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P48546 | GIPR_HUMAN | Gastric inhibitory polypeptide receptor (GIPR)

3D structures mapped by conservation among orthologs

[ Domain: "Hormone receptor domain (HRM, Pfam 02793)" // HRM ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL198736 OBDepict OH O N H O N N H O CH 3 H 3 C CH 3 O F F F IC50 = 28.3 nM 563.62 CC(C)(C)C1CCC(N(Cc2ccc(C(=O)NCCC(=O)O)cc2)C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL219384 OBDepict OH O N H O N N H O CH 3 H 3 C CH 3 O F F F IC50 = 38.0 nM 557.57 CC(C)(C)c1ccc(N(Cc2ccc(C(=O)NCCC(=O)O)cc2)C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL386446 OBDepict OH O N H O N N H O Cl Cl IC50 = 64.0 nM 566.49 O=C(O)CCNC(=O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C3=CCCCC3)cc2)cc1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL447742 OBDepict OH O HO H HN O N NH O H 3 C CH 3 H 3 C IC50 = 74.0 nM 571.72 CC(C)(C)c1cccc(NC(=O)N(Cc2ccc(C(=O)NC[C@@H](O)C(=O)O)cc2)c2ccc(C3CCCCC3)cc2)c1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL487668 OBDepict H HO O HO NH O N N H O Cl Cl IC50 = 93.0 nM 584.5 O=C(NC[C@@H](O)C(=O)O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C3CCCCC3)cc2)cc1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL486651 OBDepict CH 3 N H F F F N O H H H 3 C H 3 C CH 3 NH O OH H O HO IC50 = 98.0 nM 577.64 Cc1cc(NC(=O)N(Cc2ccc(C(=O)NC[C@@H](O)C(=O)O)cc2)[C@H]2CC[C@H](C(C)(C)C)CC2)cc(C(F)(F)F)c1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL452311 OBDepict OH O HO H N H O N N H O Br IC50 = 216.0 nM 594.51 O=C(NC[C@@H](O)C(=O)O)c1ccc(CN(C(=O)Nc2cccc(Br)c2)c2ccc(C3CCCCC3)cc2)cc1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL452067 OBDepict CH 3 N H CH 3 N O H H H 3 C H 3 C CH 3 NH O HO H O OH IC50 = 220.0 nM 523.67 Cc1cc(C)cc(NC(=O)N(Cc2ccc(C(=O)NC[C@@H](O)C(=O)O)cc2)[C@H]2CC[C@H](C(C)(C)C)CC2)c1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL447684 OBDepict F HN F F F N O N H O OH H O OH IC50 = 277.0 nM 599.58 O=C(NC[C@@H](O)C(=O)O)c1ccc(CN(C(=O)Nc2cc(F)cc(C(F)(F)F)c2)c2ccc(C3=CCCCC3)cc2)cc1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL1933364 OBDepict HO O N H O N H N N F F F F F F Ki = 300.0 nM 528.45 O=C(O)CCNC(=O)c1ccc(C(CCC(F)(F)F)Nc2cnn(-c3ccc(C(F)(F)F)cc3)c2)cc1 Homo sapiens CHEMBL1937454 single protein format
CHEMBL486650 OBDepict OH O OH N H O N N H O H 3 C CH 3 H 3 C O F F F IC50 = 315.0 nM 573.57 CC(C)(C)c1ccc(N(Cc2ccc(C(=O)NCC(O)C(=O)O)cc2)C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL493020 OBDepict OH O HN O S N O F F F Cl IC50 = 316.0 nM 575.01 O=C(O)CCNC(=O)c1ccc(CC(c2ccc(OC(F)(F)F)cc2)c2nc(-c3ccc(Cl)cc3)cs2)cc1 Homo sapiens CHEMBL973452 cell-based format
CHEMBL487476 OBDepict OH O OH H N H O N N H O Cl Cl IC50 = 359.0 nM 582.48 O=C(NC[C@@H](O)C(=O)O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C3=CCCCC3)cc2)cc1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL491920 OBDepict OH O HN O S N Cl F F F IC50 = 381.0 nM 559.01 O=C(O)CCNC(=O)c1ccc(CC(c2ccc(Cl)cc2)c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 Homo sapiens CHEMBL973452 cell-based format
CHEMBL521650 OBDepict OH O HN O N S N IC50 = 389.0 nM 537.69 O=C(O)CCNC(=O)c1ccc(CN(c2ccc(C3=CCCCC3)cc2)c2nc(-c3ccccc3)cs2)cc1 Homo sapiens CHEMBL973452 cell-based format
CHEMBL520893 OBDepict OH O HO H N H O N N H O Cl IC50 = 406.0 nM 548.04 O=C(NC[C@@H](O)C(=O)O)c1ccc(CN(C(=O)Nc2cccc(Cl)c2)c2ccc(C3=CCCCC3)cc2)cc1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL528775 OBDepict CH 3 S HN N O N H O OH H O OH IC50 = 411.0 nM 561.7 CSc1cccc(NC(=O)N(Cc2ccc(C(=O)NC[C@@H](O)C(=O)O)cc2)c2ccc(C3CCCCC3)cc2)c1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL493019 OBDepict OH O HN O S N Cl O F F F IC50 = 429.0 nM 575.01 O=C(O)CCNC(=O)c1ccc(CC(c2ccc(Cl)cc2)c2nc(-c3ccc(OC(F)(F)F)cc3)cs2)cc1 Homo sapiens CHEMBL973452 cell-based format
CHEMBL519903 OBDepict OH O OH H N H O N N H O Cl Cl IC50 = 445.0 nM 582.48 O=C(NC[C@H](O)C(=O)O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C3=CCCCC3)cc2)cc1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL492605 OBDepict OH O HN O N S N F F F IC50 = 510.0 nM 565.62 O=C(O)CCNC(=O)c1ccc(CN(c2ccc3c(c2)CCC3)c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 Homo sapiens CHEMBL995931 cell-based format
CHEMBL448561 OBDepict OH O N H O N S N Cl IC50 = 555.0 nM 580.11 O=C(O)CCNC(=O)c1ccc(N(Cc2ccc3c(c2)Cc2ccccc2-3)c2nc(-c3ccc(Cl)cc3)cs2)cc1 Homo sapiens CHEMBL973452 cell-based format
CHEMBL451288 OBDepict OH O HN O N S N F F F IC50 = 564.0 nM 579.64 O=C(O)CCNC(=O)c1ccc(CN(c2ccc3c(c2)CCCC3)c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 Homo sapiens CHEMBL973452 cell-based format
CHEMBL523847 OBDepict OH O NH O N S N CH 3 H 3 C CH 3 F F F IC50 = 633.0 nM 581.66 Cc1cc(N(Cc2ccc(C(=O)NCCC(=O)O)cc2)c2nc(-c3ccc(C(F)(F)F)cc3)cs2)ccc1C(C)C Homo sapiens CHEMBL973452 cell-based format
CHEMBL491352 OBDepict HO O NH O N S N Cl Cl IC50 = 638.0 nM 566.51 O=C(O)CCNC(=O)c1ccc(CN(c2ccc3c(c2)CCC3)c2nc(-c3ccc(Cl)c(Cl)c3)cs2)cc1 Homo sapiens CHEMBL973452 cell-based format
CHEMBL471580 OBDepict OH O HN O N S N Cl F F F IC50 = 649.0 nM 560.0 O=C(O)CCNC(=O)c1ccc(CN(c2ccc(Cl)cc2)c2nc(-c3ccc(C(F)(F)F)cc3)cs2)cc1 Homo sapiens CHEMBL973452 cell-based format
CHEMBL486634 OBDepict OH O OH N H O N N H O Cl Cl IC50 = 701.0 nM 582.48 O=C(NCC(O)C(=O)O)c1ccc(CN(C(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C3=CCCCC3)cc2)cc1 Homo sapiens CHEMBL977342 cell-based format
CHEMBL450411 OBDepict OH O HN O N S N CH 3 CH 3 H 3 C IC50 = 721.0 nM 593.79 CC(C)(C)c1ccc(-c2csc(N(Cc3ccc(C(=O)NCCC(=O)O)cc3)c3ccc(C4=CCCCC4)cc3)n2)cc1 Homo sapiens CHEMBL973452 cell-based format
CHEMBL493233 OBDepict OH O HN O N S N CH 3 CH 3 H 3 C CH 3 CH 3 CH 3 IC50 = 729.0 nM 569.77 CC(C)(C)c1ccc(-c2csc(N(Cc3ccc(C(=O)NCCC(=O)O)cc3)c3ccc(C(C)(C)C)cc3)n2)cc1 Homo sapiens CHEMBL973452 cell-based format
CHEMBL492813 OBDepict OH O NH O N S N Cl Cl IC50 = 830.0 nM 580.54 O=C(O)CCNC(=O)c1ccc(CN(c2ccc3c(c2)CCCC3)c2nc(-c3ccc(Cl)c(Cl)c3)cs2)cc1 Homo sapiens CHEMBL973452 cell-based format
CHEMBL519776 OBDepict OH O HN O N S N Cl O F F F IC50 = 869.0 nM 576.0 O=C(O)CCNC(=O)c1ccc(CN(c2ccc(Cl)cc2)c2nc(-c3ccc(OC(F)(F)F)cc3)cs2)cc1 Homo sapiens CHEMBL973452 cell-based format
CHEMBL1933365 OBDepict HO O N H O N H N N F F F Ki = 927.0 nM 500.52 O=C(O)CCNC(=O)c1ccc(C(Nc2cnn(-c3ccc(C(F)(F)F)cc3)c2)C2CCCC2)cc1 Homo sapiens CHEMBL1937454 single protein format
CHEMBL1933360 OBDepict CH 3 O N N NH O O HO F F F Ki = 939.0 nM 475.47 CCCC(Oc1cnn(-c2ccc(C(F)(F)F)cc2)c1)c1ccc(C(=O)NCCC(=O)O)cc1 Homo sapiens CHEMBL1937454 single protein format
CHEMBL446821 OBDepict OH O NH O N S N O F F F IC50 = 950.0 nM 581.62 O=C(O)CCNC(=O)c1ccc(CN(c2ccc3c(c2)CCC3)c2nc(-c3ccc(OC(F)(F)F)cc3)cs2)cc1 Homo sapiens CHEMBL973452 cell-based format
CHEMBL470729 OBDepict OH O NH O N S N F F F Cl IC50 = 990.0 nM 560.0 O=C(O)CCNC(=O)c1ccc(CN(c2ccc(C(F)(F)F)cc2)c2nc(-c3ccc(Cl)cc3)cs2)cc1 Homo sapiens CHEMBL973452 cell-based format
CHEMBL499372 OBDepict O N H N N N H N N H N N H 3 C H H 3 C CH 3 H 3 C O IC50 = 1000.0 nM 592.75 Cn1c(N(Cc2ccc(C(=O)Nc3nnn[nH]3)cc2)[C@H]2CC[C@H](C(C)(C)C)CC2)nc2cc(OCc3ccccc3)ccc21 Homo sapiens CHEMBL945218 single protein format