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P45983 | MK08_HUMAN | Mitogen-activated protein kinase 8 (MAPK8)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4859660 OBDepict NH 2 N F + N O NH O _ O IC50 = -24200.0 nM 378.36 Nc1ncc(-c2cccc([N+](=O)[O-])c2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804400 cell-based format
CHEMBL4860979 OBDepict F S N O O CH 3 N H 2 N O N H IC50 = -12900.0 nM 466.54 CN(C1CC1)S(=O)(=O)c1ccc(-c2cnc(N)c(-c3ccc4c(c3)CCNC4=O)c2)c(F)c1 Homo sapiens CHEMBL4804400 cell-based format
CHEMBL4546504 OBDepict CH 3 N CH 3 O O N H CH 3 H N N F F F O N H H Cl H 3 C HO IC50 = 0.032 nM 555.99 C[C@@H](Oc1cc(C(=O)N(C)C)ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(F)(F)F Homo sapiens CHEMBL4349099 assay format
CHEMBL3220502 OBDepict O N N H N N N H Cl O H 2 N IC50 = 0.24 nM 422.88 NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCCC3=O)cc2)ncc1Cl Homo sapiens CHEMBL3395896 single protein format
CHEMBL3393600 OBDepict CH 3 O N H O N N N H 3 C IC50 = 0.8 nM 372.43 COc1ccc(CC(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)cc1 Homo sapiens CHEMBL3395896 single protein format
CHEMBL378627 OBDepict H 3 C O S O O O CH 3 N H O H 3 C N NH 2 O N H 3 C CH 3 Ki = 1.0 nM 448.5 COc1cc(S(C)(=O)=O)c(OC)cc1CC(=O)Nc1cc(N)c(C#N)c(OC(C)C)n1 Homo sapiens CHEMBL860181 single protein format
CHEMBL1822152 OBDepict N N O N H O S Br N N H N IC50 = 1.0 nM 455.3 N#Cc1ccc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c2c1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL1822151 OBDepict N N O N H O S Br N N H N IC50 = 1.0 nM 455.3 N#Cc1ccc2c(ccc(=O)n2CC(=O)Nc2scc(Br)c2-c2ncn[nH]2)c1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL1822305 OBDepict O HN N S O N Br N N N H 3 C IC50 = 1.0 nM 447.32 Cn1cnc(-c2c(Br)csc2NC(=O)CN2C(=O)CCc3ncccc32)n1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL4849353 OBDepict CH 3 O H H N H N N N H O NH 2 H H HO IC50 = 1.0 nM 377.49 CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCCC[C@H](O)C3)n2)CC1 Homo sapiens CHEMBL4842273 single protein format
CHEMBL3679421 OBDepict Cl N O N O N H O N O IC50 = 1.0 nM 563.01 O=C(NCc1c(-c2ncco2)n(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccn(Cc2ccccc2)c(=O)c1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL4856984 OBDepict CH 3 O H H N H N N N H O NH 2 H H 3 C HO IC50 = 1.0 nM 377.49 CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCC[C@](C)(O)C3)n2)CC1 Homo sapiens CHEMBL4842273 single protein format
CHEMBL3220493 OBDepict Cl N N NH N H O NH 2 N O IC50 = 1.0 nM 424.89 NC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1Cl Homo sapiens CHEMBL3395896 single protein format
CHEMBL3393607 OBDepict CH 3 N CH 3 NH O N H O N H N N N IC50 = 1.5 nM 493.57 CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2ccc(Nc3nccc(-c4cccnc4)n3)cc2)c1 Homo sapiens CHEMBL3396757 single protein format
CHEMBL4853125 OBDepict CH 3 O H H N H N N N H O NH 2 H H HO IC50 = 2.0 nM 363.46 CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCC[C@@H](O)C3)n2)CC1 Homo sapiens CHEMBL4842273 single protein format
CHEMBL1822146 OBDepict O NH N S O Br N N H N F F F IC50 = 2.0 nM 498.28 O=C(Cn1c(=O)ccc2cc(C(F)(F)F)ccc21)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL4878370 OBDepict H 3 C O H H N H N N N H O H 2 N H H OH H CH 3 IC50 = 2.0 nM 377.49 CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CC[C@@H](C)[C@H](O)C3)n2)CC1 Homo sapiens CHEMBL4842273 single protein format
CHEMBL4864618 OBDepict H 2 N O N N N H N H H H H HO H O F F F IC50 = 2.0 nM 431.46 NC(=O)c1cnc(N[C@H]2CC[C@H](OCC(F)(F)F)CC2)nc1N[C@@H]1CCC[C@H](O)C1 Homo sapiens CHEMBL4842273 single protein format
CHEMBL3674700 OBDepict HO H H N H N N N N N O N IC50 = 2.0 nM 473.58 N#CCC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](CO)CC3)n2)CC1 Homo sapiens CHEMBL3705344 single protein format
CHEMBL437747 OBDepict H 3 C N N N N H N N H Cl Cl IC50 = 2.0 nM 513.52 CCCn1c(C2CCNCC2)nc(-c2ccc(Cl)c(Cl)c2)c1-c1ccnc(NC2CCCCC2)n1 Homo sapiens CHEMBL902320 single protein format
CHEMBL1822309 OBDepict N S N HN S O N O F F F IC50 = 2.0 nM 460.46 N#Cc1csc(NC(=O)Cn2c(=O)ccc3cc(C(F)(F)F)ccc32)c1-c1cscn1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL210618 OBDepict H 3 C O N N H N NH 2 O O O CH 3 H 3 C Ki = 2.0 nM 356.38 CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N Homo sapiens CHEMBL860181 single protein format
CHEMBL1822149 OBDepict O NH N S O Br N N H N O F F F IC50 = 2.0 nM 514.28 O=C(Cn1c(=O)ccc2cc(OC(F)(F)F)ccc21)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL3674715 OBDepict N N O N N N N N H H H S O O CH 3 IC50 = 2.4 nM 535.67 CS(=O)(=O)C[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(C(=O)CC#N)CC5)cccc43)n2)CC1 Homo sapiens CHEMBL3705344 single protein format
CHEMBL3220495 OBDepict CH 3 O N H N N N O HN Cl O H 2 N IC50 = 3.0 nM 454.92 COc1cc(N2CCOCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1 Homo sapiens CHEMBL3395896 single protein format
CHEMBL2392825 OBDepict H N H N N H N H S N O O CH 3 N S O O H 3 C IC50 = 3.0 nM 546.72 CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 Homo sapiens CHEMBL2393735 single protein format
CHEMBL2392833 OBDepict H HO H N H N N N N S O O CH 3 IC50 = 3.0 nM 469.61 CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)CC1 Homo sapiens CHEMBL2393735 single protein format
CHEMBL4853525 OBDepict H 2 N O N N N H NH H H H HO H HO IC50 = 3.0 nM 349.44 NC(=O)c1cnc(N[C@H]2CC[C@H](O)CC2)nc1N[C@@H]1CCC[C@H](O)C1 Homo sapiens CHEMBL4842273 single protein format
CHEMBL4862107 OBDepict NH 2 O N N N H N H H H H OH H O D D D IC50 = 3.0 nM 366.48 [2H]C([2H])([2H])O[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCC[C@H](O)C3)n2)CC1 Homo sapiens CHEMBL4842273 single protein format
CHEMBL4845965 OBDepict F O F H H NH N N HN O H 2 N H H HO IC50 = 3.0 nM 399.44 NC(=O)c1cnc(N[C@H]2CC[C@H](OC(F)F)CC2)nc1N[C@@H]1CCC[C@H](O)C1 Homo sapiens CHEMBL4842273 single protein format
CHEMBL1822144 OBDepict O NH N S O N N Br N N H N F F F IC50 = 3.0 nM 488.25 O=C(Cn1c(=O)ccn2nc(C(F)(F)F)cc12)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL3674690 OBDepict H N H N N H HO CH 3 CH 3 N N S O O CH 3 IC50 = 3.0 nM 511.69 CC(C)(O)[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 Homo sapiens CHEMBL3705344 single protein format
CHEMBL210963 OBDepict H 3 C O N N H N H 2 N O O O H 3 C H 3 C S O O CH 3 Ki = 3.0 nM 434.47 CCOc1nc(NC(=O)Cc2cc(OC)c(S(C)(=O)=O)cc2OC)cc(N)c1C#N Homo sapiens CHEMBL860181 single protein format
CHEMBL1822145 OBDepict O NH N S O Br N N F H N F IC50 = 3.0 nM 466.27 O=C(Cn1c(=O)ccc2cc(F)c(F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL4847078 OBDepict CH 3 O H H N H N N N H O NH 2 H H HO IC50 = 3.0 nM 363.46 CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(N[C@@H]3CCC[C@H](O)C3)n2)CC1 Homo sapiens CHEMBL4842273 single protein format
CHEMBL1094014 OBDepict CH 3 N H 3 C N N N N HN H H OH Ki = 3.0 nM 392.51 CN(C)c1c(-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)cnn1Cc1ccccc1 Homo sapiens CHEMBL1116944 single protein format
CHEMBL210928 OBDepict H 3 C O N Cl N H H 2 N O O O H 3 C H 3 C S O O CH 3 Ki = 3.0 nM 443.91 CCOc1nc(NC(=O)Cc2cc(OC)c(S(C)(=O)=O)cc2OC)cc(N)c1Cl Homo sapiens CHEMBL860181 single protein format
CHEMBL3674691 OBDepict H 3 C N S CH 3 N H O O H H HN N N N N S O O CH 3 IC50 = 3.6 nM 575.76 CN(C)S(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 Homo sapiens CHEMBL3705344 single protein format
CHEMBL377383 OBDepict H 3 C O N Cl H 2 N N H O S O O CH 3 Ki = 3.8 nM 383.86 CCOc1nc(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cc(N)c1Cl Homo sapiens CHEMBL866012 single protein format
CHEMBL1822141 OBDepict O NH N S O Br N N N H N F F F IC50 = 4.0 nM 499.27 O=C(Cn1c(=O)ccc2cnc(C(F)(F)F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL1822140 OBDepict O NH N S O Br N N N H N IC50 = 4.0 nM 431.27 O=C(Cn1c(=O)ccc2cnccc21)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL3679588 OBDepict CH 3 O O N N H O O F N N O IC50 = 4.0 nM 516.53 COC(=O)c1c(CNC(=O)c2ccc(N3CCOCC3)nc2)c(=O)c2ccc(F)cc2n1-c1ccccc1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL1822307 OBDepict N S N O HN O N O F F F IC50 = 4.0 nM 444.39 N#Cc1csc(NC(=O)Cn2c(=O)ccc3cc(C(F)(F)F)ccc32)c1-c1ncco1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL2425635 OBDepict H N H N N H HO CH 3 CH 3 N N O S O O CH 3 IC50 = 4.0 nM 487.63 CC(C)(O)[C@H]1CC[C@H](Nc2nccc(-n3ncc4c(OCCCS(C)(=O)=O)cccc43)n2)CC1 Homo sapiens CHEMBL2429340 single protein format
CHEMBL1923217 OBDepict CH 3 O O N N N H Cl O H 2 N IC50 = 4.0 nM 370.8 COc1ccc(Oc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 Homo sapiens CHEMBL1925288 single protein format
CHEMBL3679529 OBDepict CH 3 O O N NH O O Cl O N IC50 = 4.0 nM 513.94 COC(=O)c1c(CNC(=O)c2ccc(-c3cnco3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL1682014 OBDepict O NH N S O Cl N N H N IC50 = 4.0 nM 387.85 O=C(CN1C(=O)CCc2ccccc21)Nc1scc(Cl)c1-c1ncn[nH]1 Homo sapiens CHEMBL1686760 single protein format
CHEMBL211584 OBDepict CH 3 O N N NH 2 NH O N O OH IC50 = 4.0 nM 417.43 CCOc1nc(C(=O)NCc2ccc(-c3ccc(C(=O)O)cc3)nc2)cc(N)c1C#N Homo sapiens CHEMBL866012 single protein format
CHEMBL2425634 OBDepict H N H N N H HO CH 3 CH 3 N O S O O CH 3 IC50 = 4.0 nM 486.64 CC(C)(O)[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(OCCCS(C)(=O)=O)cccc43)n2)CC1 Homo sapiens CHEMBL2429340 single protein format
CHEMBL3679429 OBDepict O N H N O O N N O N IC50 = 4.0 nM 529.56 O=C(NCc1c(-c2ncco2)n(-c2ccccc2)c2ncccc2c1=O)c1ccn(Cc2ccccc2)c(=O)c1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL3679528 OBDepict CH 3 O O N N H O O Cl S O O CH 3 IC50 = 4.0 nM 524.98 COC(=O)c1c(CNC(=O)c2ccc(S(C)(=O)=O)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL3674698 OBDepict N N O N N N N N H H H N H HO IC50 = 4.2 nM 542.69 N#CCC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](CN4CC[C@@H](O)C4)CC3)n2)CC1 Homo sapiens CHEMBL3705344 single protein format
CHEMBL3674727 OBDepict N N O N N N N HN H H OH IC50 = 4.4 nM 459.55 N#CCC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)CC1 Homo sapiens CHEMBL3705344 single protein format
CHEMBL2425630 OBDepict CH 3 O N O H H NH N N N O S O O CH 3 IC50 = 4.7 nM 569.73 COC1CCN(C(=O)[C@H]2CC[C@H](Nc3nccc(-n4ccc5c(OCCCS(C)(=O)=O)cccc54)n3)CC2)CC1 Homo sapiens CHEMBL2429340 single protein format
CHEMBL2216824 OBDepict H 3 C N CH 3 N H O N H O CH 3 N H N N N IC50 = 4.7 nM 507.6 Cc1cc(NC(=O)c2cccc(NC(=O)/C=C/CN(C)C)c2)ccc1Nc1nccc(-c2cccnc2)n1 Homo sapiens CHEMBL2217255 single protein format
CHEMBL3674711 OBDepict N N O N N N N HN IC50 = 4.9 nM 443.56 N#CCC(=O)N1CCN(c2cccc3c2ccn3-c2ccnc(NC3CCCCC3)n2)CC1 Homo sapiens CHEMBL3705344 single protein format
CHEMBL2392827 OBDepict N N O N N N N N H H H NH S O O CH 3 IC50 = 5.0 nM 536.66 CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCN(C(=O)CC#N)CC5)cccc43)n2)CC1 Homo sapiens CHEMBL2393735 single protein format
CHEMBL1822139 OBDepict N S HN N N H N O N O N IC50 = 5.0 nM 379.4 N#Cc1csc(NC(=O)CN2C(=O)CCc3ncccc32)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL4875131 OBDepict CH 3 O H H HN N N N H O NH 2 IC50 = 5.0 nM 331.42 CO[C@H]1CC[C@H](Nc2ncc(C(N)=O)c(NC34CC(C3)C4)n2)CC1 Homo sapiens CHEMBL4842273 single protein format
CHEMBL3679530 OBDepict CH 3 O O N NH O O Cl N N N H IC50 = 5.0 nM 513.94 COC(=O)c1c(CNC(=O)c2ccc(-c3nnc[nH]3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL2392832 OBDepict H HO H N H N N N N N S O O CH 3 IC50 = 6.0 nM 470.6 CS(=O)(=O)C1CCN(c2cccc3c2cnn3-c2ccnc(N[C@H]3CC[C@H](O)CC3)n2)CC1 Homo sapiens CHEMBL2393735 single protein format
CHEMBL3679552 OBDepict CH 3 O O N N H O O Cl O O H 3 C IC50 = 6.0 nM 504.93 COC(=O)c1ccc(C(=O)NCc2c(C(=O)OC)n(-c3ccccc3)c3cc(Cl)ccc3c2=O)cc1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL4878046 OBDepict H N H N N H OH HN O H 2 N IC50 = 6.0 nM 327.39 NC(=O)c1cnc(N[C@H]2CC[C@H](O)CC2)nc1Nc1ccccc1 Homo sapiens CHEMBL4842273 single protein format
CHEMBL1822147 OBDepict O NH N S O Br N N H N F F F IC50 = 6.0 nM 498.28 O=C(Cn1c(=O)ccc2ccc(C(F)(F)F)cc21)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL3679531 OBDepict CH 3 O O N N H O O Cl N N O IC50 = 6.0 nM 532.98 COC(=O)c1c(CNC(=O)c2ccc(N3CCOCC3)nc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL3674693 OBDepict H 3 C HN O H H N H N N N N S O O CH 3 IC50 = 6.1 nM 524.69 CCNC(=O)[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 Homo sapiens CHEMBL3705344 single protein format
CHEMBL2390974 OBDepict H HO H N H N N N N O S O O CH 3 IC50 = 6.2 nM 445.55 CS(=O)(=O)CCCOc1cccc2c1cnn2-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 Homo sapiens CHEMBL2393735 single protein format
CHEMBL258618 OBDepict CH 3 O N O N Cl N H 3 C HN O IC50 = 6.4 nM 488.98 CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(C(=O)NC2CC2)n(C)n1 Homo sapiens CHEMBL921935 single protein format
CHEMBL259484 OBDepict CH 3 O N O N Cl N CH 3 N H O CH 3 IC50 = 6.8 nM 462.94 CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cn(C(=O)NC)c(C)n1 Homo sapiens CHEMBL921935 single protein format
CHEMBL2392831 OBDepict H NH N N H HN S N O O CH 3 O S O O IC50 = 6.8 nM 533.68 CS(=O)(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(OCC5CCS(=O)(=O)C5)cccc43)n2)CC1 Homo sapiens CHEMBL2393735 single protein format
CHEMBL3679532 OBDepict H 3 C O O N N H O O Cl N S IC50 = 7.0 nM 503.97 COC(=O)c1c(CNC(=O)c2ccc3scnc3c2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL3679533 OBDepict CH 3 O O N NH O O Cl N N H IC50 = 7.0 nM 512.95 COC(=O)c1c(CNC(=O)c2ccc(-c3ncc[nH]3)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL3679422 OBDepict Cl N O N O N H O N N O IC50 = 7.0 nM 542.0 O=C(NCc1c(-c2ncco2)n(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccnc(N2CCOCC2)c1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL1822153 OBDepict O NH N S O Br N O N IC50 = 7.0 nM 433.29 O=C(CN1C(=O)CCc2ncccc21)Nc1scc(Br)c1-c1ncco1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL2392837 OBDepict H 3 C O O H H N H N N N N S O O CH 3 IC50 = 7.0 nM 525.68 CCOC(=O)[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 Homo sapiens CHEMBL2393735 single protein format
CHEMBL3679553 OBDepict CH 3 O O N N H O O Cl O H 3 C IC50 = 7.0 nM 476.92 COC(=O)c1c(CNC(=O)c2ccc(OC)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL3679432 OBDepict OH N N HN O N O N O N IC50 = 7.0 nM 536.59 O=C(NCc1c(-c2ncco2)n(-c2ccccc2)c2ncccc2c1=O)c1ccc(N2CCC(CO)CC2)nc1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL1822308 OBDepict N S NH N S O N O F F F IC50 = 7.0 nM 460.46 N#Cc1csc(NC(=O)Cn2c(=O)ccc3cc(C(F)(F)F)ccc32)c1-c1nccs1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL2392834 OBDepict H 3 C HN O H H N H N N N N S O O CH 3 IC50 = 7.0 nM 510.66 CC(=O)N[C@H]1CC[C@H](Nc2nccc(-n3ccc4c(N5CCC(S(C)(=O)=O)CC5)cccc43)n2)CC1 Homo sapiens CHEMBL2393735 single protein format
CHEMBL3577877 OBDepict H 3 C N H CH 3 NH O H H N H N N N O IC50 = 7.0 nM 412.54 CC(C)NC(=O)N[C@H]1CC[C@H](Nc2ncc3ccc(=O)n(C4CCCC4)c3n2)CC1 Homo sapiens CHEMBL3578953 single protein format
CHEMBL437107 OBDepict CH 3 O N O N Cl N CH 3 O NH 2 IC50 = 7.3 nM 448.91 CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(C(N)=O)n(C)n1 Homo sapiens CHEMBL921935 single protein format
CHEMBL260064 OBDepict H 3 C O N O N Cl N S O O CH 3 O H 3 C IC50 = 7.6 nM 526.01 CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(S(C)(=O)=O)n(CC(C)=O)n1 Homo sapiens CHEMBL921935 single protein format
CHEMBL3679535 OBDepict CH 3 O O N N H O O Cl S N N O IC50 = 8.0 nM 539.01 COC(=O)c1c(CNC(=O)c2cnc(N3CCOCC3)s2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL3679554 OBDepict CH 3 O O N N H O O Cl O H 3 C IC50 = 8.0 nM 476.92 COC(=O)c1c(CNC(=O)c2cccc(OC)c2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL1923187 OBDepict H 3 C O O N N H Cl O H 2 N IC50 = 8.0 nM 369.81 COc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(Cl)cn2)cc1 Homo sapiens CHEMBL1925288 single protein format
CHEMBL1822142 OBDepict O NH N S O N Br N N H N F F F IC50 = 8.0 nM 499.27 O=C(Cn1c(=O)ccc2nc(C(F)(F)F)ccc21)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL1822143 OBDepict O NH N S O N N Br N N H N IC50 = 8.0 nM 420.25 O=C(Cn1c(=O)ccn2nccc12)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL3679534 OBDepict CH 3 O O N N H O O Cl S O O NH 2 IC50 = 8.0 nM 525.97 COC(=O)c1c(CNC(=O)c2ccc(S(N)(=O)=O)cc2)c(=O)c2ccc(Cl)cc2n1-c1ccccc1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL2392838 OBDepict OH N O H H N H N N N N S O O CH 3 IC50 = 8.0 nM 580.76 CS(=O)(=O)C1CCN(c2cccc3c2ccn3-c2ccnc(N[C@H]3CC[C@H](C(=O)N4CCC(O)CC4)CC3)n2)CC1 Homo sapiens CHEMBL2393735 single protein format
CHEMBL260065 OBDepict H 3 C O N O N Cl N S O O CH 3 O H 2 N IC50 = 8.2 nM 527.0 CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(S(C)(=O)=O)n(CC(N)=O)n1 Homo sapiens CHEMBL921935 single protein format
CHEMBL258705 OBDepict H 3 C NH N O N N O O CH 3 Cl IC50 = 8.6 nM 462.94 CCNC(=O)n1ccc(Cn2c(C(=O)CC)c(-c3ccccc3)c3cc(Cl)ccc3c2=O)n1 Homo sapiens CHEMBL921935 single protein format
CHEMBL1089007 OBDepict H N N N O N N H H H OH Ki = 9.0 nM 343.43 O[C@H]1CC[C@H](Nc2nccc(-c3c[nH]nc3C3CCCOC3)n2)CC1 Homo sapiens CHEMBL1116944 single protein format
CHEMBL482559 OBDepict H N N H N N N H H NH S O O CH 3 Ki = 9.0 nM 404.54 CS(=O)(=O)N[C@H]1CC[C@H](c2n[nH]cc2-c2ccnc(NC3CCCC3)n2)CC1 Homo sapiens CHEMBL985050 single protein format
CHEMBL1822138 OBDepict O NH N S O Br N N N H N IC50 = 9.0 nM 433.29 O=C(CN1C(=O)CCc2ncccc21)Nc1scc(Br)c1-c1ncn[nH]1 Homo sapiens CHEMBL1825598 single protein format
CHEMBL3679423 OBDepict Cl N O N O N H O N N O IC50 = 9.0 nM 542.0 O=C(NCc1c(-c2ncco2)n(-c2ccccc2)c2cc(Cl)ccc2c1=O)c1ccc(N2CCOCC2)nc1 Homo sapiens CHEMBL3705299 single protein format
CHEMBL1682015 OBDepict N S HN N N H N O N O IC50 = 9.0 nM 378.42 N#Cc1csc(NC(=O)CN2C(=O)CCc3ccccc32)c1-c1ncn[nH]1 Homo sapiens CHEMBL1686760 single protein format
CHEMBL242237 OBDepict OH N H N N HN O H 2 N IC50 = 9.0 nM 321.34 NC(=O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 Homo sapiens CHEMBL905885 single protein format
CHEMBL3674728 OBDepict N N O N N N N N H H H N O N H 3 C IC50 = 9.2 nM 583.74 CCN1CCN(C(=O)[C@H]2CC[C@H](Nc3nccc(-n4ccc5c(N6CCN(C(=O)CC#N)CC6)cccc54)n3)CC2)CC1 Homo sapiens CHEMBL3705344 single protein format
CHEMBL261014 OBDepict H 3 C O O N O Br N H O O HO IC50 = 9.2 nM 563.4 COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(NC(=O)CCC(=O)O)cc1 Homo sapiens CHEMBL939932 single protein format
CHEMBL259720 OBDepict CH 3 O N O N Cl N CH 3 N H O CH 3 IC50 = 9.4 nM 462.94 CCC(=O)c1c(-c2ccccc2)c2cc(Cl)ccc2c(=O)n1Cc1cc(C(=O)NC)n(C)n1 Homo sapiens CHEMBL921935 single protein format