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P43250 | GRK6_HUMAN | G protein-coupled receptor kinase 6 (GRK6)

3D structures mapped by conservation among orthologs

[ Domain: "Regulator of G-protein signaling, RGS" // RGS ]

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[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4867931 OBDepict H 3 C O N H S N O O H 2 N O HN IC50 = -40500.0 nM 464.55 COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(-c2ccc3c(c2)CCNC3=O)c1 Homo sapiens CHEMBL4804723 cell-based format
CHEMBL4852125 OBDepict CH 3 O N N H N NH N N CH 3 H H N CH 3 Cl IC50 = 3.5 nM 423.91 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(Cl)cn3)nc3cccc(OC)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4860332 OBDepict H 3 C O Cl HN N N N H N H 3 C N H H 3 C IC50 = 6.0 nM 422.92 CCc1cc(Nc2nc(NCc3ccc(Cl)cc3OC)nc3cccc(C)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4854871 OBDepict CH 3 O N N H N NH N N CH 3 H H N CH 3 F IC50 = 7.2 nM 407.45 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc3cccc(OC)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4877302 OBDepict CH 3 O N NH N N H N N H H 3 C O H 3 C Cl IC50 = 8.0 nM 438.92 CCc1cc(Nc2nc(NCc3ccc(Cl)cc3OC)nc3cccc(OC)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4855000 OBDepict CH 3 O N HN N N H N N H CH 3 IC50 = 10.0 nM 388.48 CCc1cc(Nc2nc(NCCc3ccccc3)nc3cccc(OC)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4875929 OBDepict H 3 C N H N N H N N HN H 3 C H 3 C H N F IC50 = 11.0 nM 391.45 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc3cccc(C)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4874424 OBDepict CH 3 O N NH N N H N N H H 3 C Cl IC50 = 16.0 nM 408.89 CCc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3cccc(OC)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4847703 OBDepict CH 3 O N NH N N H N N H N H 3 C F IC50 = 18.0 nM 393.43 CCc1cc(Nc2nc(NCc3ccc(F)cn3)nc3cccc(OC)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4876072 OBDepict CH 3 N H N NH N N H N F IC50 = 20.0 nM 376.44 CCc1cc(Nc2nc(NCCc3ccccc3)nc3cccc(F)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4871944 OBDepict H 3 C N H N N H N N HN F H 3 C H CH 3 IC50 = 27.0 nM 390.47 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(C)cc3)nc3cccc(F)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4872426 OBDepict CH 3 N H N NH N N H N CH 3 Cl IC50 = 27.0 nM 392.89 CCc1cc(Nc2nc(NCc3ccc(Cl)cc3)nc3cccc(C)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4870615 OBDepict H 3 C N H N N H N N HN F H 3 C H N F IC50 = 29.0 nM 395.42 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc3cccc(F)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4846282 OBDepict CH 3 O Cl N H N N N H N N H CH 3 IC50 = 40.0 nM 408.89 CCc1cc(Nc2nc(NCc3ccc(Cl)cc3OC)nc3ccccc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4847311 OBDepict H 3 C N H N N H N N HN F H 3 C H F IC50 = 41.0 nM 394.43 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc3cccc(F)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL388978 OBDepict CH 3 HN H H O H O N H 3 C H 3 C N O N H IC50 = 61.7 nM 466.54 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 Homo sapiens CHEMBL4328437 single protein format
CHEMBL4850937 OBDepict CH 3 N H N N H N N N H H 3 C H Cl IC50 = 70.0 nM 392.89 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(Cl)cc3)nc3ccccc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4849245 OBDepict CH 3 N H N N H N N NH F CH 3 H N N IC50 = 91.0 nM 402.44 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(C#N)cn3)nc3cccc(F)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4860927 OBDepict CH 3 N H N N H N N N H H 3 C H F F IC50 = 100.0 nM 394.43 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc3cc(F)ccc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4876138 OBDepict H 3 C N H N HN N N H N F F IC50 = 110.0 nM 394.43 CCc1cc(Nc2nc(NCCc3ccc(F)cc3)nc3cccc(F)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4848826 OBDepict CH 3 N H N N H N N N H H 3 C H F IC50 = 120.0 nM 376.44 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc3ccccc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4860406 OBDepict CH 3 O N N NH N H N N CH 3 H H CH 3 F IC50 = 140.0 nM 406.47 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc3ccc(OC)cc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4860226 OBDepict CH 3 N H N N H N N N H F H 3 C H F IC50 = 160.0 nM 394.43 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc3ccc(F)cc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4848792 OBDepict CH 3 N H N N H N N H N F F IC50 = 180.0 nM 394.43 CCc1cc(Nc2nc(NCCc3ccc(F)cc3)nc3cc(F)ccc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4858397 OBDepict H 3 C N H N N H N N H N F IC50 = 190.0 nM 376.44 CCc1cc(Nc2nc(NCCc3ccc(F)cc3)nc3ccccc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4875743 OBDepict H 3 C N H N N H N N HN F H 3 C H N N F IC50 = 230.0 nM 396.4 CCc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc3cccc(F)c23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4856820 OBDepict CH 3 N H N N H N N H N F IC50 = 250.0 nM 362.41 CCc1cc(Nc2nc(NCc3ccc(F)cc3)nc3ccccc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4857672 OBDepict CH 3 N N N H N N NH F CH 3 H N F IC50 = 280.0 nM 395.42 CCn1cnc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc3cccc(F)c23)c1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4876835 OBDepict H 3 C N H N NH N N HN Cl IC50 = 280.0 nM 404.91 CCc1cc(Nc2nc(NC3(c4ccc(Cl)cc4)CC3)nc3ccccc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4865412 OBDepict CH 3 N H N N H N N N H H 3 C H O H 3 C IC50 = 290.0 nM 388.48 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(OC)cc3)nc3ccccc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4856240 OBDepict CH 3 N H N N H N N H N F F IC50 = 310.0 nM 394.43 CCc1cc(Nc2nc(NCCc3ccc(F)cc3)nc3ccc(F)cc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4869975 OBDepict H 3 C N H N N H N N N H CH 3 H F IC50 = 340.0 nM 376.44 CCc1cc(Nc2nc(N[C@@H](C)c3cccc(F)c3)nc3ccccc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL3718518 OBDepict OH O S N N N H IC50 = 417.0 nM 361.43 O=C(O)CSc1nnc(-c2cccc(-c3ccc4ccccc4c3)c2)[nH]1 Homo sapiens CHEMBL3721076 single protein format
CHEMBL3718739 OBDepict H 3 C O Cl N N N H S O OH IC50 = 426.0 nM 375.84 COc1cc(Cl)cc(-c2cccc(-c3nnc(SCC(=O)O)[nH]3)c2)c1 Homo sapiens CHEMBL3721076 single protein format
CHEMBL4865487 OBDepict CH 3 N H N N H N N N H H 3 C H Cl F IC50 = 440.0 nM 410.88 CCc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cc3)nc3cc(Cl)ccc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL4875677 OBDepict CH 3 O N N NH N H N N H H 3 C F IC50 = 460.0 nM 406.47 CCc1cc(Nc2nc(NCCc3ccc(F)cc3)nc3ccc(OC)cc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL60254 OBDepict OH HN O H N H H O O OH HO O OH O HO IC50 = 490.0 nM 550.52 O=C(N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(=O)O)c(O)c1)c1ccc(O)cc1 Homo sapiens CHEMBL1106960 single protein format
CHEMBL4568087 OBDepict H 3 C N N N N N S N H O H H H 2 N IC50 = 500.0 nM 421.53 Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 Homo sapiens CHEMBL4479723 assay format
CHEMBL3718989 OBDepict CH 3 O N N N H S O HO IC50 = 510.0 nM 391.45 COc1ccc2cc(-c3cccc(-c4nnc(SCC(=O)O)[nH]4)c3)ccc2c1 Homo sapiens CHEMBL3721076 single protein format
CHEMBL3716736 OBDepict HO O S N N N H + N CH 3 O _ O IC50 = 751.0 nM 294.29 Cc1ccc(-c2nnc(SCC(=O)O)[nH]2)cc1[N+](=O)[O-] Homo sapiens CHEMBL3721076 single protein format
CHEMBL3717012 OBDepict OH O S N N N H S IC50 = 757.0 nM 317.4 O=C(O)CSc1nnc(-c2cccc(-c3cccs3)c2)[nH]1 Homo sapiens CHEMBL3721076 single protein format
CHEMBL3716413 OBDepict N N N N H S O OH IC50 = 919.0 nM 336.38 N#Cc1cccc(-c2cccc(-c3nnc(SCC(=O)O)[nH]3)c2)c1 Homo sapiens CHEMBL3721076 single protein format
CHEMBL4860741 OBDepict CH 3 N H N N H N N N H H 3 C H IC50 = 960.0 nM 364.5 CCc1cc(Nc2nc(N[C@@H](C)C3CCCCC3)nc3ccccc23)n[nH]1 Homo sapiens CHEMBL4810421 single protein format
CHEMBL3717241 OBDepict H 2 C N N H 2 N N O O CH 3 IC50 = 973.0 nM 282.3 C=CCn1c(N)c(C(=O)OC)c2nc3ccccc3nc21 Homo sapiens CHEMBL3721076 single protein format