCCCC2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804372 cell-based format
CHEMBL4106978 OBDepict O N H H N N N H 2 N HN O N F F F IC50 = 162.0 nM 535.53 Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 Homo sapiens CHEMBL4727420 single protein format
CHEMBL460472 OBDepict CH 3 O N O N N H O CH 3 N O N OH CH 3 H 3 C IC50 = 165.0 nM 539.59 COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1 Homo sapiens CHEMBL985579 single protein format
CHEMBL4862806 OBDepict CH 3 N N N H 2 N CH 3 NH O F F F F F F IC50 = 187.0 nM 543.47 Cc1ccc(C(=O)Nc2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1C#Cc1cc(-c2cnn(C)c2)cnc1N Homo sapiens CHEMBL4839605 single protein format
CHEMBL4103954 OBDepict O N H CH 3 H N N N H 2 N F HN O N F F F IC50 = 201.0 nM 581.57 C[C@H]1CC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CN1C(=O)C1CC1 Homo sapiens CHEMBL4717039 single protein format
CHEMBL4114929 OBDepict CH 3 O N N H O N H 2 N N N H N F F F H O IC50 = 227.0 nM 565.56 COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 Homo sapiens CHEMBL4727420 single protein format
CHEMBL4799627 OBDepict O N CH 3 O H N N N NH 2 F N H O N F F F IC50 = 253.0 nM 597.57 CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4F)c4c(N)nccn34)C2)COC1 Homo sapiens CHEMBL4717039 single protein format
CHEMBL4076024 OBDepict CH 3 O N O H N N N H 2 N F N H O N F F F IC50 = 261.0 nM 571.54 COCC(=O)N1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 Homo sapiens CHEMBL4057954 single protein format
CHEMBL217090 OBDepict Cl N H O O N N O O O N IC50 = 270.0 nM 527.02 Clc1ccc2c(c1Nc1ncnc3cc(OCCCN4CCCC4)cc(OC4CCOCC4)c13)OCO2 Homo sapiens CHEMBL854964 single protein format
CHEMBL3577124 OBDepict CH 3 N H N N N H 3 C CH 3 NH F N H O H 3 C CH 3 H 3 C IC50 = 290.0 nM 424.52 CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(C)nc2n1 Homo sapiens CHEMBL3578505 cell-based format
CHEMBL4749037 OBDepict O O N H H N N N H 2 N HN O N F F F IC50 = 290.0 nM 537.5 Nc1nccn2c([C@@H]3CC[C@H]4COC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 Homo sapiens CHEMBL4727420 single protein format
CHEMBL4108687 OBDepict O O N H 3 C CH 3 H H N N N H 2 N N H O N F F F IC50 = 350.0 nM 565.56 CC1(C)OC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@H]21 Homo sapiens CHEMBL4727420 single protein format
CHEMBL4436086 OBDepict OH N H N N Br O O IC50 = 402.0 nM 462.3 Oc1cccc(Nc2nc(/C=C/c3cc4c(cc3Br)OCO4)nc3ccccc23)c1 Homo sapiens CHEMBL4412234 single protein format
CHEMBL4588040 OBDepict CH 3 HN N N O CH 3 H N O N N N H O H 3 C CH 3 H 3 C IC50 = 430.0 nM 555.68 CCc1cc(NC(=O)c2nn(C3CCN(C(=O)NC(C)(C)C)CC3)c3ccccc23)ccc1-c1cc(C)c(=O)[nH]n1 Homo sapiens CHEMBL4308759 single protein format
CHEMBL4077588 OBDepict F N HN O N H 2 N N N H N F F F O IC50 = 455.0 nM 583.59 Nc1nccn2c([C@@H]3CCCN(C4CCOCC4)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 Homo sapiens CHEMBL4057954 single protein format
CHEMBL4437669 OBDepict OH N H N N + N O _ O IC50 = 473.0 nM 384.4 O=[N+]([O-])c1cccc(/C=C/c2nc(Nc3cccc(O)c3)c3ccccc3n2)c1 Homo sapiens CHEMBL4412234 single protein format
CHEMBL573578 OBDepict H 2 N N N N N CH 3 H 3 C CH 3 IC50 = 510.0 nM 331.42 CC(C)(C)n1nc(Cc2cccc3ccccc23)c2c(N)ncnc21 Homo sapiens CHEMBL1061991 single protein format
CHEMBL4062498 OBDepict CH 3 O N O O H N N N H 2 N F N H O N F F F IC50 = 626.0 nM 573.51 COCC(=O)N1CCO[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 Homo sapiens CHEMBL4057954 single protein format
CHEMBL306380 OBDepict CH 3 N N NH 2 N N CH 3 CH 3 H 3 C IC50 = 640.0 nM 281.36 Cc1ccc(-c2nn(C(C)(C)C)c3ncnc(N)c23)cc1 Homo sapiens CHEMBL1061991 single protein format
CHEMBL436137 OBDepict CH 3 CH 3 CH 3 N N N N H O N IC50 = 659.0 nM 453.59 Cc1cccc(C)c1-c1cc(C)c2nc(Nc3ccc(OCCN4CCCC4)cc3)nnc2c1 Homo sapiens CHEMBL908998 single protein format
CHEMBL4060757 OBDepict F N NH O N NH 2 N N H O N F F F O IC50 = 665.0 nM 585.56 Nc1nccn2c([C@H]3CN(C4CCOCC4)CCO3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 Homo sapiens CHEMBL4057954 single protein format
CHEMBL1090672 OBDepict CH 3 O N N H O IC50 = 704.0 nM 278.31 COc1ccccc1/C=C/c1nc2ccccc2c(=O)[nH]1 Homo sapiens CHEMBL4412234 single protein format
CHEMBL4476482 OBDepict CH 3 O N N HN O O IC50 = 706.0 nM 397.43 COc1ccccc1/C=C/c1nc(Nc2ccc3c(c2)OCO3)c2ccccc2n1 Homo sapiens CHEMBL4412234 single protein format
CHEMBL4107779 OBDepict O N H H N N N H 2 N O N H O N F F F IC50 = 717.0 nM 591.59 Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3OC3CC3)c12 Homo sapiens CHEMBL4727420 single protein format
CHEMBL217092 OBDepict H 3 C N N O O N N HN O Cl O O IC50 = 840.0 nM 542.04 CN1CCN(CCOc2cc(OC3CCOCC3)c3c(Nc4c(Cl)ccc5c4OCO5)ncnc3c2)CC1 Homo sapiens CHEMBL854964 single protein format