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P43003 | EAA1_HUMAN | Excitatory amino acid transporter 1 (SLC1A3)

3D structures mapped by conservation among orthologs

[ Domain: "Proton glutamate symport protein" // SDF ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL1257519 OBDepict OH O O H NH 2 H O OH N H O F F F IC50 = 3.6 nM 426.35 N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)c2ccc(C(F)(F)F)cc2)c1)C(=O)O Homo sapiens CHEMBL4150966 cell-based format
CHEMBL4176427 OBDepict O HN O H F F F NH 2 H O OH O HO IC50 = 5.1 nM 454.4 N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)CCc2ccc(C(F)(F)F)cc2)c1)C(=O)O Homo sapiens CHEMBL4150966 cell-based format
CHEMBL4173045 OBDepict OH O O H NH 2 H O OH N H O F F F IC50 = 6.1 nM 426.35 N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)c2cccc(C(F)(F)F)c2)c1)C(=O)O Homo sapiens CHEMBL4150966 cell-based format
CHEMBL4176482 OBDepict O N H O H NH 2 H O HO O Br F F IC50 = 11.0 nM 521.31 N[C@H](C(=O)O)[C@H](OCc1ccccc1)C(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1 Homo sapiens CHEMBL4150966 cell-based format
CHEMBL4177507 OBDepict OH O H 2 N H O H N H O IC50 = 12.0 nM 402.45 N[C@H](C(=O)O)[C@H](OCc1ccccc1)C(=O)Nc1ccc2c(c1)Cc1ccccc1-2 Homo sapiens CHEMBL4150966 cell-based format
CHEMBL4165811 OBDepict O HN O F F F H NH 2 H O HO O OH IC50 = 21.0 nM 440.37 N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)Cc2ccc(C(F)(F)F)cc2)c1)C(=O)O Homo sapiens CHEMBL4150966 cell-based format
CHEMBL4162363 OBDepict O N H F F F O H NH 2 H O OH O OH IC50 = 31.0 nM 426.35 N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1)C(=O)O Homo sapiens CHEMBL4150966 cell-based format
CHEMBL2113122 OBDepict O NH NH 2 H O OH F F F IC50 = 100.0 nM 352.31 N[C@@H](CC(=O)Nc1ccc(-c2cccc(C(F)(F)F)c2)cc1)C(=O)O Homo sapiens CHEMBL881962 cell-based format
CHEMBL2113115 OBDepict O HN H 2 N H O HO F IC50 = 100.0 nM 314.32 N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1cc(F)ccc1-2)C(=O)O Homo sapiens CHEMBL881962 cell-based format
CHEMBL2113112 OBDepict O N H H 2 N H O OH CH 3 F F F IC50 = 130.0 nM 366.34 Cc1cc(NC(=O)C[C@H](N)C(=O)O)ccc1-c1cccc(C(F)(F)F)c1 Homo sapiens CHEMBL881962 cell-based format
CHEMBL2113116 OBDepict O HN H 2 N H O HO Cl IC50 = 150.0 nM 330.77 N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1cc(Cl)ccc1-2)C(=O)O Homo sapiens CHEMBL881962 cell-based format
CHEMBL2113111 OBDepict CH 3 HN O Cl H 2 N H F O HO IC50 = 200.0 nM 364.8 CCc1cc(-c2ccc(F)c(Cl)c2)ccc1NC(=O)C[C@H](N)C(=O)O Homo sapiens CHEMBL881962 cell-based format
CHEMBL2113118 OBDepict O NH NH 2 H O OH Cl Cl IC50 = 200.0 nM 365.22 N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1c(Cl)cc(Cl)cc1-2)C(=O)O Homo sapiens CHEMBL881962 cell-based format
CHEMBL2113117 OBDepict O HN H 2 N H O HO Br IC50 = 300.0 nM 375.22 N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1cc(Br)ccc1-2)C(=O)O Homo sapiens CHEMBL881962 cell-based format
CHEMBL1628570 OBDepict O HN H 2 N H O HO IC50 = 300.0 nM 296.33 N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2)C(=O)O Homo sapiens CHEMBL881962 cell-based format
CHEMBL424838 OBDepict O N H NH 2 CH 3 O OH IC50 = 300.0 nM 298.34 Cc1cc(-c2ccccc2)ccc1NC(=O)CC(N)C(=O)O Homo sapiens CHEMBL881962 cell-based format
CHEMBL3960774 OBDepict H NH 2 HN O HO O OH S O O Cl IC50 = 320.0 nM 322.73 N[C@H](C(=O)O)C(NS(=O)(=O)c1ccc(Cl)cc1)C(=O)O Homo sapiens CHEMBL3861224 cell-based format
CHEMBL3975687 OBDepict H NH 2 HN O HO O OH S O O Br IC50 = 350.0 nM 367.18 N[C@H](C(=O)O)C(NS(=O)(=O)c1ccc(Br)cc1)C(=O)O Homo sapiens CHEMBL3861224 cell-based format
CHEMBL3974720 OBDepict H NH 2 NH O OH O OH S O O CH 3 IC50 = 380.0 nM 302.31 Cc1ccc(S(=O)(=O)NC(C(=O)O)[C@H](N)C(=O)O)cc1 Homo sapiens CHEMBL3861224 cell-based format
CHEMBL2113113 OBDepict O NH NH 2 H O OH F F F Cl F IC50 = 400.0 nM 404.75 N[C@@H](CC(=O)Nc1ccc(-c2ccc(F)c(Cl)c2)c(C(F)(F)F)c1)C(=O)O Homo sapiens CHEMBL881962 cell-based format
CHEMBL1259233 OBDepict N NH 2 O H 3 C O IC50 = 430.0 nM 330.39 CC1C(C#N)=C(N)OC2=C1C(=O)CC(c1cccc3ccccc13)C2 Homo sapiens CHEMBL1261598 cell-based format
CHEMBL4164207 OBDepict H O NH 2 H O HO O OH IC50 = 620.0 nM 245.27 N[C@H](C(=O)O)[C@H](OCC1CCCCC1)C(=O)O Homo sapiens CHEMBL4150966 cell-based format
CHEMBL474133 OBDepict CH 3 O O O N NH 2 IC50 = 660.0 nM 422.48 COc1ccc(C2C(C#N)=C(N)OC3=C2C(=O)CC(c2cccc4ccccc24)C3)cc1 Homo sapiens CHEMBL998472 cell-based format
CHEMBL2113126 OBDepict O N H H 2 N H O OH CH 3 Cl Cl IC50 = 700.0 nM 367.23 Cc1cc(NC(=O)C[C@H](N)C(=O)O)ccc1-c1ccc(Cl)c(Cl)c1 Homo sapiens CHEMBL881962 cell-based format
CHEMBL425569 OBDepict CH 3 N O HN O H 2 N O OH IC50 = 700.0 nM 341.37 CCN1c2ccccc2Oc2ccc(NC(=O)CC(N)C(=O)O)cc21 Homo sapiens CHEMBL881962 cell-based format
CHEMBL3937517 OBDepict H HN NH 2 H O HO S O OH O O IC50 = 800.0 nM 288.28 N[C@H](C(=O)O)[C@H](NS(=O)(=O)c1ccccc1)C(=O)O Homo sapiens CHEMBL3861224 cell-based format
CHEMBL3909952 OBDepict OH O HN H 2 N H S O OH O O F F IC50 = 800.0 nM 324.26 N[C@H](C(=O)O)C(NS(=O)(=O)c1ccc(F)c(F)c1)C(=O)O Homo sapiens CHEMBL3861224 cell-based format
CHEMBL1628669 OBDepict O N H H 2 N H O OH O Br F F IC50 = 860.0 nM 415.19 N[C@@H](CC(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1)C(=O)O Homo sapiens CHEMBL4150966 cell-based format
CHEMBL2113123 OBDepict O NH H 2 N H O OH CH 3 F F F IC50 = 1000.0 nM 366.34 Cc1cc(-c2cccc(C(F)(F)F)c2)ccc1NC(=O)C[C@H](N)C(=O)O Homo sapiens CHEMBL881962 cell-based format
CHEMBL2113120 OBDepict O N H NH 2 H O OH O F F IC50 = 1000.0 nM 334.28 N[C@@H](CC(=O)Nc1ccc2oc3cc(F)c(F)cc3c2c1)C(=O)O Homo sapiens CHEMBL881962 cell-based format