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P48736 | PK3CG_HUMAN | "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform" (PIK3CG)

3D structures mapped by conservation among orthologs

[ Domain: "ARM repeat" // PI3Ka ]

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[ Domain: "C2 domain" // PI3K_C2 ]

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[ Domain: "Protein kinase" // PI3_PI4_kinase ]

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[ Domain: "Ubiquitin-like" // PI3K_rbd ]

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[ Domain: pdbs with more than 2 multi-domains ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL4855730 OBDepict F NH S N O O H 2 N O HN IC50 = -146500.0 nM 452.51 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2F)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804468 cell-based format
CHEMBL4868141 OBDepict H 2 N N O O HN NH S O O IC50 = -64000.0 nM 532.67 Nc1ncc(-c2ccc(NS(=O)(=O)C3CC3)cc2OC2CCCCC2)cc1-c1ccc2c(c1)CCNC2=O Homo sapiens CHEMBL4804468 cell-based format
CHEMBL4867931 OBDepict H 3 C O N H S N O O H 2 N O HN IC50 = -5500.0 nM 464.55 COc1cc(NS(=O)(=O)C2CC2)ccc1-c1cnc(N)c(-c2ccc3c(c2)CCNC3=O)c1 Homo sapiens CHEMBL4804468 cell-based format
CHEMBL3586678 OBDepict CH 3 O N N N S N N H NH O N N F F Ki = 0.002 nM 464.5 COc1cncc(N2CCc3nc(NC(=O)NCCc4cn(CC(F)F)cn4)sc3C2)n1 Homo sapiens CHEMBL3587028 single protein format
CHEMBL3585362 OBDepict H 3 C O Cl N N S N N H HN O N N F F Ki = 0.003 nM 497.96 COc1cc(N2CCc3nc(NC(=O)NCCc4cn(CC(F)F)cn4)sc3C2)cnc1Cl Homo sapiens CHEMBL3587028 single protein format
CHEMBL3586677 OBDepict CH 3 O N N S N N H NH O N N F F Ki = 0.003 nM 463.51 COc1cncc(N2CCc3nc(NC(=O)NCCc4cn(CC(F)F)cn4)sc3C2)c1 Homo sapiens CHEMBL3587028 single protein format
CHEMBL3586676 OBDepict F N N N H N H O N S N N O CH 3 Ki = 0.006 nM 445.52 COc1cncc(N2CCc3nc(NC(=O)NCCc4cn(CCF)cn4)sc3C2)c1 Homo sapiens CHEMBL3587028 single protein format
CHEMBL3586679 OBDepict CH 3 O N N S N N H NH O N N F F F Ki = 0.009 nM 481.5 COc1cncc(N2CCc3nc(NC(=O)NCCc4cn(CC(F)(F)F)cn4)sc3C2)c1 Homo sapiens CHEMBL3587028 single protein format
CHEMBL3586674 OBDepict H 3 C N N N H N H O N S N N O H 3 C Ki = 0.01 nM 441.56 CCCn1cnc(CCNC(=O)Nc2nc3c(s2)CN(c2cncc(OC)c2)CC3)c1 Homo sapiens CHEMBL3587028 single protein format
CHEMBL3586672 OBDepict H 3 C O N H N H O N S N N O H 3 C Ki = 0.011 nM 391.5 CCCOCCNC(=O)Nc1nc2c(s1)CN(c1cncc(OC)c1)CC2 Homo sapiens CHEMBL3587028 single protein format
CHEMBL3586668 OBDepict CH 3 O O N N CH 3 S N N H O H 3 C Ki = 0.013 nM 334.4 COc1cc(N2CCc3nc(NC(C)=O)sc3C2)cnc1OC Homo sapiens CHEMBL3587028 single protein format
CHEMBL3586673 OBDepict CH 3 O N N S N N H NH O N N H 3 C H 3 C Ki = 0.016 nM 441.56 COc1cncc(N2CCc3nc(NC(=O)NCCc4cn(C(C)C)cn4)sc3C2)c1 Homo sapiens CHEMBL3587028 single protein format
CHEMBL3586670 OBDepict H 3 C O N N N S N N H O CH 3 Ki = 0.017 nM 305.36 COc1cncc(N2CCc3nc(NC(C)=O)sc3C2)n1 Homo sapiens CHEMBL3587028 single protein format
CHEMBL3586669 OBDepict CH 3 O Cl N N S N N H O H 3 C Ki = 0.024 nM 338.82 COc1cc(N2CCc3nc(NC(C)=O)sc3C2)cnc1Cl Homo sapiens CHEMBL3587028 single protein format
CHEMBL3586680 OBDepict HO N N N H N H O N S N N O CH 3 Ki = 0.025 nM 443.53 COc1cncc(N2CCc3nc(NC(=O)NCCc4cn(CCO)cn4)sc3C2)c1 Homo sapiens CHEMBL3587028 single protein format
CHEMBL3586675 OBDepict CH 3 O N N S N N H NH O N N H 3 C CH 3 Ki = 0.034 nM 455.59 COc1cncc(N2CCc3nc(NC(=O)NCCc4cn(CC(C)C)cn4)sc3C2)c1 Homo sapiens CHEMBL3587028 single protein format
CHEMBL3586666 OBDepict H 3 C O N N S N N H O CH 3 Ki = 0.048 nM 304.37 COc1cncc(N2CCc3nc(NC(C)=O)sc3C2)c1 Homo sapiens CHEMBL3587028 single protein format
CHEMBL3586671 OBDepict H 3 C N H N H O N S N N O H 3 C Ki = 0.066 nM 333.42 CCNC(=O)Nc1nc2c(s1)CN(c1cncc(OC)c1)CC2 Homo sapiens CHEMBL3587028 single protein format
CHEMBL2331664 OBDepict O N OH H 3 C H N O N H 3 C N N N CH 3 Ki = 0.111 nM 446.51 Cc1ccc(-c2ccc3ncc4c(c3n2)n(C2CCN(C(=O)[C@H](C)O)CC2)c(=O)n4C)cn1 Homo sapiens CHEMBL2346294 single protein format
CHEMBL3586665 OBDepict CH 3 N H O N S N N Ki = 0.157 nM 274.35 CC(=O)Nc1nc2c(s1)CN(c1cccnc1)CC2 Homo sapiens CHEMBL3587028 single protein format
CHEMBL4878958 OBDepict CH 3 O N N H S O O S CH 3 N N F O HN S Ki = 0.17 nM 567.65 COc1ncc2cc1NS(=O)(=O)c1ccc(F)c(c1)C(=O)NCc1ccc(s1)-c1ncnc3c(C)c-2sc13 Homo sapiens CHEMBL4845576 single protein format
CHEMBL4168702 OBDepict CH 3 O OH N H N NH N H 3 C H N N N O H 3 C IC50 = 0.3 nM 507.55 COc1cc(-c2c[nH]c3ncnc(N[C@@H](C)c4nn5ccc(C)c5c(=O)n4-c4ccccc4)c23)ccc1O Homo sapiens CHEMBL4158778 single protein format
CHEMBL3586667 OBDepict CH 3 O N N S N N H O H 3 C Ki = 0.33 nM 304.38 COc1ccc(N2CCc3nc(NC(C)=O)sc3C2)cn1 Homo sapiens CHEMBL3587028 single protein format
CHEMBL4860369 OBDepict H 3 C O N N H S O O S CH 3 N N O HN S Ki = 0.44 nM 549.66 COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1ccc(s1)-c1ncnc3c(C)c-2sc13 Homo sapiens CHEMBL4845576 single protein format
CHEMBL4217725 OBDepict Cl N HN S O O N N H N IC50 = 0.5 nM 461.93 O=S(=O)(Nc1cc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)cnc1Cl)c1ccccc1 Homo sapiens CHEMBL4193871 assay format
CHEMBL1236962 OBDepict CH 3 O N HN S O O F F N N N Ki = 0.51 nM 505.51 COc1ncc(-c2ccc3nccc(-c4ccnnc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL4820292 single protein format
CHEMBL4780201 OBDepict OH N N N H N N N HN O S H 3 C O O F F IC50 = 0.58 nM 553.55 COc1ncc(-c2ccc3ncnc(Nc4cnn(CCO)c4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL4667355 single protein format
CHEMBL3901855 OBDepict OH F N H N NH N H 3 C H N N N O H 3 C IC50 = 0.6 nM 495.52 Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(O)cc(F)c5)c34)n(-c3ccccc3)c(=O)c12 Homo sapiens CHEMBL4158778 single protein format
CHEMBL2381271 OBDepict H 3 C N N O N S N N N CH 3 H 3 C IC50 = 0.6 nM 392.49 CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cn(C)cn3)ccc1-2 Homo sapiens CHEMBL2383016 cell-based format
CHEMBL1236962 OBDepict CH 3 O N HN S O O F F N N N IC50 = 0.6 nM 505.51 COc1ncc(-c2ccc3nccc(-c4ccnnc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL3768550 single protein format
CHEMBL2381269 OBDepict H N N O N S N N N CH 3 H 3 C IC50 = 0.7 nM 378.46 CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3cn[nH]c3)ccc1-2 Homo sapiens CHEMBL2383016 cell-based format
CHEMBL4176898 OBDepict OH N H N NH N H 3 C H N N N O H 3 C IC50 = 0.7 nM 477.53 Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5ccc(O)cc5)c34)n(-c3ccccc3)c(=O)c12 Homo sapiens CHEMBL4158778 single protein format
CHEMBL4166977 OBDepict OH N H S O O CH 3 N H N NH N CH 3 H N N N O H 3 C IC50 = 0.7 nM 570.64 Cc1ccn2nc([C@H](C)Nc3ncnc4[nH]cc(-c5cc(O)cc(NS(C)(=O)=O)c5)c34)n(-c3ccccc3)c(=O)c12 Homo sapiens CHEMBL4158778 single protein format
CHEMBL4208385 OBDepict F S HN O O Cl N N N H N IC50 = 0.7 nM 479.92 O=S(=O)(Nc1cc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)cnc1Cl)c1ccc(F)cc1 Homo sapiens CHEMBL4193871 assay format
CHEMBL4213317 OBDepict Cl N HN S O O F N N H N IC50 = 0.7 nM 479.92 O=S(=O)(Nc1cc(-c2cnc3[nH]cc(-c4ccncc4)c3c2)cnc1Cl)c1ccccc1F Homo sapiens CHEMBL4193871 assay format
CHEMBL3968925 OBDepict H 3 C O N HN S O O F F N N N N IC50 = 0.74 nM 584.61 COc1ncc(-c2ccc3nccc(-c4ccc(Cn5cncn5)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL3867036 single protein format
CHEMBL4174909 OBDepict CH 3 O N HN S O O F F O N CH 3 N H O N H CH 3 IC50 = 0.93 nM 557.58 CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(O[C@@H]3CCOC3)c2n1 Homo sapiens CHEMBL4150389 single protein format
CHEMBL2387080 OBDepict CH 3 N N N CH 3 H 3 C N N O N N H 3 C H 3 C O H 2 N Ki = 0.97 nM 460.54 Cc1nc(-c2cn3c(n2)-c2ccc(-c4cnn(C(C)(C)C(N)=O)c4)cc2OCC3)n(C(C)C)n1 Homo sapiens CHEMBL2388234 single protein format
CHEMBL4864407 OBDepict CH 3 O N NH S O O N N O N H N Ki = 0.98 nM 512.55 COc1ncc2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)-c1cnc3ccc-2cn13 Homo sapiens CHEMBL4820292 single protein format
CHEMBL4288258 OBDepict CH 3 O N HN S O O F F N N O Cl IC50 = 1.0 nM 478.86 COc1ncc(-c2ccc3ncc(Cl)c(=O)n3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL4255948 single protein format
CHEMBL4740423 OBDepict O N H 3 C H F F F N N N NH 2 H 3 C CH 3 O OH IC50 = 1.0 nM 563.58 CC(C)c1cc(-c2c(N)nn3ccc(-c4cc5c(c(C(F)(F)F)c4)C(=O)N([C@@H](C)C4CC4)C5)nc23)ccc1C(=O)O Homo sapiens CHEMBL4670192 cell-based format
CHEMBL3356896 OBDepict H 3 C O N S N N H HN O HN O F F F Ki = 1.0 nM 453.45 COc1cncc(-c2ccc3nc(NC(=O)NCCC(=O)NCC(F)(F)F)sc3c2)c1 Homo sapiens CHEMBL3363927 single protein format
CHEMBL2206921 OBDepict Cl N N H N N CH 3 N H 2 N N N H Cl S N O O H 3 C CH 3 Ki = 1.0 nM 470.35 Cc1nc(N)nc(-c2cc(Cl)cnc2Nc2cnc(Cl)c(NS(=O)(=O)N(C)C)c2)n1 Homo sapiens CHEMBL2211631 cell-based format
CHEMBL2170081 OBDepict CH 3 O N F N H N N N N CH 3 H H 3 C N NH 2 N S O O CH 3 Ki = 1.0 nM 517.59 COc1ncc(Nc2ncc([C@@H](C)N3CCN(S(C)(=O)=O)CC3)cc2-c2nc(C)nc(N)n2)cc1F Homo sapiens CHEMBL2173754 cell-based format
CHEMBL3356889 OBDepict CH 3 O O N CH 3 S N N H O H 3 C Ki = 1.0 nM 329.38 COc1cc(-c2ccc3nc(NC(C)=O)sc3c2)cnc1OC Homo sapiens CHEMBL3363927 single protein format
CHEMBL3905146 OBDepict HO N H 3 C N N HN O S H 3 C O O F F IC50 = 1.1 nM 590.65 COc1ncc(-c2ccc3nccc(-c4ccc(CN(C)CCO)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL3867036 single protein format
CHEMBL4749505 OBDepict CH 3 O N N H 3 C H N H H 3 C O HO IC50 = 1.2 nM 505.62 Cc1cc(-c2cnc3[nH]cc(-c4cc(C)c(C(=O)O)c(C5CC5)c4)c3c2)cc2c1C(=O)N([C@@H](C)C1CC1)C2 Homo sapiens CHEMBL4731655 single protein format
CHEMBL4176771 OBDepict CH 3 O N HN S O O F F O N H 3 C N H O NH 2 IC50 = 1.2 nM 543.55 COc1ncc(-c2cc(O[C@@H]3CCOC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL4150389 single protein format
CHEMBL4740643 OBDepict O N CH 3 H F F F N N H H 3 C O HO IC50 = 1.2 nM 519.52 Cc1cc(-c2c[nH]c3ncc(-c4cc5c(c(C(F)(F)F)c4)C(=O)N([C@@H](C)C4CC4)C5)cc23)ccc1C(=O)O Homo sapiens CHEMBL4731655 single protein format
CHEMBL4739883 OBDepict CH 3 O N HN S O O F F N H 3 C N O N H 3 C IC50 = 1.3 nM 593.66 COc1ncc(-c2ccc3nccc(/C(C)=C/C(=O)N4CCN(C)CC4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL4737605 assay format
CHEMBL4778393 OBDepict CH 3 N H O N N N N H N S O O O CH 3 H 3 C H IC50 = 1.3 nM 468.54 CC(=O)Nc1cc2nc(-c3cc4c(c(NS(C)(=O)=O)c3)C(=O)N([C@@H](C)C3CC3)C4)ccn2n1 Homo sapiens CHEMBL4670192 cell-based format
CHEMBL4061855 OBDepict CH 3 N O H CH 3 N H H 3 C N N N N H 2 N N O IC50 = 1.3 nM 514.63 CC(=O)N1C[C@H](C)N(c2cccc(-c3cc(-c4ccnn4C4CCOCC4)c4c(N)ncnn34)c2)[C@H](C)C1 Homo sapiens CHEMBL3996854 single protein format
CHEMBL4166144 OBDepict CH 3 O N HN S O O F F O N H 3 C N NH 2 O IC50 = 1.3 nM 557.58 COc1ncc(-c2cc(OC3CCOCC3)c3nc(N)nc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL4150389 single protein format
CHEMBL2381379 OBDepict H 3 C OH CH 3 N N O N S N N N F F F IC50 = 1.4 nM 490.51 CC(C)(O)Cn1cc(-c2ccc3c(c2)OCCc2sc(-c4ncnn4CC(F)(F)F)nc2-3)cn1 Homo sapiens CHEMBL2383016 cell-based format
CHEMBL3963018 OBDepict CH 3 O N HN S O O F F N N CH 3 H 3 C IC50 = 1.5 nM 560.63 COc1ncc(-c2ccc3nccc(-c4ccc(CN(C)C)cc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL3867036 single protein format
CHEMBL4781463 OBDepict H 3 C O O OH N H N CH 3 N O CH 3 H IC50 = 1.5 nM 481.55 COc1cc(-c2c[nH]c3ncc(-c4cc(C)c5c(c4)CN([C@@H](C)C4CC4)C5=O)cc23)ccc1C(=O)O Homo sapiens CHEMBL4731655 single protein format
CHEMBL4531499 OBDepict CH 3 O N HN S O O F F O N H 3 C N H O IC50 = 1.5 nM 528.54 COc1ncc(-c2cc(O[C@@H]3CCOC3)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL4322189 cell-based format
CHEMBL2381270 OBDepict H N N O N S N N N CH 3 H 3 C IC50 = 1.5 nM 378.46 CC(C)n1ncnc1-c1nc2c(s1)CCOc1cc(-c3ncc[nH]3)ccc1-2 Homo sapiens CHEMBL2383016 cell-based format
CHEMBL4758027 OBDepict H 3 C N N N H N S N O O H 3 C O H 3 C H IC50 = 1.5 nM 475.57 C[C@@H](C1CC1)N1Cc2cc(-c3cnc4[nH]cc(-c5cnn(C)c5)c4c3)cc(S(C)(=O)=O)c2C1=O Homo sapiens CHEMBL4731655 single protein format
CHEMBL4450219 OBDepict CH 3 O N HN S O O F F O N H 3 C N CH 3 O IC50 = 1.6 nM 542.56 COc1ncc(-c2cc(OCC3(C)COC3)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL4322189 cell-based format
CHEMBL4794110 OBDepict CH 3 O N N H 3 C H N H O HO IC50 = 1.6 nM 491.59 Cc1cc(-c2cnc3[nH]cc(-c4ccc(C(=O)O)c(C5CC5)c4)c3c2)cc2c1C(=O)N([C@@H](C)C1CC1)C2 Homo sapiens CHEMBL4731655 single protein format
CHEMBL4744413 OBDepict CH 3 O N N CH 3 H N H F F F O HO IC50 = 1.64 nM 519.52 Cc1cc(-c2cnc3[nH]cc(-c4ccc(C(=O)O)c(C(F)(F)F)c4)c3c2)cc2c1C(=O)N([C@@H](C)C1CC1)C2 Homo sapiens CHEMBL4731655 single protein format
CHEMBL4166594 OBDepict CH 3 O N HN S O O F F O N CH 3 N N H O CH 3 IC50 = 1.7 nM 571.61 CNc1nc(C)c2cc(-c3cnc(OC)c(NS(=O)(=O)c4ccc(F)cc4F)c3)cc(OC3CCOCC3)c2n1 Homo sapiens CHEMBL4150389 single protein format
CHEMBL4168514 OBDepict H 2 N N N NH H 3 C H NH N N S N O O H 3 C O CH 3 IC50 = 1.7 nM 530.61 Cc1ccn2nc([C@H](C)Nc3ncnc(N)c3-c3cccc(NS(C)(=O)=O)c3)n(-c3ccccc3)c(=O)c12 Homo sapiens CHEMBL4158778 single protein format
CHEMBL4872728 OBDepict Cl N HN S O O N N N N O IC50 = 1.89 nM 559.05 O=S(=O)(Nc1cc(-c2ccc3nncc(-c4ccc(N5CCOCC5)nc4)c3c2)cnc1Cl)c1ccccc1 Homo sapiens CHEMBL4825000 single protein format
CHEMBL1822054 OBDepict CH 3 HN O N N N N N H Cl S O O F Ki = 1.9 nM 460.88 CC(=O)Nc1cn2nc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)ccc2n1 Homo sapiens CHEMBL1826066 cell-based format
CHEMBL4782083 OBDepict H 3 C N N NH 2 N N N N F F F O H 3 C H IC50 = 1.9 nM 481.48 C[C@@H](C1CC1)N1Cc2cc(-c3ccn4nc(N)c(-c5cnn(C)c5)c4n3)cc(C(F)(F)F)c2C1=O Homo sapiens CHEMBL4670192 cell-based format
CHEMBL393121 OBDepict S HN S O N O O F F F IC50 = 1.92 nM 464.49 O=C1NC(=S)S/C1=Cc1ccc2c(c1)N(CCc1ccc(C(F)(F)F)cc1)C(=O)CO2 Homo sapiens CHEMBL902509 single protein format
CHEMBL2165030 OBDepict CH 3 O N N H N N N CH 3 N H 2 N O Ki = 2.0 nM 391.44 COc1ccc(Nc2ncc(C3=CCOCC3)cc2-c2nc(C)nc(N)n2)cn1 Homo sapiens CHEMBL2166655 cell-based format
CHEMBL3356899 OBDepict CH 3 O N S N N H HN O N N CH 3 Ki = 2.0 nM 422.51 CCn1cnc(CCNC(=O)Nc2nc3ccc(-c4cncc(OC)c4)cc3s2)c1 Homo sapiens CHEMBL3363927 single protein format
CHEMBL3356900 OBDepict H 3 C N N N H N H O N S N O H 3 C Ki = 2.0 nM 436.54 CCCn1cnc(CCNC(=O)Nc2nc3ccc(-c4cncc(OC)c4)cc3s2)c1 Homo sapiens CHEMBL3363927 single protein format
CHEMBL3582356 OBDepict CH 3 N S N HN S O O N H O OH O O IC50 = 2.0 nM 538.61 Cc1nnc(NS(=O)(=O)c2ccc(NCc3cc(C(=O)O)cc(-c4ccc5c(c4)OCCO5)c3)cc2)s1 Homo sapiens CHEMBL3584209 single protein format
CHEMBL4443378 OBDepict CH 3 N H H N N N O NH 2 N N CH 3 NH O OH IC50 = 2.0 nM 540.63 CC[C@H](Nc1nc(N)nc(C)c1C#N)c1nc2cccc(CCCCCC(=O)NO)c2c(=O)n1-c1ccccc1 Homo sapiens CHEMBL4405140 single protein format
CHEMBL4798343 OBDepict CH 3 O N HN S O O F F S N N N N O IC50 = 2.0 nM 520.54 COc1ncc(-c2nc3c(N4CCOCC4)ncnc3s2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL4678714 assay format
CHEMBL4450613 OBDepict OH HN O N O N N H H CH 3 N NH 2 N N NH 2 IC50 = 2.0 nM 575.63 CC[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(CCc3ccc(C(=O)NO)cc3)c2c(=O)n1-c1ccccc1 Homo sapiens CHEMBL4405140 single protein format
CHEMBL4446047 OBDepict CH 3 O N H N N N H N N N O Cl IC50 = 2.0 nM 473.92 CC(=O)c1c[nH]c2ncnc(N3CCC[C@H]3c3nn4ccc(Cl)c4c(=O)n3-c3ccccc3)c12 Homo sapiens CHEMBL4352638 assay format
CHEMBL4468088 OBDepict N O N CH 3 N N NH H N O N IC50 = 2.0 nM 465.52 COc1ncc(-c2ccc3ncnc(N[C@H]4CCCN(C(=O)c5cccnc5)C4)c3c2)cc1C#N Homo sapiens CHEMBL4399812 single protein format
CHEMBL4526673 OBDepict HO N H O NH N O N NH CH 3 H N H 2 N N N CH 3 IC50 = 2.0 nM 561.61 Cc1nc(N)nc(N[C@@H](C)c2nc3cccc(NCc4ccc(C(=O)NO)cc4)c3c(=O)n2-c2ccccc2)c1C#N Homo sapiens CHEMBL4405140 single protein format
CHEMBL4743121 OBDepict OH O H 2 N N N N CH 3 N O CH 3 H IC50 = 2.1 nM 481.56 Cc1cc(-c2ccn3nc(N)c(-c4ccc(CC(=O)O)cc4)c3n2)cc2c1C(=O)N([C@@H](C)C1CC1)C2 Homo sapiens CHEMBL4670192 cell-based format
CHEMBL4527563 OBDepict CH 3 O N HN S O O F F O N H 3 C N O IC50 = 2.1 nM 542.56 COc1ncc(-c2cc(OC3CCOCC3)c3ncnc(C)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F Homo sapiens CHEMBL4322189 cell-based format
CHEMBL4754968 OBDepict CH 3 O N N CH 3 H N H CH 3 CH 3 O HO IC50 = 2.1 nM 493.61 Cc1cc(-c2cnc3[nH]cc(-c4ccc(C(=O)O)c(C(C)C)c4)c3c2)cc2c1C(=O)N([C@@H](C)C1CC1)C2 Homo sapiens CHEMBL4731655 single protein format
CHEMBL4742062 OBDepict O N H 3 C H F F F N N N H 3 C CH 3 O OH IC50 = 2.1 nM 548.57 CC(C)c1cc(-c2cnn3ccc(-c4cc5c(c(C(F)(F)F)c4)C(=O)N([C@@H](C)C4CC4)C5)nc23)ccc1C(=O)O Homo sapiens CHEMBL4670192 cell-based format
CHEMBL4761831 OBDepict CH 3 O N N H 3 C H N H H 3 C CH 3 O HO IC50 = 2.1 nM 493.61 Cc1cc(-c2cnc3[nH]cc(-c4ccc(C(C)(C)C(=O)O)cc4)c3c2)cc2c1C(=O)N([C@@H](C)C1CC1)C2 Homo sapiens CHEMBL4731655 single protein format
CHEMBL2206904 OBDepict H 3 C O N N H N N H 3 C N NH 2 N N H Cl S N O O CH 3 H 3 C Ki = 2.2 nM 465.93 COc1cnc(Nc2cnc(Cl)c(NS(=O)(=O)N(C)C)c2)c(-c2nc(C)nc(N)n2)c1 Homo sapiens CHEMBL2211631 cell-based format
CHEMBL4746279 OBDepict CH 3 O N N H 3 C H N H CH 3 H 3 C O OH IC50 = 2.2 nM 479.58 Cc1cc(-c2c[nH]c3ncc(-c4cc(C)c5c(c4)CN([C@@H](C)C4CC4)C5=O)cc23)cc(C)c1C(=O)O Homo sapiens CHEMBL4731655 single protein format
CHEMBL4762555 OBDepict CH 3 O N N H 3 C H N N NH 2 CH 3 O OH IC50 = 2.2 nM 481.56 Cc1cc(-c2c(N)nn3ccc(-c4cc(C)c5c(c4)CN([C@@H](C)C4CC4)C5=O)nc23)ccc1C(=O)O Homo sapiens CHEMBL4670192 cell-based format
CHEMBL2322764 OBDepict NH 2 O O S N N N H 3 C CH 3 IC50 = 2.2 nM 354.44 CC(C)n1ncnc1-c1cc2c(s1)-c1ccc(C(N)=O)cc1OCC2 Homo sapiens CHEMBL2383016 cell-based format
CHEMBL4785086 OBDepict H 3 C N H O N N N N F F F O CH 3 H IC50 = 2.2 nM 443.43 CC(=O)Nc1cc2nc(-c3cc4c(c(C(F)(F)F)c3)C(=O)N([C@@H](C)C3CC3)C4)ccn2n1 Homo sapiens CHEMBL4670192 cell-based format
CHEMBL4864419 OBDepict Cl N HN S O O N N N IC50 = 2.25 nM 473.95 O=S(=O)(Nc1cc(-c2ccc3nncc(-c4ccncc4)c3c2)cnc1Cl)c1ccccc1 Homo sapiens CHEMBL4825000 single protein format
CHEMBL4853440 OBDepict Cl N HN S O O N N N O IC50 = 2.29 nM 558.06 O=S(=O)(Nc1cc(-c2ccc3nncc(-c4ccc(N5CCOCC5)cc4)c3c2)cnc1Cl)c1ccccc1 Homo sapiens CHEMBL4825000 single protein format
CHEMBL3774448 OBDepict S N H S O N IC50 = 2.3 nM 272.35 O=C1NC(=S)S/C1=Cc1ccc2ncccc2c1 Homo sapiens CHEMBL3778439 single protein format
CHEMBL3775393 OBDepict S N H S O S N IC50 = 2.3 nM 278.38 O=C1NC(=S)S/C1=Cc1ccc2ncsc2c1 Homo sapiens CHEMBL3778439 single protein format
CHEMBL246440 OBDepict O N O S Br O N H S IC50 = 2.34 nM 475.39 O=C1NC(=S)S/C1=Cc1ccc2c(c1)N(CCc1ccc(Br)cc1)C(=O)CO2 Homo sapiens CHEMBL902509 single protein format
CHEMBL2206913 OBDepict H 3 C N N NH 2 N N N H N HN Cl S O O H 3 C Ki = 2.4 nM 406.86 Cc1nc(N)nc(-c2cccnc2Nc2cnc(Cl)c(NS(C)(=O)=O)c2)n1 Homo sapiens CHEMBL2211631 cell-based format
CHEMBL4748899 OBDepict H 3 C N N N H N N F F F O H 3 C H IC50 = 2.4 nM 465.48 C[C@@H](C1CC1)N1Cc2cc(-c3cnc4[nH]cc(-c5cnn(C)c5)c4c3)cc(C(F)(F)F)c2C1=O Homo sapiens CHEMBL4731655 single protein format
CHEMBL1914743 OBDepict F S HN O O Cl N N N N O IC50 = 2.4 nM 499.96 O=S(=O)(Nc1cc(-c2ccc3ncc(N4CCOCC4)nc3c2)cnc1Cl)c1ccc(F)cc1 Homo sapiens CHEMBL1919683 cell-based format
CHEMBL4752613 OBDepict H 3 C N N N H N Cl N O H 3 C H IC50 = 2.4 nM 431.93 C[C@@H](C1CC1)N1Cc2cc(-c3cnc4[nH]cc(-c5cnn(C)c5)c4c3)cc(Cl)c2C1=O Homo sapiens CHEMBL4731655 single protein format
CHEMBL241710 OBDepict S HN S O N O O CH 3 CH 3 CH 3 IC50 = 2.42 nM 438.57 CC(C)(C)c1ccc(CN2C(=O)COc3ccc(/C=C4SC(=S)NC4=O)cc32)cc1 Homo sapiens CHEMBL902509 single protein format
CHEMBL4764811 OBDepict CH 3 HN O O N N H 3 C H N H N N H 3 C IC50 = 2.5 nM 454.53 CC(=O)Nc1cc(-c2cnc3[nH]cc(-c4cnn(C)c4)c3c2)cc2c1C(=O)N([C@@H](C)C1CC1)C2 Homo sapiens CHEMBL4731655 single protein format
CHEMBL4751253 OBDepict OH O N H N CH 3 N O CH 3 H IC50 = 2.5 nM 451.53 Cc1cc(-c2cnc3[nH]cc(-c4ccc(C(=O)O)cc4)c3c2)cc2c1C(=O)N([C@@H](C)C1CC1)C2 Homo sapiens CHEMBL4731655 single protein format