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P41440 | S19A1_HUMAN | Reduced folate transporter (SLC19A1)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL1201746 OBDepict HC N N N H O N H 2 N N H NH 2 O HO O OH IC50 = 0.69 nM 477.48 C#CCC(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 Homo sapiens CHEMBL4194627 cell-based format
CHEMBL225071 OBDepict OH O N H H O HO O S N CH 3 N O N H H 3 C IC50 = 6.3 nM 458.5 Cc1nc(=O)c2cc(CN(C)c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)ccc2[nH]1 Homo sapiens CHEMBL3387469 cell-based format
CHEMBL34259 OBDepict OH O HN H O HO O N CH 3 N N N NH 2 N H 2 N IC50 = 12.0 nM 454.45 CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 Homo sapiens CHEMBL3387469 cell-based format
CHEMBL4445651 OBDepict OH O NH H O HO O S F N H N O N H H 2 N IC50 = 20.1 nM 465.46 Nc1nc2[nH]c(CCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3F)cc2c(=O)[nH]1 Homo sapiens CHEMBL4309283 cell-based format
CHEMBL3409335 OBDepict HO O HN H O OH O S N H N O N H NH 2 IC50 = 38.3 nM 461.5 Nc1nc2[nH]cc(CCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)c2c(=O)[nH]1 Homo sapiens CHEMBL3412689 cell-based format
CHEMBL3628345 OBDepict HO O N H H O OH O S O NH 2 N N H 2 N IC50 = 54.0 nM 447.47 Nc1nc(N)c2c(CCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3)coc2n1 Homo sapiens CHEMBL3632250 cell-based format
CHEMBL3407519 OBDepict HO O HN H O OH O S N H N O N H NH 2 IC50 = 59.8 nM 433.45 Nc1nc2[nH]cc(CCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)c2c(=O)[nH]1 Homo sapiens CHEMBL3412689 cell-based format
CHEMBL4538151 OBDepict HO O N H H O OH O F N H N O N H H 2 N IC50 = 62.0 nM 459.43 Nc1nc2[nH]c(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)cc2c(=O)[nH]1 Homo sapiens CHEMBL4309283 cell-based format
CHEMBL1834488 OBDepict OH O NH H O HO O S N H N O N H H 2 N IC50 = 101.0 nM 447.47 Nc1nc2[nH]c(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)cc2c(=O)[nH]1 Homo sapiens CHEMBL3387469 cell-based format
CHEMBL3409334 OBDepict OH O N H H O HO O S N H N O N H NH 2 IC50 = 116.0 nM 447.47 Nc1nc2[nH]cc(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)c2c(=O)[nH]1 Homo sapiens CHEMBL3412689 cell-based format
CHEMBL225072 OBDepict HO O HN H O OH O N H N O N H H 2 N IC50 = 138.0 nM 427.42 Nc1nc2[nH]cc(CCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)c2c(=O)[nH]1 Homo sapiens CHEMBL3387469 cell-based format
CHEMBL3628346 OBDepict HO O N H H O OH O S N H N O N H H 2 N IC50 = 189.0 nM 447.47 Nc1nc2[nH]c(CCCc3cc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cs3)cc2c(=O)[nH]1 Homo sapiens CHEMBL3632250 cell-based format
CHEMBL3628344 OBDepict OH O NH H O HO O S N H N O N H H 2 N IC50 = 197.0 nM 447.47 Nc1nc2[nH]c(CCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3)cc2c(=O)[nH]1 Homo sapiens CHEMBL3632250 cell-based format
CHEMBL4465095 OBDepict HO O N H H O OH O S F N H N O N H H 2 N IC50 = 213.0 nM 479.49 Nc1nc2[nH]c(CCCCc3csc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c3F)cc2c(=O)[nH]1 Homo sapiens CHEMBL4309288 cell-based format
CHEMBL3409336 OBDepict OH O N H H O HO O S N H N O N H NH 2 IC50 = 243.2 nM 475.53 Nc1nc2[nH]cc(CCCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)s3)c2c(=O)[nH]1 Homo sapiens CHEMBL3412689 cell-based format
CHEMBL390990 OBDepict OH O N H O HO O N H N N N NH 2 N NH 2 Ki = 280.0 nM 452.43 Nc1nc(N)c2nc(CNc3ccc4c(c3)CN([C@@H](CCC(=O)O)C(=O)O)C4=O)cnc2n1 Homo sapiens CHEMBL919632 cell-based format
CHEMBL192632 OBDepict HO O N H H O OH O N H N O N H H 2 N IC50 = 304.0 nM 441.44 Nc1nc2[nH]c(CCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 Homo sapiens CHEMBL4309283 cell-based format
CHEMBL4557278 OBDepict OH O NH H O HO O N F N H N O N H NH 2 IC50 = 468.0 nM 474.45 Nc1nc2[nH]c(CCCCc3cnc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)c(F)c3)cc2c(=O)[nH]1 Homo sapiens CHEMBL4309283 cell-based format
CHEMBL4437824 OBDepict HO O N H H O OH O N H N H N O N H H 2 N IC50 = 510.0 nM 442.43 Nc1nc2[nH]c(CCNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 Homo sapiens CHEMBL4432141 cell-based format
CHEMBL388501 OBDepict OH O N O OH O N H N N N NH 2 N NH 2 Ki = 530.0 nM 452.43 Nc1nc(N)c2nc(CNc3ccc4c(c3)CN(C(CCC(=O)O)C(=O)O)C4=O)cnc2n1 Homo sapiens CHEMBL919632 cell-based format
CHEMBL4214638 OBDepict HO O HN H O OH O N N H N O N H H 2 N IC50 = 634.0 nM 456.46 Nc1nc2[nH]c(CCCCc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)nc3)cc2c(=O)[nH]1 Homo sapiens CHEMBL4309288 cell-based format
CHEMBL4447805 OBDepict HO O N H H O OH O O N H N O N H H 2 N IC50 = 641.0 nM 443.42 Nc1nc2[nH]c(CCOc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 Homo sapiens CHEMBL4432141 cell-based format
CHEMBL4471269 OBDepict O N N H HN O N O N H H NH 2 O HO O OH IC50 = 642.0 nM 470.44 Nc1nc2[nH]c(CCN(C=O)c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 Homo sapiens CHEMBL4432141 cell-based format
CHEMBL4553188 OBDepict HO O NH H O OH O N O F F F N H N O N H NH 2 IC50 = 783.0 nM 538.44 Nc1nc2[nH]c(CCN(C(=O)C(F)(F)F)c3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cc2c(=O)[nH]1 Homo sapiens CHEMBL4432141 cell-based format
CHEMBL4444011 OBDepict OH O N H H O HO O N O H 3 C N H N O N H H 2 N IC50 = 808.0 nM 484.47 CC(=O)N(CCc1cc2c(=O)[nH]c(N)nc2[nH]1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 Homo sapiens CHEMBL4432141 cell-based format