molecule_chembl_id |
structure |
assay_type |
relation |
values |
units |
mol_wt |
smiles |
organism |
assay_chembl_id |
bao_label |
CHEMBL3287050 |
|
IC50 |
= |
0.03 |
nM |
560.55 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1csc(Cl)n1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3292933 |
assay format |
CHEMBL3287043 |
OBDepict
N
N
HO
N
NH
NH
O
CH
3
H
3
C
CH
3
O
F
F
F
|
IC50 |
= |
0.04 |
nM |
593.65 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1c(O)ccc(C#N)c12 |
Homo sapiens |
CHEMBL3292933 |
assay format |
CHEMBL3287049 |
OBDepict
O
N
H
N
H
N
S
N
OH
F
Cl
N
H
3
C
CH
3
H
3
C
|
IC50 |
= |
0.06 |
nM |
594.16 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3ccc(F)cc3s1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3292933 |
assay format |
CHEMBL3287051 |
OBDepict
O
NH
N
H
N
HO
F
F
F
Cl
N
CH
3
H
3
C
CH
3
|
IC50 |
= |
0.08 |
nM |
587.09 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(C(F)(F)F)cc1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3292933 |
assay format |
CHEMBL3287047 |
OBDepict
O
NH
N
H
N
O
HO
F
F
F
N
CH
3
H
3
C
CH
3
|
IC50 |
= |
0.23 |
nM |
568.64 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1c(O)cccc12 |
Homo sapiens |
CHEMBL3292933 |
assay format |
CHEMBL3287045 |
OBDepict
O
NH
N
H
N
O
HO
F
F
F
F
N
H
3
C
H
3
C
CH
3
|
IC50 |
= |
0.37 |
nM |
586.63 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1c(O)ccc(F)c12 |
Homo sapiens |
CHEMBL3292933 |
assay format |
CHEMBL444278 |
OBDepict
H
3
C
N
H
N
N
I
N
N
H
H
H
O
P
O
O
OH
OH
P
O
HO
HO
|
Ki |
= |
0.78 |
nM |
561.17 |
CNc1nc(I)nc2c1ncn2[C@H]1C[C@H](OP(=O)(O)O)[C@]2(COP(=O)(O)O)C[C@H]12 |
Homo sapiens |
CHEMBL750161 |
cell-based format |
CHEMBL3939310 |
OBDepict
O
N
H
NH
S
N
N
N
CH
3
H
3
C
OH
F
N
H
3
C
CH
3
H
3
C
|
Ki |
= |
1.9 |
nM |
552.72 |
CC(C)c1nsc(NC(=O)Nc2ccccc2N2CC3(CCN(CC(C)(C)C)CC3)c3c(F)ccc(O)c32)n1 |
Homo sapiens |
CHEMBL3888986 |
single protein format |
CHEMBL2112864 |
OBDepict
H
3
C
N
H
N
N
Cl
N
N
H
H
H
O
P
O
O
OH
OH
P
O
HO
HO
|
Ki |
= |
2.5 |
nM |
469.72 |
CNc1nc(Cl)nc2c1ncn2[C@H]1C[C@H](OP(=O)(O)O)[C@]2(COP(=O)(O)O)C[C@H]12 |
Homo sapiens |
CHEMBL750161 |
cell-based format |
CHEMBL3944036 |
OBDepict
O
N
H
NH
F
N
F
HO
N
F
F
F
H
3
C
H
3
C
CH
3
|
Ki |
= |
3.2 |
nM |
588.62 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(F)cc1F)c1c(O)ccc(C(F)(F)F)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3963797 |
OBDepict
O
N
H
NH
S
N
N
N
CH
3
OH
Cl
N
H
3
C
H
3
C
CH
3
|
Ki |
= |
3.3 |
nM |
541.12 |
Cc1nsc(NC(=O)Nc2ccccc2N2CC3(CCN(CC(C)(C)C)CC3)c3c(Cl)ccc(O)c32)n1 |
Homo sapiens |
CHEMBL3888986 |
single protein format |
CHEMBL2112867 |
OBDepict
H
3
C
N
H
N
N
H
3
C
N
N
H
H
H
O
P
O
O
OH
OH
P
O
HO
HO
|
Ki |
= |
3.6 |
nM |
449.3 |
CNc1nc(C)nc2c1ncn2[C@H]1C[C@H](OP(=O)(O)O)[C@]2(COP(=O)(O)O)C[C@H]12 |
Homo sapiens |
CHEMBL750161 |
cell-based format |
CHEMBL3944669 |
OBDepict
O
N
H
N
H
N
S
N
OH
Cl
F
N
H
3
C
CH
3
H
3
C
|
Ki |
= |
3.7 |
nM |
594.16 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3ccc(Cl)cc3s1)c1c(O)ccc(F)c12 |
Homo sapiens |
CHEMBL3888986 |
single protein format |
CHEMBL3968847 |
OBDepict
O
N
H
N
H
N
S
N
HO
H
3
C
F
N
CH
3
CH
3
H
3
C
|
Ki |
= |
3.7 |
nM |
573.74 |
Cc1ccc2nc(NC(=O)Nc3ccccc3N3CC4(CCN(CC(C)(C)C)CC4)c4c(F)ccc(O)c43)sc2c1 |
Homo sapiens |
CHEMBL3888986 |
single protein format |
CHEMBL3980633 |
OBDepict
N
N
OH
N
N
H
N
H
O
CH
3
CH
3
H
3
C
N
S
Cl
|
Ki |
= |
3.7 |
nM |
551.12 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1csc(Cl)n1)c1c(O)ccc(C#N)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3287049 |
OBDepict
O
N
H
N
H
N
S
N
OH
F
Cl
N
H
3
C
CH
3
H
3
C
|
Ki |
= |
3.8 |
nM |
594.16 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3ccc(F)cc3s1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3892050 |
OBDepict
H
3
C
O
N
S
N
N
H
N
H
O
N
HO
F
N
CH
3
H
3
C
CH
3
|
Ki |
= |
3.8 |
nM |
590.73 |
COc1ccc2nc(NC(=O)Nc3ccccc3N3CC4(CCN(CC(C)(C)C)CC4)c4c(F)ccc(O)c43)sc2n1 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3287047 |
OBDepict
O
NH
N
H
N
O
HO
F
F
F
N
CH
3
H
3
C
CH
3
|
Ki |
= |
4.0 |
nM |
568.64 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1c(O)cccc12 |
Homo sapiens |
CHEMBL3292349 |
assay format |
CHEMBL3924844 |
OBDepict
O
NH
N
H
N
HO
H
3
C
H
3
C
CH
3
F
N
CH
3
H
3
C
CH
3
|
Ki |
= |
4.0 |
nM |
558.74 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(C(C)(C)C)cc1)c1c(O)ccc(F)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3104636 |
OBDepict
O
NH
N
H
N
O
F
F
F
N
H
3
C
H
3
C
CH
3
|
Ki |
= |
4.3 |
nM |
552.64 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1ccccc12 |
Homo sapiens |
CHEMBL3107684 |
cell-based format |
CHEMBL3287045 |
OBDepict
O
NH
N
H
N
O
HO
F
F
F
F
N
H
3
C
H
3
C
CH
3
|
Ki |
= |
4.4 |
nM |
586.63 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1c(O)ccc(F)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3969194 |
OBDepict
O
N
H
NH
S
N
N
N
CH
3
H
3
C
OH
Cl
N
H
3
C
CH
3
H
3
C
|
Ki |
= |
4.4 |
nM |
569.18 |
CC(C)c1nsc(NC(=O)Nc2ccccc2N2CC3(CCN(CC(C)(C)C)CC3)c3c(Cl)ccc(O)c32)n1 |
Homo sapiens |
CHEMBL3888986 |
single protein format |
CHEMBL3105199 |
OBDepict
O
NH
N
H
N
O
F
F
F
N
CH
3
H
3
C
CH
3
|
Ki |
= |
4.6 |
nM |
566.67 |
CC(C)(C)CN1CCC2(CC1)CCN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1ccccc12 |
Homo sapiens |
CHEMBL3107684 |
cell-based format |
CHEMBL3287046 |
OBDepict
O
NH
N
H
N
O
OH
F
F
F
N
CH
3
H
3
C
CH
3
|
IC50 |
= |
4.6 |
nM |
568.64 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1cc(O)ccc12 |
Homo sapiens |
CHEMBL3292933 |
assay format |
CHEMBL3972717 |
OBDepict
O
N
H
N
H
N
N
S
F
F
F
OH
Cl
N
H
3
C
CH
3
H
3
C
|
Ki |
= |
4.9 |
nM |
594.1 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1csc(C(F)(F)F)n1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3954912 |
OBDepict
O
N
H
NH
N
N
S
CH
3
OH
N
F
F
F
H
3
C
H
3
C
CH
3
|
Ki |
= |
4.9 |
nM |
573.69 |
Cc1nc(NC(=O)Nc2ccccc2N2CC3(CCN(CC(C)(C)C)CC3)c3c(C(F)(F)F)ccc(O)c32)cs1 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL2401804 |
OBDepict
CH
3
O
O
S
N
HN
F
F
F
N
O
H
3
C
H
3
C
CH
3
|
Ki |
= |
5.0 |
nM |
465.5 |
CCOC(=O)c1sc(Nc2cccnc2Oc2ccccc2C(C)(C)C)nc1C(F)(F)F |
Homo sapiens |
CHEMBL2406600 |
cell-based format |
CHEMBL3964440 |
OBDepict
N
N
HO
N
N
H
N
H
O
H
3
C
H
3
C
CH
3
N
S
F
|
Ki |
= |
5.0 |
nM |
584.72 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3ccc(F)cc3s1)c1c(O)ccc(C#N)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL146342 |
OBDepict
CH
3
N
H
N
N
Br
N
N
H
O
P
O
O
OH
HO
P
O
HO
OH
|
Ki |
= |
5.1 |
nM |
514.17 |
CNc1nc(Br)nc2c1ncn2C1CC(OP(=O)(O)O)[C@]2(COP(=O)(O)O)C[C@H]12 |
Homo sapiens |
CHEMBL750161 |
cell-based format |
CHEMBL3951466 |
OBDepict
O
NH
N
H
N
F
F
HO
N
F
F
F
H
3
C
H
3
C
CH
3
|
Ki |
= |
5.1 |
nM |
588.62 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(F)c(F)c1)c1c(O)ccc(C(F)(F)F)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3890927 |
OBDepict
O
N
H
N
H
N
S
N
N
OH
Cl
N
H
3
C
CH
3
H
3
C
|
Ki |
= |
5.3 |
nM |
577.15 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3ccc(Cl)nc3s1)c1c(O)cccc12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3892612 |
OBDepict
O
N
H
N
H
N
S
N
HO
H
3
C
Cl
N
CH
3
CH
3
H
3
C
|
Ki |
= |
5.6 |
nM |
590.19 |
Cc1ccc2nc(NC(=O)Nc3ccccc3N3CC4(CCN(CC(C)(C)C)CC4)c4c(Cl)ccc(O)c43)sc2c1 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3287043 |
OBDepict
N
N
HO
N
NH
NH
O
CH
3
H
3
C
CH
3
O
F
F
F
|
Ki |
= |
5.7 |
nM |
593.65 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1c(O)ccc(C#N)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3287050 |
OBDepict
O
N
H
N
H
N
N
S
Cl
OH
Cl
N
H
3
C
CH
3
H
3
C
|
Ki |
= |
5.8 |
nM |
560.55 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1csc(Cl)n1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3105201 |
OBDepict
O
HN
N
H
N
O
N
F
F
F
H
3
C
H
3
C
CH
3
|
Ki |
= |
5.8 |
nM |
538.61 |
CC(C)(C)CN1CCC2(C1)CN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1ccccc12 |
Homo sapiens |
CHEMBL3107684 |
cell-based format |
CHEMBL3104624 |
OBDepict
O
HN
HN
N
O
F
F
F
|
Ki |
= |
5.9 |
nM |
481.52 |
O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1ccccc1N1CC2(CCCCC2)c2ccccc21 |
Homo sapiens |
CHEMBL3107684 |
cell-based format |
CHEMBL2333770 |
OBDepict
O
N
H
NH
N
O
O
CH
3
H
3
C
CH
3
F
F
F
|
Ki |
= |
6.0 |
nM |
445.44 |
CC(C)(C)c1ccccc1Oc1ncccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1 |
Homo sapiens |
CHEMBL2339550 |
cell-based format |
CHEMBL2401853 |
OBDepict
CH
3
N
N
O
S
N
HN
F
F
F
N
O
H
3
C
H
3
C
CH
3
|
Ki |
= |
6.0 |
nM |
475.5 |
Cc1noc(-c2sc(Nc3cccnc3Oc3ccccc3C(C)(C)C)nc2C(F)(F)F)n1 |
Homo sapiens |
CHEMBL2406600 |
cell-based format |
CHEMBL3263058 |
OBDepict
HO
N
Cl
N
H
N
S
N
N
CH
3
H
3
C
CH
3
|
Ki |
= |
6.0 |
nM |
560.17 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nc(-c3ccccc3)ns1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3267606 |
cell-based format |
CHEMBL3903953 |
OBDepict
Cl
N
S
N
N
H
N
HO
F
N
H
3
C
H
3
C
CH
3
|
IC50 |
= |
6.0 |
nM |
578.16 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nnc(-c3ccc(Cl)cc3)s1)c1c(O)ccc(F)c12 |
Homo sapiens |
CHEMBL3887218 |
assay format |
CHEMBL3263058 |
OBDepict
HO
N
Cl
N
H
N
S
N
N
CH
3
H
3
C
CH
3
|
IC50 |
= |
6.0 |
nM |
560.17 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nc(-c3ccccc3)ns1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3887218 |
assay format |
CHEMBL3932008 |
OBDepict
O
N
H
N
H
N
N
S
Cl
OH
N
F
F
F
CH
3
CH
3
CH
3
|
Ki |
= |
6.2 |
nM |
594.1 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1csc(Cl)n1)c1c(O)ccc(C(F)(F)F)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3263059 |
OBDepict
HO
N
Cl
N
H
N
N
O
N
CH
3
H
3
C
CH
3
|
Ki |
= |
6.2 |
nM |
544.1 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nnc(-c3ccccc3)o1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3267606 |
cell-based format |
CHEMBL3915990 |
OBDepict
O
HN
HN
S
N
N
HO
Cl
N
CH
3
H
3
C
CH
3
|
Ki |
= |
6.2 |
nM |
566.17 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3c(s1)CCC3)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3904405 |
OBDepict
H
3
C
O
O
S
N
N
H
F
F
F
N
N
CH
3
CH
3
H
3
C
|
IC50 |
= |
6.3 |
nM |
572.7 |
CCOC(=O)c1sc(Nc2ccccc2N2CC3(CCN(CC(C)(C)C)CC3)c3ccccc32)nc1C(F)(F)F |
Homo sapiens |
CHEMBL3887217 |
cell-based format |
CHEMBL3287051 |
OBDepict
O
NH
N
H
N
HO
F
F
F
Cl
N
CH
3
H
3
C
CH
3
|
Ki |
= |
6.4 |
nM |
587.09 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(C(F)(F)F)cc1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3909955 |
OBDepict
O
HN
HN
N
F
CH
3
OH
Cl
N
H
3
C
H
3
C
CH
3
|
Ki |
= |
6.4 |
nM |
551.11 |
Cc1ccc(NC(=O)Nc2ccccc2N2CC3(CCN(CC(C)(C)C)CC3)c3c(Cl)ccc(O)c32)cc1F |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3987044 |
OBDepict
O
N
H
N
H
N
S
N
OH
N
F
F
F
CH
3
CH
3
CH
3
|
Ki |
= |
6.4 |
nM |
559.66 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nccs1)c1c(O)ccc(C(F)(F)F)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3263075 |
OBDepict
HO
N
Cl
N
H
N
N
S
N
CH
3
H
3
C
CH
3
N
N
|
IC50 |
= |
6.5 |
nM |
562.14 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nnc(-c3cnccn3)s1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3887217 |
cell-based format |
CHEMBL3263075 |
OBDepict
HO
N
Cl
N
H
N
N
S
N
CH
3
H
3
C
CH
3
N
N
|
Ki |
= |
6.5 |
nM |
562.14 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nnc(-c3cnccn3)s1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3267606 |
cell-based format |
CHEMBL3947595 |
OBDepict
O
N
H
N
H
N
S
N
N
OH
F
Cl
N
H
3
C
CH
3
H
3
C
|
Ki |
= |
6.5 |
nM |
595.14 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3ccc(F)nc3s1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3939735 |
OBDepict
CH
3
H
3
C
N
N
Cl
HO
NH
NH
O
F
F
F
|
Ki |
= |
6.5 |
nM |
573.06 |
CC(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(C(F)(F)F)cc1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3954066 |
OBDepict
O
N
H
N
H
N
S
N
S
OH
Cl
N
CH
3
CH
3
CH
3
|
Ki |
= |
6.5 |
nM |
598.24 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3c(s1)CSCC3)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3263076 |
OBDepict
CH
3
N
N
H
3
C
N
S
N
N
H
N
OH
Cl
N
H
3
C
H
3
C
CH
3
|
IC50 |
= |
6.6 |
nM |
578.19 |
Cc1cc(-c2nnc(Nc3ccccc3N3CC4(CCN(CC(C)(C)C)CC4)c4c(Cl)ccc(O)c43)s2)n(C)n1 |
Homo sapiens |
CHEMBL3887217 |
cell-based format |
CHEMBL3103636 |
OBDepict
O
HN
HN
N
O
F
F
F
|
Ki |
= |
6.6 |
nM |
467.49 |
O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1ccccc1N1CC2(CCCC2)c2ccccc21 |
Homo sapiens |
CHEMBL3107684 |
cell-based format |
CHEMBL3263076 |
OBDepict
CH
3
N
N
H
3
C
N
S
N
N
H
N
OH
Cl
N
H
3
C
H
3
C
CH
3
|
Ki |
= |
6.6 |
nM |
578.19 |
Cc1cc(-c2nnc(Nc3ccccc3N3CC4(CCN(CC(C)(C)C)CC4)c4c(Cl)ccc(O)c43)s2)n(C)n1 |
Homo sapiens |
CHEMBL3267606 |
cell-based format |
CHEMBL3932713 |
OBDepict
HO
N
Cl
N
H
N
N
S
N
CH
3
H
3
C
CH
3
N
|
IC50 |
= |
6.8 |
nM |
561.16 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nnc(-c3ccccn3)s1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3887218 |
assay format |
CHEMBL3900888 |
OBDepict
H
3
C
O
N
N
S
N
H
N
H
O
N
HO
Cl
N
CH
3
H
3
C
CH
3
|
Ki |
= |
6.8 |
nM |
557.12 |
COc1nsc(NC(=O)Nc2ccccc2N2CC3(CCN(CC(C)(C)C)CC3)c3c(Cl)ccc(O)c32)n1 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL2401857 |
OBDepict
F
S
N
N
H
F
F
F
N
O
H
3
C
H
3
C
CH
3
|
Ki |
= |
7.0 |
nM |
487.52 |
CC(C)(C)c1ccccc1Oc1ncccc1Nc1nc(C(F)(F)F)c(-c2ccccc2F)s1 |
Homo sapiens |
CHEMBL2406600 |
cell-based format |
CHEMBL2333766 |
OBDepict
O
NH
N
H
N
O
CH
3
CH
3
H
3
C
CH
3
|
Ki |
= |
7.0 |
nM |
375.47 |
Cc1ccc(NC(=O)Nc2cccnc2Oc2ccccc2C(C)(C)C)cc1 |
Homo sapiens |
CHEMBL2339550 |
cell-based format |
CHEMBL2381888 |
OBDepict
CH
3
O
O
N
H
NH
O
N
O
CH
3
CH
3
CH
3
|
Ki |
= |
7.0 |
nM |
459.55 |
COC(=O)C1(c2ccc(NC(=O)Nc3cccnc3Oc3ccccc3C(C)(C)C)cc2)CC1 |
Homo sapiens |
CHEMBL2382617 |
single protein format |
CHEMBL2401800 |
OBDepict
F
F
F
N
S
NH
N
O
H
3
C
H
3
C
CH
3
|
Ki |
= |
7.0 |
nM |
469.53 |
CC(C)(C)c1ccccc1Oc1ncccc1Nc1nc(C(F)(F)F)c(-c2ccccc2)s1 |
Homo sapiens |
CHEMBL2406600 |
cell-based format |
CHEMBL2333772 |
OBDepict
O
HN
N
H
N
O
CH
3
H
3
C
CH
3
CH
3
H
3
C
|
Ki |
= |
7.0 |
nM |
403.53 |
CC(C)c1ccccc1Oc1ncccc1NC(=O)Nc1ccc(C(C)(C)C)cc1 |
Homo sapiens |
CHEMBL2339550 |
cell-based format |
CHEMBL2381894 |
OBDepict
O
NH
N
H
N
O
N
CH
3
CH
3
CH
3
N
|
Ki |
= |
7.0 |
nM |
535.69 |
CC(C)(C)c1ccccc1Oc1ncccc1NC(=O)Nc1ccc(N2CCN(Cc3ccccc3)CC2)cc1 |
Homo sapiens |
CHEMBL2382617 |
single protein format |
CHEMBL3961041 |
OBDepict
O
N
H
N
H
N
S
N
N
OH
F
F
N
H
3
C
CH
3
H
3
C
|
Ki |
= |
7.0 |
nM |
578.69 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3ccc(F)nc3s1)c1c(O)ccc(F)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL2393201 |
OBDepict
CH
3
CH
3
CH
3
O
N
N
H
N
S
N
F
F
F
|
Ki |
= |
7.0 |
nM |
470.52 |
CC(C)(C)c1ccccc1Oc1ncccc1Nc1nnc(-c2ccc(C(F)(F)F)cc2)s1 |
Homo sapiens |
CHEMBL2394755 |
cell-based format |
CHEMBL3930322 |
OBDepict
O
NH
N
H
N
HO
F
F
F
F
N
CH
3
H
3
C
CH
3
|
Ki |
= |
7.2 |
nM |
570.63 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(C(F)(F)F)cc1)c1c(O)ccc(F)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3102866 |
OBDepict
O
NH
N
H
N
O
CH
3
CH
3
F
F
F
|
Ki |
= |
7.3 |
nM |
455.48 |
CC1(C)CCN(c2ccccc2NC(=O)Nc2ccc(OC(F)(F)F)cc2)c2ccccc21 |
Homo sapiens |
CHEMBL3107684 |
cell-based format |
CHEMBL3896118 |
OBDepict
O
N
H
N
H
N
S
Cl
OH
N
F
F
F
CH
3
CH
3
CH
3
|
Ki |
= |
7.3 |
nM |
593.12 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1csc(Cl)c1)c1c(O)ccc(C(F)(F)F)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3897234 |
OBDepict
H
3
C
S
N
N
S
HN
N
H
O
N
HO
Cl
N
CH
3
H
3
C
CH
3
|
Ki |
= |
7.3 |
nM |
587.22 |
CCSc1nsc(NC(=O)Nc2ccccc2N2CC3(CCN(CC(C)(C)C)CC3)c3c(Cl)ccc(O)c32)n1 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3947952 |
OBDepict
O
N
H
N
H
N
S
N
OH
F
F
N
H
3
C
CH
3
H
3
C
|
Ki |
= |
7.4 |
nM |
577.7 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3ccc(F)cc3s1)c1c(O)ccc(F)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3937101 |
OBDepict
O
N
H
N
H
N
S
N
OH
Cl
N
CH
3
CH
3
CH
3
|
Ki |
= |
7.5 |
nM |
576.17 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3ccccc3s1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3898038 |
OBDepict
O
N
H
N
H
N
S
N
OH
Cl
N
H
3
C
CH
3
H
3
C
|
Ki |
= |
7.5 |
nM |
576.17 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3ccc(Cl)cc3s1)c1c(O)cccc12 |
Homo sapiens |
CHEMBL3888986 |
single protein format |
CHEMBL3103635 |
OBDepict
O
N
H
N
H
N
O
F
F
F
|
Ki |
= |
7.6 |
nM |
453.46 |
O=C(Nc1ccc(OC(F)(F)F)cc1)Nc1ccccc1N1CC2(CCC2)c2ccccc21 |
Homo sapiens |
CHEMBL3107684 |
cell-based format |
CHEMBL3961685 |
OBDepict
CH
3
H
3
C
N
N
Cl
HO
N
H
N
H
O
N
S
Cl
|
Ki |
= |
7.8 |
nM |
596.58 |
CC(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3ccc(Cl)cc3s1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3943381 |
OBDepict
H
3
C
H
3
C
CH
3
N
N
N
H
N
S
F
F
F
|
IC50 |
= |
7.9 |
nM |
576.73 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nc(C(F)(F)F)c(-c3ccccc3)s1)c1ccccc12 |
Homo sapiens |
CHEMBL3887217 |
cell-based format |
CHEMBL3954433 |
OBDepict
H
3
C
O
S
N
N
H
N
H
O
N
HO
F
N
CH
3
H
3
C
CH
3
|
Ki |
= |
7.9 |
nM |
589.74 |
COc1ccc2nc(NC(=O)Nc3ccccc3N3CC4(CCN(CC(C)(C)C)CC4)c4c(F)ccc(O)c43)sc2c1 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3943263 |
OBDepict
CH
3
O
O
N
HO
N
NH
N
H
O
H
3
C
H
3
C
CH
3
F
F
|
Ki |
= |
7.9 |
nM |
578.66 |
COC(=O)c1ccc(O)c2c1C1(CCN(CC(C)(C)C)CC1)CN2c1ccccc1NC(=O)Nc1ccc(F)cc1F |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3967844 |
OBDepict
OH
N
Cl
N
H
N
S
N
N
H
3
C
CH
3
H
3
C
CH
3
H
3
C
CH
3
|
IC50 |
= |
8.0 |
nM |
540.18 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nc(C(C)(C)C)ns1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3887218 |
assay format |
CHEMBL2401858 |
OBDepict
CH
3
O
S
N
HN
F
F
F
N
O
H
3
C
H
3
C
CH
3
|
Ki |
= |
8.0 |
nM |
499.56 |
COc1cccc(-c2sc(Nc3cccnc3Oc3ccccc3C(C)(C)C)nc2C(F)(F)F)c1 |
Homo sapiens |
CHEMBL2406600 |
cell-based format |
CHEMBL2401859 |
OBDepict
CH
3
O
S
N
HN
F
F
F
N
O
H
3
C
H
3
C
CH
3
|
Ki |
= |
8.0 |
nM |
499.56 |
COc1ccc(-c2sc(Nc3cccnc3Oc3ccccc3C(C)(C)C)nc2C(F)(F)F)cc1 |
Homo sapiens |
CHEMBL2406600 |
cell-based format |
CHEMBL2401856 |
OBDepict
CH
3
S
N
HN
F
F
F
N
O
H
3
C
H
3
C
CH
3
|
Ki |
= |
8.0 |
nM |
483.56 |
Cc1ccc(-c2sc(Nc3cccnc3Oc3ccccc3C(C)(C)C)nc2C(F)(F)F)cc1 |
Homo sapiens |
CHEMBL2406600 |
cell-based format |
CHEMBL2333771 |
OBDepict
O
HN
N
H
N
O
CH
3
H
3
C
CH
3
H
3
C
H
3
C
CH
3
|
Ki |
= |
8.0 |
nM |
417.55 |
CC(C)(C)c1ccc(NC(=O)Nc2cccnc2Oc2ccccc2C(C)(C)C)cc1 |
Homo sapiens |
CHEMBL2339550 |
cell-based format |
CHEMBL3958698 |
OBDepict
O
N
H
N
H
N
S
N
O
OH
Cl
N
CH
3
CH
3
CH
3
|
Ki |
= |
8.0 |
nM |
582.17 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3c(s1)COCC3)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3952542 |
OBDepict
O
NH
N
H
N
HO
H
3
C
H
3
C
CH
3
N
H
3
C
H
3
C
CH
3
|
Ki |
= |
8.3 |
nM |
540.75 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(C(C)(C)C)cc1)c1c(O)cccc12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3906462 |
OBDepict
O
N
H
N
H
N
S
N
N
OH
Cl
F
N
H
3
C
CH
3
H
3
C
|
Ki |
= |
8.6 |
nM |
595.14 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3ccc(Cl)nc3s1)c1c(O)ccc(F)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3103625 |
OBDepict
O
HN
N
H
N
O
H
3
C
CH
3
F
F
F
|
Ki |
= |
8.7 |
nM |
441.45 |
CC1(C)CN(c2ccccc2NC(=O)Nc2ccc(OC(F)(F)F)cc2)c2ccccc21 |
Homo sapiens |
CHEMBL3107684 |
cell-based format |
CHEMBL3973199 |
OBDepict
N
S
N
N
H
CH
3
H
3
C
CH
3
N
OH
Cl
N
CH
3
CH
3
CH
3
|
IC50 |
= |
9.0 |
nM |
564.2 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nc(C(C)(C)C)c(C#N)s1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3887218 |
assay format |
CHEMBL3928411 |
OBDepict
O
NH
N
H
N
HO
H
3
C
H
3
C
CH
3
F
N
CH
3
H
3
C
CH
3
|
Ki |
= |
9.0 |
nM |
558.74 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(C(C)(C)C)cc1)c1c2ccc(F)c1O |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3975389 |
OBDepict
O
NH
N
H
N
O
HO
F
F
F
N
F
H
3
C
H
3
C
CH
3
|
Ki |
= |
9.1 |
nM |
586.63 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1)c1c(O)cc(F)cc12 |
Homo sapiens |
CHEMBL3888986 |
single protein format |
CHEMBL3977624 |
OBDepict
O
N
H
N
H
N
S
N
OH
Cl
N
CH
3
CH
3
CH
3
|
Ki |
= |
9.5 |
nM |
580.2 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3c(s1)CCCC3)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3263057 |
OBDepict
HO
N
F
F
F
N
H
N
N
S
N
CH
3
H
3
C
CH
3
|
Ki |
= |
9.6 |
nM |
593.72 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nnc(-c3ccccc3)s1)c1c(O)ccc(C(F)(F)F)c12 |
Homo sapiens |
CHEMBL3267606 |
cell-based format |
CHEMBL3922387 |
OBDepict
O
N
H
NH
F
N
F
HO
Cl
N
CH
3
H
3
C
CH
3
|
Ki |
= |
9.6 |
nM |
555.07 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(F)cc1F)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3946708 |
OBDepict
O
NH
N
H
N
HO
H
3
C
H
3
C
CH
3
Cl
N
CH
3
H
3
C
CH
3
|
Ki |
= |
9.7 |
nM |
575.2 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(C(C)(C)C)cc1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3987193 |
OBDepict
CH
3
H
3
C
N
N
Cl
HO
N
H
N
H
O
N
S
F
|
Ki |
= |
9.9 |
nM |
580.13 |
CC(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1nc3ccc(F)cc3s1)c1c(O)ccc(Cl)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3263057 |
OBDepict
HO
N
F
F
F
N
H
N
N
S
N
CH
3
H
3
C
CH
3
|
IC50 |
= |
10.0 |
nM |
593.72 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nnc(-c3ccccc3)s1)c1c(O)ccc(C(F)(F)F)c12 |
Homo sapiens |
CHEMBL3887218 |
assay format |
CHEMBL255724 |
OBDepict
H
3
C
N
N
O
CH
3
HN
HN
O
|
Ki |
= |
10.0 |
nM |
494.64 |
CCc1ccccc1-n1nc(C)cc1Oc1ccccc1NC(=O)Nc1ccc(C2CCCCC2)cc1 |
Homo sapiens |
CHEMBL930506 |
single protein format |
CHEMBL2393200 |
OBDepict
F
O
F
F
N
S
N
N
H
N
O
CH
3
H
3
C
CH
3
|
Ki |
= |
10.0 |
nM |
486.52 |
CC(C)(C)c1ccccc1Oc1ncccc1Nc1nnc(-c2ccc(OC(F)(F)F)cc2)s1 |
Homo sapiens |
CHEMBL2394755 |
cell-based format |
CHEMBL3961227 |
OBDepict
O
NH
N
H
N
HO
H
3
C
H
3
C
CH
3
F
N
F
CH
3
H
3
C
CH
3
|
Ki |
= |
10.5 |
nM |
576.73 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1NC(=O)Nc1ccc(C(C)(C)C)cc1)c1c(O)cc(F)c(F)c12 |
Homo sapiens |
CHEMBL3888987 |
assay format |
CHEMBL3900332 |
OBDepict
HO
N
F
F
F
N
H
N
N
S
N
CH
3
H
3
C
CH
3
N
|
IC50 |
= |
11.0 |
nM |
594.71 |
CC(C)(C)CN1CCC2(CC1)CN(c1ccccc1Nc1nnc(-c3ccccn3)s1)c1c(O)ccc(C(F)(F)F)c12 |
Homo sapiens |
CHEMBL3887218 |
assay format |