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P49721 | PSB2_HUMAN | Proteasome subunit beta type-2 (PSMB2)

3D structures mapped by conservation among orthologs

[ Domain: "Proteasome subunits" // Proteasome ]

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[ Alpha Fold Model ] (go)


Known binders annotated in ChEMBL

IC50 table Ki table

molecule_chembl_id structure assay_type relation values units mol_wt smiles organism assay_chembl_id bao_label
CHEMBL64925 OBDepict O N H H O CH 3 H 3 C HN H O CH 3 CH 3 N H H O O H 3 C CH 3 Ki = 1.0 nM 475.63 CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 Homo sapiens CHEMBL4185005 single protein format
CHEMBL210439 OBDepict H 3 C O O N H H O CH 3 CH 3 NH H O NH H O H 2 N CH 3 CH 3 O CH 3 OH IC50 = 20.0 nM 546.67 CCOC(=O)/C=C/[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)c1cccc(O)c1C)C(C)C Homo sapiens CHEMBL869329 single protein format
CHEMBL371405 OBDepict Cl H O NH H 3 C O O OH H H IC50 = 28.0 nM 313.78 C[C@@]12OC(=O)[C@]1([C@@H](O)[C@@H]1C=CCCC1)NC(=O)[C@@H]2CCCl Homo sapiens CHEMBL2184803 single protein format
CHEMBL4297468 OBDepict CH 3 O HO H NH H NH O O H N H CH 3 H O CH 3 O O N O IC50 = 28.0 nM 586.69 COc1ccc([C@@H](O)[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](CC2=CCCC2)C(=O)[C@@]2(C)CO2)cc1 Homo sapiens CHEMBL4403373 single protein format
CHEMBL2141296 OBDepict OH B HO NH H O H 3 C H 3 C HN O Cl Cl IC50 = 30.0 nM 361.03 CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O Homo sapiens CHEMBL4403373 single protein format
CHEMBL208162 OBDepict H 3 C O O N H H O CH 3 CH 3 NH H O N H H O H 2 N O H 3 C OH IC50 = 32.0 nM 594.71 CCOC(=O)/C=C/[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc(O)c1C Homo sapiens CHEMBL869329 single protein format
CHEMBL207774 OBDepict CH 3 O O N H H O H 3 C CH 3 HN H O HN H O NH 2 CH 3 H 3 C O NH 2 H IC50 = 42.0 nM 559.71 CCOC(=O)/C=C/[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C Homo sapiens CHEMBL869329 single protein format
CHEMBL64925 OBDepict O N H H O CH 3 H 3 C HN H O CH 3 CH 3 N H H O O H 3 C CH 3 IC50 = 52.0 nM 475.63 CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 Homo sapiens CHEMBL3804706 single protein format
CHEMBL210091 OBDepict CH 3 O O NH H O CH 3 H 3 C N H H O N H H O H 2 N H 3 C CH 3 O NH 2 H OH IC50 = 83.0 nM 575.71 CCOC(=O)/C=C/[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C Homo sapiens CHEMBL869329 single protein format
CHEMBL4075225 OBDepict CH 3 CH 3 B HN H HO HO O NH H N H O IC50 = 150.0 nM 461.37 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)NCc1ccc2ccccc2c1)B(O)O Homo sapiens CHEMBL4042188 cell-based format
CHEMBL207990 OBDepict H 3 C H 3 C H NH H HN O O H N H HO CH 3 H N H O CH 3 H CH 3 H 3 C O CH 3 H O CH 3 O CH 3 H 3 C IC50 = 160.0 nM 554.73 CC[C@H](C)[C@H](NC(=O)[C@H]([C@@H](C)CC)N(C)C(C)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1)[C@@H](C)O Homo sapiens CHEMBL861974 single protein format
CHEMBL4068221 OBDepict H 3 C CH 3 B N H H HO OH O HN H N O CH 3 IC50 = 190.0 nM 425.34 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)N(C)Cc1ccccc1)B(O)O Homo sapiens CHEMBL4042188 cell-based format
CHEMBL4076838 OBDepict H 3 C CH 3 B NH H OH OH O HN H N H O + N O _ O IC50 = 190.0 nM 456.31 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)NCc1cccc([N+](=O)[O-])c1)B(O)O Homo sapiens CHEMBL4042188 cell-based format
CHEMBL2326539 OBDepict HO N H H HN O O H N H H H 3 C CH 3 S O O O CH 3 H 3 C OH H 2 N IC50 = 200.0 nM 574.7 Cc1c(O)cccc1C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](/C=C/S(C)(=O)=O)Cc1ccc(CN)cc1)C(C)C Homo sapiens CHEMBL2327093 cell-based format
CHEMBL3099640 OBDepict O O N N IC50 = 200.0 nM 518.79 c1cc(C2(c3ccc(OCCN4CCCCCC4)cc3)CCCCC2)ccc1OCCN1CCCCCC1 Homo sapiens CHEMBL3100303 single protein format
CHEMBL4128074 OBDepict H 3 C CH 3 N H H N H O O H N H H S O O F O CH 3 H 3 C NH NH 2 H NH H 2 N IC50 = 250.0 nM 599.77 CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)CS(=O)(=O)F Homo sapiens CHEMBL4123721 single protein format
CHEMBL4282642 OBDepict CH 3 H 3 C H H O O H NH O N H O H O O CH 3 H 3 C IC50 = 261.0 nM 418.49 CC[C@H](C)[C@@H]1C(=O)O[C@H]1C(=O)NCC(=O)N[C@H](C(=O)OCc1ccccc1)C(C)C Homo sapiens CHEMBL4275390 assay format
CHEMBL3099622 OBDepict CH 3 O O N N IC50 = 280.0 nM 580.86 CCCC(=C(c1ccc(OCCN2CCCCCC2)cc1)c1ccc(OCCN2CCCCCC2)cc1)c1ccccc1 Homo sapiens CHEMBL3100303 single protein format
CHEMBL3099618 OBDepict CH 3 O O N N IC50 = 340.0 nM 566.83 CCC(=C(c1ccc(OCCN2CCCCCC2)cc1)c1ccc(OCCN2CCCCCC2)cc1)c1ccccc1 Homo sapiens CHEMBL3100303 single protein format
CHEMBL4077037 OBDepict H 3 C CH 3 B N H H HO OH O N H H NH O H 3 C CH 3 IC50 = 340.0 nM 439.37 Cc1cccc(CNC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(C)C)B(O)O)c1C Homo sapiens CHEMBL4042188 cell-based format
CHEMBL4100727 OBDepict CH 3 CH 3 B HN H HO HO O NH H N H O F F IC50 = 340.0 nM 447.29 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)NCc1ccc(F)c(F)c1)B(O)O Homo sapiens CHEMBL4042188 cell-based format
CHEMBL3099623 OBDepict H 3 C O O N N IC50 = 360.0 nM 552.8 CC(=C(c1ccc(OCCN2CCCCCC2)cc1)c1ccc(OCCN2CCCCCC2)cc1)c1ccccc1 Homo sapiens CHEMBL3100303 single protein format
CHEMBL4793363 OBDepict CH 3 H 3 C N H H N H O O H N H H O NH O H 3 C CH 3 O O H 3 C CH 3 IC50 = 381.4 nM 594.75 CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)C(=O)Nc1ccccc1 Homo sapiens CHEMBL4739047 tissue-based format
CHEMBL4584892 OBDepict CH 3 H 3 C N H H HN O O H NH H O N H O CH 3 CH 3 O O H 3 C CH 3 H 3 C H 3 C IC50 = 430.0 nM 574.76 CC(C)CNC(=O)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 Homo sapiens CHEMBL4399425 assay format
CHEMBL4127967 OBDepict H 2 N N H H S O O F O N H H O H 3 C CH 3 N H H O CH 3 H 3 C H 2 N H IC50 = 470.0 nM 571.76 CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)CS(=O)(=O)F Homo sapiens CHEMBL4123721 single protein format
CHEMBL4749207 OBDepict CH 3 CH 3 B HN H HO HO O N H H O OH Ki = 487.0 nM 412.3 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(O)cc1)B(O)O Homo sapiens CHEMBL4682123 single protein format
CHEMBL4091983 OBDepict CH 3 CH 3 B HN H HO HO O NH H N H O Cl Cl IC50 = 530.0 nM 480.2 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)NCc1cc(Cl)ccc1Cl)B(O)O Homo sapiens CHEMBL4042188 cell-based format
CHEMBL325041 OBDepict H 3 C CH 3 B NH H OH OH O N H H O N N IC50 = 590.0 nM 384.25 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O Homo sapiens CHEMBL2184803 single protein format
CHEMBL4080306 OBDepict H 3 C CH 3 B NH H OH OH O HN H N H O H 3 C H IC50 = 610.0 nM 425.34 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)N[C@H](C)c1ccccc1)B(O)O Homo sapiens CHEMBL4042188 cell-based format
CHEMBL4749207 OBDepict CH 3 CH 3 B HN H HO HO O N H H O OH IC50 = 680.0 nM 412.3 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccc(O)cc1)B(O)O Homo sapiens CHEMBL4682116 single protein format
CHEMBL3099624 OBDepict N O O N IC50 = 690.0 nM 538.78 C(=C(c1ccc(OCCN2CCCCCC2)cc1)c1ccc(OCCN2CCCCCC2)cc1)c1ccccc1 Homo sapiens CHEMBL3100303 single protein format
CHEMBL4130258 OBDepict H 2 N N H H S O O F O N H H O H 3 C CH 3 N H H O CH 3 H 3 C N H + N _ N IC50 = 700.0 nM 597.76 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)CS(=O)(=O)F Homo sapiens CHEMBL4123721 single protein format
CHEMBL4282576 OBDepict CH 3 H 3 C H H O O H N H O H HN O O H O O H 3 C CH 3 IC50 = 759.0 nM 538.64 CC[C@H](C)[C@@H]1C(=O)O[C@H]1C(=O)N[C@@H](COCc1ccccc1)C(=O)N[C@H](C(=O)OCc1ccccc1)C(C)C Homo sapiens CHEMBL4275390 assay format
CHEMBL3099635 OBDepict CH 2 O O N N IC50 = 880.0 nM 462.68 C=C(c1ccc(OCCN2CCCCCC2)cc1)c1ccc(OCCN2CCCCCC2)cc1 Homo sapiens CHEMBL3100303 single protein format
CHEMBL2326272 OBDepict OH N H H N H O O H N H H O H 3 C CH 3 H 3 C O O HN CH 3 NH H 2 N OH IC50 = 900.0 nM 534.61 Cc1c(O)cccc1C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)[C@@]1(C)CO1)C(C)C Homo sapiens CHEMBL2327093 cell-based format
CHEMBL3237875 OBDepict CH 3 O N H H HN O O H N H CH 3 H O H 3 C O O N O IC50 = 930.0 nM 580.68 COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1 Homo sapiens CHEMBL3997515 assay format
CHEMBL3099631 OBDepict CH 3 O O N N CH 3 IC50 = 960.0 nM 518.79 CCC(CC)=C(c1ccc(OCCN2CCCCCC2)cc1)c1ccc(OCCN2CCCCCC2)cc1 Homo sapiens CHEMBL3100303 single protein format
CHEMBL3099636 OBDepict N O O N IC50 = 990.0 nM 450.67 c1cc(OCCN2CCCCCC2)ccc1Cc1ccc(OCCN2CCCCCC2)cc1 Homo sapiens CHEMBL3100303 single protein format