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P42680 | TEC_HUMAN | Tyrosine-protein kinase Tec (TEC)

3D structures mapped by conservation among orthologs

[ Domain: "PH domain-like" // PH ]

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[ Domain: "Btk/CHORD zinc fingers" // BTK ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4206765 OBDepict CH 2 N O H N NH N O S N O H IC50 = 0.09 nM 499.6 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cc[nH]c(=O)c4)s3)nc3ccccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4217959 OBDepict CH 2 N O H N NH N O S N N NH 2 IC50 = 0.1 nM 499.6 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4ccnc(N)n4)s3)nc3ccccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4214683 OBDepict CH 2 N O H N NH N O S N N CH 3 IC50 = 0.11 nM 498.61 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4ccnc(C)n4)s3)nc3ccccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4219011 OBDepict CH 3 NH N S N H O N N H N O CH 2 IC50 = 0.16 nM 512.64 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4ccnc(NC)c4)s3)nc3ccccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4207292 OBDepict CH 2 N O H N NH N O S N NH 2 IC50 = 0.2 nM 498.61 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4ccnc(N)c4)s3)nc3ccccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4211372 OBDepict CH 2 N O H N NH N O S O N IC50 = 0.62 nM 473.56 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3ccccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4216187 OBDepict CH 2 N O H N NH N O S N H H 3 C O N IC50 = 0.67 nM 502.6 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3cc(NC)ccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4208358 OBDepict CH 2 N O H N NH N O S F O N IC50 = 0.74 nM 491.55 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3cc(F)ccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4248386 OBDepict CH 2 S N H O O H 3 C CH 3 N CH 3 H O H 2 N IC50 = 0.9 nM 383.47 C=CS(=O)(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)c1C Homo sapiens CHEMBL4235703 single protein format
CHEMBL4297674 OBDepict H 3 C N H O H N F H 3 C N CH 3 H O NH 2 IC50 = 0.9 nM 370.43 CC#CC(=O)N[C@H]1CCCN(c2c(F)cc(C(N)=O)c3[nH]c(C)c(C)c23)C1 Homo sapiens CHEMBL4616778 single protein format
CHEMBL4204572 OBDepict CH 2 N O H N NH N O S F F H 3 C IC50 = 0.98 nM 470.55 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C(C)(F)F)s3)nc3ccccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4203077 OBDepict CH 2 N O H N NH N O S N H O H 3 C H N H 3 C H 3 C CH 3 IC50 = 1.65 nM 586.76 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4206487 OBDepict CH 2 N O H N NH N O S N H F F H 3 C H H 3 C H 3 C CH 3 IC50 = 1.78 nM 569.72 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C(F)F)s3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4215147 OBDepict CH 2 N O H N NH N O S N H O N H 3 C CH 3 HO IC50 = 1.96 nM 588.73 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3cc(CNCC(C)(C)CO)ccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4218914 OBDepict CH 2 N O H N NH N O S N F F O IC50 = 2.27 nM 555.65 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C(F)F)s3)nc3cc(CN4CCOCC4)ccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4241958 OBDepict CH 2 HN O H 3 C N H O H 2 N OH H 3 C H 3 C IC50 = 2.3 nM 431.54 C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c4c(c23)CCC(C(C)(C)O)C4)c1C Homo sapiens CHEMBL4235703 single protein format
CHEMBL3928976 OBDepict Cl O NH 2 N CH 3 H N O O N OH H 3 C H 3 C Cl IC50 = 3.0 nM 587.46 Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)cc2c(Cl)cccn2c1=O Homo sapiens CHEMBL4672808 single protein format
CHEMBL4202941 OBDepict CH 2 N O H N NH N O S N H F F H 3 C CH 3 HO IC50 = 3.13 nM 571.69 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C(F)F)s3)nc3cc(CNCC(C)(C)CO)ccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4215807 OBDepict CH 2 N O H N NH N O S N N H H 3 C H H 3 C H 3 C CH 3 IC50 = 3.16 nM 520.7 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccns3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4210857 OBDepict CH 2 N O H N NH N O N H H 3 C H N H 3 C H 3 C CH 3 IC50 = 4.32 nM 538.7 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C#N)cc3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4202618 OBDepict CH 2 N O H N NH N O S N N H H 3 C H H 3 C H 3 C CH 3 IC50 = 4.5 nM 520.7 C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3cncs3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 Homo sapiens CHEMBL4199506 single protein format
CHEMBL4175428 OBDepict CH 3 N O H N O N N N H 2 N O IC50 = 5.3 nM 468.52 CC#CC(=O)N1CCC[C@@H](n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL4152875 single protein format
CHEMBL3301625 OBDepict CH 3 O O N H N N N H F N H O CH 2 IC50 = 6.2 nM 423.45 C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCOC)cc3)ncc2F)c1 Homo sapiens CHEMBL4152875 single protein format
CHEMBL4237557 OBDepict CH 2 N H O CH 3 CH 3 N H 3 C H O NH 2 IC50 = 6.4 nM 347.42 C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)c1C Homo sapiens CHEMBL4235703 single protein format
CHEMBL3290142 OBDepict CH 2 N H O N H N N HN O CH 3 NH O F F F IC50 = 8.2 nM 560.54 C=CC(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)cn2)c1 Homo sapiens CHEMBL3292444 single protein format
CHEMBL3900554 OBDepict F O NH 2 N CH 3 H N H O O N OH CH 3 H 3 C H 3 C F IC50 = 10.0 nM 572.61 Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4c(c23)CC[C@H](C(C)(C)O)C4)cccc1-n1c(=O)c2cccc(F)c2n(C)c1=O Homo sapiens CHEMBL3858959 single protein format
CHEMBL3918580 OBDepict CH 3 N N O N H O NH 2 OH H 3 C H 3 C IC50 = 13.0 nM 502.57 Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1cnc2ccccc2c1=O Homo sapiens CHEMBL4429376 assay format
CHEMBL3263640 OBDepict CH 3 NH N N O HN N N H H 3 C H 3 C CH 3 N O O IC50 = 14.0 nM 589.7 Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1nc(Nc2ccc(C(=O)N3CCOCC3)cc2)c2nc[nH]c2n1 Homo sapiens CHEMBL3270601 single protein format
CHEMBL4864983 OBDepict CH 2 N O H N N NH 2 O H 2 N N H O N F F F IC50 = 15.7 nM 527.51 C=CC(=O)N1CCCC[C@H]1c1nc(-c2ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc2)c(C(N)=O)n1N Homo sapiens CHEMBL4841679 single protein format
CHEMBL4108687 OBDepict O O N H 3 C CH 3 H H N N N H 2 N N H O N F F F IC50 = 27.0 nM 565.56 CC1(C)OC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@H]21 Homo sapiens CHEMBL4727430 single protein format
CHEMBL3707348 OBDepict H 3 C N O H N N N H 2 N N H O N IC50 = 29.0 nM 465.52 CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(C(=O)Nc3ccccn3)cc2)c2c(N)nccn12 Homo sapiens CHEMBL4726193 assay format
CHEMBL4752700 OBDepict CH 2 HN O N O HN O N CH 3 IC50 = 38.0 nM 438.49 C=CC(=O)Nc1ccc2nccc(Oc3ccc(C(=O)Nc4cc(CC)ccn4)cc3)c2c1 Homo sapiens CHEMBL4726193 assay format
CHEMBL3622193 OBDepict H 3 C N N O N H O H 2 N F HN O N CH 3 CH 3 IC50 = 41.0 nM 592.68 CN1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(-c4cccc(NC(=O)c5ccc(N(C)C)cc5)c4F)c23)CC1 Homo sapiens CHEMBL3627426 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 43.1 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328629 single protein format
CHEMBL4525187 OBDepict H 2 N N N N H N O H O IC50 = 44.0 nM 441.54 Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2C[C@H]1CCCN1C[C@@H]1CO1 Homo sapiens CHEMBL4347052 single protein format
CHEMBL4237800 OBDepict CH 3 N N O N H O NH 2 OH H 3 C H 3 C IC50 = 56.0 nM 506.61 Cc1c(-c2ccc(C(N)=O)c3[nH]c4c(c23)CCC(C(C)(C)O)C4)cccc1-n1cnc2ccccc2c1=O Homo sapiens CHEMBL4235703 single protein format
CHEMBL3586447 OBDepict CH 3 N N N H N NH 2 O NH 2 IC50 = 57.0 nM 318.34 Cc1cc2cn[nH]c2cc1-c1cccc2c(N)c(C(N)=O)nnc12 Homo sapiens CHEMBL3588279 single protein format
CHEMBL4172284 OBDepict CH 3 N H N N N NH 2 O NH 2 IC50 = 57.0 nM 318.34 Cc1cc2[nH]ncc2cc1-c1cccc2c(N)c(C(N)=O)nnc12 Homo sapiens CHEMBL4152875 single protein format
CHEMBL4103954 OBDepict O N H CH 3 H N N N H 2 N F HN O N F F F IC50 = 63.0 nM 581.57 C[C@H]1CC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CN1C(=O)C1CC1 Homo sapiens CHEMBL4717050 single protein format
CHEMBL4076024 OBDepict CH 3 O N O H N N N H 2 N F N H O N F F F IC50 = 63.0 nM 571.54 COCC(=O)N1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 Homo sapiens CHEMBL4057974 single protein format
CHEMBL4106978 OBDepict O N H H N N N H 2 N HN O N F F F IC50 = 63.0 nM 535.53 Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 Homo sapiens CHEMBL4727430 single protein format
CHEMBL4114929 OBDepict CH 3 O N N H O N H 2 N N N H N F F F H O IC50 = 67.0 nM 565.56 COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 Homo sapiens CHEMBL4727430 single protein format
CHEMBL4799627 OBDepict O N CH 3 O H N N N NH 2 F N H O N F F F IC50 = 69.0 nM 597.57 CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4F)c4c(N)nccn34)C2)COC1 Homo sapiens CHEMBL4717050 single protein format
CHEMBL1873475 OBDepict CH 2 N O H N N N N H 2 N O IC50 = 77.8 nM 440.51 C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL3887532 single protein format
CHEMBL3647964 OBDepict CH 2 N O H N N N N H 2 N O IC50 = 78.0 nM 440.51 C=CC(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 Homo sapiens CHEMBL4152870 single protein format
CHEMBL4749037 OBDepict O O N H H N N N H 2 N HN O N F F F IC50 = 92.0 nM 537.5 Nc1nccn2c([C@@H]3CC[C@H]4COC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 Homo sapiens CHEMBL4727430 single protein format
CHEMBL3647967 OBDepict CH 2 HN O H H N N N N H 2 N O IC50 = 108.0 nM 454.53 C=CC(=O)N[C@H]1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 Homo sapiens CHEMBL3887532 single protein format
CHEMBL4095253 OBDepict CH 2 S N O O H N N N H 2 N O O IC50 = 114.8 nM 427.49 C=CS(=O)(=O)N1CCC[C@@H]1Cn1cc(-c2ccc3c(c2)OCO3)c2c(N)ncnc21 Homo sapiens CHEMBL4058121 cell-based format
CHEMBL3621496 OBDepict CH 3 N N O N H O NH 2 F IC50 = 116.0 nM 430.48 CN1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(-c4ccccc4F)c23)CC1 Homo sapiens CHEMBL3627426 single protein format
CHEMBL3621515 OBDepict CH 3 N N O N H O NH 2 CH 3 N H O H 3 C IC50 = 162.0 nM 483.57 CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c4cc(C(=O)N5CCN(C)CC5)ccc4c23)c1C Homo sapiens CHEMBL3627426 single protein format
CHEMBL4094125 OBDepict O N CH 3 O H N N N NH 2 N H O N F F F IC50 = 167.0 nM 579.58 CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)C2)COC1 Homo sapiens CHEMBL4717050 single protein format
CHEMBL4077588 OBDepict F N HN O N H 2 N N N H N F F F O IC50 = 170.0 nM 583.59 Nc1nccn2c([C@@H]3CCCN(C4CCOCC4)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 Homo sapiens CHEMBL4057974 single protein format
CHEMBL4755977 OBDepict CH 3 O NH N O O N NH O O N IC50 = 184.0 nM 551.6 COc1cc2nccc(Oc3ccc(C(=O)Nc4ccccn4)cc3)c2cc1NC(=O)C#CCCN1CCOCC1 Homo sapiens CHEMBL4726193 assay format
CHEMBL4060757 OBDepict F N NH O N NH 2 N N H O N F F F O IC50 = 191.0 nM 585.56 Nc1nccn2c([C@H]3CN(C4CCOCC4)CCO3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 Homo sapiens CHEMBL4057974 single protein format
CHEMBL4782725 OBDepict CH 3 NH O O O N N O N H O N IC50 = 219.0 nM 551.6 CC#CC(=O)Nc1cc2c(Oc3ccc(C(=O)Nc4ccccn4)cc3)ccnc2cc1OCCN1CCOCC1 Homo sapiens CHEMBL4726193 assay format
CHEMBL3746293 OBDepict CH 3 N N N N H O N N H CH 3 N H F O S IC50 = 230.0 nM 529.6 Cc1c(-c2cc(Nc3cc4n(n3)CCN(C)C4)c(=O)[nH]n2)ccc(F)c1NC(=O)c1cc2ccccc2s1 Homo sapiens CHEMBL3750473 single protein format
CHEMBL4062498 OBDepict CH 3 O N O O H N N N H 2 N F N H O N F F F IC50 = 232.0 nM 573.51 COCC(=O)N1CCO[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 Homo sapiens CHEMBL4057974 single protein format
CHEMBL4107779 OBDepict O N H H N N N H 2 N O N H O N F F F IC50 = 277.0 nM 591.59 Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3OC3CC3)c12 Homo sapiens CHEMBL4727430 single protein format
CHEMBL288441 OBDepict CH 3 O O N N H N N Cl O H 3 C Cl N CH 3 IC50 = 282.0 nM 530.46 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl Homo sapiens CHEMBL1244347 single protein format
CHEMBL1421 OBDepict HO N N N N N H CH 3 N S N H O H 3 C Cl IC50 = 297.0 nM 488.02 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 Homo sapiens CHEMBL924605 single protein format
CHEMBL4069387 OBDepict O N CH 3 H 3 C H N N N H 2 N F N H O N F F F IC50 = 378.0 nM 569.56 CC(C)C(=O)N1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 Homo sapiens CHEMBL4057974 single protein format
CHEMBL4851021 OBDepict H 2 C N O H HN O S N H N O N CH 3 O IC50 = 409.0 nM 539.62 C=CC(=O)N1CC[C@@H](NC(=O)c2sc3nccc4c3c2NC(=O)N4c2ccc(Oc3ccccc3)cc2C)C1 Homo sapiens CHEMBL4818915 single protein format
CHEMBL4075954 OBDepict O N CH 3 H 3 C O H N N N H 2 N F N H O N F F F IC50 = 428.0 nM 571.54 CC(C)C(=O)N1CCO[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 Homo sapiens CHEMBL4057974 single protein format
CHEMBL4085457 OBDepict CH 2 N O H CH 3 H HN N N N H IC50 = 592.0 nM 285.35 C=CC(=O)N1C[C@H](Nc2ncnc3[nH]ccc23)CC[C@@H]1C Homo sapiens CHEMBL4005778 single protein format
CHEMBL4085457 OBDepict CH 2 N O H CH 3 H HN N N N H Ki = 679.0 nM 285.35 C=CC(=O)N1C[C@H](Nc2ncnc3[nH]ccc23)CC[C@@H]1C Homo sapiens CHEMBL4005764 single protein format