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P43405 | KSYK_HUMAN | Tyrosine-protein kinase SYK (SYK)

3D structures mapped by conservation among orthologs

[ Domain: "Protein kinase" // Pkinase_Tyr ]

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[ Domain: "SH2" // SH2 ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3653779 OBDepict O N H H O CH 3 H N N CH 3 O CH 3 IC50 = 0.0 nM 417.51 CC(=O)N(C)Cc1ccc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cc1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3653842 OBDepict CH 3 N N O N CH 3 H H HN O IC50 = 0.0 nM 364.45 CCCn1cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cn1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3653843 OBDepict O NH H O CH 3 H N N N H 3 C CH 3 IC50 = 0.0 nM 364.45 CC(C)n1cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cn1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3415598 OBDepict H 3 C N HN N N N N N N H O NH 2 H H H 2 N IC50 = 0.01 nM 408.47 Cc1cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)nc(-n2nccn2)n1 Homo sapiens CHEMBL3420413 single protein format
CHEMBL4744190 OBDepict H 3 C O O N N CH 3 N H CH 3 N N N N H 3 C N CH 3 H 3 C IC50 = 0.03 nM 434.5 COC(=O)c1nn(C)c2c(C)cc(Nc3nccc(-c4cc(CN(C)C)n(C)n4)n3)cc12 Homo sapiens CHEMBL4675674 single protein format
CHEMBL3415583 OBDepict CH 3 N NH H 3 C N N H O NH 2 H H NH 2 IC50 = 0.06 nM 354.46 Cc1cc(C)nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)c1 Homo sapiens CHEMBL3420413 single protein format
CHEMBL4780257 OBDepict H 3 C N H O N N CH 3 N H N N N N CH 3 N OH IC50 = 0.06 nM 447.5 CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(CN5CC(O)C5)c(C)n4)n3)cc12 Homo sapiens CHEMBL4675674 single protein format
CHEMBL4776352 OBDepict H 3 C N H 3 C N N N N N H N H 3 C S O O H 3 C IC50 = 0.077 nM 449.54 CN(C)Cc1cnn(-c2ccnc3[nH]c(-c4cn(C)c5ccc(S(C)(=O)=O)cc45)nc23)c1 Homo sapiens CHEMBL4669219 single protein format
CHEMBL4753469 OBDepict H 3 C N H O N N N H N N N N N CH 3 H 3 C IC50 = 0.09 nM 391.44 CNC(=O)c1ncn2ccc(Nc3nccc(-n4cc(CN(C)C)cn4)n3)cc12 Homo sapiens CHEMBL4675674 single protein format
CHEMBL4762995 OBDepict CH 3 N H 3 C N CH 3 N N N N H N H 3 C N O N CH 3 IC50 = 0.098 nM 467.54 Cc1nnc(-c2ccc3c(c2)c(-c2nc4c(-n5cc(CN(C)C)c(C)n5)ccnc4[nH]2)cn3C)o1 Homo sapiens CHEMBL4669219 single protein format
CHEMBL3653847 OBDepict O NH H O CH 3 H N N N O O CH 3 IC50 = 0.1 nM 408.46 CC(=O)OCCn1cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cn1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3653846 OBDepict HO N N O N H 3 C H H HN O IC50 = 0.1 nM 366.42 C[C@@H](Oc1cc(-c2cnn(CCO)c2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3898524 OBDepict HO O H H HO H 3 C N S N CH 3 N H N CH 3 F IC50 = 0.1 nM 470.57 Cc1cc(Nc2cc(C)c(F)cn2)nc(-c2cnc(C(C)(O)[C@H]3CC[C@H](C(=O)O)CC3)s2)c1 Homo sapiens CHEMBL3887213 single protein format
CHEMBL3415594 OBDepict CH 3 N N CH 3 CH 3 N N H N NH O H 2 N H H NH 2 IC50 = 0.1 nM 434.55 Cc1cc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)nc(C)c1-c1cnn(C)c1 Homo sapiens CHEMBL3420413 single protein format
CHEMBL3696047 OBDepict H 3 C O H H N H N O N O O CH 3 CH 3 CH 3 IC50 = 0.1 nM 435.52 CC[C@@H](Oc1nc(-c2ccc(OC(C)C)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3705989 single protein format
CHEMBL3415589 OBDepict CH 3 N NH H 3 C N N H O NH 2 H S H NH 2 O O IC50 = 0.1 nM 404.5 Cc1cc(C)nc(Nc2cc(N[C@@H]3CS(=O)(=O)CC[C@@H]3N)cnc2C(N)=O)c1 Homo sapiens CHEMBL3420413 single protein format
CHEMBL3696046 OBDepict H 3 C O O N H 3 C CH 3 O N CH 3 H H N H O IC50 = 0.1 nM 421.5 COc1cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)ccc1OC(C)C Homo sapiens CHEMBL3705989 single protein format
CHEMBL3653791 OBDepict O N H H O H 3 C H N N H O O IC50 = 0.1 nM 403.44 C[C@@H](Oc1cc(-c2ccc3c(c2)COC(=O)N3)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3696005 OBDepict CH 3 O O N O N O H 3 C H H NH O IC50 < 0.1 nM 463.53 COc1cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)ccc1OC1CCOCC1 Homo sapiens CHEMBL3705989 single protein format
CHEMBL3653776 OBDepict O N H H O H 3 C H N N N O IC50 = 0.1 nM 418.5 C[C@@H](Oc1cc(-c2ccc(N3CCOCC3)nc2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3696035 OBDepict CH 3 O H H N H N O N O O CH 3 H 3 C IC50 = 0.1 nM 407.47 CC[C@@H](Oc1nc(-c2ccc(OC)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3705989 single protein format
CHEMBL3696026 OBDepict CH 3 O O CH 3 N O N CH 3 H H N H O IC50 = 0.1 nM 393.44 COc1ccc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc1OC Homo sapiens CHEMBL3705989 single protein format
CHEMBL3695989 OBDepict O N H H O H 3 C H N N N N O IC50 = 0.1 nM 419.49 C[C@@H](Oc1nc(-c2ccc(N3CCOCC3)nc2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3705989 single protein format
CHEMBL3657550 OBDepict CH 3 N N N N N HN H OH N H 3 C O IC50 = 0.1 nM 471.57 Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(C(=O)C3CC3)cn4C)n2)cc1CN1CC[C@@H](O)C1 Homo sapiens CHEMBL3705866 single protein format
CHEMBL3415606 OBDepict NH 2 O N NH HN N H N H H 2 N N N IC50 = 0.1 nM 393.46 NC(=O)c1ncc(N[C@@H]2CCCC[C@@H]2N)cc1Nc1cccc(-n2nccn2)n1 Homo sapiens CHEMBL3420413 single protein format
CHEMBL3657551 OBDepict CH 3 N N N N N H H OH N H 3 C O F F F IC50 = 0.1 nM 498.51 Cc1nn(-c2cccc(Nc3ccc4c(c3)c(C(=O)C(F)(F)F)cn4C)n2)cc1CN1CC[C@@H](O)C1 Homo sapiens CHEMBL3705866 single protein format
CHEMBL3696044 OBDepict CH 3 O CH 3 O H 3 C N O N CH 3 H H N H O IC50 = 0.1 nM 407.47 COc1cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc(C)c1OC Homo sapiens CHEMBL3705989 single protein format
CHEMBL3696011 OBDepict CH 3 O O CH 3 N O N H F F F HN O IC50 = 0.1 nM 447.41 COc1ccc(-c2cc3ncccc3c(OC([C@H]3CNC(=O)C3)C(F)(F)F)n2)cc1OC Homo sapiens CHEMBL3705989 single protein format
CHEMBL3696007 OBDepict CH 3 O H H N H N O N O O CH 3 O IC50 = 0.1 nM 477.56 CC[C@@H](Oc1nc(-c2ccc(OC3CCOCC3)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3705989 single protein format
CHEMBL4753141 OBDepict H 3 C N H O N N CH 3 N H N N N N O N CH 3 CH 3 H 3 C IC50 = 0.11 nM 435.49 CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(CN(C)C)c(OC)n4)n3)cc12 Homo sapiens CHEMBL4675674 single protein format
CHEMBL4784088 OBDepict CH 3 N H 3 C N CH 3 N N N NH N N H 3 C N O N CH 3 IC50 = 0.13 nM 444.5 Cc1nnc(-c2nn(C)c3ccc(Nc4nccc(-c5cc(CN(C)C)n(C)n5)n4)cc23)o1 Homo sapiens CHEMBL4675674 single protein format
CHEMBL4752008 OBDepict H 3 C N H O N N CH 3 N H N N N N F N CH 3 H 3 C IC50 = 0.14 nM 423.46 CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(CN(C)C)c(F)n4)n3)cc12 Homo sapiens CHEMBL4675674 single protein format
CHEMBL4754597 OBDepict CH 3 N H O N CH 3 N N H N N N N H 3 C CH 3 IC50 = 0.15 nM 428.5 CNC(=O)c1ccc2c(c1)c(-c1nc3c(-n4cc(CN(C)C)cn4)ccnc3[nH]1)cn2C Homo sapiens CHEMBL4669219 single protein format
CHEMBL4776842 OBDepict CH 3 N CH 3 N H 3 C N N N N H N CH 3 HN O H 3 C IC50 = 0.17 nM 442.53 CC(=O)Nc1ccc2c(c1)c(-c1nc3c(-n4cc(CN(C)C)c(C)n4)ccnc3[nH]1)cn2C Homo sapiens CHEMBL4669219 single protein format
CHEMBL4752127 OBDepict H 3 C HN O N N CH 3 N N H N N N N H 3 C CH 3 IC50 = 0.18 nM 429.49 CNC(=O)c1cc2c(-c3nc4c(-n5cc(CN(C)C)cn5)ccnc4[nH]3)cn(C)c2cn1 Homo sapiens CHEMBL4669219 single protein format
CHEMBL4753164 OBDepict CH 3 N H 3 C N CH 3 N N N NH N N H 3 C N O N CH 3 IC50 = 0.19 nM 444.5 Cc1nnc(-c2nc(C)n3ccc(Nc4nccc(-c5cc(CN(C)C)n(C)n5)n4)cc23)o1 Homo sapiens CHEMBL4675674 single protein format
CHEMBL4758052 OBDepict H 3 C N H O N N CH 3 N H N N N N O H 3 C H NH IC50 = 0.19 nM 461.53 CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(O[C@@H]5CCCNC5)c(C)n4)n3)cc12 Homo sapiens CHEMBL4701487 single protein format
CHEMBL4740533 OBDepict H 3 C N O N N N CH 3 N H N N N N N H H 3 C H H H 2 N O IC50 = 0.2 nM 501.56 Cc1nnc(-c2nn(C)c3ccc(Nc4nccc(-n5cc(N[C@@H]6CCOC[C@@H]6N)c(C)n5)n4)cc23)o1 Homo sapiens CHEMBL4701487 single protein format
CHEMBL3695979 OBDepict H 3 C O O CH 3 O N CH 3 O N CH 3 H H N H O IC50 = 0.2 nM 423.47 COc1cc(-c2cc3ncccc3c(O[C@H](C)[C@H]3CNC(=O)C3)n2)cc(OC)c1OC Homo sapiens CHEMBL3705989 single protein format
CHEMBL3653813 OBDepict O N H H O CH 3 H N S N CH 3 IC50 = 0.2 nM 403.51 Cc1nc2ccc(-c3cc(O[C@H](C)[C@H]4CNC(=O)C4)c4cccnc4c3)cc2s1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3653814 OBDepict O N H H O CH 3 H N Cl NH 2 IC50 = 0.2 nM 421.93 C[C@@H](Oc1cc(-c2ccc(C3(N)CC3)c(Cl)c2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3653833 OBDepict O N H H O H 3 C H N N N H 3 C H 3 C IC50 = 0.2 nM 400.48 Cc1nc2cc(-c3cc(O[C@H](C)[C@H]4CNC(=O)C4)c4cccnc4c3)ccc2n1C Homo sapiens CHEMBL3706124 single protein format
CHEMBL4792651 OBDepict H 3 C N H O N N CH 3 N H N N N N H N CH 3 H F IC50 = 0.2 nM 449.49 CNC(=O)c1nc(C)n2ccc(Nc3nccc(-n4cc([C@@H]5C[C@@H](F)CN5C)cn4)n3)cc12 Homo sapiens CHEMBL4675674 single protein format
CHEMBL3696058 OBDepict O N H H O H 3 C H N N IC50 = 0.2 nM 333.39 C[C@@H](Oc1nc(-c2ccccc2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3705989 single protein format
CHEMBL3653775 OBDepict O N H H O CH 3 H N N N H 3 C IC50 = 0.2 nM 336.4 C[C@@H](Oc1cc(-c2cnn(C)c2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3696023 OBDepict H 3 C O O H H HN N O N O O CH 3 CH 3 IC50 = 0.2 nM 437.5 COCC[C@@H](Oc1nc(-c2ccc(OC)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3705989 single protein format
CHEMBL3696013 OBDepict CH 3 O O CH 3 N O N H H F F F N H O IC50 = 0.2 nM 447.41 COc1ccc(-c2cc3ncccc3c(O[C@@H]([C@H]3CNC(=O)C3)C(F)(F)F)n2)cc1OC Homo sapiens CHEMBL3705989 single protein format
CHEMBL3653796 OBDepict CH 3 N O H 3 C O N CH 3 H H N H O IC50 = 0.2 nM 431.54 CCN(Cc1ccc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cc1)C(C)=O Homo sapiens CHEMBL3706124 single protein format
CHEMBL3653806 OBDepict CH 3 N N O N H 3 C H H NH O IC50 = 0.2 nM 350.42 CCn1cc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cn1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3415597 OBDepict CH 3 N N HN O N OH H 3 C H 3 C N H O NH 2 H H H 2 N IC50 = 0.2 nM 429.53 Cc1nc(Nc2cc(N[C@@H]3CCCC[C@@H]3N)cnc2C(N)=O)cc(OCC(C)(C)O)n1 Homo sapiens CHEMBL3420413 single protein format
CHEMBL4740065 OBDepict H N N N N N N H 3 C N H H H H 2 N O IC50 = 0.21 nM 428.5 Cn1ccc2c(-c3nc4c(-n5cc(N[C@@H]6CCOC[C@@H]6N)cn5)ccnc4[nH]3)cccc21 Homo sapiens CHEMBL4669219 single protein format
CHEMBL4786316 OBDepict H 3 C N H O N N CH 3 N H N N N N N CH 3 H 3 C IC50 = 0.21 nM 405.47 CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(CN(C)C)cn4)n3)cc12 Homo sapiens CHEMBL4675674 single protein format
CHEMBL4759636 OBDepict CH 3 N H 3 C N CH 3 N N N NH N N N O N CH 3 IC50 = 0.21 nM 430.48 Cc1nnc(-c2ncn3ccc(Nc4nccc(-c5cc(CN(C)C)n(C)n5)n4)cc23)o1 Homo sapiens CHEMBL4669219 single protein format
CHEMBL4762290 OBDepict H 3 C N H O N N CH 3 N H CH 3 N N N N N CH 3 H 3 C IC50 = 0.22 nM 419.49 CNC(=O)c1nn(C)c2c(C)cc(Nc3nccc(-n4cc(CN(C)C)cn4)n3)cc12 Homo sapiens CHEMBL4675674 single protein format
CHEMBL3942835 OBDepict NH 2 O N N N NH N H H N H NH 2 F F IC50 = 0.22 nM 416.44 NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2c1ccn2C(F)F Homo sapiens CHEMBL3887308 single protein format
CHEMBL4797815 OBDepict CH 3 N N N H N H H NH 2 N NH O N H 3 C O F F F IC50 = 0.22 nM 514.51 Cc1nn(-c2ccnc(Nc3ccc4c(c3)c(C(=O)C(F)(F)F)cn4C)n2)cc1N[C@@H]1CCOC[C@@H]1N Homo sapiens CHEMBL4701487 single protein format
CHEMBL4785413 OBDepict NH 2 N H N N N N N H N N CH 3 N H O H 3 C IC50 = 0.23 nM 406.45 CNC(=O)c1nc(C)n2ccc(Nc3nccc(-n4cc(NCCN)cn4)n3)cc12 Homo sapiens CHEMBL4701487 single protein format
CHEMBL3951701 OBDepict CH 3 N N HN N N N N H O NH 2 H H H 2 N IC50 = 0.23 nM 457.54 Cn1cc2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cc(-c3ccccc3)c2n1 Homo sapiens CHEMBL3887308 single protein format
CHEMBL4800498 OBDepict H 3 C N H O N N CH 3 N H N N N N N CH 3 H 3 C IC50 = 0.24 nM 405.47 CNC(=O)c1nc(C)n2ccc(Nc3nccc(-n4cc(CN(C)C)cn4)n3)cc12 Homo sapiens CHEMBL4701487 single protein format
CHEMBL4784783 OBDepict H 3 C N H O N N CH 3 N H N N N N H N CH 3 H HO IC50 = 0.24 nM 447.5 CNC(=O)c1nc(C)n2ccc(Nc3nccc(-n4cc([C@@H]5C[C@H](O)CN5C)cn4)n3)cc12 Homo sapiens CHEMBL4675674 single protein format
CHEMBL4790107 OBDepict H 3 C N H O N N CH 3 N H CH 3 N N N N H 3 C N CH 3 H 3 C IC50 = 0.26 nM 433.52 CNC(=O)c1nn(C)c2c(C)cc(Nc3nccc(-c4cc(CN(C)C)n(C)n4)n3)cc12 Homo sapiens CHEMBL4675674 single protein format
CHEMBL3985707 OBDepict CH 3 N N CH 3 N H N N N NH O H 2 N H H NH 2 IC50 = 0.26 nM 395.47 Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)cc2nn(C)cc12 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3966264 OBDepict CH 3 N N N HN N N N N H O NH 2 H H H 2 N IC50 = 0.26 nM 446.52 Cn1cc(-n2ccc3c(Nc4nc(N[C@@H]5CCCC[C@@H]5N)nnc4C(N)=O)cccc32)cn1 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3925148 OBDepict NH 2 O N N NH N HN H H H 2 N S IC50 = 0.26 nM 383.48 NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1ccc2sccc2c1 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3928419 OBDepict CH 3 O S H 3 C N H N N N N H O NH 2 H H H 2 N IC50 = 0.27 nM 427.53 COc1ccc2sc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)c(C)c2c1 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3903852 OBDepict H 2 N O N N N H N HN S H H H 2 N IC50 = 0.28 nM 383.48 NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cc2ccccc2s1 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3927595 OBDepict NH 2 O N N N N H N H S H H NH 2 IC50 = 0.29 nM 409.52 NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cc(-c2ccccc2)cs1 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3942131 OBDepict NH 2 O N N N HN NH S H H NH 2 IC50 = 0.29 nM 383.48 NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1csc2ccccc12 Homo sapiens CHEMBL3887308 single protein format
CHEMBL4109655 OBDepict CH 3 O H 2 N H NH CH 3 H N N N N H O H 2 N N N CH 3 IC50 = 0.29 nM 461.53 COC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(-c3ccccc3)c3nn(C)cc3c2)n1 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3653822 OBDepict O N H H O CH 3 H N N N H 3 C IC50 = 0.3 nM 386.46 C[C@@H](Oc1cc(-c2ccc3c(c2)ncn3C)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3696033 OBDepict H 3 C O H HN N O N O O CH 3 CH 3 IC50 = 0.3 nM 407.47 CCC(Oc1nc(-c2ccc(OC)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3705989 single protein format
CHEMBL4776734 OBDepict H 3 C N H O N N CH 3 N H N N N N N H H 3 C H N H H F IC50 = 0.3 nM 464.51 CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(N[C@H]5CNC[C@@H]5F)c(C)n4)n3)cc12 Homo sapiens CHEMBL4701487 single protein format
CHEMBL3653771 OBDepict O N H H O CH 3 H N N O IC50 = 0.3 nM 431.54 C[C@@H](Oc1cc(-c2ccc(CN3CCOCC3)cc2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3653769 OBDepict O N H H O CH 3 H N N N H IC50 = 0.3 nM 372.43 C[C@@H](Oc1cc(-c2ccc3[nH]cnc3c2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3653816 OBDepict CH 3 O N O N H 3 C H H N H O IC50 = 0.3 nM 363.42 COc1ccc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)nc1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3653797 OBDepict H 3 C O N O N H 3 C H H N H O IC50 = 0.3 nM 377.44 CCOc1ccc(-c2cc(O[C@H](C)[C@H]3CNC(=O)C3)c3cccnc3c2)cn1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3695985 OBDepict CH 3 O H H N H N O N O O CH 3 O CH 3 H 3 C IC50 = 0.3 nM 437.5 CC[C@@H](Oc1nc(-c2cc(OC)c(OC)c(OC)c2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3705989 single protein format
CHEMBL3696014 OBDepict CH 3 O O CH 3 N O N H O N H O IC50 = 0.3 nM 381.39 COc1ccc(-c2cc3ncccc3c(OC[C@H]3CNC(=O)O3)n2)cc1OC Homo sapiens CHEMBL3705989 single protein format
CHEMBL3653783 OBDepict O N H H O H 3 C H N N O IC50 = 0.3 nM 443.55 C[C@@H](Oc1cc(-c2ccc(CN3CCCCC3=O)cc2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3653758 OBDepict O N H H O H 3 C H N N IC50 = 0.3 nM 383.45 C[C@@H](Oc1cc(-c2ccc3ncccc3c2)cc2ncccc12)[C@H]1CNC(=O)C1 Homo sapiens CHEMBL3706124 single protein format
CHEMBL3696024 OBDepict CH 3 O O CH 3 N O N CH 3 H N H O IC50 = 0.3 nM 393.44 COc1ccc(-c2cc3ncccc3c(O[C@@H](C)C3CNC(=O)C3)n2)cc1OC Homo sapiens CHEMBL3705989 single protein format
CHEMBL4751083 OBDepict H 3 C N H O N N CH 3 N H N N N N H 3 C N CH 3 H 3 C IC50 = 0.31 nM 419.49 CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(CN(C)C)c(C)n4)n3)cc12 Homo sapiens CHEMBL4669219 single protein format
CHEMBL3977902 OBDepict CH 3 N N N H N N N NH O H 2 N H H NH 2 IC50 = 0.31 nM 409.5 CCn1cc2ccc(Nc3nc(N[C@@H]4CCCCC[C@@H]4N)nnc3C(N)=O)cc2n1 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3935081 OBDepict H 3 C NH N CH 3 N N N N H O NH 2 H H NH 2 IC50 = 0.33 nM 394.48 Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)c2ccn(C)c2c1 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3937625 OBDepict H 2 N O N N N HN N H H N N H H 2 N F F IC50 = 0.33 nM 417.42 NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2nn(C(F)F)cc12 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3954832 OBDepict NH 2 O N N HN N N H H CH 3 H H 2 N N IC50 = 0.33 nM 392.47 Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)cc2cccnc12 Homo sapiens CHEMBL3887308 single protein format
CHEMBL4786007 OBDepict CH 3 HN O N N CH 3 N H N N N N N H H H H 2 N O IC50 = 0.33 nM 462.52 CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(N[C@@H]5CCOC[C@@H]5N)cn4)n3)cc12 Homo sapiens CHEMBL4701487 single protein format
CHEMBL4748041 OBDepict CH 3 N H O N N CH 3 N H N N N N N H H 3 C NH 2 IC50 = 0.34 nM 446.52 CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(NCC5(N)CC5)c(C)n4)n3)cc12 Homo sapiens CHEMBL4701487 single protein format
CHEMBL4106524 OBDepict H 3 C O H 2 N H NH CH 3 H N N N N H O H 2 N CH 3 N N CH 3 CH 3 IC50 = 0.34 nM 427.51 COC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(C)c3c(cnn3C(C)C)c2)n1 Homo sapiens CHEMBL3887308 single protein format
CHEMBL4742918 OBDepict CH 3 HN O N N CH 3 N H N N N N N H H 3 C H H H 2 N O IC50 = 0.34 nM 476.55 CNC(=O)c1nn(C)c2ccc(Nc3nccc(-n4cc(N[C@@H]5CCOC[C@@H]5N)c(C)n4)n3)cc12 Homo sapiens CHEMBL4701487 single protein format
CHEMBL4106498 OBDepict H 3 C O H 2 N H NH CH 3 H N N N N H O H 2 N CH 3 N CH 3 IC50 = 0.35 nM 398.47 COC[C@H](N)[C@@H](C)Nc1nnc(C(N)=O)c(Nc2cc(C)cc3c2ccn3C)n1 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3964579 OBDepict CH 3 H 2 N H HN N N N N H O NH 2 S IC50 = 0.35 nM 357.44 CC[C@H](N)CNc1nnc(C(N)=O)c(Nc2cccc3sccc23)n1 Homo sapiens CHEMBL3887308 single protein format
CHEMBL4763433 OBDepict CH 3 HN O N N CH 3 N H N N N N N H H H H 2 N O IC50 = 0.36 nM 462.52 CNC(=O)c1nc(C)n2ccc(Nc3nccc(-n4cc(N[C@@H]5CCOC[C@@H]5N)cn4)n3)cc12 Homo sapiens CHEMBL4701487 single protein format
CHEMBL3916136 OBDepict H 2 N O N N N H N HN H N H H 2 N N F F IC50 = 0.36 nM 417.42 NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1ccc2cnn(C(F)F)c2c1 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3915461 OBDepict NH 2 O N N N NH N H H N H NH 2 CH 3 IC50 = 0.36 nM 380.46 Cn1ccc2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cccc21 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3956355 OBDepict CH 3 N N N NH N N N N H O NH 2 H H NH 2 IC50 = 0.36 nM 446.52 Cn1ccc(-n2ccc3c(Nc4nc(N[C@@H]5CCCC[C@@H]5N)nnc4C(N)=O)cccc32)n1 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3962569 OBDepict H 2 N O N N N H N HN H H 3 C H H 2 N N N O CH 3 CH 3 H 3 C IC50 = 0.37 nM 439.52 Cc1cc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)cc2cn(C(C)(C)C)nc12 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3980587 OBDepict H 2 N O N N N H N HN H H 3 C H H 2 N N N F F IC50 = 0.37 nM 431.45 Cc1cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nnc2C(N)=O)cc2cn(C(F)F)nc12 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3891798 OBDepict H 2 N O N N N H N HN H H 3 C H H 2 N S O IC50 = 0.37 nM 399.48 Cc1cc(Nc2nc(N[C@@H]3CCOC[C@@H]3N)nnc2C(N)=O)cc2ccsc12 Homo sapiens CHEMBL3887308 single protein format
CHEMBL3915963 OBDepict H 3 C N N N N N H N N N HN O NH 2 H H H 2 N IC50 = 0.37 nM 461.53 CCn1cc2cc(Nc3nc(N[C@@H]4CCCC[C@@H]4N)nnc3C(N)=O)cc(-n3cccn3)c2n1 Homo sapiens CHEMBL3887308 single protein format