HOME LIGAND hPROTEOME OTHERS DOCUMENT

P48764 | SL9A3_HUMAN | Sodium/hydrogen exchanger 3 (SLC9A3)

3D structures mapped by conservation among orthologs



[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL3904640 OBDepict Cl Cl H O H N Cl Cl H NH 2 S O O NH 2 IC50 = 0.2 nM 525.29 N[C@@H]1CCCN([C@H]2Cc3c(Cl)cc(Cl)cc3[C@@H]2Oc2ccc(S(N)(=O)=O)c(Cl)c2Cl)C1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3967635 OBDepict Cl Cl H O H N Cl NH S O O CH 3 IC50 = 2.0 nM 489.85 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCCNCC2)c(Cl)c1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3946835 OBDepict Cl Cl H O H N H NH 2 S O O CH 3 IC50 = 4.0 nM 455.41 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCC[C@@H](N)C2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3978001 OBDepict OH HN H N H H O Cl Cl S O O H 3 C IC50 = 4.0 nM 499.46 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCC[C@@H](NCCO)C2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3914729 OBDepict Cl Cl H O H N NH S O O CH 3 IC50 = 6.0 nM 455.41 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCCNCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3943277 OBDepict Cl Cl H O H N S N H O O CH 3 IC50 = 11.0 nM 481.45 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCC3(CCNC3)C2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3954374 OBDepict H 3 C N N H H O Cl Cl N CH 3 N CH 3 N IC50 = 17.0 nM 486.45 Cc1nnc(C)n1-c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCCN(C)CC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3897683 OBDepict NH 2 HN NH O CH 3 CH 3 CH 3 N O H 2 N NH 2 IC50 = 20.0 nM 342.4 C/C(=Cc1cc(C)ccc1/C=C(C)C(=O)NC(=N)N)C(=O)N=C(N)N Homo sapiens CHEMBL3881461 cell-based format
CHEMBL3895884 OBDepict CH 3 N H 3 C N H 3 C H H O Cl Cl S O O CH 3 IC50 = 20.0 nM 457.42 CN(C)CCN(C)[C@H]1Cc2c(Cl)cc(Cl)cc2[C@@H]1Oc1ccc(S(C)(=O)=O)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3916229 OBDepict Cl Cl H O H N N H H CH 3 S O O CH 3 IC50 = 20.0 nM 455.41 C[C@@H]1CN([C@H]2Cc3c(Cl)cc(Cl)cc3[C@@H]2Oc2ccc(S(C)(=O)=O)cc2)CCN1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3893158 OBDepict Cl Cl H O H N NH S O O CH 3 IC50 = 22.0 nM 441.38 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCNCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3938033 OBDepict Cl Cl H O H N N H N H 3 C N CH 3 N IC50 = 23.0 nM 472.42 Cc1nnc(C)n1-c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCCNCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3947901 OBDepict Cl Cl H O H N H NH 2 N N IC50 = 23.0 nM 443.38 N[C@@H]1CCCN([C@H]2Cc3c(Cl)cc(Cl)cc3[C@@H]2Oc2ccc(-n3ccnc3)cc2)C1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3921160 OBDepict Cl Cl H O H N H H S N H O O CH 3 IC50 = 28.0 nM 467.42 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2C[C@@H]3CNC[C@@H]3C2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3920102 OBDepict Cl Cl H O H N H NH 2 N N N IC50 = 30.0 nM 444.37 N[C@@H]1CCCN([C@H]2Cc3c(Cl)cc(Cl)cc3[C@@H]2Oc2ccc(-n3cncn3)cc2)C1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3894965 OBDepict OH N N H H O Cl Cl S O O CH 3 IC50 = 30.0 nM 499.46 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCCN(CCO)CC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3949677 OBDepict Cl Cl H O H N F H OH N H 3 C N CH 3 N IC50 = 34.0 nM 477.37 Cc1nnc(C)n1-c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CC[C@@H](O)C2)c(F)c1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3916425 OBDepict Cl Cl H O H N NH S O O CH 3 IC50 = 43.0 nM 455.41 CS(=O)(=O)c1ccc(O[C@H]2c3c(ccc(Cl)c3Cl)C[C@@H]2N2CCCNCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3905100 OBDepict H 3 C N CH 3 N H 3 C H H O Cl Cl S O O CH 3 IC50 = 48.0 nM 471.45 CN(C)CCCN(C)[C@H]1Cc2c(Cl)cc(Cl)cc2[C@@H]1Oc1ccc(S(C)(=O)=O)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3907461 OBDepict F HN H N H H O Cl Cl S O O H 3 C IC50 = 56.0 nM 501.45 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CCC[C@@H](NCCF)C2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3974787 OBDepict CH 3 O N N H H O Cl Cl S O O CH 3 IC50 = 64.0 nM 513.49 COCCN1CCCN([C@H]2Cc3c(Cl)cc(Cl)cc3[C@@H]2Oc2ccc(S(C)(=O)=O)cc2)CC1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3920420 OBDepict Cl O N H H 3 C N CH 3 N H N IC50 = 78.0 nM 408.93 Cc1nnc(C)n1-c1ccc(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)c(Cl)c1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3963951 OBDepict Cl H O H N Cl H OH N H 3 C N CH 3 N IC50 = 90.0 nM 459.38 Cc1nnc(C)n1-c1ccc(O[C@H]2c3cc(Cl)ccc3C[C@@H]2N2CC[C@@H](O)C2)c(Cl)c1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3943573 OBDepict H 3 C N N H H O Cl Cl S O O CH 3 IC50 = 93.0 nM 469.43 CN1CCCN([C@H]2Cc3c(Cl)cc(Cl)cc3[C@@H]2Oc2ccc(S(C)(=O)=O)cc2)CC1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3909954 OBDepict Cl H O H N Cl N H 3 C N CH 3 N IC50 = 94.0 nM 443.38 Cc1nnc(C)n1-c1ccc(O[C@H]2c3cc(Cl)ccc3C[C@@H]2N2CCCC2)c(Cl)c1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3946706 OBDepict CH 3 N N N H 3 C O F F F H H N IC50 = 118.0 nM 442.49 Cc1nnc(C)n1-c1ccc(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)c(C(F)(F)F)c1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3977928 OBDepict Cl O Cl S H O O NH 2 H N IC50 = 123.0 nM 427.35 NS(=O)(=O)c1ccc(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)c(Cl)c1Cl Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3906332 OBDepict F Cl H O H N NH S O O CH 3 IC50 = 123.0 nM 424.93 CS(=O)(=O)c1ccc(O[C@H]2c3cc(F)cc(Cl)c3C[C@@H]2N2CCNCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3925415 OBDepict Cl Cl H O H N NH S O O CH 3 IC50 = 135.0 nM 441.38 CS(=O)(=O)c1ccc(O[C@H]2c3c(Cl)cc(Cl)cc3C[C@@H]2N2CCNCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3942095 OBDepict Cl Cl H O H N H F S O O CH 3 IC50 = 166.0 nM 444.36 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CC[C@@H](F)C2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3934310 OBDepict Cl F H O H N NH S O O CH 3 IC50 = 168.0 nM 424.93 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(F)c3C[C@@H]2N2CCNCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3924446 OBDepict CH 3 O H 3 C N H H N CH 3 N CH 3 N IC50 = 170.0 nM 402.54 Cc1c(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)ccc(-n2c(C)nnc2C)c1C Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3985610 OBDepict CH 3 N O N O H H N IC50 = 197.0 nM 375.47 Cn1ccn(-c2cccc(O[C@H]3c4ccccc4C[C@@H]3N3CCCC3)c2)c1=O Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3966292 OBDepict H 3 C N H H N H H O Cl Cl S O O CH 3 IC50 = 241.0 nM 481.45 CN1C[C@H]2CN([C@H]3Cc4c(Cl)cc(Cl)cc4[C@@H]3Oc3ccc(S(C)(=O)=O)cc3)C[C@H]2C1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3965126 OBDepict H 3 C N N N O H H N IC50 = 272.0 nM 400.53 Cc1nnc(C2CC2)n1-c1ccc(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3957418 OBDepict H N O N O H H N IC50 = 281.0 nM 361.44 O=c1[nH]ccn1-c1cccc(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)c1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3962659 OBDepict NH 2 HN O O H H N H NH 2 IC50 = 330.0 nM 366.47 NC(=O)Nc1cccc(O[C@H]2c3ccccc3C[C@@H]2N2CCC[C@@H](N)C2)c1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3956951 OBDepict H 3 C N N N CH 3 O H H N IC50 = 345.0 nM 374.49 Cc1nnc(C)n1-c1ccc(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3959535 OBDepict Cl Cl H O H N H OH S O O CH 3 IC50 = 384.0 nM 442.36 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CC[C@H](O)C2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3900887 OBDepict H 3 C O N CH 3 O H H N IC50 = 411.0 nM 374.48 Cc1noc(C)c1-c1ccc(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3892592 OBDepict CH 3 HN O O H H N IC50 = 438.0 nM 336.43 CC(=O)Nc1cccc(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)c1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3935176 OBDepict CH 3 HN O O H H N H NH 2 IC50 = 440.0 nM 365.48 CC(=O)Nc1cccc(O[C@H]2c3ccccc3C[C@@H]2N2CCC[C@@H](N)C2)c1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3897294 OBDepict CH 3 HN S O O Cl Cl O H H N IC50 = 475.0 nM 441.38 CNS(=O)(=O)c1ccc(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)c(Cl)c1Cl Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3986104 OBDepict H N H O S O O NH 2 IC50 = 500.0 nM 358.46 NS(=O)(=O)c1ccc(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3929014 OBDepict Cl H O H N NH S O O CH 3 IC50 = 540.0 nM 406.94 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)ccc3C[C@@H]2N2CCNCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3976954 OBDepict Cl O Cl S H O O CH 3 H N IC50 = 540.0 nM 426.37 CS(=O)(=O)c1ccc(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)c(Cl)c1Cl Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3968418 OBDepict H N H O S O O CH 3 IC50 = 572.0 nM 357.48 CS(=O)(=O)c1ccc(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3896021 OBDepict Cl Cl H O H N H OH S O O CH 3 IC50 = 588.0 nM 442.36 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CC[C@@H](O)C2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3977522 OBDepict H 3 C N N N O H H N IC50 = 640.0 nM 360.46 Cc1nncn1-c1ccc(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3961582 OBDepict Cl O Cl S H O O NH 2 H N H NH 2 IC50 = 650.0 nM 456.4 N[C@@H]1CCCN([C@H]2Cc3ccccc3[C@@H]2Oc2ccc(S(N)(=O)=O)c(Cl)c2Cl)C1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3930910 OBDepict Cl F H O H N S O O CH 3 IC50 = 737.0 nM 409.91 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(F)c3C[C@@H]2N2CCCC2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3939789 OBDepict Cl Cl H O H N H F S O O CH 3 IC50 = 883.0 nM 444.36 CS(=O)(=O)c1ccc(O[C@H]2c3cc(Cl)cc(Cl)c3C[C@@H]2N2CC[C@H](F)C2)cc1 Homo sapiens CHEMBL3861031 cell-based format
CHEMBL3976498 OBDepict O O N O H H N IC50 = 955.0 nM 364.44 O=C1OCCN1c1cccc(O[C@H]2c3ccccc3C[C@@H]2N2CCCC2)c1 Homo sapiens CHEMBL3861031 cell-based format