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P47712 | PA24A_HUMAN | Cytosolic phospholipase A2 (PLA2G4A)

3D structures mapped by conservation among orthologs

[ Domain: "C2 domain" // C2_1 ]

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[ Domain: "FabD/lysophospholipase-like" // PLA2_B ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL443834 OBDepict H 3 C O O O N O O CH 3 O OH IC50 = 4.3 nM 523.63 CCCCCCCCCCOc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL863829 single protein format
CHEMBL426665 OBDepict CH 3 O O N O O H 3 C O HO IC50 = 4.9 nM 479.57 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)OC)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL863829 single protein format
CHEMBL484413 OBDepict H 3 C O O N N O OH IC50 = 5.0 nM 422.53 CCCCCCCCc1ccc(OCC(=O)Cn2ncc3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL982355 assay format
CHEMBL3326971 OBDepict CH 3 O N O OH IC50 = 7.0 nM 427.54 CCCOc1ccc(-n2cc(CCc3ccccc3)c3cc(CCC(=O)O)ccc32)cc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL3327088 OBDepict OH O N O CH 3 H 3 C IC50 = 7.0 nM 427.54 CC(C)Oc1ccc(-n2cc(CCc3ccccc3)c3cc(CCC(=O)O)ccc32)cc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL4097068 OBDepict H 3 C O O N O CH 3 CH 3 O OH IC50 = 10.0 nM 491.63 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)C(C)C)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL4000778 assay format
CHEMBL1800991 OBDepict CH 3 O O N O CH 3 O HO IC50 = 10.0 nM 491.63 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCC)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL4000778 assay format
CHEMBL3326966 OBDepict HO O N HO IC50 = 11.0 nM 385.46 O=C(O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccc(O)cc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL30108 OBDepict CH 3 O O O O O HO IC50 = 11.0 nM 442.55 CCCCCCCCCCOc1ccc(OCC(=O)COc2ccc(C(=O)O)cc2)cc1 Homo sapiens CHEMBL863829 single protein format
CHEMBL1085637 OBDepict O N O O H 3 C CH 3 O O OH IC50 = 12.0 nM 471.51 CC(C)C(=O)c1cn(CC(=O)COc2ccc(Oc3ccccc3)cc2)c2ccc(C(=O)O)cc12 Homo sapiens CHEMBL4000778 assay format
CHEMBL3327089 OBDepict OH NH 2 HO HO OH O N O OH IC50 = 14.0 nM 550.65 NC(CO)(CO)CO.O=C(O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccc(OCCO)cc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL4079052 OBDepict CH 3 O O N O O HO O H 3 C IC50 = 15.0 nM 521.65 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCOC)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL4000778 assay format
CHEMBL381294 OBDepict H 3 C O O N N O OH IC50 = 15.0 nM 446.55 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C#N)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL863829 single protein format
CHEMBL3326970 OBDepict OH NH 2 HO HO CH 3 O N O OH IC50 = 15.0 nM 534.65 CCOc1ccc(-n2cc(CCc3ccccc3)c3cc(CCC(=O)O)ccc32)cc1.NC(CO)(CO)CO Homo sapiens CHEMBL3361803 single protein format
CHEMBL204618 OBDepict CH 3 O O N O O HO IC50 = 16.0 nM 449.55 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C=O)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL863829 single protein format
CHEMBL207977 OBDepict CH 3 O O N O CH 3 O HO IC50 = 16.0 nM 463.57 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(C)=O)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL863829 single protein format
CHEMBL484954 OBDepict H 3 C O O N N N O OH IC50 = 16.0 nM 423.51 CCCCCCCCc1ccc(OCC(=O)Cn2nnc3ccc(C(=O)O)cc32)cc1 Homo sapiens CHEMBL982355 assay format
CHEMBL208401 OBDepict CH 3 O O O N O HO IC50 = 20.0 nM 465.59 CCCCCCCCCCOc1ccc(OCC(=O)Cn2ccc3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL863829 single protein format
CHEMBL3327092 OBDepict OH O N O HO NH 2 OH OH IC50 = 20.0 nM 582.7 NC(CO)(CO)CO.O=C(O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccc(Oc2ccccc2)cc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL1801026 OBDepict H 3 C O O N O O OH O OH IC50 = 22.0 nM 549.66 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCC(=O)O)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL4000778 assay format
CHEMBL4086908 OBDepict CH 3 O O N O O HO HO IC50 = 23.0 nM 507.63 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCO)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL4000778 assay format
CHEMBL484953 OBDepict H 3 C O O N N N O OH IC50 = 26.0 nM 423.51 CCCCCCCCc1ccc(OCC(=O)Cn2nnc3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL982355 assay format
CHEMBL3326969 OBDepict OH NH 2 HO HO CH 3 O N O OH IC50 = 26.0 nM 520.63 COc1ccc(-n2cc(CCc3ccccc3)c3cc(CCC(=O)O)ccc32)cc1.NC(CO)(CO)CO Homo sapiens CHEMBL3361803 single protein format
CHEMBL482775 OBDepict H 3 C O O N N O OH IC50 = 26.0 nM 422.53 CCCCCCCCc1ccc(OCC(=O)Cn2ncc3ccc(C(=O)O)cc32)cc1 Homo sapiens CHEMBL982355 assay format
CHEMBL3327090 OBDepict HO O N O F F OH NH 2 HO HO IC50 = 28.0 nM 556.61 NC(CO)(CO)CO.O=C(O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccc(OC(F)F)cc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL4067166 OBDepict H 3 C O O N O O OH OH IC50 = 31.0 nM 535.68 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCCO)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL4000778 assay format
CHEMBL205892 OBDepict H 3 C O O N O OH IC50 = 35.0 nM 421.54 CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL863829 single protein format
CHEMBL3327094 OBDepict OH O N Cl OH NH 2 HO HO IC50 = 36.0 nM 525.05 NC(CO)(CO)CO.O=C(O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccc(Cl)cc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL29838 OBDepict O O O S O HO IC50 = 40.0 nM 464.58 O=C(COc1ccc(SCCCCCc2ccccc2)cc1)COc1ccc(C(=O)O)cc1 Homo sapiens CHEMBL853015 single protein format
CHEMBL4100466 OBDepict H 3 C O O N O O OH O CH 3 IC50 = 49.0 nM 549.71 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCCOC)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL4000778 assay format
CHEMBL3327095 OBDepict HO O N F IC50 = 58.0 nM 387.45 O=C(O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccc(F)cc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL1800992 OBDepict CH 3 O O N O O HO H 3 C IC50 = 71.0 nM 519.68 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCCCC)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL4000778 assay format
CHEMBL3326948 OBDepict HO O N IC50 = 75.0 nM 369.46 O=C(O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccccc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL3327093 OBDepict OH O N CH 3 HO NH 2 OH OH IC50 = 77.0 nM 504.63 Cc1ccc(-n2cc(CCc3ccccc3)c3cc(CCC(=O)O)ccc32)cc1.NC(CO)(CO)CO Homo sapiens CHEMBL3361803 single protein format
CHEMBL520836 OBDepict H 3 C O O N N O OH IC50 = 85.0 nM 422.53 CCCCCCCCc1ccc(OCC(=O)Cn2cnc3ccc(C(=O)O)cc32)cc1 Homo sapiens CHEMBL982355 assay format
CHEMBL205753 OBDepict H 3 C O O N Cl O OH IC50 = 110.0 nM 455.98 CCCCCCCCc1ccc(OCC(=O)Cn2cc(Cl)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL863829 single protein format
CHEMBL204302 OBDepict H 3 C O O N O NH 2 IC50 = 120.0 nM 420.55 CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(C(N)=O)ccc32)cc1 Homo sapiens CHEMBL863829 single protein format
CHEMBL3326949 OBDepict OH O N CH 3 IC50 = 130.0 nM 383.49 Cc1c(CCc2ccccc2)c2cc(CCC(=O)O)ccc2n1-c1ccccc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL3327091 OBDepict HO O N O F F F OH NH 2 HO HO IC50 = 140.0 nM 574.6 NC(CO)(CO)CO.O=C(O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccc(OC(F)(F)F)cc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL482959 OBDepict H 3 C O O N N O OH IC50 = 150.0 nM 422.53 CCCCCCCCc1ccc(OCC(=O)Cn2cnc3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL982355 assay format
CHEMBL3326947 OBDepict OH O N IC50 = 180.0 nM 355.44 O=C(O)CCc1ccc2c(c1)c(Cc1ccccc1)cn2-c1ccccc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL3326967 OBDepict OH O N OH IC50 = 190.0 nM 385.46 O=C(O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1cccc(O)c1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL1801024 OBDepict H 3 C O O N O O OH O OH IC50 = 210.0 nM 521.61 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)CCC(=O)O)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL4000778 assay format
CHEMBL3329874 OBDepict CH 3 O O S N O O CH 3 IC50 = 300.0 nM 403.54 CCCCCCCCc1ccc(OCC(=O)c2nc(C(=O)OCC)cs2)cc1 Homo sapiens CHEMBL3365792 single protein format
CHEMBL260247 OBDepict CH 3 O O O N O HO O HO IC50 = 300.0 nM 495.57 CCCCCCCCc1ccc(OCC(=O)COc2ccc3c(c2)cc(C(=O)O)n3CC(=O)O)cc1 Homo sapiens CHEMBL923242 assay format
CHEMBL242320 OBDepict H 3 C O O N S N H O O H 3 C IC50 = 310.0 nM 470.64 CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(S(=O)(=O)NC)ccc32)cc1 Homo sapiens CHEMBL892787 assay format
CHEMBL3326960 OBDepict HO O N IC50 = 320.0 nM 367.45 O=C(O)/C=C/c1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccccc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL206943 OBDepict CH 3 O O N H 3 C CH 3 H 3 C O HO IC50 = 340.0 nM 477.65 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(C)(C)C)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL863829 single protein format
CHEMBL242960 OBDepict CH 3 O O N HN O CH 3 IC50 = 370.0 nM 434.58 CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(C(=O)NC)ccc32)cc1 Homo sapiens CHEMBL892787 assay format
CHEMBL242101 OBDepict CH 3 O O N S O O H 2 N IC50 = 390.0 nM 456.61 CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(S(N)(=O)=O)ccc32)cc1 Homo sapiens CHEMBL892787 assay format
CHEMBL3326964 OBDepict OH O N OH NH 2 HO HO IC50 = 400.0 nM 490.6 NC(CO)(CO)CO.O=C(O)CCc1ccc2c(CCc3ccccc3)cn(-c3ccccc3)c2c1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL343124 OBDepict H 3 C O O HO N Cl IC50 = 400.0 nM 481.98 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12 Homo sapiens CHEMBL665921 single protein format
CHEMBL344176 OBDepict CH 3 O O OH N + N O _ O IC50 = 400.0 nM 492.53 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12 Homo sapiens CHEMBL665295 single protein format
CHEMBL260248 OBDepict CH 3 O O O N O HO O HO IC50 = 400.0 nM 523.63 CCCCCCCCc1ccc(OCC(=O)COc2ccc3c(c2)cc(C(=O)O)n3CCCC(=O)O)cc1 Homo sapiens CHEMBL923242 assay format
CHEMBL9021 OBDepict CH 3 O F F F IC50 = 420.0 nM 370.5 CCCCC/C=CC/C=CC/C=CC/C=CCCCC(=O)CC(F)(F)F Homo sapiens CHEMBL820842 single protein format
CHEMBL397954 OBDepict H 3 C O O N S N O O H 3 C H 3 C IC50 = 500.0 nM 484.66 CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(S(=O)(=O)N(C)C)ccc32)cc1 Homo sapiens CHEMBL892787 assay format
CHEMBL428391 OBDepict CH 3 O O N N O O IC50 = 500.0 nM 490.64 CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(C(=O)N4CCOCC4)ccc32)cc1 Homo sapiens CHEMBL892787 assay format
CHEMBL383420 OBDepict HO O S O O H 3 C N Cl IC50 = 500.0 nM 572.13 Cc1c(CCS(=O)(=O)c2ccc(CCC(=O)O)cc2)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1 Homo sapiens CHEMBL853015 single protein format
CHEMBL598974 OBDepict CH 3 O O N N IC50 = 500.0 nM 328.46 CCCCCCCCc1ccc(OCC(=O)Cn2ccnc2)cc1 Homo sapiens CHEMBL1066442 assay format
CHEMBL3326950 OBDepict HO O N F OH NH 2 HO HO IC50 = 570.0 nM 508.59 NC(CO)(CO)CO.O=C(O)CCc1ccc2c(c1)c(CCc1ccc(F)cc1)cn2-c1ccccc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL140539 OBDepict H 3 C O O HO N Br IC50 = 600.0 nM 526.43 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12 Homo sapiens CHEMBL665921 single protein format
CHEMBL260708 OBDepict CH 3 O O O N O HO O HO IC50 = 600.0 nM 551.68 CCCCCCCCc1ccc(OCC(=O)COc2ccc3c(c2)cc(C(=O)O)n3CCCCCC(=O)O)cc1 Homo sapiens CHEMBL923242 assay format
CHEMBL260365 OBDepict CH 3 O O O N H 3 C O HO IC50 = 600.0 nM 451.56 CCCCCCCCc1ccc(OCC(=O)COc2ccc3c(c2)cc(C(=O)O)n3C)cc1 Homo sapiens CHEMBL923246 assay format
CHEMBL113262 OBDepict CH 3 P O O F H 3 C IC50 = 640.0 nM 370.49 CCCCC/C=CC/C=CC/C=CC/C=CCCCCP(=O)(F)OC Homo sapiens CHEMBL1066442 assay format
CHEMBL3326952 OBDepict OH NH 2 HO HO H 3 C O N O HO IC50 = 720.0 nM 520.63 COc1ccc(CCc2cn(-c3ccccc3)c3ccc(CCC(=O)O)cc23)cc1.NC(CO)(CO)CO Homo sapiens CHEMBL3361803 single protein format
CHEMBL3326968 OBDepict HO O N OH IC50 = 780.0 nM 385.46 O=C(O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccccc1O Homo sapiens CHEMBL3361803 single protein format
CHEMBL372790 OBDepict Cl N H 3 C S O O O HO IC50 = 800.0 nM 544.07 Cc1c(CCS(=O)(=O)c2ccc(C(=O)O)cc2)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1 Homo sapiens CHEMBL853015 single protein format
CHEMBL424290 OBDepict H 3 C O O HO N N IC50 = 800.0 nM 472.54 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12 Homo sapiens CHEMBL665921 single protein format
CHEMBL139858 OBDepict H 3 C O O HO N Cl IC50 = 800.0 nM 481.98 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2cc(Cl)ccc12 Homo sapiens CHEMBL665294 single protein format
CHEMBL242961 OBDepict H 3 C O O N N O H 3 C CH 3 IC50 = 840.0 nM 448.61 CCCCCCCCc1ccc(OCC(=O)Cn2ccc3cc(C(=O)N(C)C)ccc32)cc1 Homo sapiens CHEMBL892787 assay format
CHEMBL425596 OBDepict CH 3 O O N O OH O HO IC50 = 890.0 nM 465.55 CCCCCCCCc1ccc(OCC(=O)Cn2cc(C(=O)O)c3cc(C(=O)O)ccc32)cc1 Homo sapiens CHEMBL863829 single protein format
CHEMBL337790 OBDepict H 3 C O O HO N H 3 C IC50 = 900.0 nM 461.56 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12 Homo sapiens CHEMBL665921 single protein format
CHEMBL3326956 OBDepict N N H O N IC50 = 980.0 nM 393.49 N#CNC(=O)CCc1ccc2c(c1)c(CCc1ccccc1)cn2-c1ccccc1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL139435 OBDepict H 3 C O O HO N F IC50 = 1000.0 nM 465.52 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(F)cc12 Homo sapiens CHEMBL665294 single protein format
CHEMBL3326953 OBDepict OH NH 2 HO HO H 3 C O N O OH IC50 = 1000.0 nM 520.63 COc1cccc(CCc2cn(-c3ccccc3)c3ccc(CCC(=O)O)cc23)c1.NC(CO)(CO)CO Homo sapiens CHEMBL3361803 single protein format
CHEMBL381471 OBDepict Cl N CH 3 + S _ O O OH IC50 = 1000.0 nM 528.07 Cc1c(CC[S+]([O-])c2ccc(C(=O)O)cc2)c2cc(Cl)ccc2n1C(c1ccccc1)c1ccccc1 Homo sapiens CHEMBL853015 single protein format
CHEMBL380631 OBDepict Cl Cl N H 3 C S O O O HO IC50 = 1000.0 nM 578.52 Cc1c(CCS(=O)(=O)c2ccc(C(=O)O)cc2)c2c(Cl)c(Cl)ccc2n1C(c1ccccc1)c1ccccc1 Homo sapiens CHEMBL853015 single protein format
CHEMBL3327096 OBDepict OH O + N S O _ O Cl IC50 = 1000.0 nM 335.77 O=C(O)/C=C/c1ccc(Sc2ccc(Cl)cc2)c([N+](=O)[O-])c1 Homo sapiens CHEMBL3361803 single protein format
CHEMBL199669 OBDepict F N H 3 C S O O O HO IC50 = 1000.0 nM 527.62 Cc1c(CCS(=O)(=O)c2ccc(C(=O)O)cc2)c2cc(F)ccc2n1C(c1ccccc1)c1ccccc1 Homo sapiens CHEMBL853015 single protein format