HOME LIGAND hPROTEOME OTHERS DOCUMENT

P42226 | STAT6_HUMAN | Signal transducer and activator of transcription 6 (STAT6)

3D structures mapped by conservation among orthologs

[ Domain: "EF-hand" // STAT_bind_C ]

download pymol session

[ Domain: "Common fold of diphtheria toxin/transcription factors/cytochrome f" // STAT_bind_N ]

download pymol session

[ Domain: "SH2" // SH2 ]

download pymol session

[ Domain: "STAT" // STAT_alpha ]

download pymol session

[ Domain: pdbs with more than 2 multi-domains ]

download pymol session



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL593171 OBDepict H 2 N O N HN N N H F F F N O IC50 = 0.7 nM 458.44 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1c(F)ccc(F)c1F Homo sapiens CHEMBL1042440 assay format
CHEMBL487451 OBDepict F F F NH N N N H O NH 2 N O IC50 = 0.7 nM 458.44 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1c(F)cc(F)cc1F Homo sapiens CHEMBL982109 cell-based format
CHEMBL470963 OBDepict H 2 N O N HN N N H F N O IC50 = 1.4 nM 422.46 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1ccccc1F Homo sapiens CHEMBL982109 cell-based format
CHEMBL488814 OBDepict F F NH N N N H O NH 2 N O IC50 = 1.6 nM 440.45 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1cc(F)ccc1F Homo sapiens CHEMBL982109 cell-based format
CHEMBL519249 OBDepict F F NH F N N N H O NH 2 N O IC50 = 1.8 nM 458.44 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1cc(F)cc(F)c1F Homo sapiens CHEMBL982109 cell-based format
CHEMBL512874 OBDepict F HN N N N H O H 2 N N O IC50 = 1.8 nM 422.46 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1cccc(F)c1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL595058 OBDepict NH 2 O N N N H N N N F F IC50 = 1.9 nM 477.52 NC(=O)CN1CCN(c2ccc(Nc3ncc4ccn(Cc5cc(F)cc(F)c5)c4n3)cc2)CC1 Homo sapiens CHEMBL1042440 assay format
CHEMBL529443 OBDepict H 2 N O N HN N N H F F N O IC50 = 2.1 nM 440.45 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1cccc(F)c1F Homo sapiens CHEMBL982109 cell-based format
CHEMBL519410 OBDepict NH 2 O N NH N N H F F N O IC50 = 2.2 nM 440.45 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1c(F)cccc1F Homo sapiens CHEMBL982109 cell-based format
CHEMBL596420 OBDepict CH 3 N N N H N N N F F IC50 = 3.2 nM 434.49 CN1CCN(c2ccc(Nc3ncc4ccn(Cc5cc(F)cc(F)c5)c4n3)cc2)CC1 Homo sapiens CHEMBL1042440 assay format
CHEMBL606350 OBDepict CH 3 HN O N N N H N N N F F IC50 = 4.7 nM 491.55 CNC(=O)CN1CCN(c2ccc(Nc3ncc4ccn(Cc5cc(F)cc(F)c5)c4n3)cc2)CC1 Homo sapiens CHEMBL1042440 assay format
CHEMBL487450 OBDepict F F HN N N N H O H 2 N N O IC50 = 5.5 nM 440.45 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1cc(F)cc(F)c1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL596421 OBDepict OH N N N H N N N N F F IC50 = 5.6 nM 465.51 OCCN1CCN(c2ccc(Nc3ncc4ncn(Cc5cc(F)cc(F)c5)c4n3)cc2)CC1 Homo sapiens CHEMBL1042440 assay format
CHEMBL470949 OBDepict CH 3 N N N H N N N H O NH 2 IC50 = 6.2 nM 417.52 CN1CCN(c2ccc(Nc3ncc(C(N)=O)c(NCc4ccccc4)n3)cc2)CC1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL471114 OBDepict NH 2 O N N H N NH N O IC50 = 6.5 nM 404.47 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1ccccc1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL471113 OBDepict NH 2 O N N H N NH N HN IC50 = 7.0 nM 403.49 NC(=O)c1cnc(Nc2ccc(N3CCNCC3)cc2)nc1NCc1ccccc1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL471131 OBDepict H 2 N O N HN N N H Cl N O IC50 = 7.9 nM 438.92 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1ccccc1Cl Homo sapiens CHEMBL982109 cell-based format
CHEMBL469910 OBDepict CH 3 O N H N N NH O H 2 N N O IC50 = 8.2 nM 434.5 COc1ccccc1CNc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1C(N)=O Homo sapiens CHEMBL982109 cell-based format
CHEMBL512533 OBDepict NH 2 O N HN N N H CH 3 N O IC50 = 11.0 nM 418.5 Cc1ccccc1CNc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1C(N)=O Homo sapiens CHEMBL982109 cell-based format
CHEMBL594344 OBDepict F F N N N N H N HN IC50 = 12.0 nM 420.47 Fc1cc(F)cc(Cn2ccc3cnc(Nc4ccc(N5CCNCC5)cc4)nc32)c1 Homo sapiens CHEMBL1042440 assay format
CHEMBL517122 OBDepict HO N N H N N N H O NH 2 IC50 = 16.0 nM 418.5 NC(=O)c1cnc(Nc2ccc(N3CCC(O)CC3)cc2)nc1NCc1ccccc1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL513401 OBDepict CH 3 N N H N N N H O NH 2 IC50 = 17.0 nM 416.53 CN1CCC(c2ccc(Nc3ncc(C(N)=O)c(NCc4ccccc4)n3)cc2)CC1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL487460 OBDepict HO HN N N N H O H 2 N N O IC50 = 19.0 nM 420.47 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1cccc(O)c1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL228192 OBDepict NH 2 O N HN N NH Cl OH IC50 = 21.0 nM 397.87 NC(=O)c1cnc(NCCc2ccc(O)c(Cl)c2)nc1NCc1ccccc1 Homo sapiens CHEMBL915562 assay format
CHEMBL471130 OBDepict H 2 N O N HN N N H OH N O IC50 = 22.0 nM 420.47 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1ccccc1O Homo sapiens CHEMBL982109 cell-based format
CHEMBL486643 OBDepict CH 3 S N H N N NH O H 2 N N O IC50 = 23.0 nM 450.57 CSc1ccccc1CNc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1C(N)=O Homo sapiens CHEMBL982109 cell-based format
CHEMBL512519 OBDepict NH 2 O N NH N N H F F F N O IC50 = 25.0 nM 472.47 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1ccccc1C(F)(F)F Homo sapiens CHEMBL982109 cell-based format
CHEMBL471743 OBDepict CH 3 O N H N N HN O NH 2 N O IC50 = 25.0 nM 434.5 COc1cccc(CNc2nc(Nc3ccc(N4CCOCC4)cc3)ncc2C(N)=O)c1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL595488 OBDepict OH O N N N H N N N F F IC50 = 26.0 nM 478.5 O=C(O)CN1CCN(c2ccc(Nc3ncc4ccn(Cc5cc(F)cc(F)c5)c4n3)cc2)CC1 Homo sapiens CHEMBL1042440 assay format
CHEMBL226930 OBDepict CH 3 HN O N HN N NH Cl OH IC50 = 30.0 nM 411.89 CNC(=O)c1cnc(NCCc2ccc(O)c(Cl)c2)nc1NCc1ccccc1 Homo sapiens CHEMBL915562 assay format
CHEMBL594821 OBDepict NH 2 N N N H N N N F F IC50 = 34.0 nM 463.54 NCCN1CCN(c2ccc(Nc3ncc4ccn(Cc5cc(F)cc(F)c5)c4n3)cc2)CC1 Homo sapiens CHEMBL1042440 assay format
CHEMBL471559 OBDepict Cl HN N N N H O H 2 N N O IC50 = 36.0 nM 438.92 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1cccc(Cl)c1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL603203 OBDepict F N N N N H N O IC50 = 37.0 nM 403.46 Fc1cccc(Cn2ccc3cnc(Nc4ccc(N5CCOCC5)cc4)nc32)c1 Homo sapiens CHEMBL1042440 assay format
CHEMBL520234 OBDepict NH 2 O N NH N N H + N O _ O N O IC50 = 38.0 nM 449.47 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1ccccc1[N+](=O)[O-] Homo sapiens CHEMBL982109 cell-based format
CHEMBL228018 OBDepict H 3 C HN N N H N O NH 2 Cl OH IC50 = 45.0 nM 397.87 Cc1cccc(Nc2nc(NCCc3ccc(O)c(Cl)c3)ncc2C(N)=O)c1 Homo sapiens CHEMBL915562 assay format
CHEMBL518350 OBDepict NH 2 O N HN N NH Cl Cl OH IC50 = 61.0 nM 432.31 NC(=O)c1cnc(NCCc2cc(Cl)c(O)c(Cl)c2)nc1NCc1ccccc1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL387668 OBDepict H 3 C HN N N H N O NH 2 F OH IC50 = 64.0 nM 381.41 Cc1cccc(Nc2nc(NCCc3ccc(O)c(F)c3)ncc2C(N)=O)c1 Homo sapiens CHEMBL915562 assay format
CHEMBL461721 OBDepict OH N H N N N H O NH 2 IC50 = 81.0 nM 377.45 NC(=O)c1cnc(Nc2ccc(CCCO)cc2)nc1NCc1ccccc1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL389647 OBDepict H 3 C HN N N H N O NH 2 Br OH IC50 = 83.0 nM 442.32 Cc1cccc(Nc2nc(NCCc3ccc(O)c(Br)c3)ncc2C(N)=O)c1 Homo sapiens CHEMBL915562 assay format
CHEMBL374380 OBDepict HO HN N N NH O NH 2 IC50 = 88.0 nM 363.42 NC(=O)c1cnc(NCCc2ccc(O)cc2)nc1NCc1ccccc1 Homo sapiens CHEMBL915562 assay format
CHEMBL488307 OBDepict F F F NH N N N H O NH 2 N O ClH IC50 = 88.0 nM 494.91 Cl.NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1c(F)cc(F)cc1F Homo sapiens CHEMBL982109 cell-based format
CHEMBL461720 OBDepict OH NH N N N H O H 2 N IC50 = 95.0 nM 363.42 NC(=O)c1cnc(Nc2ccc(CCO)cc2)nc1NCc1ccccc1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL458325 OBDepict OH N N H N N HN O NH 2 IC50 = 98.0 nM 404.47 NC(=O)c1cnc(Nc2ccc(N3CCC(O)C3)cc2)nc1NCc1ccccc1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL427436 OBDepict OH NH N N HN O H 2 N IC50 = 100.0 nM 355.44 NC(=O)c1cnc(NCCc2ccc(O)cc2)nc1NC1CCCCC1 Homo sapiens CHEMBL915562 assay format
CHEMBL3741674 OBDepict O N H H CH 3 H 3 C H 3 C CH 3 N H O CH 3 H N O O H 3 C P O OH OH IC50 = 120.0 nM 531.55 C/C(=CC(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N(C)c1ccccc1)C(C)(C)C)c1ccc(OP(=O)(O)O)cc1 Homo sapiens CHEMBL3743438 assay format
CHEMBL596223 OBDepict F F N N N N H N O IC50 = 120.0 nM 421.45 Fc1cc(F)cc(Cn2ccc3cnc(Nc4ccc(N5CCOCC5)cc4)nc32)c1 Homo sapiens CHEMBL1042440 assay format
CHEMBL461304 OBDepict NH 2 O N N H N NH N IC50 = 120.0 nM 402.5 NC(=O)c1cnc(Nc2ccc(N3CCCCC3)cc2)nc1NCc1ccccc1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL3739524 OBDepict O N H H CH 3 H 3 C H 3 C CH 3 N O H N O O H 3 C P O OH OH IC50 = 120.0 nM 557.58 C/C(=CC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N(C)c1ccccc1)C(C)(C)C)c1ccc(OP(=O)(O)O)cc1 Homo sapiens CHEMBL3743438 assay format
CHEMBL471560 OBDepict H 2 N O N HN N N H F F F N O IC50 = 130.0 nM 472.47 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1cccc(C(F)(F)F)c1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL226770 OBDepict H 3 C HN N N H N O NH 2 H 3 C OH IC50 = 130.0 nM 377.45 Cc1cccc(Nc2nc(NCCc3ccc(O)c(C)c3)ncc2C(N)=O)c1 Homo sapiens CHEMBL915562 assay format
CHEMBL227748 OBDepict CH 3 HN O N N H N NH CH 3 HO IC50 = 170.0 nM 377.45 CNC(=O)c1cnc(NCCc2ccc(O)cc2)nc1Nc1cccc(C)c1 Homo sapiens CHEMBL915562 assay format
CHEMBL376085 OBDepict OH N H N N NH O NH 2 CH 3 IC50 = 190.0 nM 363.42 Cc1cccc(Nc2nc(NCCc3ccc(O)cc3)ncc2C(N)=O)c1 Homo sapiens CHEMBL915562 assay format
CHEMBL596410 OBDepict F N N N N H N O IC50 = 220.0 nM 403.46 Fc1ccccc1Cn1ccc2cnc(Nc3ccc(N4CCOCC4)cc3)nc21 Homo sapiens CHEMBL1042440 assay format
CHEMBL3741189 OBDepict O N H H CH 3 H 3 C H 3 C CH 3 N O H N O O H 3 C P O OH OH IC50 = 230.0 nM 563.63 C/C(=CC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N(C)C1CCCCC1)C(C)(C)C)c1ccc(OP(=O)(O)O)cc1 Homo sapiens CHEMBL3743438 assay format
CHEMBL3739968 OBDepict O N H H CH 3 H 3 C H 3 C CH 3 N O H NH O O P O OH OH IC50 = 250.0 nM 571.61 C/C(=CC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)NCCc1ccccc1)C(C)(C)C)c1ccc(OP(=O)(O)O)cc1 Homo sapiens CHEMBL3743438 assay format
CHEMBL3740710 OBDepict O N H H CH 3 H 3 C H 3 C CH 3 N O H NH O O P O OH OH IC50 = 270.0 nM 543.56 C/C(=CC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)Nc1ccccc1)C(C)(C)C)c1ccc(OP(=O)(O)O)cc1 Homo sapiens CHEMBL3743438 assay format
CHEMBL3741243 OBDepict O N H H CH 3 H 3 C H 3 C CH 3 N O H 3 C N O O H 3 C P O OH OH IC50 = 270.0 nM 531.55 C/C(=CC(=O)N[C@H](C(=O)N(C)CC(=O)N(C)c1ccccc1)C(C)(C)C)c1ccc(OP(=O)(O)O)cc1 Homo sapiens CHEMBL3743438 assay format
CHEMBL487634 OBDepict H 2 N O N HN N N H NH 2 N O IC50 = 310.0 nM 419.49 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1ccccc1N Homo sapiens CHEMBL982109 cell-based format
CHEMBL488649 OBDepict F F N H N N HN O H 2 N N O IC50 = 310.0 nM 440.45 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1ccc(F)cc1F Homo sapiens CHEMBL982109 cell-based format
CHEMBL3739875 OBDepict O N H H CH 3 H 3 C H 3 C CH 3 N O H NH O O P O OH OH IC50 = 340.0 nM 557.58 C/C(=CC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)NCc1ccccc1)C(C)(C)C)c1ccc(OP(=O)(O)O)cc1 Homo sapiens CHEMBL3743438 assay format
CHEMBL389452 OBDepict CH 3 N H O N NH N N H CH 3 HO IC50 = 380.0 nM 391.48 CCNC(=O)c1cnc(NCCc2ccc(O)cc2)nc1Nc1cccc(C)c1 Homo sapiens CHEMBL915562 assay format
CHEMBL3739525 OBDepict CH 3 N O H 3 C H N O N H H H 3 C CH 3 H 3 C O CH 3 O P O OH OH IC50 = 380.0 nM 523.57 CCN(CC)C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)/C=C(C)c1ccc(OP(=O)(O)O)cc1)C(C)(C)C Homo sapiens CHEMBL3743438 assay format
CHEMBL593392 OBDepict O N N H N N N IC50 = 400.0 nM 385.47 c1ccc(Cn2ccc3cnc(Nc4ccc(N5CCOCC5)cc4)nc32)cc1 Homo sapiens CHEMBL1042440 assay format
CHEMBL3742269 OBDepict O N H H CH 3 H 3 C H 3 C CH 3 N O N O H 3 C P O OH OH IC50 = 410.0 nM 543.6 C/C(=CC(=O)N[C@H](C(=O)N1CCCC1CN(C)c1ccccc1)C(C)(C)C)c1ccc(OP(=O)(O)O)cc1 Homo sapiens CHEMBL3743438 assay format
CHEMBL227804 OBDepict OH NH N N HN O H 2 N IC50 = 410.0 nM 349.39 NC(=O)c1cnc(NCCc2ccc(O)cc2)nc1Nc1ccccc1 Homo sapiens CHEMBL915562 assay format
CHEMBL3740699 OBDepict O N H H CH 3 H 3 C H 3 C CH 3 N O H 3 C CH 3 H N O O H 3 C P O OH OH IC50 = 480.0 nM 545.57 C/C(=CC(=O)N[C@H](C(=O)N(C)[C@@H](C)C(=O)N(C)c1ccccc1)C(C)(C)C)c1ccc(OP(=O)(O)O)cc1 Homo sapiens CHEMBL3743438 assay format
CHEMBL3740610 OBDepict O N H H CH 3 H 3 C H 3 C CH 3 N O O P O OH OH IC50 = 540.0 nM 554.62 C/C(=CC(=O)N[C@H](C(=O)N1CCCC1/C=C/CCc1ccccc1)C(C)(C)C)c1ccc(OP(=O)(O)O)cc1 Homo sapiens CHEMBL3743438 assay format
CHEMBL461303 OBDepict NH 2 O N N H N NH N IC50 = 650.0 nM 388.48 NC(=O)c1cnc(Nc2ccc(N3CCCC3)cc2)nc1NCc1ccccc1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL470964 OBDepict F N H N N NH O NH 2 N O IC50 = 650.0 nM 422.46 NC(=O)c1cnc(Nc2ccc(N3CCOCC3)cc2)nc1NCc1ccc(F)cc1 Homo sapiens CHEMBL982109 cell-based format
CHEMBL388357 OBDepict CH 3 O OH N H N N HN O H 2 N CH 3 IC50 = 660.0 nM 393.45 COc1cc(CCNc2ncc(C(N)=O)c(Nc3cccc(C)c3)n2)ccc1O Homo sapiens CHEMBL915562 assay format
CHEMBL3741667 OBDepict O N H H CH 3 H 3 C H 3 C CH 3 N O H N O O H 3 C H 3 C P O OH OH IC50 = 740.0 nM 495.51 C/C(=CC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N(C)C)C(C)(C)C)c1ccc(OP(=O)(O)O)cc1 Homo sapiens CHEMBL3743438 assay format
CHEMBL3740611 OBDepict O N H H H 3 C H 3 C CH 3 N O H N O O CH 3 P O OH OH IC50 = 870.0 nM 543.56 CN(C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)/C=C/c1ccc(OP(=O)(O)O)cc1)C(C)(C)C)c1ccccc1 Homo sapiens CHEMBL3743438 assay format