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P43004 | EAA2_HUMAN | Excitatory amino acid transporter 2 (SLC1A2)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4173045 OBDepict OH O O H NH 2 H O OH N H O F F F IC50 = 17.0 nM 426.35 N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)c2cccc(C(F)(F)F)c2)c1)C(=O)O Homo sapiens CHEMBL4150967 cell-based format
CHEMBL1257519 OBDepict OH O O H NH 2 H O OH N H O F F F IC50 = 17.0 nM 426.35 N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)c2ccc(C(F)(F)F)cc2)c1)C(=O)O Homo sapiens CHEMBL1259930 cell-based format
CHEMBL4176427 OBDepict O HN O H F F F NH 2 H O OH O HO IC50 = 18.0 nM 454.4 N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)CCc2ccc(C(F)(F)F)cc2)c1)C(=O)O Homo sapiens CHEMBL4150967 cell-based format
CHEMBL4176482 OBDepict O N H O H NH 2 H O HO O Br F F IC50 = 36.0 nM 521.31 N[C@H](C(=O)O)[C@H](OCc1ccccc1)C(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1 Homo sapiens CHEMBL4150967 cell-based format
CHEMBL4177507 OBDepict OH O H 2 N H O H N H O IC50 = 47.0 nM 402.45 N[C@H](C(=O)O)[C@H](OCc1ccccc1)C(=O)Nc1ccc2c(c1)Cc1ccccc1-2 Homo sapiens CHEMBL4150967 cell-based format
CHEMBL2113122 OBDepict O NH NH 2 H O OH F F F IC50 = 60.0 nM 352.31 N[C@@H](CC(=O)Nc1ccc(-c2cccc(C(F)(F)F)c2)cc1)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL2113115 OBDepict O HN H 2 N H O HO F IC50 = 80.0 nM 314.32 N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1cc(F)ccc1-2)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL1628669 OBDepict O N H H 2 N H O OH O Br F F IC50 = 80.0 nM 415.19 N[C@@H](CC(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL4162363 OBDepict O N H F F F O H NH 2 H O OH O OH IC50 = 84.0 nM 426.35 N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1)C(=O)O Homo sapiens CHEMBL4150967 cell-based format
CHEMBL2113119 OBDepict O HN H 2 N H O HO F F F IC50 = 100.0 nM 364.32 N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1cc(C(F)(F)F)ccc1-2)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL2113110 OBDepict O N H H 2 N H O OH CH 3 IC50 = 100.0 nM 298.34 Cc1ccccc1-c1ccc(NC(=O)C[C@H](N)C(=O)O)cc1 Homo sapiens CHEMBL881963 cell-based format
CHEMBL2113116 OBDepict O HN H 2 N H O HO Cl IC50 = 100.0 nM 330.77 N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1cc(Cl)ccc1-2)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL2113112 OBDepict O N H H 2 N H O OH CH 3 F F F IC50 = 100.0 nM 366.34 Cc1cc(NC(=O)C[C@H](N)C(=O)O)ccc1-c1cccc(C(F)(F)F)c1 Homo sapiens CHEMBL881963 cell-based format
CHEMBL2113126 OBDepict O N H H 2 N H O OH CH 3 Cl Cl IC50 = 100.0 nM 367.23 Cc1cc(NC(=O)C[C@H](N)C(=O)O)ccc1-c1ccc(Cl)c(Cl)c1 Homo sapiens CHEMBL881963 cell-based format
CHEMBL4165811 OBDepict O HN O F F F H NH 2 H O HO O OH IC50 = 110.0 nM 440.37 N[C@H](C(=O)O)[C@H](OCc1cccc(NC(=O)Cc2ccc(C(F)(F)F)cc2)c1)C(=O)O Homo sapiens CHEMBL4150967 cell-based format
CHEMBL2113121 OBDepict O N H NH 2 H O OH O F F IC50 = 130.0 nM 336.29 N[C@@H](CC(=O)Nc1ccc(Oc2ccc(F)c(F)c2)cc1)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL2113125 OBDepict O N H H 2 N H O OH CH 3 Cl IC50 = 200.0 nM 332.79 Cc1cc(NC(=O)C[C@H](N)C(=O)O)ccc1-c1ccc(Cl)cc1 Homo sapiens CHEMBL881963 cell-based format
CHEMBL2113117 OBDepict O HN H 2 N H O HO Br IC50 = 200.0 nM 375.22 N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1cc(Br)ccc1-2)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL424838 OBDepict O N H NH 2 CH 3 O OH IC50 = 200.0 nM 298.34 Cc1cc(-c2ccccc2)ccc1NC(=O)CC(N)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL2113113 OBDepict O NH NH 2 H O OH F F F Cl F IC50 = 200.0 nM 404.75 N[C@@H](CC(=O)Nc1ccc(-c2ccc(F)c(Cl)c2)c(C(F)(F)F)c1)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL425569 OBDepict CH 3 N O HN O H 2 N O OH IC50 = 300.0 nM 341.37 CCN1c2ccccc2Oc2ccc(NC(=O)CC(N)C(=O)O)cc21 Homo sapiens CHEMBL881963 cell-based format
CHEMBL2113124 OBDepict O N H H 2 N H O OH CH 3 F F F IC50 = 300.0 nM 366.34 Cc1cc(NC(=O)C[C@H](N)C(=O)O)ccc1-c1ccc(C(F)(F)F)cc1 Homo sapiens CHEMBL881963 cell-based format
CHEMBL2113128 OBDepict O N H H 2 N H O OH IC50 = 300.0 nM 334.38 N[C@@H](CC(=O)Nc1ccc(-c2ccc3ccccc3c2)cc1)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL2113118 OBDepict O NH NH 2 H O OH Cl Cl IC50 = 300.0 nM 365.22 N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1c(Cl)cc(Cl)cc1-2)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL2113123 OBDepict O NH H 2 N H O OH CH 3 F F F IC50 = 400.0 nM 366.34 Cc1cc(-c2cccc(C(F)(F)F)c2)ccc1NC(=O)C[C@H](N)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL4164207 OBDepict H O NH 2 H O HO O OH IC50 = 490.0 nM 245.27 N[C@H](C(=O)O)[C@H](OCC1CCCCC1)C(=O)O Homo sapiens CHEMBL4150967 cell-based format
CHEMBL3939524 OBDepict H NH 2 HN O HO O OH S O O IC50 = 500.0 nM 364.38 N[C@H](C(=O)O)C(NS(=O)(=O)c1ccc(-c2ccccc2)cc1)C(=O)O Homo sapiens CHEMBL3861225 cell-based format
CHEMBL2113120 OBDepict O N H NH 2 H O OH O F F IC50 = 500.0 nM 334.28 N[C@@H](CC(=O)Nc1ccc2oc3cc(F)c(F)cc3c2c1)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL373283 OBDepict O N H NH 2 O OH CH 3 Cl F IC50 = 500.0 nM 350.78 Cc1ccc(NC(=O)CC(N)C(=O)O)cc1-c1ccc(F)c(Cl)c1 Homo sapiens CHEMBL881963 cell-based format
CHEMBL2113111 OBDepict CH 3 HN O Cl H 2 N H F O HO IC50 = 600.0 nM 364.8 CCc1cc(-c2ccc(F)c(Cl)c2)ccc1NC(=O)C[C@H](N)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL4173825 OBDepict H O H 2 N H O OH O HO IC50 = 690.0 nM 217.22 N[C@H](C(=O)O)[C@H](OCC1CCC1)C(=O)O Homo sapiens CHEMBL4150967 cell-based format
CHEMBL2113114 OBDepict O HN H 2 N H O HO CH 3 F F F IC50 = 700.0 nM 366.34 Cc1ccc(NC(=O)C[C@H](N)C(=O)O)cc1-c1cccc(C(F)(F)F)c1 Homo sapiens CHEMBL881963 cell-based format
CHEMBL198315 OBDepict NH 2 O OH N H O IC50 = 700.0 nM 284.31 NC(CC(=O)Nc1ccc(-c2ccccc2)cc1)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL1628570 OBDepict O HN H 2 N H O HO IC50 = 700.0 nM 296.33 N[C@@H](CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL4177165 OBDepict HO O O H H 2 N H O HO O IC50 = 760.0 nM 229.19 N[C@H](C(=O)O)[C@H](OCc1ccoc1)C(=O)O Homo sapiens CHEMBL4150967 cell-based format
CHEMBL4163105 OBDepict OH O O H NH 2 H O HO S IC50 = 770.0 nM 245.26 N[C@H](C(=O)O)[C@H](OCc1cccs1)C(=O)O Homo sapiens CHEMBL4150967 cell-based format
CHEMBL4166545 OBDepict OH O O H NH 2 H O HO O IC50 = 830.0 nM 229.19 N[C@H](C(=O)O)[C@H](OCc1ccco1)C(=O)O Homo sapiens CHEMBL4150967 cell-based format
CHEMBL4169695 OBDepict HO O O H H 2 N H O HO S IC50 = 920.0 nM 245.26 N[C@H](C(=O)O)[C@H](OCc1ccsc1)C(=O)O Homo sapiens CHEMBL4150967 cell-based format
CHEMBL4165574 OBDepict H O H 2 N H O HO O OH IC50 = 940.0 nM 231.25 N[C@H](C(=O)O)[C@H](OCC1CCCC1)C(=O)O Homo sapiens CHEMBL4150967 cell-based format
CHEMBL79140 OBDepict H O NH 2 H O HO O OH IC50 = 960.0 nM 239.23 N[C@H](C(=O)O)[C@H](OCc1ccccc1)C(=O)O Homo sapiens CHEMBL3861225 cell-based format
CHEMBL2113129 OBDepict H H 2 N O OH NH O IC50 = 1000.0 nM 298.34 N[C@@H](CC(=O)Nc1ccc(Cc2ccccc2)cc1)C(=O)O Homo sapiens CHEMBL881963 cell-based format
CHEMBL2113127 OBDepict O N H H 2 N H O OH F F F F F F F IC50 = 1000.0 nM 424.27 N[C@@H](CC(=O)Nc1c(F)c(F)c(-c2cccc(C(F)(F)F)c2)c(F)c1F)C(=O)O Homo sapiens CHEMBL881963 cell-based format