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P42261 | GRIA1_HUMAN | Glutamate receptor 1 (GRIA1)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL370038 OBDepict OH O H 2 N H HO N O N N N N CH 3 Ki = 5.22 nM 254.21 Cn1nnc(-c2onc(O)c2C[C@H](N)C(=O)O)n1 Homo sapiens CHEMBL829619 cell-based format
CHEMBL331696 OBDepict HO O NH 2 H N N O N Cl H O Ki = 7.1 nM 234.6 N[C@@H](Cn1nc(Cl)c(=O)[nH]c1=O)C(=O)O Homo sapiens CHEMBL878883 cell-based format
CHEMBL123132 OBDepict HO O NH 2 H N O N F H O Ki = 14.7 nM 217.16 N[C@@H](Cn1cc(F)c(=O)[nH]c1=O)C(=O)O Homo sapiens CHEMBL878883 cell-based format
CHEMBL3823961 OBDepict CH 3 O N S N S N N H O IC50 = 22.0 nM 398.51 CCOCCN(c1ccc2[nH]c(=O)sc2c1)c1nc(-c2ccccn2)cs1 Homo sapiens CHEMBL3825093 cell-based format
CHEMBL13378 OBDepict OH O H 2 N CH 3 O HO N Ki = 22.0 nM 186.17 Cc1onc(O)c1CC(N)C(=O)O Homo sapiens CHEMBL701247 cell-based format
CHEMBL331644 OBDepict HO O NH 2 H N N O N Br H O Ki = 29.0 nM 279.05 N[C@@H](Cn1nc(Br)c(=O)[nH]c1=O)C(=O)O Homo sapiens CHEMBL878883 cell-based format
CHEMBL313747 OBDepict H 2 N HN NH N H O N H O HN H O O NH 2 OH HO IC50 = 40.0 nM 565.72 NCCCNCCCCNCCC(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O Homo sapiens CHEMBL1108138 cell-based format
CHEMBL3822825 OBDepict O S N H CH 3 H N N N IC50 = 50.9 nM 322.39 C[C@@H](c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccccn2)n1 Homo sapiens CHEMBL3825093 cell-based format
CHEMBL3823445 OBDepict F N N N CH 3 H S N H O IC50 = 53.6 nM 340.38 C[C@@H](c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccc(F)cn2)n1 Homo sapiens CHEMBL3825093 cell-based format
CHEMBL3822572 OBDepict CH 3 N N N S N N N N H IC50 = 53.9 nM 387.47 Cn1ccc(CN(c2ccc3[nH]ncc3c2)c2nc(-c3ccccn3)cs2)n1 Homo sapiens CHEMBL3825093 cell-based format
CHEMBL3823351 OBDepict OH N N N CH 3 H S N H O IC50 = 61.6 nM 366.45 C[C@@H](c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccc(CCO)cn2)n1 Homo sapiens CHEMBL3825093 cell-based format
CHEMBL121388 OBDepict HO O NH 2 H N O N Cl H O Ki = 65.0 nM 233.61 N[C@@H](Cn1cc(Cl)c(=O)[nH]c1=O)C(=O)O Homo sapiens CHEMBL878883 cell-based format
CHEMBL147182 OBDepict NH 2 N H N H O N H O H 3 C OH Ki = 65.0 nM 434.63 CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN Homo sapiens CHEMBL680870 cell-based format
CHEMBL3823394 OBDepict OH O N N N CH 3 H S N H O IC50 = 65.3 nM 382.45 C[C@@H](c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccc(OCCO)cn2)n1 Homo sapiens CHEMBL3825093 cell-based format
CHEMBL3823131 OBDepict CH 3 N S N S N N H O IC50 = 70.0 nM 340.43 CN(c1ccc2[nH]c(=O)sc2c1)c1nc(-c2ccccn2)cs1 Homo sapiens CHEMBL3825093 cell-based format
CHEMBL121553 OBDepict HO O NH 2 H N N O N I H O Ki = 73.9 nM 326.05 N[C@@H](Cn1nc(I)c(=O)[nH]c1=O)C(=O)O Homo sapiens CHEMBL878883 cell-based format
CHEMBL333964 OBDepict HO O NH 2 H N O N Br H O Ki = 92.0 nM 278.06 N[C@@H](Cn1cc(Br)c(=O)[nH]c1=O)C(=O)O Homo sapiens CHEMBL878883 cell-based format
CHEMBL276815 OBDepict OH O H 2 N H CH 3 O HO N Ki = 103.0 nM 186.17 Cc1onc(O)c1C[C@H](N)C(=O)O Homo sapiens CHEMBL878883 cell-based format
CHEMBL3823222 OBDepict CH 3 N N S N N H O IC50 = 122.0 nM 322.39 CC(c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccccn2)n1 Homo sapiens CHEMBL3825093 cell-based format
CHEMBL72366 OBDepict HO O NH 2 O N Cl OH Ki = 130.0 nM 206.59 NC(Cc1onc(O)c1Cl)C(=O)O Homo sapiens CHEMBL701247 cell-based format
CHEMBL152879 OBDepict NH 2 N H N H O N H O H 3 C OH Ki = 135.0 nM 434.63 CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCNCCCCCCCN Homo sapiens CHEMBL680869 cell-based format
CHEMBL269192 OBDepict NH 2 N H N H O NH O CH 3 H 3 C CH 3 HO Ki = 140.0 nM 448.65 CC(C)(C)C(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN Homo sapiens CHEMBL680869 cell-based format
CHEMBL370941 OBDepict CH 3 N N N N O N HO H 2 N O HO Ki = 145.0 nM 268.23 CCn1nnc(-c2onc(O)c2CC(N)C(=O)O)n1 Homo sapiens CHEMBL829619 cell-based format
CHEMBL3823274 OBDepict CH 3 N S N N N N H IC50 = 147.0 nM 307.38 CN(c1ccc2[nH]ncc2c1)c1nc(-c2ccccn2)cs1 Homo sapiens CHEMBL3825093 cell-based format
CHEMBL402444 OBDepict HO O NH 2 H N S HO N Ki = 150.0 nM 189.2 N[C@H](Cc1nsnc1O)C(=O)O Homo sapiens CHEMBL934442 cell-based format
CHEMBL3823817 OBDepict O S N H CH 3 H N N N HO CH 3 CH 3 IC50 = 160.0 nM 408.53 C[C@@H](c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccc(CCC(C)(C)O)cn2)n1 Homo sapiens CHEMBL3825093 cell-based format
CHEMBL122656 OBDepict OH O H 2 N H N N O N H O Ki = 163.0 nM 200.15 N[C@@H](Cn1ncc(=O)[nH]c1=O)C(=O)O Homo sapiens CHEMBL878883 cell-based format
CHEMBL121915 OBDepict HO O NH 2 H N O N I H O Ki = 163.0 nM 325.06 N[C@@H](Cn1cc(I)c(=O)[nH]c1=O)C(=O)O Homo sapiens CHEMBL878883 cell-based format
CHEMBL422515 OBDepict NH 2 N H N H O N H O H 3 C OH Ki = 168.0 nM 434.63 CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCNCCCCN Homo sapiens CHEMBL680870 cell-based format
CHEMBL213645 OBDepict NH 2 NH NH O N H H O CH 3 HO Ki = 168.0 nM 434.63 CCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCCCCNCCCCN Homo sapiens CHEMBL1108951 cell-based format
CHEMBL73698 OBDepict HO O NH 2 O N Br OH Ki = 170.0 nM 251.04 NC(Cc1onc(O)c1Br)C(=O)O Homo sapiens CHEMBL701247 cell-based format
CHEMBL152736 OBDepict NH 2 N H N H O N H O OH Ki = 170.0 nM 494.68 NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)/C=C/c1ccccc1 Homo sapiens CHEMBL680869 cell-based format
CHEMBL345521 OBDepict NH 2 N H N H O NH O N HO Ki = 170.0 nM 469.63 NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)c1ccccn1 Homo sapiens CHEMBL680869 cell-based format
CHEMBL429594 OBDepict HO O NH 2 H N S HO N Ki = 185.0 nM 189.2 N[C@@H](Cc1nsnc1O)C(=O)O Homo sapiens CHEMBL934442 cell-based format
CHEMBL152425 OBDepict NH 2 N H N H O NH O N HO Ki = 210.0 nM 469.63 NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)c1cccnc1 Homo sapiens CHEMBL680869 cell-based format
CHEMBL120808 OBDepict OH O H 2 N H N N O N CH 3 H O Ki = 240.0 nM 214.18 Cc1nn(C[C@H](N)C(=O)O)c(=O)[nH]c1=O Homo sapiens CHEMBL878883 cell-based format
CHEMBL153995 OBDepict NH 2 N H N H O NH O HO Ki = 240.0 nM 474.69 NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)C1CCCCC1 Homo sapiens CHEMBL680869 cell-based format
CHEMBL352030 OBDepict NH 2 N H N H O NH O HO Ki = 250.0 nM 468.64 NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)c1ccccc1 Homo sapiens CHEMBL680869 cell-based format
CHEMBL350228 OBDepict NH 2 HN NH O HN O HO Ki = 250.0 nM 482.67 NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)Cc1ccccc1 Homo sapiens CHEMBL680869 cell-based format
CHEMBL154012 OBDepict NH 2 N H N H O N H O OH Ki = 254.0 nM 496.7 NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)CCc1ccccc1 Homo sapiens CHEMBL680869 cell-based format
CHEMBL121191 OBDepict OH O H 2 N H N O N + N H O _ O O Ki = 279.0 nM 244.16 N[C@@H](Cn1cc([N+](=O)[O-])c(=O)[nH]c1=O)C(=O)O Homo sapiens CHEMBL878883 cell-based format
CHEMBL355977 OBDepict NH 2 HN NH O HN O CH 3 HO Ki = 280.0 nM 420.6 CCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN Homo sapiens CHEMBL680869 cell-based format
CHEMBL153017 OBDepict NH 2 N H N H O N H O H 3 C OH Ki = 287.0 nM 434.63 CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCNCCCCCCN Homo sapiens CHEMBL680869 cell-based format
CHEMBL422161 OBDepict NH 2 N H N H O N H O CH 3 OH Ki = 300.0 nM 406.57 CC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN Homo sapiens CHEMBL680869 cell-based format
CHEMBL153996 OBDepict NH 2 N H N H O NH O N HO Ki = 330.0 nM 469.63 NCCCNCCCCCCCCNC(=O)C(Cc1ccc(O)cc1)NC(=O)c1ccncc1 Homo sapiens CHEMBL680869 cell-based format
CHEMBL154184 OBDepict H 3 C NH O N H OH HN OH NH 2 Ki = 350.0 nM 436.64 CCCC(=O)NC(Cc1ccc(O)cc1)C(O)NCCCNCCCCCCCCN Homo sapiens CHEMBL680870 cell-based format
CHEMBL3823956 OBDepict CH 3 N N N N N N H IC50 = 353.0 nM 290.33 CN(c1ccc2[nH]ncc2c1)c1ccn(-c2ccccn2)n1 Homo sapiens CHEMBL3825093 cell-based format
CHEMBL122005 OBDepict OH O H 2 N H N O N H O Ki = 386.0 nM 199.17 N[C@@H](Cn1ccc(=O)[nH]c1=O)C(=O)O Homo sapiens CHEMBL878883 cell-based format
CHEMBL434273 OBDepict NH 2 N H N H O N H O H 3 C OH Ki = 410.0 nM 434.63 CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCCNCCN Homo sapiens CHEMBL680870 cell-based format
CHEMBL152153 OBDepict NH 2 N H N H O N H O H 3 C OH Ki = 468.0 nM 434.63 CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCNCCCCCN Homo sapiens CHEMBL680870 cell-based format
CHEMBL1214124 OBDepict N O N N IC50 = 485.0 nM 349.39 N#Cc1ccccc1-c1cc(-c2ccccn2)cn(-c2ccccc2)c1=O Homo sapiens CHEMBL3825094 cell-based format
CHEMBL3823247 OBDepict O S N H CH 3 H N N N IC50 = 615.0 nM 322.39 C[C@H](c1ccc2[nH]c(=O)sc2c1)c1ccn(-c2ccccn2)n1 Homo sapiens CHEMBL3825093 cell-based format
CHEMBL299180 OBDepict H NH 2 O HO O OH CH 3 CH 3 Ki = 700.0 nM 201.22 CC(C)/C=C(C[C@H](N)C(=O)O)C(=O)O Homo sapiens CHEMBL701240 cell-based format
CHEMBL152410 OBDepict H 3 C NH O N H O OH NH NH 2 Ki = 1000.0 nM 462.68 CCCCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCCCCCNCCCN Homo sapiens CHEMBL680869 cell-based format