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P42684 | ABL2_HUMAN | Tyrosine-protein kinase ABL2 (ABL2)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: "SH2" // SH2 ]

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[ Domain: "SH3" // SH3_1 ]

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[ Domain: "F-actin binding domain of Abl" // F_actin_bind ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4867931 OBDepict H 3 C O N H S N O O H 2 N O HN IC50 = -53700.0 nM 464.55 COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(-c2ccc3c(c2)CCNC3=O)c1 Homo sapiens CHEMBL4804336 cell-based format
CHEMBL4855730 OBDepict F NH S N O O H 2 N O HN IC50 = -3000.0 nM 452.51 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804336 cell-based format
CHEMBL4868141 OBDepict H 2 N N O O HN NH S O O IC50 = -2800.0 nM 532.67 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2OC2CCCCC2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804336 cell-based format
CHEMBL288441 OBDepict CH 3 O O N N H N N Cl O H 3 C Cl N CH 3 IC50 = 0.5 nM 530.46 COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl Homo sapiens CHEMBL1244324 single protein format
CHEMBL2324924 OBDepict H 3 C N N F F F N H O CH 3 N N N IC50 = 1.0 nM 532.57 Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cncc2nccn12 Homo sapiens CHEMBL2330092 single protein format
CHEMBL4798527 OBDepict H 3 C N H N O N NH 2 N N H CH 3 F F F H HO IC50 = 4.0 nM 548.57 Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 Homo sapiens CHEMBL4766153 single protein format
CHEMBL2324926 OBDepict CH 3 N N F F F N H N H O N N H 3 C N N N IC50 = 6.0 nM 537.55 CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cnc5cccnn45)n(C)n3)cc2C(F)(F)F)CC1 Homo sapiens CHEMBL2330092 single protein format
CHEMBL2324930 OBDepict CH 3 N N F F F HN O CH 3 N N N IC50 = 8.0 nM 532.57 Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 Homo sapiens CHEMBL2330092 single protein format
CHEMBL2324925 OBDepict CH 3 N N F F F N H N H O N N H 3 C N N N IC50 = 10.0 nM 537.55 CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cnc5cnccn45)n(C)n3)cc2C(F)(F)F)CC1 Homo sapiens CHEMBL2330092 single protein format
CHEMBL2324927 OBDepict CH 3 N N F F F N H N H O N N H 3 C N N IC50 = 12.0 nM 536.56 CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cnc5ccccn45)n(C)n3)cc2C(F)(F)F)CC1 Homo sapiens CHEMBL2330092 single protein format
CHEMBL2324928 OBDepict CH 3 N N F F F N H N H O N N H 3 C N IC50 = 14.0 nM 497.53 CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cccnc4)n(C)n3)cc2C(F)(F)F)CC1 Homo sapiens CHEMBL2330092 single protein format
CHEMBL2324923 OBDepict CH 3 N N F F F N H N H O N N H 3 C N N N IC50 = 15.0 nM 537.55 CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cncc5nccn45)n(C)n3)cc2C(F)(F)F)CC1 Homo sapiens CHEMBL2330092 single protein format
CHEMBL2324931 OBDepict OH N N F F F HN O CH 3 N N IC50 = 18.0 nM 561.61 Cc1ccc(NC(=O)c2ccc(CN3CCN(CCO)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2ccccn12 Homo sapiens CHEMBL2330092 single protein format
CHEMBL2324929 OBDepict CH 3 N N F F F N H N H O N N H 3 C N H 2 N IC50 = 36.0 nM 512.54 CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4ccc(N)nc4)n(C)n3)cc2C(F)(F)F)CC1 Homo sapiens CHEMBL2330092 single protein format
CHEMBL2324932 OBDepict O HN F F F N CH 3 N N N IC50 = 40.0 nM 461.45 Cc1ccc(NC(=O)c2ccc(Cn3ccnc3)c(C(F)(F)F)c2)cc1C#Cc1cncnc1 Homo sapiens CHEMBL2330092 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 75.9 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL3820470 single protein format
CHEMBL3288854 OBDepict H 3 C N N N H O H 3 C CH 3 N H O HN F Ki = 180.0 nM 425.51 Cc1[nH]c(/C=C2C(=O)Nc3ccc(F)cc32)c(C)c1NC(=O)CCN1CCN(C)CC1 Homo sapiens CHEMBL3296767 single protein format
CHEMBL941 OBDepict H 3 C N N N H O N H CH 3 N N N IC50 = 272.0 nM 493.62 Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1 Homo sapiens CHEMBL3877208 cell-based format
CHEMBL2321908 OBDepict CH 3 N H N N O N H F F F N N IC50 = 298.0 nM 552.56 Cc1ccc(NC(=O)c2ccc(Cn3ccnc3)c(C(F)(F)F)c2)cc1C#Cc1ncc(Nc2ccccc2)cn1 Homo sapiens CHEMBL2330092 single protein format
CHEMBL4281823 OBDepict CH 3 N N N NH 2 N O O F F F IC50 = 306.0 nM 481.48 CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 Homo sapiens CHEMBL4261400 single protein format
CHEMBL4473548 OBDepict O N H H 3 C OH N O H H 3 C OH IC50 = 540.0 nM 494.59 C[C@@H]1CN(C(=O)CCCC(=O)N2C[C@@H](C)c3c2cc(O)c2ccccc32)c2cc(O)c3ccccc3c21 Homo sapiens CHEMBL4373573 cell-based format
CHEMBL4465918 OBDepict Cl H N O HO N O H Cl OH IC50 = 685.0 nM 563.48 O=C(CCCC(=O)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21 Homo sapiens CHEMBL4373573 cell-based format
CHEMBL2380834 OBDepict F F F F N H O NH N N H O IC50 = 863.0 nM 492.43 O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccc(F)cc1C(F)(F)F Homo sapiens CHEMBL2384609 single protein format
CHEMBL119385 OBDepict F F S N N N O Cl Cl IC50 < 1000.0 nM 436.27 O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl Homo sapiens CHEMBL4602908 single protein format