P42224 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta (STAT1)

3D structures mapped by conservation among orthologs

[ Domain: "EF-hand" // STAT_bind_C ]

download pymol session

[ Domain: "Common fold of diphtheria toxin/transcription factors/cytochrome f" // STAT_bind_N ]

download pymol session

[ Domain: "SH2" // SH2 ]

download pymol session

[ Domain: "Transcription factor STAT-4 N-domain" // STAT_int ]

download pymol session

[ Domain: "STAT" // STAT_alpha ]

download pymol session

[ Domain: pdbs with more than 2 multi-domains ]

download pymol session

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id	structure	assay_type	relation	values	units	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL4864495		IC50	=	350.0	nM	577.77	CCCC(C)Oc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N[C@@H](C)c4ccccc4)sc3c2)c(OC)c1C	Homo sapiens	CHEMBL4816238	cell-based format
CHEMBL4846078		IC50	=	880.0	nM	242.23	CC(=O)C1=CC2C(=O)c3ccccc3C(=O)C2O1	Homo sapiens	CHEMBL4816238	cell-based format